YDR454C / GUK1

Guanylate kinase, converts GMP to GDP; required for growth and mannose outer chain elongation of cell wall N-linked glycoproteins

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDR454C / GUK1

Click on Significant Values for Screen Details ID:SGTC_30|Compound:5-(2-thienylidene)-Rhodanine|FD-Score:2.47|P-value:9.26E-4 ID:SGTC_192|Compound:3455-0609|FD-Score:-3.32|P-value:1.24E-5 ID:SGTC_353|Compound:1988-1175|FD-Score:3.17|P-value:3.23E-5 ID:SGTC_396|Compound:dithiazanine|FD-Score:-2.73|P-value:2.58E-4 ID:SGTC_399|Compound:oxolinic acid|FD-Score:-2.49|P-value:7.85E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:-3.91|P-value:3.49E-7 ID:SGTC_413|Compound:propylparaben|FD-Score:-3.36|P-value:1.01E-5 ID:SGTC_427|Compound:1354-0053|FD-Score:-2.56|P-value:5.61E-4 ID:SGTC_480|Compound:am 92016|FD-Score:-2.71|P-value:2.83E-4 ID:SGTC_481|Compound:bay k-8644|FD-Score:-2.64|P-value:3.93E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:3.59|P-value:2.99E-6 ID:SGTC_517|Compound:1365-0151|FD-Score:2.60|P-value:5.42E-4 ID:SGTC_551|Compound:k048-0028|FD-Score:2.71|P-value:3.26E-4 ID:SGTC_725|Compound:1497-0963|FD-Score:2.82|P-value:1.93E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.05|P-value:5.36E-5 ID:SGTC_874|Compound:0599-0792|FD-Score:2.71|P-value:3.22E-4 ID:SGTC_883|Compound:0850-0245|FD-Score:2.53|P-value:7.34E-4 ID:SGTC_900|Compound:1112-0045|FD-Score:-2.51|P-value:7.09E-4 ID:SGTC_1290|Compound:0986-0249|FD-Score:-2.48|P-value:8.00E-4 ID:SGTC_1303|Compound:1160-0052|FD-Score:-2.61|P-value:4.51E-4 ID:SGTC_1311|Compound:1190-0148|FD-Score:-2.62|P-value:4.31E-4 ID:SGTC_1322|Compound:1348-1070|FD-Score:2.75|P-value:2.67E-4 ID:SGTC_1325|Compound:1431-0015|FD-Score:-2.57|P-value:5.46E-4 ID:SGTC_1570|Compound:verbenone|FD-Score:2.60|P-value:5.25E-4 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:2.73|P-value:2.93E-4 ID:SGTC_1635|Compound:st007035|FD-Score:3.39|P-value:1.00E-5 ID:SGTC_1689|Compound:st020265|FD-Score:3.51|P-value:4.93E-6 ID:SGTC_1709|Compound:st033179|FD-Score:-2.52|P-value:6.96E-4 ID:SGTC_1907|Compound:st060210|FD-Score:5.02|P-value:1.24E-10 ID:SGTC_2011|Compound:4012611|FD-Score:2.67|P-value:3.83E-4 ID:SGTC_2096|Compound:5468907|FD-Score:2.61|P-value:5.10E-4 ID:SGTC_2108|Compound:5365811|FD-Score:3.38|P-value:1.03E-5 ID:SGTC_2299|Compound:7976368|FD-Score:-3.43|P-value:6.61E-6 ID:SGTC_2301|Compound:7769476|FD-Score:-2.84|P-value:1.55E-4 ID:SGTC_2302|Compound:7771753|FD-Score:-3.99|P-value:2.07E-7 ID:SGTC_2329|Compound:6138490|FD-Score:3.77|P-value:1.00E-6 ID:SGTC_2332|Compound:7982454|FD-Score:3.22|P-value:2.50E-5 ID:SGTC_2335|Compound:9018011|FD-Score:4.11|P-value:1.13E-7 ID:SGTC_2336|Compound:9001819|FD-Score:3.48|P-value:5.85E-6 ID:SGTC_2340|Compound:7987427|FD-Score:2.59|P-value:5.50E-4 ID:SGTC_2376|Compound:9072922|FD-Score:2.47|P-value:9.29E-4 ID:SGTC_2433|Compound:5607874|FD-Score:-2.78|P-value:2.09E-4 ID:SGTC_2447|Compound:5741742|FD-Score:2.46|P-value:9.76E-4 ID:SGTC_2492|Compound:derrusnin|FD-Score:2.46|P-value:9.80E-4 ID:SGTC_2684|Compound:capsaicin|FD-Score:3.66|P-value:1.96E-6 