YDR529C / QCR7

Subunit 7 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the mitochondrial matrix; N-terminus appears to play a role in complex assembly

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR529C / QCR7

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:3.57|P-value:6.47E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:4.71|P-value:1.07E-5 ID:SGTC_68|Compound:0986-0284|FD-Score:7.69|P-value:1.95E-12 ID:SGTC_70|Compound:0141-0289|FD-Score:13.90|P-value:1.32E-36 ID:SGTC_72|Compound:0744-0168|FD-Score:4.34|P-value:4.52E-5 ID:SGTC_173|Compound:1273-0061|FD-Score:5.56|P-value:2.70E-7 ID:SGTC_236|Compound:1509-0011|FD-Score:10.80|P-value:9.33E-23 ID:SGTC_275|Compound:trichlorophene|FD-Score:5.12|P-value:1.98E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:8.48|P-value:9.51E-15 ID:SGTC_339|Compound:3091-4833|FD-Score:-3.55|P-value:6.44E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:-3.58|P-value:5.82E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:-3.77|P-value:3.09E-4 ID:SGTC_403|Compound:arphamenine a|FD-Score:-3.82|P-value:2.59E-4 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:3.83|P-value:2.82E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:3.68|P-value:4.57E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:4.35|P-value:4.40E-5 ID:SGTC_720|Compound:r052-1644|FD-Score:3.44|P-value:9.75E-4 ID:SGTC_738|Compound:1315-0003|FD-Score:3.98|P-value:1.66E-4 ID:SGTC_845|Compound:0330-0138|FD-Score:-3.48|P-value:8.01E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:3.92|P-value:2.04E-4 ID:SGTC_1041|Compound:0206-0046|FD-Score:9.10|P-value:1.07E-16 ID:SGTC_1042|Compound:0350-0096|FD-Score:6.47|P-value:2.64E-9 ID:SGTC_1056|Compound:3448-1962|FD-Score:-3.56|P-value:6.11E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:3.65|P-value:5.05E-4 ID:SGTC_1307|Compound:1187-1599|FD-Score:3.77|P-value:3.45E-4 ID:SGTC_1453|Compound:4237-0541|FD-Score:3.76|P-value:3.54E-4 ID:SGTC_1615|Compound:st002656|FD-Score:4.66|P-value:1.30E-5 ID:SGTC_1621|Compound:st003705|FD-Score:3.70|P-value:4.25E-4 ID:SGTC_1622|Compound:st003707|FD-Score:4.67|P-value:1.25E-5 ID:SGTC_1624|Compound:st003710|FD-Score:3.93|P-value:2.00E-4 ID:SGTC_1700|Compound:st030840|FD-Score:3.63|P-value:5.31E-4 ID:SGTC_1707|Compound:st032323|FD-Score:-3.82|P-value:2.61E-4 ID:SGTC_1723|Compound:st034307|FD-Score:3.54|P-value:7.15E-4 ID:SGTC_1742|Compound:st038235|FD-Score:3.68|P-value:4.56E-4 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:-3.53|P-value:6.87E-4 ID:SGTC_2014|Compound:4013930|FD-Score:4.07|P-value:1.20E-4 ID:SGTC_2021|Compound:4019055|FD-Score:-3.73|P-value:3.56E-4 ID:SGTC_2161|Compound:5662504|FD-Score:3.90|P-value:2.19E-4 ID:SGTC_2183|Compound:6420625|FD-Score:3.86|P-value:2.52E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:4.26|P-value:6.21E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:5.34|P-value:7.38E-7 ID:SGTC_2526|Compound:patulin|FD-Score:4.19|P-value:7.90E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:-4.08|P-value:1.06E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:4.26|P-value:6.22E-5 ID:SGTC_2639|Compound:lactacystin|FD-Score:4.12|P-value:1.02E-4 ID:SGTC_2682|Compound:pyrogallin|FD-Score:3.50|P-value:8.07E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.36|P-value:6.62E-7 ID:SGTC_2754|Compound:granisetron|FD-Score:5.62|P-value:1.98E-7 ID:SGTC_2833|Compound:9001315|FD-Score:-4.44|P-value:2.83E-5 ID:SGTC_2834|Compound:9001755|FD-Score:3.54|P-value:7.24E-4 ID:SGTC_2874|Compound:9043904|FD-Score:3.43|P-value:9.93E-4 