YDR511W / ACN9

Protein of the mitochondrial intermembrane space, required for acetate utilization and gluconeogenesis; has orthologs in higher eukaryotes

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR511W / ACN9

Click on Significant Values for Screen Details ID:SGTC_159|Compound:3970-0959|FD-Score:4.34|P-value:1.28E-6 ID:SGTC_422|Compound:cantharidin|FD-Score:-3.19|P-value:4.66E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:4.97|P-value:3.88E-8 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:4.60|P-value:3.16E-7 ID:SGTC_461|Compound:N-acetylfarnesylcysteine|FD-Score:-3.23|P-value:3.99E-4 ID:SGTC_720|Compound:r052-1644|FD-Score:3.50|P-value:6.82E-5 ID:SGTC_724|Compound:3910-0327|FD-Score:3.02|P-value:4.80E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:3.46|P-value:8.08E-5 ID:SGTC_786|Compound:4544-0069|FD-Score:3.65|P-value:3.58E-5 ID:SGTC_840|Compound:0245-0196|FD-Score:4.45|P-value:7.08E-7 ID:SGTC_854|Compound:0422-0053|FD-Score:-3.06|P-value:7.51E-4 ID:SGTC_868|Compound:0527-0199|FD-Score:-3.55|P-value:1.12E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:-3.47|P-value:1.51E-4 ID:SGTC_875|Compound:0709-0210|FD-Score:3.72|P-value:2.66E-5 ID:SGTC_878|Compound:0828-0289|FD-Score:-4.19|P-value:6.00E-6 ID:SGTC_907|Compound:3448-6986|FD-Score:4.05|P-value:5.54E-6 ID:SGTC_914|Compound:3820-6779|FD-Score:-4.32|P-value:3.23E-6 ID:SGTC_1200|Compound:1643-0193|FD-Score:2.91|P-value:7.33E-4 ID:SGTC_1821|Compound:st053465|FD-Score:2.94|P-value:6.57E-4 ID:SGTC_1886|Compound:st057356|FD-Score:-3.18|P-value:4.87E-4 ID:SGTC_1913|Compound:st060213|FD-Score:3.14|P-value:3.06E-4 ID:SGTC_1969|Compound:st069479|FD-Score:3.13|P-value:3.13E-4 ID:SGTC_2025|Compound:5147754|FD-Score:3.08|P-value:3.80E-4 ID:SGTC_2088|Compound:5278280|FD-Score:3.93|P-value:9.98E-6 ID:SGTC_2287|Compound:7945887|FD-Score:-3.24|P-value:3.90E-4 ID:SGTC_2290|Compound:7904846|FD-Score:-4.28|P-value:3.90E-6 ID:SGTC_2302|Compound:7771753|FD-Score:-4.83|P-value:2.18E-7 ID:SGTC_2378|Compound:9074213|FD-Score:2.88|P-value:8.11E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:3.01|P-value:5.10E-4 ID:SGTC_2521|Compound:angolensin|FD-Score:3.07|P-value:4.03E-4 ID:SGTC_3125|Compound:9127534|FD-Score:3.52|P-value:6.48E-5 ID:SGTC_3320|Compound:9137005|FD-Score:-3.84|P-value:3.18E-5 ID:SGTC_3324|Compound:9138759|FD-Score:-3.45|P-value:1.66E-4 ID:SGTC_3334|Compound:9142812|FD-Score:-3.01|P-value:9.06E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:4.34|P-value:1.28E-6 ID:SGTC_422|Compound:cantharidin|FD-Score:-3.19|P-value:4.66E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:4.97|P-value:3.88E-8 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:4.60|P-value:3.16E-7 ID:SGTC_461|Compound:N-acetylfarnesylcysteine|FD-Score:-3.23|P-value:3.99E-4 ID:SGTC_720|Compound:r052-1644|FD-Score:3.50|P-value:6.82E-5 ID:SGTC_724|Compound:3910-0327|FD-Score:3.02|P-value:4.80E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:3.46|P-value:8.08E-5 ID:SGTC_786|Compound:4544-0069|FD-Score:3.65|P-value:3.58E-5 ID:SGTC_840|Compound:0245-0196|FD-Score:4.45|P-value:7.08E-7 ID:SGTC_854|Compound:0422-0053|FD-Score:-3.06|P-value:7.51E-4 ID:SGTC_868|Compound:0527-0199|FD-Score:-3.55|P-value:1.12E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:-3.47|P-value:1.51E-4 ID:SGTC_875|Compound:0709-0210|FD-Score:3.72|P-value:2.66E-5 ID:SGTC_878|Compound:0828-0289|FD-Score:-4.19|P-value:6.00E-6 ID:SGTC_907|Compound:3448-6986|FD-Score:4.05|P-value:5.54E-6 ID:SGTC_914|Compound:3820-6779|FD-Score:-4.32|P-value:3.23E-6 ID:SGTC_1200|Compound:1643-0193|FD-Score:2.91|P-value:7.33E-4 ID:SGTC_1821|Compound:st053465|FD-Score:2.94|P-value:6.57E-4 ID:SGTC_1886|Compound:st057356|FD-Score:-3.18|P-value:4.87E-4 ID:SGTC_1913|Compound:st060213|FD-Score:3.14|P-value:3.06E-4 ID:SGTC_1969|Compound:st069479|FD-Score:3.13|P-value:3.13E-4 ID:SGTC_2025|Compound:5147754|FD-Score:3.08|P-value:3.80E-4 ID:SGTC_2088|Compound:5278280|FD-Score:3.93|P-value:9.98E-6 ID:SGTC_2287|Compound:7945887|FD-Score:-3.24|P-value:3.90E-4 ID:SGTC_2290|Compound:7904846|FD-Score:-4.28|P-value:3.90E-6 ID:SGTC_2302|Compound:7771753|FD-Score:-4.83|P-value:2.18E-7 ID:SGTC_2378|Compound:9074213|FD-Score:2.88|P-value:8.11E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:3.01|P-value:5.10E-4 ID:SGTC_2521|Compound:angolensin|FD-Score:3.07|P-value:4.03E-4 ID:SGTC_3125|Compound:9127534|FD-Score:3.52|P-value:6.48E-5 ID:SGTC_3320|Compound:9137005|FD-Score:-3.84|P-value:3.18E-5 ID:SGTC_3324|Compound:9138759|FD-Score:-3.45|P-value:1.66E-4 ID:SGTC_3334|Compound:9142812|FD-Score:-3.01|P-value:9.06E-4