ID:SGTC_2821|Compound:7996764|FD-Score:2.63|P-value:4.63E-4 ID:SGTC_2823|Compound:7987624|FD-Score:-2.69|P-value:3.12E-4 ID:SGTC_2841|Compound:9004761|FD-Score:-2.63|P-value:4.15E-4 ID:SGTC_2940|Compound:9060638|FD-Score:-5.78|P-value:1.17E-13 ID:SGTC_3029|Compound:9088683|FD-Score:-3.26|P-value:1.79E-5 ID:SGTC_3032|Compound:9089427|FD-Score:2.67|P-value:3.94E-4 ID:SGTC_3035|Compound:9091303|FD-Score:-2.86|P-value:1.43E-4 ID:SGTC_3116|Compound:9124943|FD-Score:-2.58|P-value:5.32E-4 ID:SGTC_3145|Compound:9085516|FD-Score:-2.57|P-value:5.52E-4 ID:SGTC_3148|Compound:9097893|FD-Score:-3.41|P-value:7.71E-6 ID:SGTC_3151|Compound:9099821|FD-Score:-2.91|P-value:1.10E-4 ID:SGTC_3177|Compound:9107506|FD-Score:3.61|P-value:2.74E-6 ID:SGTC_3213|Compound:9129884|FD-Score:-2.73|P-value:2.69E-4 ID:SGTC_3250|Compound:9135583|FD-Score:-2.54|P-value:6.20E-4 ID:SGTC_3283|Compound:9109332|FD-Score:-2.72|P-value:2.73E-4 ID:SGTC_3329|Compound:9141233|FD-Score:2.75|P-value:2.71E-4 ID:SGTC_30|Compound:5-(2-thienylidene)-Rhodanine|FD-Score:2.47|P-value:9.26E-4 ID:SGTC_192|Compound:3455-0609|FD-Score:-3.32|P-value:1.24E-5 ID:SGTC_353|Compound:1988-1175|FD-Score:3.17|P-value:3.23E-5 ID:SGTC_396|Compound:dithiazanine|FD-Score:-2.73|P-value:2.58E-4 ID:SGTC_399|Compound:oxolinic acid|FD-Score:-2.49|P-value:7.85E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:-3.91|P-value:3.49E-7 ID:SGTC_413|Compound:propylparaben|FD-Score:-3.36|P-value:1.01E-5 ID:SGTC_427|Compound:1354-0053|FD-Score:-2.56|P-value:5.61E-4 ID:SGTC_480|Compound:am 92016|FD-Score:-2.71|P-value:2.83E-4 ID:SGTC_481|Compound:bay k-8644|FD-Score:-2.64|P-value:3.93E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:3.59|P-value:2.99E-6 ID:SGTC_517|Compound:1365-0151|FD-Score:2.60|P-value:5.42E-4 ID:SGTC_551|Compound:k048-0028|FD-Score:2.71|P-value:3.26E-4 ID:SGTC_725|Compound:1497-0963|FD-Score:2.82|P-value:1.93E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.05|P-value:5.36E-5 ID:SGTC_874|Compound:0599-0792|FD-Score:2.71|P-value:3.22E-4 ID:SGTC_883|Compound:0850-0245|FD-Score:2.53|P-value:7.34E-4 ID:SGTC_900|Compound:1112-0045|FD-Score:-2.51|P-value:7.09E-4 ID:SGTC_1290|Compound:0986-0249|FD-Score:-2.48|P-value:8.00E-4 ID:SGTC_1303|Compound:1160-0052|FD-Score:-2.61|P-value:4.51E-4 ID:SGTC_1311|Compound:1190-0148|FD-Score:-2.62|P-value:4.31E-4 ID:SGTC_1322|Compound:1348-1070|FD-Score:2.75|P-value:2.67E-4 ID:SGTC_1325|Compound:1431-0015|FD-Score:-2.57|P-value:5.46E-4 ID:SGTC_1570|Compound:verbenone|FD-Score:2.60|P-value:5.25E-4 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:2.73|P-value:2.93E-4 ID:SGTC_1635|Compound:st007035|FD-Score:3.39|P-value:1.00E-5 ID:SGTC_1689|Compound:st020265|FD-Score:3.51|P-value:4.93E-6 ID:SGTC_1709|Compound:st033179|FD-Score:-2.52|P-value:6.96E-4 ID:SGTC_1907|Compound:st060210|FD-Score:5.02|P-value:1.24E-10 ID:SGTC_2011|Compound:4012611|FD-Score:2.67|P-value:3.83E-4 ID:SGTC_2096|Compound:5468907|FD-Score:2.61|P-value:5.10E-4 ID:SGTC_2108|Compound:5365811|FD-Score:3.38|P-value:1.03E-5 ID:SGTC_2299|Compound:7976368|FD-Score:-3.43|P-value:6.61E-6 ID:SGTC_2301|Compound:7769476|FD-Score:-2.84|P-value:1.55E-4 