YDR447C / RPS17B

Ribosomal protein 51 (rp51) of the small (40s) subunit; homologous to mammalian ribosomal protein S17, no bacterial homolog; RPS17B has a paralog, RPS17A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR447C / RPS17B

Click on Significant Values for Screen Details ID:SGTC_15|Compound:0266-0086|FD-Score:4.23|P-value:2.36E-5 ID:SGTC_114|Compound:0364-0001|FD-Score:4.69|P-value:3.23E-6 ID:SGTC_118|Compound:0083-0097|FD-Score:4.99|P-value:8.01E-7 ID:SGTC_314|Compound:1671-0008|FD-Score:-3.97|P-value:9.56E-5 ID:SGTC_327|Compound:1273-0057|FD-Score:-3.86|P-value:1.44E-4 ID:SGTC_337|Compound:1315-0038|FD-Score:4.92|P-value:1.13E-6 ID:SGTC_364|Compound:0083-0097|FD-Score:5.84|P-value:1.06E-8 ID:SGTC_371|Compound:0195-0006|FD-Score:4.85|P-value:1.60E-6 ID:SGTC_500|Compound:h-89|FD-Score:-3.30|P-value:9.79E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.87|P-value:1.38E-4 ID:SGTC_547|Compound:1120-0019|FD-Score:-4.52|P-value:1.04E-5 ID:SGTC_553|Compound:k007-0256|FD-Score:-3.51|P-value:4.95E-4 ID:SGTC_561|Compound:1550-0330|FD-Score:-3.99|P-value:8.86E-5 ID:SGTC_702|Compound:1488-0190|FD-Score:-3.34|P-value:8.52E-4 ID:SGTC_707|Compound:0865-0008|FD-Score:4.39|P-value:1.20E-5 ID:SGTC_778|Compound:3456-2434|FD-Score:-5.77|P-value:2.57E-8 ID:SGTC_791|Compound:1348-1292|FD-Score:8.21|P-value:1.90E-15 ID:SGTC_1000|Compound:4048-0884|FD-Score:3.97|P-value:6.70E-5 ID:SGTC_1035|Compound:k081-0041|FD-Score:-3.31|P-value:9.59E-4 ID:SGTC_1175|Compound:0741-0056|FD-Score:3.55|P-value:3.08E-4 ID:SGTC_1369|Compound:1866-0067|FD-Score:4.39|P-value:1.23E-5 ID:SGTC_1419|Compound:3993-2473|FD-Score:3.63|P-value:2.30E-4 ID:SGTC_1522|Compound:st012842|FD-Score:-3.32|P-value:9.32E-4 ID:SGTC_1635|Compound:st007035|FD-Score:-4.28|P-value:2.79E-5 ID:SGTC_1636|Compound:st007707|FD-Score:4.91|P-value:1.20E-6 ID:SGTC_1669|Compound:st015249|FD-Score:3.47|P-value:4.02E-4 ID:SGTC_1885|Compound:st057546|FD-Score:3.84|P-value:1.10E-4 ID:SGTC_2021|Compound:4019055|FD-Score:-3.42|P-value:6.72E-4 ID:SGTC_2066|Compound:5222451|FD-Score:3.82|P-value:1.18E-4 ID:SGTC_2070|Compound:5230947|FD-Score:3.24|P-value:8.67E-4 ID:SGTC_2125|Compound:5246583|FD-Score:4.37|P-value:1.28E-5 ID:SGTC_2308|Compound:7584454|FD-Score:-3.37|P-value:7.81E-4 ID:SGTC_2340|Compound:7987427|FD-Score:3.66|P-value:2.12E-4 ID:SGTC_2570|Compound:licareol|FD-Score:3.67|P-value:2.03E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-6.53|P-value:3.47E-10 ID:SGTC_2584|Compound:androsterone|FD-Score:-5.41|P-value:1.63E-7 ID:SGTC_2587|Compound:piperic acid|FD-Score:3.98|P-value:6.22E-5 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.50|P-value:3.74E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:-5.23|P-value:4.12E-7 ID:SGTC_2688|Compound:kanamycin b|FD-Score:7.09|P-value:5.34E-12 ID:SGTC_2724|Compound:maprotiline|FD-Score:-4.17|P-value:4.41E-5 ID:SGTC_2794|Compound:7785382|FD-Score:-6.06|P-value:5.13E-9 ID:SGTC_2823|Compound:7987624|FD-Score:-5.44|P-value:1.42E-7 ID:SGTC_2941|Compound:9056145|FD-Score:-3.97|P-value:9.44E-5 ID:SGTC_2987|Compound:9018338|FD-Score:3.21|P-value:9.61E-4 ID:SGTC_3210|Compound:9128157|FD-Score:-3.51|P-value:4.96E-4 ID:SGTC_15|Compound:0266-0086|FD-Score:4.23|P-value:2.36E-5 ID:SGTC_114|Compound:0364-0001|FD-Score:4.69|P-value:3.23E-6 ID:SGTC_118|Compound:0083-0097|FD-Score:4.99|P-value:8.01E-7 