YDR506C / GMC1

Protein involved in meiotic progression; mutants are delayed in meiotic nuclear division and are defective in synaptonemal complex assembly; possible membrane-localized protein

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR506C / GMC1

Click on Significant Values for Screen Details ID:SGTC_26|Compound:0302-0163|FD-Score:3.27|P-value:2.53E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:3.61|P-value:5.97E-5 ID:SGTC_529|Compound:4076-0302|FD-Score:6.38|P-value:5.77E-12 ID:SGTC_538|Compound:2922-0838|FD-Score:4.84|P-value:1.27E-7 ID:SGTC_649|Compound:1123-0311|FD-Score:3.35|P-value:1.83E-4 ID:SGTC_813|Compound:k007-0158|FD-Score:2.95|P-value:8.35E-4 ID:SGTC_938|Compound:3126-1755|FD-Score:3.08|P-value:5.27E-4 ID:SGTC_956|Compound:1185-0240|FD-Score:3.52|P-value:9.06E-5 ID:SGTC_1021|Compound:4476-0760|FD-Score:-3.01|P-value:6.88E-4 ID:SGTC_1024|Compound:4507-0395|FD-Score:3.97|P-value:1.17E-5 ID:SGTC_1195|Compound:1502-0147|FD-Score:-3.05|P-value:5.98E-4 ID:SGTC_1198|Compound:1612-1005|FD-Score:3.31|P-value:2.11E-4 ID:SGTC_1200|Compound:1643-0193|FD-Score:3.82|P-value:2.42E-5 ID:SGTC_1293|Compound:1000-1278|FD-Score:3.40|P-value:1.49E-4 ID:SGTC_1747|Compound:st037496|FD-Score:-3.85|P-value:2.13E-5 ID:SGTC_1756|Compound:st041558|FD-Score:-3.32|P-value:2.12E-4 ID:SGTC_1764|Compound:st044502|FD-Score:-3.35|P-value:1.85E-4 ID:SGTC_1767|Compound:st044992|FD-Score:3.52|P-value:8.87E-5 ID:SGTC_1769|Compound:st044406|FD-Score:3.11|P-value:4.69E-4 ID:SGTC_1826|Compound:st055655|FD-Score:-3.64|P-value:5.43E-5 ID:SGTC_1836|Compound:st055642|FD-Score:4.87|P-value:1.08E-7 ID:SGTC_1837|Compound:st055472|FD-Score:3.48|P-value:1.04E-4 ID:SGTC_1896|Compound:st058441|FD-Score:3.15|P-value:3.92E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.78|P-value:2.93E-5 ID:SGTC_2174|Compound:5790901|FD-Score:3.49|P-value:1.03E-4 ID:SGTC_2306|Compound:7482397|FD-Score:-3.93|P-value:1.46E-5 ID:SGTC_2351|Compound:9026858|FD-Score:3.20|P-value:3.24E-4 ID:SGTC_2439|Compound:5492030|FD-Score:3.14|P-value:4.12E-4 ID:SGTC_2442|Compound:5158906|FD-Score:4.16|P-value:4.68E-6 ID:SGTC_2444|Compound:5485484|FD-Score:4.83|P-value:1.36E-7 ID:SGTC_2449|Compound:5812982|FD-Score:-4.04|P-value:8.76E-6 ID:SGTC_2480|Compound:5767542|FD-Score:-5.12|P-value:2.70E-8 ID:SGTC_2487|Compound:5918373|FD-Score:-4.66|P-value:3.71E-7 ID:SGTC_2488|Compound:5268135|FD-Score:3.16|P-value:3.80E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:-3.05|P-value:6.02E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:-2.91|P-value:9.94E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:3.17|P-value:3.66E-4 ID:SGTC_2763|Compound:lisinopril|FD-Score:4.60|P-value:4.92E-7 ID:SGTC_3082|Compound:9117008|FD-Score:3.20|P-value:3.29E-4 ID:SGTC_3090|Compound:9117696|FD-Score:3.08|P-value:5.18E-4 ID:SGTC_3325|Compound:9138760|FD-Score:-5.11|P-value:2.76E-8 ID:SGTC_3331|Compound:9141060|FD-Score:-5.37|P-value:5.84E-9 ID:SGTC_26|Compound:0302-0163|FD-Score:3.27|P-value:2.53E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:3.61|P-value:5.97E-5 ID:SGTC_529|Compound:4076-0302|FD-Score:6.38|P-value:5.77E-12 ID:SGTC_538|Compound:2922-0838|FD-Score:4.84|P-value:1.27E-7 ID:SGTC_649|Compound:1123-0311|FD-Score:3.35|P-value:1.83E-4 ID:SGTC_813|Compound:k007-0158|FD-Score:2.95|P-value:8.35E-4 ID:SGTC_938|Compound:3126-1755|FD-Score:3.08|P-value:5.27E-4 