YDR452W / PPN1

Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer; relocalizes from vacuole to cytoplasm upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR452W / PPN1

Click on Significant Values for Screen Details ID:SGTC_56|Compound:0957-0365|FD-Score:-3.53|P-value:4.00E-4 ID:SGTC_122|Compound:0236-0016|FD-Score:3.58|P-value:6.57E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:5.13|P-value:1.69E-6 ID:SGTC_249|Compound:wiskostatin|FD-Score:-4.39|P-value:1.68E-5 ID:SGTC_560|Compound:2332-1943|FD-Score:3.45|P-value:9.92E-4 ID:SGTC_572|Compound:0960-0087|FD-Score:4.29|P-value:5.32E-5 ID:SGTC_573|Compound:3702-0553|FD-Score:3.97|P-value:1.76E-4 ID:SGTC_716|Compound:1683-5115|FD-Score:-3.25|P-value:9.75E-4 ID:SGTC_739|Compound:1486-1183|FD-Score:-3.50|P-value:4.39E-4 ID:SGTC_763|Compound:3453-1109|FD-Score:-5.62|P-value:6.01E-8 ID:SGTC_766|Compound:1391-0721|FD-Score:-4.95|P-value:1.50E-6 ID:SGTC_822|Compound:1487-0950|FD-Score:-4.42|P-value:1.48E-5 ID:SGTC_865|Compound:0488-0499|FD-Score:-4.50|P-value:1.05E-5 ID:SGTC_1046|Compound:2001-0062|FD-Score:3.45|P-value:9.89E-4 ID:SGTC_1088|Compound:bifonazole|FD-Score:-3.47|P-value:4.85E-4 ID:SGTC_1270|Compound:0831-1170|FD-Score:-3.80|P-value:1.58E-4 ID:SGTC_1508|Compound:1080-0625|FD-Score:-3.53|P-value:3.96E-4 ID:SGTC_1924|Compound:st058459|FD-Score:-3.45|P-value:5.16E-4 ID:SGTC_2107|Compound:5363541|FD-Score:-3.59|P-value:3.21E-4 ID:SGTC_2167|Compound:5876490|FD-Score:-4.50|P-value:1.03E-5 ID:SGTC_2176|Compound:5809774|FD-Score:-3.48|P-value:4.60E-4 ID:SGTC_2430|Compound:5571206|FD-Score:-6.34|P-value:1.27E-9 ID:SGTC_2435|Compound:5706476|FD-Score:-5.65|P-value:5.30E-8 ID:SGTC_2550|Compound:chrysin dimethyl ether|FD-Score:-3.62|P-value:2.91E-4 ID:SGTC_2762|Compound:leflunomide|FD-Score:3.72|P-value:4.12E-4 ID:SGTC_2763|Compound:lisinopril|FD-Score:-4.39|P-value:1.63E-5 ID:SGTC_2770|Compound:toltrazuril|FD-Score:-4.35|P-value:1.92E-5 ID:SGTC_2861|Compound:9024595|FD-Score:-4.64|P-value:5.96E-6 ID:SGTC_2866|Compound:9034245|FD-Score:-3.82|P-value:1.44E-4 ID:SGTC_2935|Compound:9038016|FD-Score:-3.79|P-value:1.61E-4 ID:SGTC_3018|Compound:9082602|FD-Score:-3.32|P-value:7.87E-4 ID:SGTC_3336|Compound:9143619|FD-Score:-3.47|P-value:4.89E-4 ID:SGTC_3342|Compound:9147791|FD-Score:-3.32|P-value:7.84E-4 ID:SGTC_56|Compound:0957-0365|FD-Score:-3.53|P-value:4.00E-4 ID:SGTC_122|Compound:0236-0016|FD-Score:3.58|P-value:6.57E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:5.13|P-value:1.69E-6 ID:SGTC_249|Compound:wiskostatin|FD-Score:-4.39|P-value:1.68E-5 ID:SGTC_560|Compound:2332-1943|FD-Score:3.45|P-value:9.92E-4 ID:SGTC_572|Compound:0960-0087|FD-Score:4.29|P-value:5.32E-5 ID:SGTC_573|Compound:3702-0553|FD-Score:3.97|P-value:1.76E-4 ID:SGTC_716|Compound:1683-5115|FD-Score:-3.25|P-value:9.75E-4 ID:SGTC_739|Compound:1486-1183|FD-Score:-3.50|P-value:4.39E-4 ID:SGTC_763|Compound:3453-1109|FD-Score:-5.62|P-value:6.01E-8 