YDR538W / PAD1

Phenylacrylic acid decarboxylase, confers resistance to cinnamic acid, decarboxylates aromatic carboxylic acids to the corresponding vinyl derivatives; also has mRNA binding activity; homolog of E. coli UbiX

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR538W / PAD1

Click on Significant Values for Screen Details ID:SGTC_199|Compound:4063-0024|FD-Score:4.33|P-value:4.79E-6 ID:SGTC_203|Compound:k066-0004|FD-Score:3.67|P-value:8.48E-5 ID:SGTC_359|Compound:0081-0058|FD-Score:4.94|P-value:2.18E-7 ID:SGTC_507|Compound:nimesulide|FD-Score:-3.82|P-value:5.47E-5 ID:SGTC_523|Compound:1934-0222|FD-Score:5.46|P-value:1.22E-8 ID:SGTC_527|Compound:4476-4215|FD-Score:-3.13|P-value:7.75E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:4.40|P-value:3.42E-6 ID:SGTC_541|Compound:4513-1321|FD-Score:3.06|P-value:8.43E-4 ID:SGTC_611|Compound:3453-1652|FD-Score:3.21|P-value:4.95E-4 ID:SGTC_663|Compound:1486-0733|FD-Score:3.53|P-value:1.50E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:3.23|P-value:4.67E-4 ID:SGTC_695|Compound:3505-6186|FD-Score:-3.43|P-value:2.59E-4 ID:SGTC_700|Compound:3453-2283|FD-Score:3.52|P-value:1.59E-4 ID:SGTC_703|Compound:3875-0075|FD-Score:3.08|P-value:8.07E-4 ID:SGTC_744|Compound:1594-0068|FD-Score:3.15|P-value:6.34E-4 ID:SGTC_762|Compound:1165-0429|FD-Score:4.54|P-value:1.74E-6 ID:SGTC_785|Compound:1270-0111|FD-Score:6.21|P-value:1.11E-10 ID:SGTC_816|Compound:0325-0417|FD-Score:-5.16|P-value:8.43E-8 ID:SGTC_849|Compound:0386-0493|FD-Score:3.74|P-value:6.46E-5 ID:SGTC_940|Compound:3232-1287|FD-Score:-3.42|P-value:2.68E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:5.71|P-value:2.74E-9 ID:SGTC_1047|Compound:2043-3044|FD-Score:3.77|P-value:5.65E-5 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:3.44|P-value:2.15E-4 ID:SGTC_1078|Compound:idebenone|FD-Score:3.76|P-value:5.99E-5 ID:SGTC_1152|Compound:3909-8331|FD-Score:3.60|P-value:1.13E-4 ID:SGTC_1186|Compound:1319-0216|FD-Score:3.84|P-value:4.29E-5 ID:SGTC_1206|Compound:3978-0017|FD-Score:4.09|P-value:1.42E-5 ID:SGTC_1215|Compound:3852-0577|FD-Score:3.03|P-value:9.38E-4 ID:SGTC_1390|Compound:3413-2614|FD-Score:5.69|P-value:2.98E-9 ID:SGTC_1419|Compound:3993-2473|FD-Score:3.26|P-value:4.19E-4 ID:SGTC_1473|Compound:k844-0725|FD-Score:4.89|P-value:2.83E-7 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:3.49|P-value:1.79E-4 ID:SGTC_1547|Compound:harmine|FD-Score:3.39|P-value:2.56E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:4.01|P-value:2.03E-5 ID:SGTC_1573|Compound:oleylamine|FD-Score:3.24|P-value:4.45E-4 ID:SGTC_1583|Compound:clindamycin|FD-Score:3.59|P-value:1.20E-4 ID:SGTC_1645|Compound:Cervolide|FD-Score:3.31|P-value:3.48E-4 ID:SGTC_1651|Compound:st011928|FD-Score:5.42|P-value:1.50E-8 ID:SGTC_1733|Compound:st037357|FD-Score:3.07|P-value:8.36E-4 ID:SGTC_1765|Compound:st044815|FD-Score:4.57|P-value:1.51E-6 ID:SGTC_1819|Compound:st053448|FD-Score:3.69|P-value:7.81E-5 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:3.15|P-value:6.12E-4 