ID:SGTC_2875|Compound:9039966|FD-Score:-3.51|P-value:7.19E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-5.00|P-value:2.93E-6 ID:SGTC_3020|Compound:9089140|FD-Score:-3.52|P-value:7.04E-4 ID:SGTC_3025|Compound:9087895|FD-Score:-3.78|P-value:3.03E-4 ID:SGTC_3027|Compound:9089541|FD-Score:4.49|P-value:2.61E-5 ID:SGTC_3043|Compound:9092303|FD-Score:4.04|P-value:1.36E-4 ID:SGTC_3214|Compound:9129694|FD-Score:-3.40|P-value:0.00100 ID:SGTC_10|Compound:0279-0212|FD-Score:3.57|P-value:6.47E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:4.71|P-value:1.07E-5 ID:SGTC_68|Compound:0986-0284|FD-Score:7.69|P-value:1.95E-12 ID:SGTC_70|Compound:0141-0289|FD-Score:13.90|P-value:1.32E-36 ID:SGTC_72|Compound:0744-0168|FD-Score:4.34|P-value:4.52E-5 ID:SGTC_173|Compound:1273-0061|FD-Score:5.56|P-value:2.70E-7 ID:SGTC_236|Compound:1509-0011|FD-Score:10.80|P-value:9.33E-23 ID:SGTC_275|Compound:trichlorophene|FD-Score:5.12|P-value:1.98E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:8.48|P-value:9.51E-15 ID:SGTC_339|Compound:3091-4833|FD-Score:-3.55|P-value:6.44E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:-3.58|P-value:5.82E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:-3.77|P-value:3.09E-4 ID:SGTC_403|Compound:arphamenine a|FD-Score:-3.82|P-value:2.59E-4 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:3.83|P-value:2.82E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:3.68|P-value:4.57E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:4.35|P-value:4.40E-5 ID:SGTC_720|Compound:r052-1644|FD-Score:3.44|P-value:9.75E-4 ID:SGTC_738|Compound:1315-0003|FD-Score:3.98|P-value:1.66E-4 ID:SGTC_845|Compound:0330-0138|FD-Score:-3.48|P-value:8.01E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:3.92|P-value:2.04E-4 ID:SGTC_1041|Compound:0206-0046|FD-Score:9.10|P-value:1.07E-16 ID:SGTC_1042|Compound:0350-0096|FD-Score:6.47|P-value:2.64E-9 ID:SGTC_1056|Compound:3448-1962|FD-Score:-3.56|P-value:6.11E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:3.65|P-value:5.05E-4 ID:SGTC_1307|Compound:1187-1599|FD-Score:3.77|P-value:3.45E-4 ID:SGTC_1453|Compound:4237-0541|FD-Score:3.76|P-value:3.54E-4 ID:SGTC_1615|Compound:st002656|FD-Score:4.66|P-value:1.30E-5 ID:SGTC_1621|Compound:st003705|FD-Score:3.70|P-value:4.25E-4 ID:SGTC_1622|Compound:st003707|FD-Score:4.67|P-value:1.25E-5 ID:SGTC_1624|Compound:st003710|FD-Score:3.93|P-value:2.00E-4 ID:SGTC_1700|Compound:st030840|FD-Score:3.63|P-value:5.31E-4 ID:SGTC_1707|Compound:st032323|FD-Score:-3.82|P-value:2.61E-4 ID:SGTC_1723|Compound:st034307|FD-Score:3.54|P-value:7.15E-4 ID:SGTC_1742|Compound:st038235|FD-Score:3.68|P-value:4.56E-4 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:-3.53|P-value:6.87E-4 ID:SGTC_2014|Compound:4013930|FD-Score:4.07|P-value:1.20E-4 ID:SGTC_2021|Compound:4019055|FD-Score:-3.73|P-value:3.56E-4 ID:SGTC_2161|Compound:5662504|FD-Score:3.90|P-value:2.19E-4 ID:SGTC_2183|Compound:6420625|FD-Score:3.86|P-value:2.52E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:4.26|P-value:6.21E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:5.34|P-value:7.38E-7 ID:SGTC_2526|Compound:patulin|FD-Score:4.19|P-value:7.90E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:-4.08|P-value:1.06E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:4.26|P-value:6.22E-5 ID:SGTC_2639|Compound:lactacystin|FD-Score:4.12|P-value:1.02E-4 ID:SGTC_2682|Compound:pyrogallin|FD-Score:3.50|P-value:8.07E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.36|P-value:6.62E-7 ID:SGTC_2754|Compound:granisetron|FD-Score:5.62|P-value:1.98E-7 ID:SGTC_2833|Compound:9001315|FD-Score:-4.44|P-value:2.83E-5 ID:SGTC_2834|Compound:9001755|FD-Score:3.54|P-value:7.24E-4 ID:SGTC_2874|Compound:9043904|FD-Score:3.43|P-value:9.93E-4 ID:SGTC_2875|Compound:9039966|FD-Score:-3.51|P-value:7.19E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-5.00|P-value:2.93E-6 ID:SGTC_3020|Compound:9089140|FD-Score:-3.52|P-value:7.04E-4 ID:SGTC_3025|Compound:9087895|FD-Score:-3.78|P-value:3.03E-4 ID:SGTC_3027|Compound:9089541|FD-Score:4.49|P-value:2.61E-5 ID:SGTC_3043|Compound:9092303|FD-Score:4.04|P-value:1.36E-4 ID:SGTC_3214|Compound:9129694|FD-Score:-3.40|P-value:0.00100