ID:SGTC_314|Compound:1671-0008|FD-Score:-3.97|P-value:9.56E-5 ID:SGTC_327|Compound:1273-0057|FD-Score:-3.86|P-value:1.44E-4 ID:SGTC_337|Compound:1315-0038|FD-Score:4.92|P-value:1.13E-6 ID:SGTC_364|Compound:0083-0097|FD-Score:5.84|P-value:1.06E-8 ID:SGTC_371|Compound:0195-0006|FD-Score:4.85|P-value:1.60E-6 ID:SGTC_500|Compound:h-89|FD-Score:-3.30|P-value:9.79E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.87|P-value:1.38E-4 ID:SGTC_547|Compound:1120-0019|FD-Score:-4.52|P-value:1.04E-5 ID:SGTC_553|Compound:k007-0256|FD-Score:-3.51|P-value:4.95E-4 ID:SGTC_561|Compound:1550-0330|FD-Score:-3.99|P-value:8.86E-5 ID:SGTC_702|Compound:1488-0190|FD-Score:-3.34|P-value:8.52E-4 ID:SGTC_707|Compound:0865-0008|FD-Score:4.39|P-value:1.20E-5 ID:SGTC_778|Compound:3456-2434|FD-Score:-5.77|P-value:2.57E-8 ID:SGTC_791|Compound:1348-1292|FD-Score:8.21|P-value:1.90E-15 ID:SGTC_1000|Compound:4048-0884|FD-Score:3.97|P-value:6.70E-5 ID:SGTC_1035|Compound:k081-0041|FD-Score:-3.31|P-value:9.59E-4 ID:SGTC_1175|Compound:0741-0056|FD-Score:3.55|P-value:3.08E-4 ID:SGTC_1369|Compound:1866-0067|FD-Score:4.39|P-value:1.23E-5 ID:SGTC_1419|Compound:3993-2473|FD-Score:3.63|P-value:2.30E-4 ID:SGTC_1522|Compound:st012842|FD-Score:-3.32|P-value:9.32E-4 ID:SGTC_1635|Compound:st007035|FD-Score:-4.28|P-value:2.79E-5 ID:SGTC_1636|Compound:st007707|FD-Score:4.91|P-value:1.20E-6 ID:SGTC_1669|Compound:st015249|FD-Score:3.47|P-value:4.02E-4 ID:SGTC_1885|Compound:st057546|FD-Score:3.84|P-value:1.10E-4 ID:SGTC_2021|Compound:4019055|FD-Score:-3.42|P-value:6.72E-4 ID:SGTC_2066|Compound:5222451|FD-Score:3.82|P-value:1.18E-4 ID:SGTC_2070|Compound:5230947|FD-Score:3.24|P-value:8.67E-4 ID:SGTC_2125|Compound:5246583|FD-Score:4.37|P-value:1.28E-5 ID:SGTC_2308|Compound:7584454|FD-Score:-3.37|P-value:7.81E-4 ID:SGTC_2340|Compound:7987427|FD-Score:3.66|P-value:2.12E-4 ID:SGTC_2570|Compound:licareol|FD-Score:3.67|P-value:2.03E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-6.53|P-value:3.47E-10 ID:SGTC_2584|Compound:androsterone|FD-Score:-5.41|P-value:1.63E-7 ID:SGTC_2587|Compound:piperic acid|FD-Score:3.98|P-value:6.22E-5 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.50|P-value:3.74E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:-5.23|P-value:4.12E-7 ID:SGTC_2688|Compound:kanamycin b|FD-Score:7.09|P-value:5.34E-12 ID:SGTC_2724|Compound:maprotiline|FD-Score:-4.17|P-value:4.41E-5 ID:SGTC_2794|Compound:7785382|FD-Score:-6.06|P-value:5.13E-9 ID:SGTC_2823|Compound:7987624|FD-Score:-5.44|P-value:1.42E-7 ID:SGTC_2941|Compound:9056145|FD-Score:-3.97|P-value:9.44E-5 ID:SGTC_2987|Compound:9018338|FD-Score:3.21|P-value:9.61E-4 ID:SGTC_3210|Compound:9128157|FD-Score:-3.51|P-value:4.96E-4

Top fitness defect scores for YDR447C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_791 1348-1292 8.21 225.0 µM 1.90E-15 4 1.07E-16
2 SGTC_2688 kanamycin b 7.09 96.7 µM 5.34E-12 calcium & mitochondrial duress 104 6.47E-13
3 SGTC_364 0083-0097 5.84 67.7 µM 1.06E-8 7 2.64E-9
4 SGTC_118 0083-0097 4.99 135.3 µM 8.01E-7 translation 58 2.95E-7
5 SGTC_337 1315-0038 4.92 354.0 µM 1.13E-6 amide catabolism 17 4.29E-7
6 SGTC_1636 st007707 4.91 68.9 µM 1.20E-6 29 4.60E-7
7 SGTC_371 0195-0006 4.85 7.4 µM 1.60E-6 7 6.28E-7
8 SGTC_114 0364-0001 4.69 490.3 µM 3.23E-6 23 1.35E-6
9 SGTC_707 0865-0008 4.39 204.0 µM 1.20E-5 DNA damage response 1 5.61E-6