ID:SGTC_2302|Compound:7771753|FD-Score:-3.99|P-value:2.07E-7 ID:SGTC_2329|Compound:6138490|FD-Score:3.77|P-value:1.00E-6 ID:SGTC_2332|Compound:7982454|FD-Score:3.22|P-value:2.50E-5 ID:SGTC_2335|Compound:9018011|FD-Score:4.11|P-value:1.13E-7 ID:SGTC_2336|Compound:9001819|FD-Score:3.48|P-value:5.85E-6 ID:SGTC_2340|Compound:7987427|FD-Score:2.59|P-value:5.50E-4 ID:SGTC_2376|Compound:9072922|FD-Score:2.47|P-value:9.29E-4 ID:SGTC_2433|Compound:5607874|FD-Score:-2.78|P-value:2.09E-4 ID:SGTC_2447|Compound:5741742|FD-Score:2.46|P-value:9.76E-4 ID:SGTC_2492|Compound:derrusnin|FD-Score:2.46|P-value:9.80E-4 ID:SGTC_2684|Compound:capsaicin|FD-Score:3.66|P-value:1.96E-6 ID:SGTC_2821|Compound:7996764|FD-Score:2.63|P-value:4.63E-4 ID:SGTC_2823|Compound:7987624|FD-Score:-2.69|P-value:3.12E-4 ID:SGTC_2841|Compound:9004761|FD-Score:-2.63|P-value:4.15E-4 ID:SGTC_2940|Compound:9060638|FD-Score:-5.78|P-value:1.17E-13 ID:SGTC_3029|Compound:9088683|FD-Score:-3.26|P-value:1.79E-5 ID:SGTC_3032|Compound:9089427|FD-Score:2.67|P-value:3.94E-4 ID:SGTC_3035|Compound:9091303|FD-Score:-2.86|P-value:1.43E-4 ID:SGTC_3116|Compound:9124943|FD-Score:-2.58|P-value:5.32E-4 ID:SGTC_3145|Compound:9085516|FD-Score:-2.57|P-value:5.52E-4 ID:SGTC_3148|Compound:9097893|FD-Score:-3.41|P-value:7.71E-6 ID:SGTC_3151|Compound:9099821|FD-Score:-2.91|P-value:1.10E-4 ID:SGTC_3177|Compound:9107506|FD-Score:3.61|P-value:2.74E-6 ID:SGTC_3213|Compound:9129884|FD-Score:-2.73|P-value:2.69E-4 ID:SGTC_3250|Compound:9135583|FD-Score:-2.54|P-value:6.20E-4 ID:SGTC_3283|Compound:9109332|FD-Score:-2.72|P-value:2.73E-4 ID:SGTC_3329|Compound:9141233|FD-Score:2.75|P-value:2.71E-4

Top fitness defect scores for YDR454C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1907 st060210 5.02 83.7 µM 1.24E-10 4 2.61E-7 0.24
2 SGTC_2335 9018011 4.11 154.2 µM 1.13E-7 8 2.01E-5 0.08
3 SGTC_2329 6138490 3.77 200.0 µM 1.00E-6 14 8.10E-5 0.03
4 SGTC_2684 capsaicin 3.66 100.0 µM 1.96E-6 7 1.24E-4 0.16
5 SGTC_3177 9107506 3.61 49.5 µM 2.74E-6 ERG2 2 1.54E-4 0.37
6 SGTC_513 4245-1575 3.59 41.7 µM 2.99E-6 unfolded protein response 35 1.63E-4 0.02
7 SGTC_1689 st020265 3.51 53.5 µM 4.93E-6 6 2.25E-4 0.10
8 SGTC_2336 9001819 3.48 198.7 µM 5.85E-6 heme biosynthesis & mitochondrial translocase 45 2.51E-4 0.06
9 SGTC_1635 st007035 3.39 42.4 µM 1.00E-5 26 3.55E-4 0.01
10 SGTC_2108 5365811 3.38 200.0 µM 1.03E-5 12 3.61E-4 0.32
11 SGTC_2332 7982454 3.22 138.9 µM 2.50E-5 19 6.39E-4 0.03
12 SGTC_353 1988-1175 3.17 58.3 µM 3.23E-5 unfolded protein response 21 7.56E-4 0.11
13 SGTC_725 1497-0963 2.82 19.0 µM 1.93E-4 copper-dependent oxidative stress 17 0.00240 0.10
14 SGTC_1322 1348-1070 2.75 12.0 µM 2.67E-4 11 0.00296 0.03
15 SGTC_3329 9141233 2.75 27.6 µM 2.71E-4 14 0.00300 0.11
16 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 2.73 66.5 µM 2.93E-4 18 0.00315 0.00
17 SGTC_874 0599-0792 2.71 117.0 µM 3.22E-4 28 0.00335 0.01
18 SGTC_551 k048-0028 2.71 34.9 µM 3.26E-4 26 0.00338 0.01
19 SGTC_2011 4012611 2.67 177.0 µM 3.83E-4 mitochondrial processes 23 0.00375 0.07
20 SGTC_3032 9089427 2.67 49.5 µM 3.94E-4 60S ribosome export 14 0.00382 0.06

