YDR501W / PLM2

Putative transcription factor, contains Forkhead Associated domain; found associated with chromatin; target of SBF transcription factor; induced in response to DNA damaging agents and deletion of telomerase; PLM2 has a paralog, TOS4, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR501W / PLM2

Click on Significant Values for Screen Details ID:SGTC_375|Compound:3970-0961|FD-Score:-3.09|P-value:4.89E-4 ID:SGTC_633|Compound:0437-0093|FD-Score:-2.96|P-value:7.83E-4 ID:SGTC_667|Compound:1498-1044|FD-Score:-3.31|P-value:2.00E-4 ID:SGTC_798|Compound:1287-0182|FD-Score:3.11|P-value:3.77E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:3.11|P-value:3.78E-4 ID:SGTC_886|Compound:0866-0150|FD-Score:3.33|P-value:1.57E-4 ID:SGTC_982|Compound:1491-0518|FD-Score:-2.95|P-value:8.21E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:-3.02|P-value:6.39E-4 ID:SGTC_1216|Compound:1165-0504|FD-Score:5.99|P-value:4.69E-11 ID:SGTC_1217|Compound:1183-1422|FD-Score:3.17|P-value:2.91E-4 ID:SGTC_1220|Compound:1838-0075|FD-Score:3.09|P-value:3.98E-4 ID:SGTC_1223|Compound:0764-0573|FD-Score:-4.14|P-value:4.64E-6 ID:SGTC_1230|Compound:0170-0365|FD-Score:6.96|P-value:2.83E-14 ID:SGTC_1237|Compound:0330-0133|FD-Score:3.48|P-value:8.27E-5 ID:SGTC_1290|Compound:0986-0249|FD-Score:-2.92|P-value:9.19E-4 ID:SGTC_1380|Compound:2291-0730|FD-Score:-3.87|P-value:1.74E-5 ID:SGTC_2383|Compound:9036125|FD-Score:-3.06|P-value:5.45E-4 ID:SGTC_2794|Compound:7785382|FD-Score:4.34|P-value:1.30E-6 ID:SGTC_2806|Compound:7952793|FD-Score:-4.67|P-value:2.91E-7 ID:SGTC_2808|Compound:7946468|FD-Score:3.74|P-value:2.59E-5 ID:SGTC_2955|Compound:9076254|FD-Score:3.28|P-value:1.85E-4 ID:SGTC_2960|Compound:9079389|FD-Score:2.95|P-value:6.88E-4 ID:SGTC_375|Compound:3970-0961|FD-Score:-3.09|P-value:4.89E-4 ID:SGTC_633|Compound:0437-0093|FD-Score:-2.96|P-value:7.83E-4 ID:SGTC_667|Compound:1498-1044|FD-Score:-3.31|P-value:2.00E-4 ID:SGTC_798|Compound:1287-0182|FD-Score:3.11|P-value:3.77E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:3.11|P-value:3.78E-4 ID:SGTC_886|Compound:0866-0150|FD-Score:3.33|P-value:1.57E-4 ID:SGTC_982|Compound:1491-0518|FD-Score:-2.95|P-value:8.21E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:-3.02|P-value:6.39E-4 ID:SGTC_1216|Compound:1165-0504|FD-Score:5.99|P-value:4.69E-11 ID:SGTC_1217|Compound:1183-1422|FD-Score:3.17|P-value:2.91E-4 ID:SGTC_1220|Compound:1838-0075|FD-Score:3.09|P-value:3.98E-4 ID:SGTC_1223|Compound:0764-0573|FD-Score:-4.14|P-value:4.64E-6 ID:SGTC_1230|Compound:0170-0365|FD-Score:6.96|P-value:2.83E-14 ID:SGTC_1237|Compound:0330-0133|FD-Score:3.48|P-value:8.27E-5 ID:SGTC_1290|Compound:0986-0249|FD-Score:-2.92|P-value:9.19E-4 ID:SGTC_1380|Compound:2291-0730|FD-Score:-3.87|P-value:1.74E-5 ID:SGTC_2383|Compound:9036125|FD-Score:-3.06|P-value:5.45E-4 ID:SGTC_2794|Compound:7785382|FD-Score:4.34|P-value:1.30E-6 ID:SGTC_2806|Compound:7952793|FD-Score:-4.67|P-value:2.91E-7 ID:SGTC_2808|Compound:7946468|FD-Score:3.74|P-value:2.59E-5 ID:SGTC_2955|Compound:9076254|FD-Score:3.28|P-value:1.85E-4 ID:SGTC_2960|Compound:9079389|FD-Score:2.95|P-value:6.88E-4

Top fitness defect scores for YDR501W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_1230 0170-0365 6.96 3.8 µM 2.83E-14 endomembrane recycling 13 1.71E-12
2 SGTC_1216 1165-0504 5.99 9.7 µM 4.69E-11 1 1.02E-9
3 SGTC_2794 7785382 4.34 27.3 µM 1.30E-6 21 6.99E-6
4 SGTC_2808 7946468 3.74 45.5 µM 2.59E-5 31 9.30E-5
5 SGTC_1237 0330-0133 3.48 46.1 µM 8.27E-5 ergosterol biosynthesis 37 2.54E-4
6 SGTC_886 0866-0150 3.33 153.0 µM 1.57E-4 40 4.42E-4
7 SGTC_2955 9076254 3.28 12.2 µM 1.85E-4 38 5.10E-4
8 SGTC_1217 1183-1422 3.17 255.0 µM 2.91E-4 36 7.56E-4
9 SGTC_798 1287-0182 3.11 476.0 µM 3.77E-4 58 9.45E-4
10 SGTC_807 1315-0151 3.11 48.0 µM 3.78E-4 59 9.47E-4
11 SGTC_1220 1838-0075 3.09 193.0 µM 3.98E-4 40 9.90E-4
12 SGTC_2960 9079389 2.95 6.0 µM 6.88E-4 74 0.00159
13 SGTC_779 1360-0071 2.84 233.0 µM 0.00101 fatty acid desaturase (OLE1) 92 0.00223
14 SGTC_1620 st003704 2.84 16.5 µM 0.00104 54 0.00228
15 SGTC_2709 st078560 2.78 56.0 µM 0.00130 54 0.00276
16 SGTC_2003 4023581 2.74 200.0 µM 0.00145 cell wall signaling 101 0.00303
17 SGTC_2935 9038016 2.73 30.0 µM 0.00154 94 0.00320
18 SGTC_733 4069-0007 2.64 56.1 µM 0.00208 ERAD & cell cycle 194 0.00416
19 SGTC_803 4488-1585 2.61 147.0 µM 0.00228 78 0.00450
20 SGTC_1251 0490-5699 2.61 265.0 µM 0.00230 130 0.00454

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.280 1.42E-61 YNL157W IGO1 hom Protein required for initiation of G0 program; prevents degradation of nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway; phosphorylated by Rim15p; GFP protein localizes to the cytoplasm and nucleus; similar to Igo2p
0.200 1.43E-31 YDL128W VCX1 hom Vacuolar membrane antiporter with Ca2+/H+ and K+/H+ exchange activity, involved in control of cytosolic Ca2+ and K+ concentrations; has similarity to sodium/calcium exchangers, including the bovine Na+/Ca2+,K+ antiporter
0.161 8.57E-21 YMR134W ERG29 het Protein of unknown function that may be involved in iron metabolism; mutant bm-8 has a growth defect on iron-limited medium that is complemented by overexpression of Yfh1p; shows localization to the ER; highly conserved in ascomycetes
0.156 1.05E-19 YNL209W SSB2 hom Cytoplasmic ATPase that is a ribosome-associated molecular chaperone; functions with J-protein partner Zuo1p; may be involved in the folding of newly-synthesized polypeptide chains; member of the HSP70 family; SSB2 has a paralog, SSB1, that arose from the whole genome duplication
0.152 7.03E-19 YGR182C_d YGR182C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF TIM13/YGR181W
0.151 1.38E-18 YOR016C ERP4 hom Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport
0.151 1.75E-18 YPL063W TIM50 het Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); acts as receptor for the TIM23 complex guiding incoming precursors from the TOM complex; may control the gating of the Tim23p-Tim17p channel
0.149 5.23E-18 YCR093W CDC39 het Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor
0.142 1.12E-16 YMR133W REC114 hom Protein involved in early stages of meiotic recombination; possibly involved in the coordination of recombination and meiotic division; mutations lead to premature initiation of the first meiotic division
0.141 2.21E-16 YDR274C_d YDR274C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.123 1.10E-12 YDR312W SSF2 hom Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication
0.119 4.05E-12 YGR072W UPF3 hom Component of the nonsense-mediated mRNA decay (NMD) pathway, along with Nam7p and Nmd2p; involved in decay of mRNA containing nonsense codons; involved in telomere maintenance
0.117 1.11E-11 YHR001W OSH7 hom Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
0.116 1.95E-11 YGR206W MVB12 hom ESCRT-I subunit required to stabilize oligomers of the ESCRT-I core complex (Stp22p, Vps28p, Srn2p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; deletion mutant is sensitive to rapamycin and nystatin
0.115 2.83E-11 YDR480W DIG2 hom MAP kinase-responsive inhibitor of the Ste12p transcription factor, involved in the regulation of mating-specific genes and the invasive growth pathway; related regulators Dig1p and Dig2p bind to Ste12p