ID:SGTC_766|Compound:1391-0721|FD-Score:-4.95|P-value:1.50E-6 ID:SGTC_822|Compound:1487-0950|FD-Score:-4.42|P-value:1.48E-5 ID:SGTC_865|Compound:0488-0499|FD-Score:-4.50|P-value:1.05E-5 ID:SGTC_1046|Compound:2001-0062|FD-Score:3.45|P-value:9.89E-4 ID:SGTC_1088|Compound:bifonazole|FD-Score:-3.47|P-value:4.85E-4 ID:SGTC_1270|Compound:0831-1170|FD-Score:-3.80|P-value:1.58E-4 ID:SGTC_1508|Compound:1080-0625|FD-Score:-3.53|P-value:3.96E-4 ID:SGTC_1924|Compound:st058459|FD-Score:-3.45|P-value:5.16E-4 ID:SGTC_2107|Compound:5363541|FD-Score:-3.59|P-value:3.21E-4 ID:SGTC_2167|Compound:5876490|FD-Score:-4.50|P-value:1.03E-5 ID:SGTC_2176|Compound:5809774|FD-Score:-3.48|P-value:4.60E-4 ID:SGTC_2430|Compound:5571206|FD-Score:-6.34|P-value:1.27E-9 ID:SGTC_2435|Compound:5706476|FD-Score:-5.65|P-value:5.30E-8 ID:SGTC_2550|Compound:chrysin dimethyl ether|FD-Score:-3.62|P-value:2.91E-4 ID:SGTC_2762|Compound:leflunomide|FD-Score:3.72|P-value:4.12E-4 ID:SGTC_2763|Compound:lisinopril|FD-Score:-4.39|P-value:1.63E-5 ID:SGTC_2770|Compound:toltrazuril|FD-Score:-4.35|P-value:1.92E-5 ID:SGTC_2861|Compound:9024595|FD-Score:-4.64|P-value:5.96E-6 ID:SGTC_2866|Compound:9034245|FD-Score:-3.82|P-value:1.44E-4 ID:SGTC_2935|Compound:9038016|FD-Score:-3.79|P-value:1.61E-4 ID:SGTC_3018|Compound:9082602|FD-Score:-3.32|P-value:7.87E-4 ID:SGTC_3336|Compound:9143619|FD-Score:-3.47|P-value:4.89E-4 ID:SGTC_3342|Compound:9147791|FD-Score:-3.32|P-value:7.84E-4

Top fitness defect scores for YDR452W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_129 0088-0017 5.13 176.6 µM 1.69E-6 39 1.48E-7
2 SGTC_572 0960-0087 4.29 17.7 µM 5.32E-5 20 8.83E-6
3 SGTC_573 3702-0553 3.97 84.7 µM 1.76E-4 14 3.66E-5
4 SGTC_2762 leflunomide 3.72 42.1 µM 4.12E-4 42 1.00E-4
5 SGTC_122 0236-0016 3.58 402.4 µM 6.57E-4 RNA processing & uracil transport 51 1.75E-4
6 SGTC_1046 2001-0062 3.45 216.0 µM 9.89E-4 34 2.84E-4
7 SGTC_560 2332-1943 3.45 155.0 µM 9.92E-4 23 2.85E-4
8 SGTC_2429 5902844 3.44 64.4 µM 0.00102 51 2.94E-4
9 SGTC_771 0250-0039 3.38 27.3 µM 0.00120 26 3.58E-4
10 SGTC_1819 st053448 3.38 58.6 µM 0.00121 amide catabolism 37 3.61E-4
11 SGTC_1782 st039423 3.25 80.6 µM 0.00179 51 5.73E-4
12 SGTC_583 1488-1091 3.23 88.9 µM 0.00190 46 6.18E-4
13 SGTC_363 0455-0021 3.05 3.1 µM 0.00320 azole & statin 123 0.00114
14 SGTC_3135 9127742 3.05 49.5 µM 0.00322 50 0.00115
15 SGTC_79 0052-0007 3.01 94.1 µM 0.00358 75 0.00131
16 SGTC_3302 9125395 2.96 16.4 µM 0.00405 52 0.00152
17 SGTC_2868 9035608 2.96 32.5 µM 0.00411 57 0.00154
18 SGTC_362 0310-0100 2.91 9.0 µM 0.00476 RPP1 & pyrimidine depletion 89 0.00183
19 SGTC_574 1315-0397 2.89 40.0 µM 0.00498 110 0.00194
20 SGTC_1378 2093-0007 2.86 380.0 nM 0.00540 79 0.00213

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.270 2.75E-57 YMR040W YET2 hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein
0.261 3.08E-53 YLR084C RAX2 hom N-glycosylated protein involved in the maintenance of bud site selection during bipolar budding; localization requires Rax1p; RAX2 mRNA stability is regulated by Mpt5p
