YDR524C / AGE1

ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in the secretory and endocytic pathways; contains C2C2H2 cysteine/histidine motif

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR524C / AGE1

Click on Significant Values for Screen Details ID:SGTC_50|Compound:0929-0078|FD-Score:-2.88|P-value:1.65E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:2.97|P-value:5.72E-5 ID:SGTC_71|Compound:0417-1750|FD-Score:3.21|P-value:1.64E-5 ID:SGTC_90|Compound:0870-0863|FD-Score:3.00|P-value:4.89E-5 ID:SGTC_117|Compound:lucigenin|FD-Score:2.69|P-value:2.39E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:2.66|P-value:2.67E-4 ID:SGTC_244|Compound:nsc-207895|FD-Score:2.48|P-value:6.17E-4 ID:SGTC_297|Compound:0986-0032|FD-Score:-2.73|P-value:3.35E-4 ID:SGTC_298|Compound:1391-0729|FD-Score:2.97|P-value:5.94E-5 ID:SGTC_303|Compound:1348-1668|FD-Score:2.51|P-value:5.50E-4 ID:SGTC_318|Compound:1488-0629|FD-Score:2.52|P-value:5.28E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:3.13|P-value:2.53E-5 ID:SGTC_448|Compound:monastrol|FD-Score:2.79|P-value:1.47E-4 ID:SGTC_460|Compound:trequinsin|FD-Score:2.44|P-value:7.32E-4 ID:SGTC_695|Compound:3505-6186|FD-Score:-2.78|P-value:2.72E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:2.94|P-value:6.70E-5 ID:SGTC_769|Compound:0302-0231|FD-Score:-2.70|P-value:3.88E-4 ID:SGTC_875|Compound:0709-0210|FD-Score:3.71|P-value:8.41E-7 ID:SGTC_1004|Compound:4084-0029|FD-Score:2.40|P-value:8.75E-4 ID:SGTC_1029|Compound:k015-0030|FD-Score:-2.62|P-value:5.48E-4 ID:SGTC_1079|Compound:idarubicin|FD-Score:2.62|P-value:3.26E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:2.94|P-value:6.68E-5 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:3.23|P-value:1.48E-5 ID:SGTC_1242|Compound:0402-0103|FD-Score:-2.71|P-value:3.65E-4 ID:SGTC_1288|Compound:0973-0013|FD-Score:-2.73|P-value:3.38E-4 ID:SGTC_1359|Compound:1582-0056|FD-Score:3.18|P-value:1.94E-5 ID:SGTC_1372|Compound:2752-0194|FD-Score:-2.63|P-value:5.25E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:2.53|P-value:4.93E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:2.39|P-value:9.21E-4 ID:SGTC_1629|Compound:st005085|FD-Score:2.51|P-value:5.52E-4 ID:SGTC_1712|Compound:st032288|FD-Score:-3.52|P-value:5.17E-6 ID:SGTC_1781|Compound:st038725|FD-Score:-2.60|P-value:6.03E-4 ID:SGTC_2006|Compound:4011487|FD-Score:2.92|P-value:7.53E-5 ID:SGTC_2208|Compound:7283366|FD-Score:2.65|P-value:2.84E-4 ID:SGTC_2211|Compound:7117706|FD-Score:2.55|P-value:4.54E-4 ID:SGTC_2214|Compound:7179297|FD-Score:2.54|P-value:4.65E-4 ID:SGTC_2315|Compound:7733312|FD-Score:2.55|P-value:4.63E-4 ID:SGTC_2320|Compound:7373003|FD-Score:-2.89|P-value:1.59E-4 ID:SGTC_2354|Compound:9060492|FD-Score:2.51|P-value:5.48E-4 ID:SGTC_2355|Compound:9061122|FD-Score:3.11|P-value:2.83E-5 ID:SGTC_2458|Compound:5808907|FD-Score:2.79|P-value:1.48E-4 ID:SGTC_2473|Compound:5854593|FD-Score:2.63|P-value:3.16E-4 ID:SGTC_2479|Compound:5617353|FD-Score:-2.63|P-value:5.32E-4 ID:SGTC_2570|Compound:licareol|FD-Score:2.73|P-value:1.93E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:2.56|P-value:4.28E-4 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:3.15|P-value:2.24E-5 ID:SGTC_2749|Compound:bexarotene|FD-Score:-6.25|P-value:1.60E-15 ID:SGTC_2754|Compound:granisetron|FD-Score:-5.46|P-value:3.21E-12 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.22|P-value:1.50E-5 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.79|P-value:4.99E-7 ID:SGTC_2893|Compound:9048488|FD-Score:3.02|P-value:4.61E-5 ID:SGTC_2897|Compound:9048598|FD-Score:-3.10|P-value:5.48E-5 ID:SGTC_2908|Compound:7930301|FD-Score:-2.53|P-value:8.43E-4 ID:SGTC_3037|Compound:9091026|FD-Score:3.20|P-value:1.71E-5 ID:SGTC_3152|Compound:9099253|FD-Score:4.49|P-value:3.63E-9 ID:SGTC_3188|Compound:9110789|FD-Score:3.33|P-value:8.14E-6 ID:SGTC_3208|Compound:9114115|FD-Score:2.51|P-value:5.40E-4 ID:SGTC_3223|Compound:9129970|FD-Score:-3.27|P-value:2.22E-5 ID:SGTC_3224|Compound:9130643|FD-Score:2.70|P-value:2.25E-4 ID:SGTC_3307|Compound:9126885|FD-Score:-2.58|P-value:6.56E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:-2.88|P-value:1.65E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:2.97|P-value:5.72E-5 ID:SGTC_71|Compound:0417-1750|FD-Score:3.21|P-value:1.64E-5 ID:SGTC_90|Compound:0870-0863|FD-Score:3.00|P-value:4.89E-5 ID:SGTC_117|Compound:lucigenin|FD-Score:2.69|P-value:2.39E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:2.66|P-value:2.67E-4 ID:SGTC_244|Compound:nsc-207895|FD-Score:2.48|P-value:6.17E-4 ID:SGTC_297|Compound:0986-0032|FD-Score:-2.73|P-value:3.35E-4 ID:SGTC_298|Compound:1391-0729|FD-Score:2.97|P-value:5.94E-5 ID:SGTC_303|Compound:1348-1668|FD-Score:2.51|P-value:5.50E-4 ID:SGTC_318|Compound:1488-0629|FD-Score:2.52|P-value:5.28E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:3.13|P-value:2.53E-5 ID:SGTC_448|Compound:monastrol|FD-Score:2.79|P-value:1.47E-4 ID:SGTC_460|Compound:trequinsin|FD-Score:2.44|P-value:7.32E-4 ID:SGTC_695|Compound:3505-6186|FD-Score:-2.78|P-value:2.72E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:2.94|P-value:6.70E-5 ID:SGTC_769|Compound:0302-0231|FD-Score:-2.70|P-value:3.88E-4 ID:SGTC_875|Compound:0709-0210|FD-Score:3.71|P-value:8.41E-7 ID:SGTC_1004|Compound:4084-0029|FD-Score:2.40|P-value:8.75E-4 ID:SGTC_1029|Compound:k015-0030|FD-Score:-2.62|P-value:5.48E-4 ID:SGTC_1079|Compound:idarubicin|FD-Score:2.62|P-value:3.26E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:2.94|P-value:6.68E-5 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:3.23|P-value:1.48E-5 ID:SGTC_1242|Compound:0402-0103|FD-Score:-2.71|P-value:3.65E-4 ID:SGTC_1288|Compound:0973-0013|FD-Score:-2.73|P-value:3.38E-4 ID:SGTC_1359|Compound:1582-0056|FD-Score:3.18|P-value:1.94E-5 ID:SGTC_1372|Compound:2752-0194|FD-Score:-2.63|P-value:5.25E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:2.53|P-value:4.93E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:2.39|P-value:9.21E-4 ID:SGTC_1629|Compound:st005085|FD-Score:2.51|P-value:5.52E-4 ID:SGTC_1712|Compound:st032288|FD-Score:-3.52|P-value:5.17E-6 ID:SGTC_1781|Compound:st038725|FD-Score:-2.60|P-value:6.03E-4 ID:SGTC_2006|Compound:4011487|FD-Score:2.92|P-value:7.53E-5 ID:SGTC_2208|Compound:7283366|FD-Score:2.65|P-value:2.84E-4 ID:SGTC_2211|Compound:7117706|FD-Score:2.55|P-value:4.54E-4 ID:SGTC_2214|Compound:7179297|FD-Score:2.54|P-value:4.65E-4 ID:SGTC_2315|Compound:7733312|FD-Score:2.55|P-value:4.63E-4 