Top fitness defect scores for YDR511W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_427 1354-0053 4.97 47.3 µM 3.88E-8 5 3.39E-7
2 SGTC_457 grayanotoxin iii 4.60 135.0 µM 3.16E-7 37 2.11E-6
3 SGTC_840 0245-0196 4.45 390.0 µM 7.08E-7 6 4.27E-6
4 SGTC_159 3970-0959 4.34 50.0 µM 1.28E-6 62 7.14E-6
5 SGTC_907 3448-6986 4.05 75.5 µM 5.54E-6 24 2.57E-5
6 SGTC_2088 5278280 3.93 127.4 µM 9.98E-6 24 4.29E-5
7 SGTC_875 0709-0210 3.72 25.7 µM 2.66E-5 fatty acid desaturase (OLE1) 38 1.01E-4
8 SGTC_786 4544-0069 3.65 423.0 µM 3.58E-5 45 1.31E-4
9 SGTC_3125 9127534 3.52 49.5 µM 6.48E-5 20 2.19E-4
10 SGTC_720 r052-1644 3.50 49.9 µM 6.82E-5 TSC3-RPN4 42 2.29E-4
11 SGTC_764 1951-2361 3.46 146.0 µM 8.08E-5 54 2.65E-4
12 SGTC_1913 st060213 3.14 96.1 µM 3.06E-4 78 8.47E-4
13 SGTC_1969 st069479 3.13 40.1 µM 3.13E-4 31 8.63E-4
14 SGTC_2025 5147754 3.08 141.0 µM 3.80E-4 32 0.00102
15 SGTC_2521 angolensin 3.07 13.4 µM 4.03E-4 39 0.00108
16 SGTC_724 3910-0327 3.02 137.0 µM 4.80E-4 ERG2 57 0.00125
17 SGTC_2410 aloe-emodin-8-o-glycoside 3.01 46.3 µM 5.10E-4 mitochondrial processes 80 0.00132
18 SGTC_1821 st053465 2.94 65.6 µM 6.57E-4 36 0.00165
19 SGTC_1200 1643-0193 2.91 18.4 µM 7.33E-4 55 0.00181
20 SGTC_2378 9074213 2.88 121.4 µM 8.11E-4 RSC complex & mRNA processing 85 0.00198