0.248 3.97E-48 YMR026C PEX12 hom C3HC4-type RING-finger peroxin and E3 ubiquitin ligase, required for peroxisome biogenesis and peroxisomal matrix protein import; forms translocation subcomplex with Pex2p and Pex10p; mutations in human homolog cause peroxisomal disorder
0.234 8.57E-43 YMR080C NAM7 hom ATP-dependent RNA helicase of the SFI superfamily; involved in nonsense mediated mRNA decay; required for efficient translation termination at nonsense codons and targeting of NMD substrates to P-bodies; involved in telomere maintenance; forms cytoplasmic foci upon DNA replication stress
0.229 2.84E-41 YGR110W CLD1 hom Mitochondrial cardiolipin-specific phospholipase; functions upstream of Taz1p to generate monolyso-cardiolipin; transcription increases upon genotoxic stress; involved in restricting Ty1 transposition; has homology to mammalian CGI-58
0.220 4.75E-38 YLR328W NMA1 hom Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in pathways of NAD biosynthesis, including the de novo, NAD(+) salvage, and nicotinamide riboside salvage pathways; NMA1 has a paralog, NMA2, that arose from the whole genome duplication
0.196 2.06E-30 YMR031C EIS1 hom Component of the eisosome required for proper eisosome assembly; similarity to Ykl050cp and Uso1p; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; protein increases in abundance and relocalizes from plasma membrane to cytoplasm upon DNA replication stress
0.190 1.63E-28 YPL041C_p YPL041C_p hom Protein of unknown function involved in maintenance of proper telomere length
0.160 9.15E-21 YDR165W TRM82 hom Catalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p
0.149 4.19E-18 YLR354C TAL1 hom Transaldolase, enzyme in the non-oxidative pentose phosphate pathway; converts sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate to erythrose 4-phosphate and fructose 6-phosphate
0.145 2.73E-17 YDL123W SNA4 hom Protein of unknown function, localized to the vacuolar outer membrane; predicted to be palmitoylated
0.141 2.46E-16 YGL125W MET13 hom Major isozyme of methylenetetrahydrofolate reductase, catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway
0.139 7.18E-16 YML005W TRM12 hom S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; required for wybutosine formation in phenylalanine-accepting tRNA
0.132 1.49E-14 YMR304W UBP15 hom Ubiquitin-specific protease involved in protein deubiquitination; catalytic activity regulated by an N-terminal TRAF-like domain and and C-terminal sequences; physically interacts with anaphase-promoting complex/cyclosome (APC/C) activator, Cdh1p; forms a complex with AAA peroxins Pex1p and Pex6p
0.122 1.42E-12 YJL175W_d YJL175W_d hom Dubious open reading frame unlikely to encode a functional protein; deletion confers resistance to cisplatin, hypersensitivity to 5-fluorouracil, and growth defect at high pH with high calcium; overlaps gene for SWI3 transcription factor