Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YDR509W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.435 | 1.32E-154 | YMR287C | DSS1 | hom | 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs |
0.435 | 1.11E-154 | YNL005C | MRP7 | hom | Mitochondrial ribosomal protein of the large subunit |
0.425 | 2.38E-147 | YNL252C | MRPL17 | hom | Mitochondrial ribosomal protein of the large subunit |
0.421 | 2.93E-144 | YNL284C | MRPL10 | hom | Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL10 and YmL18) on two-dimensional SDS gels |
0.420 | 9.98E-144 | YDR065W | RRG1 | hom | Protein of unknown function, required for vacuolar acidification and mitochondrial genome maintenance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies |
0.416 | 2.50E-140 | YDR529C | QCR7 | hom | Subunit 7 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the mitochondrial matrix; N-terminus appears to play a role in complex assembly |
0.411 | 8.27E-137 | YPR166C | MRP2 | hom | Mitochondrial ribosomal protein of the small subunit |
0.404 | 7.96E-132 | YKL170W | MRPL38 | hom | Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels; protein abundance increases in response to DNA replication stress |
0.397 | 2.88E-127 | YJR144W | MGM101 | hom | Protein with a role in mitochondrial DNA recombinational repair;also involved in interstrand cross-link repair; binds to and catalyzes the annealing of single-stranded mtDNA; oligomerizes to form rings and filaments; related to Rad52-type recombination proteins, with limited overall similarity but sharing conserved functionally important residues; component of the mitochondrial nucleoid, required for the repair of oxidative mtDNA damage |
0.395 | 1.93E-125 | YDR237W | MRPL7 | hom | Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein |
0.395 | 2.31E-125 | YGL064C | MRH4 | hom | Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function |
0.393 | 2.49E-124 | YDR337W | MRPS28 | hom | Mitochondrial ribosomal protein of the small subunit |
0.392 | 9.48E-124 | YGR215W | RSM27 | hom | Mitochondrial ribosomal protein of the small subunit |
0.388 | 2.71E-121 | YCR024C | SLM5 | hom | Mitochondrial asparaginyl-tRNA synthetase |
0.384 | 3.71E-118 | YLR149C | YLR149C | hom | Protein of unknown function; overexpression causes a cell cycle delay or arrest; null mutation results in a decrease in plasma membrane electron transport; YLR149C is not an essential gene; protein abundance increases in response to DNA replication stress |