HIPHOP chemogenomics database

YDR509W_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain

fixedexpanded
Profile for YDR509W / YDR509W

Click on Significant Values for Screen Details

Top fitness defect scores for YDR509W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_70	0141-0289	20.40	43.3 µM	6.20E-84	mitochondrial stress	1	8.96E-93
2	SGTC_236	1509-0011	10.80	5.3 µM	6.56E-25		179	2.86E-27
3	SGTC_68	0986-0284	10.30	82.8 µM	5.01E-23		5	3.48E-25
4	SGTC_63	0099-0242	7.53	26.7 µM	3.41E-13	mitochondrial stress	14	2.61E-14
5	SGTC_908	3448-7491	6.90	47.7 µM	2.20E-11	mitochondrial stress	29	2.59E-12
6	SGTC_310	1273-0058	6.87	1.1 µM	2.72E-11	mitochondrial stress	120	3.28E-12
7	SGTC_1627	st003713	6.33	25.6 µM	7.17E-10	calcium & mitochondrial duress	26	1.21E-10
8	SGTC_1911	st060208	6.21	74.3 µM	1.49E-9		4	2.71E-10
9	SGTC_173	1273-0061	6.19	2.7 µM	1.65E-9	mitochondrial stress	105	3.03E-10
10	SGTC_1742	st038235	5.90	28.9 µM	8.53E-9	mitochondrial stress	47	1.85E-9
11	SGTC_10	0279-0212	5.70	42.6 µM	2.52E-8	TRP & mitochondrial translation	35	6.11E-9
12	SGTC_2250	alverine citrate	5.61	130.0 µM	4.01E-8		69	1.02E-8
13	SGTC_1914	st062367	5.41	72.6 µM	1.11E-7		6	3.13E-8
14	SGTC_275	trichlorophene	5.15	5.7 µM	4.13E-7	mitochondrial stress	160	1.32E-7
15	SGTC_2232	chlorophetanol	5.06	41.5 µM	6.37E-7	TRP & mitochondrial translation	77	2.13E-7
16	SGTC_1451	4152-0210	4.99	104.0 µM	8.69E-7		7	2.99E-7
17	SGTC_2133	5320837	4.97	200.0 µM	9.47E-7	ERG2	11	3.29E-7
18	SGTC_211	3455-0679	4.91	143.5 µM	1.25E-6		4	4.46E-7
19	SGTC_2283	7944793	4.78	200.0 µM	2.33E-6		21	8.85E-7
20	SGTC_1626	st003712	4.65	1.8 µM	4.08E-6		14	1.64E-6

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.435	1.32E-154	YMR287C	DSS1	hom	3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.435	1.11E-154	YNL005C	MRP7	hom	Mitochondrial ribosomal protein of the large subunit
0.425	2.38E-147	YNL252C	MRPL17	hom	Mitochondrial ribosomal protein of the large subunit
0.421	2.93E-144	YNL284C	MRPL10	hom	Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL10 and YmL18) on two-dimensional SDS gels
0.420	9.98E-144	YDR065W	RRG1	hom	Protein of unknown function, required for vacuolar acidification and mitochondrial genome maintenance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.416	2.50E-140	YDR529C	QCR7	hom	Subunit 7 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the mitochondrial matrix; N-terminus appears to play a role in complex assembly
0.411	8.27E-137	YPR166C	MRP2	hom	Mitochondrial ribosomal protein of the small subunit
0.404	7.96E-132	YKL170W	MRPL38	hom	Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels; protein abundance increases in response to DNA replication stress
0.397	2.88E-127	YJR144W	MGM101	hom	Protein with a role in mitochondrial DNA recombinational repair;also involved in interstrand cross-link repair; binds to and catalyzes the annealing of single-stranded mtDNA; oligomerizes to form rings and filaments; related to Rad52-type recombination proteins, with limited overall similarity but sharing conserved functionally important residues; component of the mitochondrial nucleoid, required for the repair of oxidative mtDNA damage
0.395	1.93E-125	YDR237W	MRPL7	hom	Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein
0.395	2.31E-125	YGL064C	MRH4	hom	Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function
0.393	2.49E-124	YDR337W	MRPS28	hom	Mitochondrial ribosomal protein of the small subunit
0.392	9.48E-124	YGR215W	RSM27	hom	Mitochondrial ribosomal protein of the small subunit
0.388	2.71E-121	YCR024C	SLM5	hom	Mitochondrial asparaginyl-tRNA synthetase
0.384	3.71E-118	YLR149C	YLR149C	hom	Protein of unknown function; overexpression causes a cell cycle delay or arrest; null mutation results in a decrease in plasma membrane electron transport; YLR149C is not an essential gene; protein abundance increases in response to DNA replication stress