ID:SGTC_956|Compound:1185-0240|FD-Score:3.52|P-value:9.06E-5 ID:SGTC_1021|Compound:4476-0760|FD-Score:-3.01|P-value:6.88E-4 ID:SGTC_1024|Compound:4507-0395|FD-Score:3.97|P-value:1.17E-5 ID:SGTC_1195|Compound:1502-0147|FD-Score:-3.05|P-value:5.98E-4 ID:SGTC_1198|Compound:1612-1005|FD-Score:3.31|P-value:2.11E-4 ID:SGTC_1200|Compound:1643-0193|FD-Score:3.82|P-value:2.42E-5 ID:SGTC_1293|Compound:1000-1278|FD-Score:3.40|P-value:1.49E-4 ID:SGTC_1747|Compound:st037496|FD-Score:-3.85|P-value:2.13E-5 ID:SGTC_1756|Compound:st041558|FD-Score:-3.32|P-value:2.12E-4 ID:SGTC_1764|Compound:st044502|FD-Score:-3.35|P-value:1.85E-4 ID:SGTC_1767|Compound:st044992|FD-Score:3.52|P-value:8.87E-5 ID:SGTC_1769|Compound:st044406|FD-Score:3.11|P-value:4.69E-4 ID:SGTC_1826|Compound:st055655|FD-Score:-3.64|P-value:5.43E-5 ID:SGTC_1836|Compound:st055642|FD-Score:4.87|P-value:1.08E-7 ID:SGTC_1837|Compound:st055472|FD-Score:3.48|P-value:1.04E-4 ID:SGTC_1896|Compound:st058441|FD-Score:3.15|P-value:3.92E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.78|P-value:2.93E-5 ID:SGTC_2174|Compound:5790901|FD-Score:3.49|P-value:1.03E-4 ID:SGTC_2306|Compound:7482397|FD-Score:-3.93|P-value:1.46E-5 ID:SGTC_2351|Compound:9026858|FD-Score:3.20|P-value:3.24E-4 ID:SGTC_2439|Compound:5492030|FD-Score:3.14|P-value:4.12E-4 ID:SGTC_2442|Compound:5158906|FD-Score:4.16|P-value:4.68E-6 ID:SGTC_2444|Compound:5485484|FD-Score:4.83|P-value:1.36E-7 ID:SGTC_2449|Compound:5812982|FD-Score:-4.04|P-value:8.76E-6 ID:SGTC_2480|Compound:5767542|FD-Score:-5.12|P-value:2.70E-8 ID:SGTC_2487|Compound:5918373|FD-Score:-4.66|P-value:3.71E-7 ID:SGTC_2488|Compound:5268135|FD-Score:3.16|P-value:3.80E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:-3.05|P-value:6.02E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:-2.91|P-value:9.94E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:3.17|P-value:3.66E-4 ID:SGTC_2763|Compound:lisinopril|FD-Score:4.60|P-value:4.92E-7 ID:SGTC_3082|Compound:9117008|FD-Score:3.20|P-value:3.29E-4 ID:SGTC_3090|Compound:9117696|FD-Score:3.08|P-value:5.18E-4 ID:SGTC_3325|Compound:9138760|FD-Score:-5.11|P-value:2.76E-8 ID:SGTC_3331|Compound:9141060|FD-Score:-5.37|P-value:5.84E-9

Top fitness defect scores for YDR506C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_529 4076-0302 6.38 30.3 µM 5.77E-12 mitochondrial processes 1 8.98E-11
2 SGTC_1836 st055642 4.87 81.0 µM 1.08E-7 9 5.52E-7
3 SGTC_538 2922-0838 4.84 53.3 µM 1.27E-7 Golgi 15 6.36E-7
4 SGTC_2444 5485484 4.83 36.4 µM 1.36E-7 16 6.78E-7
5 SGTC_2763 lisinopril 4.60 49.3 µM 4.92E-7 7 2.12E-6
6 SGTC_2442 5158906 4.16 48.5 µM 4.68E-6 14 1.57E-5
7 SGTC_1024 4507-0395 3.97 26.0 µM 1.17E-5 TSC3-RPN4 26 3.53E-5
8 SGTC_1200 1643-0193 3.82 18.4 µM 2.42E-5 23 6.76E-5
9 SGTC_163 1327-0036 3.61 7.5 µM 5.97E-5 132 1.51E-4
10 SGTC_1767 st044992 3.52 70.3 µM 8.87E-5 34 2.14E-4
11 SGTC_956 1185-0240 3.52 191.0 µM 9.06E-5 38 2.18E-4
12 SGTC_2174 5790901 3.49 200.0 µM 1.03E-4 tubulin folding & SWR complex 47 2.45E-4
13 SGTC_1837 st055472 3.48 66.5 µM 1.04E-4 33 2.47E-4
14 SGTC_1293 1000-1278 3.40 195.0 µM 1.49E-4 30 3.40E-4
15 SGTC_649 1123-0311 3.35 367.0 µM 1.83E-4 endomembrane recycling 107 4.08E-4
16 SGTC_1198 1612-1005 3.31 86.7 µM 2.11E-4 30 4.63E-4
17 SGTC_26 0302-0163 3.27 425.2 µM 2.53E-4 heme biosynthesis & mitochondrial translocase 25 5.45E-4
18 SGTC_2351 9026858 3.20 72.3 µM 3.24E-4 RNA processing & uracil transport 54 6.79E-4
19 SGTC_3082 9117008 3.20 49.5 µM 3.29E-4 44 6.89E-4
20 SGTC_2755 lomerizine 3.17 42.7 µM 3.66E-4 61 7.56E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.111 1.14E-10 YKR065C PAM17 hom Constituent of the TIM23 complex; proposed alternatively to be a component of the import motor (PAM complex) or to interact with and modulate the core TIM23 (Translocase of the Inner mitochondrial Membrane) complex; protein abundance increases in response to DNA replication stress
0.100 7.71E-9 YER052C HOM3 hom Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.096 2.55E-8 YOR082C_d YOR082C_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene YOR083W
0.085 8.66E-7 YGR193C PDX1 hom Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex, plays a structural role in the complex by binding and positioning E3 to the dihydrolipoamide acetyltransferase (E2) core
0.084 1.03E-6 YDR381W YRA1 het RNA binding protein required for export of poly(A)+ mRNA from the nucleus; proposed to couple mRNA export with 3' end processing via its interactions with Mex67p and Pcf11p; functionally redundant with Yra2p, another REF family member
0.084 1.26E-6 YCR060W TAH1 hom Component of the conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1); contains a single TPR domain with at least two TPR motifs; R2TP complex interacts with Hsp90 (Hsp82p and Hsc82p) to mediate assembly large protein complexes such as box C/D snoRNPs and RNA polymerase II
0.081 2.31E-6 YHL010C ETP1 hom Putative protein of unknown function that is required for growth on ethanol; contains a zinc finger region and has homology to human BRAP2, which is a cytoplasmic protein that binds nuclear localization sequences
0.080 3.11E-6 YJR013W GPI14 het Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M
0.079 5.08E-6 YIR008C PRI1 het Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
0.079 5.17E-6 YHR195W NVJ1 hom Nuclear envelope protein, anchored to the nuclear inner membrane, that interacts with the vacuolar membrane protein Vac8p to promote formation of nucleus-vacuole junctions during piecemeal microautophagy of the nucleus (PMN)
0.078 6.37E-6 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.076 1.11E-5 YPR041W TIF5 het Translation initiation factor eIF5; functions both as a GTPase-activating protein to mediate hydrolysis of ribosome-bound GTP and as a GDP dissociation inhibitor to prevent recycling of eIF2
0.076 1.14E-5 YBR072C-A_p YBR072C-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.075 1.36E-5 YOR163W DDP1 hom Polyphosphate phosphatase; hydrolyzes diphosphorylated inositol polyphosphates and diadenosine polyphosphates; high specificity for diadenosine hexa- and pentaphosphates; contains endopolyphosphatase activity with a high affinity for polyphosphates, an activity also observed for its human DIPP homologs; possesses mRNA decapping activity; nudix hydrolase family member; protein abundance increases in response to DNA replication stress
0.074 1.69E-5 YDR515W SLF1 hom RNA binding protein that associates with polysomes; may be involved in regulating mRNA translation; involved in the copper-dependent mineralization of copper sulfide complexes on cell surface in cells cultured in copper salts; SLF1 has a paralog, SRO9, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress