HIPHOP chemogenomics database

YDR533C / HSP31

Possible chaperone and cysteine protease; has similarity to E. coli Hsp31; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease; exists as a dimer and contains a putative metal-binding site; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain

fixedexpanded
Profile for YDR533C / HSP31

Click on Significant Values for Screen Details

Top fitness defect scores for YDR533C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_236	1509-0011	18.30	5.3 µM	6.77E-58		67	3.67E-75
2	SGTC_1635	st007035	11.80	42.4 µM	3.09E-25		61	2.08E-32
3	SGTC_275	trichlorophene	10.70	5.7 µM	4.44E-21	mitochondrial stress	36	5.67E-27
4	SGTC_386	1509-0011	9.01	3.1 µM	1.60E-15		53	1.02E-19
5	SGTC_134	0269-0018	8.58	6.9 µM	3.02E-14		54	4.74E-18
6	SGTC_70	0141-0289	8.17	43.3 µM	4.35E-13	mitochondrial stress	38	1.54E-16
7	SGTC_168	3970-0862	7.08	530.5 µM	2.82E-10		28	7.08E-13
8	SGTC_173	1273-0061	6.95	2.7 µM	5.78E-10	mitochondrial stress	89	1.80E-12
9	SGTC_908	3448-7491	6.93	47.7 µM	6.46E-10	mitochondrial stress	27	2.08E-12
10	SGTC_2250	alverine citrate	6.69	130.0 µM	2.35E-9		39	1.12E-11
11	SGTC_1188	1403-0014	6.35	4.6 µM	1.36E-8	mitochondrial stress	16	1.10E-10
12	SGTC_343	4130-2827	5.66	29.8 µM	3.51E-7		6	7.44E-9
13	SGTC_10	0279-0212	5.38	42.6 µM	1.23E-6	TRP & mitochondrial translation	45	3.78E-8
14	SGTC_38	0929-0051	5.31	58.3 µM	1.62E-6		5	5.43E-8
15	SGTC_1742	st038235	5.31	28.9 µM	1.64E-6	mitochondrial stress	68	5.49E-8
16	SGTC_767	0929-0023	5.13	86.0 µM	3.51E-6	TRP & mitochondrial translation	32	1.48E-7
17	SGTC_596	1155-0152	5.10	116.0 µM	3.95E-6	TRP & mitochondrial translation	14	1.72E-7
18	SGTC_3338	9144300	4.80	39.6 µM	1.29E-5	Golgi	11	7.96E-7
19	SGTC_2238	6671620	4.71	73.2 µM	1.83E-5		14	1.24E-6
20	SGTC_748	0136-0228	4.41	77.9 µM	5.47E-5	redox potentiating	64	5.14E-6

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.617	0	YDR518W	EUG1	hom	Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.603	0	YNL252C	MRPL17	hom	Mitochondrial ribosomal protein of the large subunit
0.595	5.05E-320	YOR330C	MIP1	hom	Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.582	5.38E-303	YDR462W	MRPL28	hom	Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.567	3.69E-285	YNL213C	RRG9	hom	Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.563	7.96E-280	YDR237W	MRPL7	hom	Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein
0.560	1.80E-276	YDR079W	PET100	hom	Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme
0.547	2.24E-261	YPL013C	MRPS16	hom	Mitochondrial ribosomal protein of the small subunit
0.545	4.24E-259	YJL023C	PET130	hom	Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.544	3.72E-258	YPR166C	MRP2	hom	Mitochondrial ribosomal protein of the small subunit
0.540	1.90E-253	YCR024C	SLM5	hom	Mitochondrial asparaginyl-tRNA synthetase
0.540	6.49E-253	YKL194C	MST1	hom	Mitochondrial threonyl-tRNA synthetase; aminoacylates both the canonical threonine tRNA tT(UGU)Q1 and the unusual threonine tRNA tT(XXX)Q2 in vitro
0.533	2.60E-245	YER141W	COX15	hom	Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase
0.528	1.26E-240	YKL068W-A_p	YKL068W-A_p	hom	Putative protein of unknown function; identified by homology to Ashbya gossypii
0.526	9.99E-239	YGR220C	MRPL9	hom	Mitochondrial ribosomal protein of the large subunit