Top fitness defect scores for YDR529C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_70 0141-0289 13.90 43.3 µM 1.32E-36 mitochondrial stress 11 2.17E-44
2 SGTC_236 1509-0011 10.80 5.3 µM 9.33E-23 176 1.84E-27
3 SGTC_1041 0206-0046 9.10 107.0 µM 1.07E-16 8 4.65E-20
4 SGTC_310 1273-0058 8.48 1.1 µM 9.51E-15 mitochondrial stress 74 1.12E-17
5 SGTC_68 0986-0284 7.69 82.8 µM 1.95E-12 7 7.44E-15
6 SGTC_1042 0350-0096 6.47 82.0 µM 2.64E-9 TSC3-RPN4 4 4.91E-11
7 SGTC_2754 granisetron 5.62 64.0 µM 1.98E-7 9 9.46E-9
8 SGTC_173 1273-0061 5.56 2.7 µM 2.70E-7 mitochondrial stress 120 1.38E-8
9 SGTC_2688 kanamycin b 5.36 96.7 µM 6.62E-7 calcium & mitochondrial duress 208 4.13E-8
10 SGTC_2250 alverine citrate 5.34 130.0 µM 7.38E-7 81 4.71E-8
11 SGTC_275 trichlorophene 5.12 5.7 µM 1.98E-6 mitochondrial stress 163 1.57E-7
12 SGTC_66 0109-0187 4.71 42.4 µM 1.07E-5 24 1.21E-6
13 SGTC_1622 st003707 4.67 19.4 µM 1.25E-5 calcium & mitochondrial duress 21 1.47E-6
14 SGTC_1615 st002656 4.66 86.5 µM 1.30E-5 redox potentiating 4 1.55E-6
15 SGTC_3027 9089541 4.49 49.5 µM 2.61E-5 fatty acid desaturase (OLE1) 12 3.60E-6
16 SGTC_673 1082-0474 4.35 110.0 µM 4.40E-5 RSC complex & mRNA processing 49 6.81E-6
17 SGTC_72 0744-0168 4.34 198.4 µM 4.52E-5 RPP1 & pyrimidine depletion 23 7.03E-6
18 SGTC_2232 chlorophetanol 4.26 41.5 µM 6.21E-5 TRP & mitochondrial translation 110 1.03E-5
19 SGTC_2614 arthonioic acid 4.26 13.4 µM 6.22E-5 18 1.04E-5
20 SGTC_2526 patulin 4.19 37.6 µM 7.90E-5 78 1.39E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.416 2.50E-140 YDR509W_d YDR509W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.408 3.52E-135 YGR215W RSM27 hom Mitochondrial ribosomal protein of the small subunit
0.408 3.58E-135 YDR065W RRG1 hom Protein of unknown function, required for vacuolar acidification and mitochondrial genome maintenance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.400 1.62E-128 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.383 1.98E-117 YER050C RSM18 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.382 4.31E-117 YNL081C SWS2 hom Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency
0.375 1.02E-112 YDR237W MRPL7 hom Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein
0.375 1.68E-112 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.375 2.26E-112 YER087W AIM10 hom Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss
0.371 4.46E-110 YPL040C ISM1 hom Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
0.371 5.02E-110 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.366 3.37E-107 YKL170W MRPL38 hom Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels; protein abundance increases in response to DNA replication stress
0.365 2.25E-106 YMR072W ABF2 hom Mitochondrial DNA-binding protein involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; activity may be regulated by protein kinase A phosphorylation
0.363 7.67E-105 YNL005C MRP7 hom Mitochondrial ribosomal protein of the large subunit
0.362 2.05E-104 YMR193W MRPL24 hom Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene