Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YDR504C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.139 | 6.89E-16 | YGR187C | HGH1 | hom | Nonessential protein of unknown function; predicted to be involved in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; similar to mammalian BRP16 (Brain protein 16); relative distribution to the nucleus increases upon DNA replication stress |
0.138 | 8.20E-16 | YML065W | ORC1 | het | Largest subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; exhibits ATPase activity |
0.128 | 9.98E-14 | YDR282C_p | YDR282C_p | hom | Putative protein of unknown function; localizes to the inner mitochondrial membrane with the C terminus facing the intermembrane space; ortholog of human RMND1, mutation in which is implicated in infantile encephaloneuromyopathy and defective mitochondrial translation |
0.125 | 4.40E-13 | YCR011C | ADP1 | hom | Putative ATP-dependent permease of the ABC transporter family of proteins |
0.116 | 1.77E-11 | YJL035C | TAD2 | het | Subunit of tRNA-specific adenosine-34 deaminase, forms a heterodimer with Tad3p that converts adenosine to inosine at the wobble position of several tRNAs |
0.111 | 1.43E-10 | YNL244C | SUI1 | het | Translation initiation factor eIF1; component of a complex involved in recognition of the initiator codon; modulates translation accuracy at the initiation phase |
0.101 | 4.63E-9 | YFR023W | PES4 | hom | Poly(A) binding protein, suppressor of DNA polymerase epsilon mutation; PES4 has a paralog, MIP6, that arose from the whole genome duplication |
0.098 | 1.23E-8 | YJR112W | NNF1 | het | Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation |
0.098 | 1.39E-8 | YOR159C | SME1 | het | Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E |
0.094 | 4.50E-8 | YER064C | VHR2 | hom | Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress |
0.091 | 1.43E-7 | YNR071C_p | YNR071C_p | hom | Putative aldose 1-epimerase |
0.088 | 3.19E-7 | YIR043C | YIR043C | hom | Possible pseudogene in strain S288C; YIR043C and the adjacent ORF, YIR044C, together may encode a non-functional member of the conserved, often subtelomerically-encoded Cos protein family |
0.088 | 3.76E-7 | YNR070W_p | PDR18_p | hom | Putative transporter of the ATP-binding cassette (ABC) family, implicated in pleiotropic drug resistance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies |
0.085 | 8.09E-7 | YDL213C | NOP6 | hom | rRNA-binding protein required for 40S ribosomal subunit biogenesis; contains an RNA recognition motif (RRM); hydrophilin essential to overcome the stress of the desiccation-rehydration process; NOP6 may be a fungal-specific gene as no homologs have been yet identified in higher eukaryotes |
0.084 | 1.19E-6 | YIR016W_p | YIR016W_p | hom | Putative protein of unknown function; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p; overexpression causes a cell cycle delay or arrest; non-essential gene; YIR016W has a paralog, YOL036W, that arose from the whole genome duplication |