10 SGTC_1369 1866-0067 4.39 208.0 µM 1.23E-5 RPP1 & pyrimidine depletion 29 5.77E-6
11 SGTC_2125 5246583 4.37 200.0 µM 1.28E-5 tubulin folding & SWR complex 35 6.07E-6
12 SGTC_15 0266-0086 4.23 27.1 µM 2.36E-5 endomembrane recycling 51 1.18E-5
13 SGTC_2587 piperic acid 3.98 92.2 µM 6.22E-5 24 3.37E-5
14 SGTC_1000 4048-0884 3.97 8.7 µM 6.70E-5 copper-dependent oxidative stress 31 3.66E-5
15 SGTC_1885 st057546 3.84 99.9 µM 1.10E-4 25 6.26E-5
16 SGTC_2066 5222451 3.82 176.0 µM 1.18E-4 heme biosynthesis & mitochondrial translocase 33 6.79E-5
17 SGTC_2570 licareol 3.67 100.0 µM 2.03E-4 40 1.22E-4
18 SGTC_2340 7987427 3.66 183.4 µM 2.12E-4 47 1.28E-4
19 SGTC_1419 3993-2473 3.63 62.6 µM 2.30E-4 27 1.40E-4
20 SGTC_1175 0741-0056 3.55 27.6 µM 3.08E-4 35 1.92E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.224 3.04E-39 YLR367W RPS22B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22B has a paralog, RPS22A, that arose from the whole genome duplication
0.196 2.52E-30 YBR048W RPS11B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S11 and bacterial S17; RPS11B has a paralog, RPS11A, that arose from the whole genome duplication
0.180 5.78E-26 YPL125W KAP120 hom Karyopherin responsible for the nuclear import of ribosome maturation factor Rfp1p
0.173 4.55E-24 YGR214W RPS0A hom Ribosomal 40S subunit protein S0A; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2; RPS0A has a paralog, RPS0B, that arose from the whole genome duplication;
0.172 8.75E-24 YLR061W RPL22A hom Ribosomal 60S subunit protein L22A; required for the oxidative stress response in yeast; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22A has a paralog, RPL22B, that arose from the whole genome duplication
0.172 1.32E-23 YDL081C RPP1A hom Ribosomal stalk protein P1 alpha, involved in the interaction between translational elongation factors and the ribosome; accumulation of P1 in the cytoplasm is regulated by phosphorylation and interaction with the P2 stalk component
0.161 5.19E-21 YLR048W RPS0B hom Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2
0.155 2.13E-19 YDR500C RPL37B hom Ribosomal 60S subunit protein L37B; protein abundance increases in response to DNA replication stress; homologous to mammalian ribosomal protein L37, no bacterial homolog; RPL37B has a paralog, RPL37A, that arose from the whole genome duplication
0.150 1.90E-18 YOR085W OST3 hom Gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins
0.147 1.21E-17 YGR160W_d YGR160W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.136 2.04E-15 YLL045C RPL8B hom Ribosomal 60S subunit protein L8B; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8B has a paralog, RPL8A, that arose from the whole genome duplication
0.135 4.30E-15 YDR024W_d FYV1_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; mutation decreases survival upon exposure to K1 killer toxin
0.134 7.91E-15 YBR191W RPL21A hom Ribosomal 60S subunit protein L21A; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21A has a paralog, RPL21B, that arose from the whole genome duplication
0.128 9.70E-14 YGL236C MTO1 hom Mitochondrial protein, forms a heterodimer complex with Mss1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; required for respiration in paromomycin-resistant 15S rRNA mutants
0.128 9.97E-14 YLR264C-A_p YLR264C-A_p hom Putative protein of unknown function