ID:SGTC_2320|Compound:7373003|FD-Score:-2.89|P-value:1.59E-4 ID:SGTC_2354|Compound:9060492|FD-Score:2.51|P-value:5.48E-4 ID:SGTC_2355|Compound:9061122|FD-Score:3.11|P-value:2.83E-5 ID:SGTC_2458|Compound:5808907|FD-Score:2.79|P-value:1.48E-4 ID:SGTC_2473|Compound:5854593|FD-Score:2.63|P-value:3.16E-4 ID:SGTC_2479|Compound:5617353|FD-Score:-2.63|P-value:5.32E-4 ID:SGTC_2570|Compound:licareol|FD-Score:2.73|P-value:1.93E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:2.56|P-value:4.28E-4 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:3.15|P-value:2.24E-5 ID:SGTC_2749|Compound:bexarotene|FD-Score:-6.25|P-value:1.60E-15 ID:SGTC_2754|Compound:granisetron|FD-Score:-5.46|P-value:3.21E-12 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.22|P-value:1.50E-5 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.79|P-value:4.99E-7 ID:SGTC_2893|Compound:9048488|FD-Score:3.02|P-value:4.61E-5 ID:SGTC_2897|Compound:9048598|FD-Score:-3.10|P-value:5.48E-5 ID:SGTC_2908|Compound:7930301|FD-Score:-2.53|P-value:8.43E-4 ID:SGTC_3037|Compound:9091026|FD-Score:3.20|P-value:1.71E-5 ID:SGTC_3152|Compound:9099253|FD-Score:4.49|P-value:3.63E-9 ID:SGTC_3188|Compound:9110789|FD-Score:3.33|P-value:8.14E-6 ID:SGTC_3208|Compound:9114115|FD-Score:2.51|P-value:5.40E-4 ID:SGTC_3223|Compound:9129970|FD-Score:-3.27|P-value:2.22E-5 ID:SGTC_3224|Compound:9130643|FD-Score:2.70|P-value:2.25E-4 ID:SGTC_3307|Compound:9126885|FD-Score:-2.58|P-value:6.56E-4

Top fitness defect scores for YDR524C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3152 9099253 4.49 49.5 µM 3.63E-9 NEO1-PIK1 105 3.58E-6
2 SGTC_2758 dehydroepiandrosterone 3.79 69.3 µM 4.99E-7 42 7.61E-5
3 SGTC_875 0709-0210 3.71 25.7 µM 8.41E-7 fatty acid desaturase (OLE1) 39 1.05E-4
4 SGTC_3188 9110789 3.33 49.5 µM 8.14E-6 iron homeostasis 44 4.34E-4
5 SGTC_1135 dihydrocapsaicin 3.23 536.7 nM 1.48E-5 64 6.29E-4
6 SGTC_2757 clomiphene 3.22 4.2 µM 1.50E-5 fatty acid desaturase (OLE1) 76 6.34E-4
7 SGTC_71 0417-1750 3.21 47.8 µM 1.64E-5 Golgi 87 6.71E-4
8 SGTC_3037 9091026 3.20 49.5 µM 1.71E-5 NEO1-PIK1 186 6.89E-4
9 SGTC_1359 1582-0056 3.18 520.0 nM 1.94E-5 48 7.46E-4
10 SGTC_2697 mebhydrolin 3.15 72.4 µM 2.24E-5 NEO1 110 8.16E-4
11 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 3.13 8.0 µM 2.53E-5 60 8.80E-4
12 SGTC_2355 9061122 3.11 103.1 µM 2.83E-5 35 9.44E-4
13 SGTC_2893 9048488 3.02 26.0 µM 4.61E-5 fatty acid desaturase (OLE1) 59 0.00128
14 SGTC_90 0870-0863 3.00 4.6 µM 4.89E-5 94 0.00133
15 SGTC_70 0141-0289 2.97 43.3 µM 5.72E-5 mitochondrial stress 288 0.00147
16 SGTC_298 1391-0729 2.97 10.0 µM 5.94E-5 calcium & mitochondrial duress 41 0.00150
17 SGTC_1083 didemethylchlorpromazine sulfoxide 2.94 707.4 nM 6.68E-5 redox potentiating 154 0.00162
18 SGTC_768 0384-0033 2.94 77.3 µM 6.70E-5 fatty acid desaturase (OLE1) 151 0.00162
19 SGTC_2006 4011487 2.92 200.0 µM 7.53E-5 endomembrane recycling 150 0.00174
20 SGTC_448 monastrol 2.79 171.0 µM 1.47E-4 48 0.00265

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.186 1.99E-27 YGL230C_p YGL230C_p hom Putative protein of unknown function; non-essential gene
0.155 1.81E-19 YJR075W HOC1 hom Alpha-1,6-mannosyltransferase involved in cell wall mannan biosynthesis; subunit of a Golgi-localized complex that also contains Anp1p, Mnn9p, Mnn11p, and Mnn10p; identified as a suppressor of a cell lysis sensitive pkc1-371 allele
