HIPHOP chemogenomics database

YDR500C / RPL37B

Ribosomal 60S subunit protein L37B; protein abundance increases in response to DNA replication stress; homologous to mammalian ribosomal protein L37, no bacterial homolog; RPL37B has a paralog, RPL37A, that arose from the whole genome duplication

Zygosity: Homozygous strain

fixedexpanded
Profile for YDR500C / RPL37B

Click on Significant Values for Screen Details

Top fitness defect scores for YDR500C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_764	1951-2361	6.03	146.0 µM	1.83E-9		6	8.09E-10
2	SGTC_2124	5246320	5.58	200.0 µM	2.38E-8	heme biosynthesis & mitochondrial translocase	4	1.24E-8
3	SGTC_361	000s-0510	5.38	1.4 µM	6.74E-8		9	3.74E-8
4	SGTC_1022	4477-0945	5.38	21.3 µM	6.79E-8		6	3.77E-8
5	SGTC_2688	kanamycin b	5.37	96.7 µM	7.12E-8	calcium & mitochondrial duress	206	3.96E-8
6	SGTC_118	0083-0097	5.05	135.3 µM	3.61E-7	translation	53	2.22E-7
7	SGTC_1021	4476-0760	5.03	85.3 µM	4.00E-7		9	2.48E-7
8	SGTC_787	4152-0075	4.47	138.0 µM	5.50E-6		14	3.98E-6
9	SGTC_519	k048-0011	4.16	62.8 µM	2.02E-5		17	1.57E-5
10	SGTC_2999	9069765	4.07	71.4 µM	3.00E-5	amide catabolism	22	2.39E-5
11	SGTC_3297	9117502	4.02	71.4 µM	3.62E-5		8	2.91E-5
12	SGTC_782	0083-0095	3.96	30.5 µM	4.59E-5		25	3.73E-5
13	SGTC_3007	9078383	3.88	71.4 µM	6.24E-5		15	5.16E-5
14	SGTC_853	0419-0306	3.85	21.0 µM	7.06E-5		14	5.88E-5
15	SGTC_2573	2',4'-dihydroxychalcone	3.82	15.0 µM	8.11E-5		56	6.80E-5
16	SGTC_1127	asiatic acid	3.69	681.4 nM	1.31E-4		29	1.13E-4
17	SGTC_371	0195-0006	3.68	7.4 µM	1.35E-4		25	1.17E-4
18	SGTC_1792	st045773	3.65	43.6 µM	1.49E-4		39	1.29E-4
19	SGTC_1506	4226-2149	3.61	212.0 µM	1.73E-4		39	1.51E-4
20	SGTC_2907	7721985	3.61	69.9 µM	1.74E-4		35	1.52E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.205	3.67E-33	YNL067W	RPL9B	hom	Ribosomal 60S subunit protein L9B; nearly identical to paralog Rpl9Ap; homologous to mammalian ribosomal protein L9 and bacterial L6
0.174	2.36E-24	YGR159C	NSR1	hom	Nucleolar protein that binds nuclear localization sequences, required for pre-rRNA processing and ribosome biogenesis
0.157	5.86E-20	YDR156W	RPA14	hom	RNA polymerase I subunit A14
0.155	1.50E-19	YLR367W	RPS22B	hom	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22B has a paralog, RPS22A, that arose from the whole genome duplication
0.155	2.13E-19	YDR447C	RPS17B	hom	Ribosomal protein 51 (rp51) of the small (40s) subunit; homologous to mammalian ribosomal protein S17, no bacterial homolog; RPS17B has a paralog, RPS17A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.147	8.87E-18	YDL081C	RPP1A	hom	Ribosomal stalk protein P1 alpha, involved in the interaction between translational elongation factors and the ribosome; accumulation of P1 in the cytoplasm is regulated by phosphorylation and interaction with the P2 stalk component
0.134	7.10E-15	YLL045C	RPL8B	hom	Ribosomal 60S subunit protein L8B; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8B has a paralog, RPL8A, that arose from the whole genome duplication
0.132	1.78E-14	YDL136W	RPL35B	hom	Ribosomal 60S subunit protein L35B; homologous to mammalian ribosomal protein L35 and bacterial L29; RPL35B has a paralog, RPL35A, that arose from the whole genome duplication
0.131	3.03E-14	YDR101C	ARX1	hom	Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex
0.129	5.67E-14	YLR061W	RPL22A	hom	Ribosomal 60S subunit protein L22A; required for the oxidative stress response in yeast; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22A has a paralog, RPL22B, that arose from the whole genome duplication
0.128	1.18E-13	YDR467C_d	YDR467C_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.126	2.12E-13	YGR160W_d	YGR160W_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.126	2.40E-13	YDR163W	CWC15	hom	Non-essential protein involved in pre-mRNA splicing, component of a complex containing Cef1p; has similarity to S. pombe Cwf15p
0.123	1.04E-12	YPL125W	KAP120	hom	Karyopherin responsible for the nuclear import of ribosome maturation factor Rfp1p
0.122	1.07E-12	YGR227W	DIE2	hom	Dolichyl-phosphoglucose-dependent alpha-1,2 glucosyltransferase of the ER, functions in the pathway that synthesizes the dolichol-linked oligosaccharide precursor for N-linked protein glycosylation, has a role in regulation of ITR1 and INO1