Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YDR534C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.241 | 1.44E-45 | YGL243W | TAD1 | hom | tRNA-specific adenosine deaminase, deaminates adenosine-37 to inosine in tRNA-Ala |
0.193 | 2.31E-29 | YLR205C | HMX1 | hom | ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants |
0.172 | 1.35E-23 | YJR056C | YJR056C | hom | Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; relative distribution to the nucleus increases upon DNA replication stress |
0.167 | 1.87E-22 | YMR139W | RIM11 | hom | Protein kinase; required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta; protein abundance increases in response to DNA replication stress |
0.161 | 7.91E-21 | YLL046C | RNP1 | hom | Ribonucleoprotein that contains two RNA recognition motifs (RRM) |
0.149 | 3.28E-18 | YOR084W | LPX1 | hom | Oleic acid-inducible, peroxisomal matrix localized lipase; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; peroxisomal import is dependent on the PTS1 receptor, Pex5p and on self-interaction |
0.147 | 9.31E-18 | YGR153W_p | YGR153W_p | hom | Putative protein of unknown function |
0.147 | 1.22E-17 | YNR032C-A | HUB1 | hom | Ubiquitin-like protein modifier; promotes alternative splicing of SRC1 pre-mRNA; binds non-covalently to the HIND domain of Snu66, may function in modification of Sph1p and Hbt1p, functionally complemented by the human or S. pombe ortholog; mechanism of Hub1p adduct formation not yet clear |
0.143 | 8.10E-17 | YHR003C | YHR003C | hom | Protein of unknown function, localized to the mitochondrial outer membrane |
0.141 | 2.28E-16 | YMR111C | YMR111C | hom | Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR111C is not an essential gene; forms nuclear foci upon DNA replication stress |
0.141 | 2.70E-16 | YER053C | PIC2 | hom | Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Mir1p but less abundant than Mir1p under normal conditions; expression is induced at high temperature |
0.135 | 4.73E-15 | YMR184W | ADD37 | hom | Protein of unknown function; involved in ER-associated protein degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YMR184W is not an essential gene; protein abundance increases in response to DNA replication stress |
0.134 | 6.97E-15 | YOR010C | TIR2 | hom | Putative cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; transcription is induced by cold shock and anaerobiosis |
0.131 | 2.62E-14 | YLL060C | GTT2 | hom | Glutathione S-transferase capable of homodimerization; functional overlap with Gtt2p, Grx1p, and Grx2p; protein abundance increases in response to DNA replication stress |
0.128 | 8.65E-14 | YOR087W | YVC1 | hom | Vacuolar cation channel, mediates release of Ca(2+) from the vacuole in response to hyperosmotic shock |