0.151 1.86E-18 YDL210W UGA4 hom Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane
0.142 1.26E-16 YLL036C PRP19 het Splicing factor associated with the spliceosome; contains a U-box, a motif found in a class of ubiquitin ligases, and a WD40 domain
0.142 1.78E-16 YGR117C_p YGR117C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.136 2.96E-15 YPR041W TIF5 het Translation initiation factor eIF5; functions both as a GTPase-activating protein to mediate hydrolysis of ribosome-bound GTP and as a GDP dissociation inhibitor to prevent recycling of eIF2
0.128 1.22E-13 YDR456W NHX1 hom Na+/H+ and K+/H+ exchanger, required for intracellular sequestration of Na+ and K+; located in the vacuole and late endosome compartments; required for osmotolerance to acute hypertonic shock and for vacuolar fusion
0.127 1.45E-13 YIL153W RRD1 hom Peptidyl-prolyl cis/trans-isomerase; activator of the phosphotyrosyl phosphatase activity of PP2A; involved in G1 phase progression, microtubule dynamics, bud morphogenesis and DNA repair; required for rapid reduction of Sgs1p levels in response to rapamycin; subunit of the Tap42p-Sit4p-Rrd1p complex; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress
0.125 3.49E-13 YEL063C CAN1 hom Plasma membrane arginine permease; requires phosphatidyl ethanolamine (PE) for localization, exclusively associated with lipid rafts; mutation confers canavanine resistance; CAN1 has a paralog, ALP1, that arose from the whole genome duplication
0.124 5.08E-13 YLL034C RIX7 het Putative ATPase of the AAA family, required for export of pre-ribosomal large subunits from the nucleus; distributed between the nucleolus, nucleoplasm, and nuclear periphery depending on growth conditions
0.123 8.67E-13 YLR355C ILV5 het Bifunctional acetohydroxyacid reductoisomerase and mtDNA binding protein; involved in branched-chain amino acid biosynthesis and maintenance of wild-type mitochondrial DNA; found in mitochondrial nucleoids
0.115 2.85E-11 YDR503C LPP1 hom Lipid phosphate phosphatase, catalyzes Mg(2+)-independent dephosphorylation of phosphatidic acid (PA), lysophosphatidic acid, and diacylglycerol pyrophosphate; involved in control of the cellular levels of phosphatidylinositol and PA
0.114 3.19E-11 YDR372C VPS74 hom Golgi phosphatidylinositol-4-kinase effector and PtdIns4P sensor; interacts with the cytosolic domains of cis and medial glycosyltransferases, and in the PtdIns4P-bound state mediates the targeting of these enzymes to the Golgi; interacts with the catalytic domain of Sac1p, the major cellular PtdIns4P phosphatase, to direct dephosphosphorylation of the Golgi pool of PtdIns4P; tetramerization required for function; ortholog of human GOLPH3/GPP34/GMx33
0.114 4.00E-11 YLR057W MNL2 hom Putative mannosidase involved in ER-associated protein degradation; localizes to the endoplasmic reticulum; sequence similarity with seven-hairpin glycosidase (GH47) family members, such as Mns1p and Mnl1p, that hydrolyze 1,2-linked alpha-D-mannose residues; non-essential gene
0.111 1.00E-10 YJR126C VPS70 hom Protein of unknown function involved in vacuolar protein sorting