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.134 8.19E-15 YJL135W_d YJL135W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL134W/LCB3
0.116 1.87E-11 YGL081W_p YGL081W_p hom Putative protein of unknown function; non-essential gene; interacts genetically with CHS5, a gene involved in chitin biosynthesis
0.105 9.36E-10 YOR239W ABP140 hom AdoMet-dependent tRNA methyltransferase and actin binding protein; C-terminal domain is responsible for 3-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA-Thr and tRNA-Ser and contains an S-adenosylmethionine (AdoMet) binding motif; N-terminal actin binding sequence interacts with actin filaments and localizes to actin patches and cables; N- and C-terminal domains are encoded in separate ORFs that are translated into one protein via a +1 frameshift
0.101 4.11E-9 YDR049W VMS1 hom Component of a Cdc48p-complex involved in protein quality control; exhibits cytosolic and ER-membrane localization, with Cdc48p, during normal growth, and contributes to ER-associated degradation (ERAD) of specific substrates at a step after their ubiquitination; forms a mitochondrially-associated complex with Cdc48p and Npl4p under oxidative stress that is required for ubiquitin-mediated mitochondria-associated protein degradation (MAD); conserved in C. elegans and humans
0.100 6.13E-9 YOR047C STD1 hom Protein involved in control of glucose-regulated gene expression; interacts with kinase Snf1p, glucose sensors Snf3p and Rgt2p, TATA-binding Spt15p; regulator of transcription factor Rgt1p; interactions with Pma1p appear to propagate [GAR+]
0.099 8.06E-9 YDR446W ECM11 hom Non-essential protein apparently involved in meiosis, GFP fusion protein is present in discrete clusters in the nucleus throughout mitosis; may be involved in maintaining chromatin structure
0.096 3.03E-8 YKL193C SDS22 het Regulatory subunit of the type 1 protein phosphatase (PP1) Glc7p; whether it functions as a positive or negative regulator of Glc7p is controversial; involved in the regulation of Glc7p nuclear localization and function
0.093 6.65E-8 YJL134W LCB3 hom Long-chain base-1-phosphate phosphatase; specific for dihydrosphingosine-1-phosphate, regulates ceramide and long-chain base phosphates levels, involved in incorporation of exogenous long chain bases in sphingolipids; LCB3 has a paralog, YSR3, that arose from the whole genome duplication
0.093 7.22E-8 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.092 1.02E-7 YDR488C PAC11 hom Dynein intermediate chain, acts in the cytoplasmic dynein pathway, forms cortical cytoplasmic microtubule capture site with Num1p; null mutant is defective in nuclear migration, essential in the absence of CIN8
0.088 3.34E-7 YHR180W_d YHR180W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.088 3.65E-7 YER095W RAD51 hom Strand exchange protein, forms a helical filament with DNA that searches for homology; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; homolog of Dmc1p and bacterial RecA protein
0.087 4.68E-7 YDR001C NTH1 hom Neutral trehalase, degrades trehalose; required for thermotolerance and may mediate resistance to other cellular stresses; may be phosphorylated by Cdc28p; NTH1 has a paralog, NTH2, that arose from the whole genome duplication
0.086 5.38E-7 YDR279W RNH202 hom Ribonuclease H2 subunit, required for RNase H2 activity; related to human AGS2 that causes Aicardi-Goutieres syndrome
0.083 1.58E-6 YGL259W_p YPS5_p hom Protein with similarity to GPI-anchored aspartic proteases such as Yap1p and Yap3p