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.164 1.38E-21 YNR018W RCF2 hom Cytochrome c oxidase subunit; has a role in assembly of respiratory supercomplexes; similar to Rcf1p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; associates with the cytochrome c oxidase - cytochrome bc1 supercomplex; null mutant accumulates reactive oxygen species; member of the conserved hypoxia induced gene family; C. elegans homolog is functional in yeast
0.148 6.34E-18 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.147 1.41E-17 YGL191W COX13 hom Subunit VIa of cytochrome c oxidase; present in a subclass of cytochrome c oxidase complexes that may have a role in mimimizing generation of reactive oxygen species; not essential for cytochrome c oxidase activity but may modulate activity in response to ATP; required for assembly of Rcf2p into cytochrome c oxidase - cytochrome bc1 supercomplexes
0.135 3.29E-15 YLL009C COX17 hom Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs
0.125 3.84E-13 YGR183C QCR9 hom Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
0.123 9.63E-13 YOR064C YNG1 hom Subunit of the NuA3 histone acetyltransferase complex that acetylates histone H3; contains PHD finger domain that interacts with methylated histone H3, has similarity to the human tumor suppressor ING1
0.122 1.23E-12 YKL087C CYT2 hom Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1
0.114 3.31E-11 YMR278W PGM3 hom Phosphoglucomutase, catalyzes interconversion of glucose-1-phosphate and glucose-6-phospate; transcription induced in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; non-essential
0.113 5.36E-11 YML069W POB3 het Subunit of the heterodimeric FACT complex (Spt16p-Pob3p); FACT associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases; protein abundance increases in response to DNA replication stress
0.112 6.90E-11 YPL189C-A COA2 hom Cytochrome oxidase assembly factor; null mutation results in respiratory deficiency with specific loss of cytochrome oxidase activity; functions downstream of assembly factors Mss51p and Coa1p and interacts with assembly factor Shy1p
0.111 1.01E-10 YLR317W_d YLR317W_d het Dubious open reading frame; may be part of a bicistronic transcript with NKP2/YLR315W; overlaps the verified ORF TAD3/YLR316C
0.111 1.05E-10 YLL056C_p YLL056C_p hom Putative protein of unknown function, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p and genes involved in pleiotropic drug resistance (PDR); expression is induced in cells treated with the mycotoxin patulin
0.111 1.06E-10 YKL155C RSM22 hom Mitochondrial ribosomal protein of the small subunit; also predicted to be an S-adenosylmethionine-dependent methyltransferase
0.109 2.77E-10 YNL172W APC1 het Largest subunit of the Anaphase-Promoting Complex/Cyclosome; APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; localizes to nuclear foci that become diffuse upon DNA replication stress
0.108 2.91E-10 YJR117W STE24 hom Highly conserved zinc metalloprotease that functions in two steps of a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; contains multiple transmembrane spans