ID:SGTC_1915|Compound:st067105|FD-Score:3.34|P-value:3.17E-4 ID:SGTC_1954|Compound:st077032|FD-Score:4.59|P-value:1.32E-6 ID:SGTC_1961|Compound:st076550|FD-Score:-3.18|P-value:6.52E-4 ID:SGTC_2147|Compound:5545932|FD-Score:3.36|P-value:2.89E-4 ID:SGTC_2260|Compound:7964312|FD-Score:3.02|P-value:9.72E-4 ID:SGTC_2393|Compound:9031399|FD-Score:-3.66|P-value:1.07E-4 ID:SGTC_2394|Compound:5221648|FD-Score:-3.52|P-value:1.82E-4 ID:SGTC_2468|Compound:5987765|FD-Score:3.66|P-value:8.80E-5 ID:SGTC_2515|Compound:chrysin|FD-Score:3.47|P-value:1.93E-4 ID:SGTC_2532|Compound:xanthone|FD-Score:3.06|P-value:8.67E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:5.14|P-value:7.53E-8 ID:SGTC_2767|Compound:sibutramine|FD-Score:3.19|P-value:5.36E-4 ID:SGTC_2798|Compound:7813637|FD-Score:-3.07|P-value:9.63E-4 ID:SGTC_2800|Compound:7887935|FD-Score:-3.28|P-value:4.62E-4 ID:SGTC_2818|Compound:7996756|FD-Score:3.38|P-value:2.72E-4 ID:SGTC_2851|Compound:9015922|FD-Score:3.09|P-value:7.72E-4 ID:SGTC_2925|Compound:9010536|FD-Score:-3.58|P-value:1.49E-4 ID:SGTC_2943|Compound:9068529|FD-Score:4.15|P-value:1.09E-5 ID:SGTC_3002|Compound:9075603|FD-Score:4.15|P-value:1.08E-5 ID:SGTC_3009|Compound:9080819|FD-Score:3.46|P-value:1.94E-4 ID:SGTC_3010|Compound:9080089|FD-Score:3.11|P-value:7.28E-4 ID:SGTC_3103|Compound:9120822|FD-Score:4.29|P-value:5.72E-6 ID:SGTC_3201|Compound:9113999|FD-Score:4.66|P-value:9.42E-7 ID:SGTC_199|Compound:4063-0024|FD-Score:4.33|P-value:4.79E-6 ID:SGTC_203|Compound:k066-0004|FD-Score:3.67|P-value:8.48E-5 ID:SGTC_359|Compound:0081-0058|FD-Score:4.94|P-value:2.18E-7 ID:SGTC_507|Compound:nimesulide|FD-Score:-3.82|P-value:5.47E-5 ID:SGTC_523|Compound:1934-0222|FD-Score:5.46|P-value:1.22E-8 ID:SGTC_527|Compound:4476-4215|FD-Score:-3.13|P-value:7.75E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:4.40|P-value:3.42E-6 ID:SGTC_541|Compound:4513-1321|FD-Score:3.06|P-value:8.43E-4 ID:SGTC_611|Compound:3453-1652|FD-Score:3.21|P-value:4.95E-4 ID:SGTC_663|Compound:1486-0733|FD-Score:3.53|P-value:1.50E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:3.23|P-value:4.67E-4 ID:SGTC_695|Compound:3505-6186|FD-Score:-3.43|P-value:2.59E-4 ID:SGTC_700|Compound:3453-2283|FD-Score:3.52|P-value:1.59E-4 ID:SGTC_703|Compound:3875-0075|FD-Score:3.08|P-value:8.07E-4 ID:SGTC_744|Compound:1594-0068|FD-Score:3.15|P-value:6.34E-4 ID:SGTC_762|Compound:1165-0429|FD-Score:4.54|P-value:1.74E-6 ID:SGTC_785|Compound:1270-0111|FD-Score:6.21|P-value:1.11E-10 ID:SGTC_816|Compound:0325-0417|FD-Score:-5.16|P-value:8.43E-8 ID:SGTC_849|Compound:0386-0493|FD-Score:3.74|P-value:6.46E-5 ID:SGTC_940|Compound:3232-1287|FD-Score:-3.42|P-value:2.68E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:5.71|P-value:2.74E-9 ID:SGTC_1047|Compound:2043-3044|FD-Score:3.77|P-value:5.65E-5 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:3.44|P-value:2.15E-4 ID:SGTC_1078|Compound:idebenone|FD-Score:3.76|P-value:5.99E-5 ID:SGTC_1152|Compound:3909-8331|FD-Score:3.60|P-value:1.13E-4 ID:SGTC_1186|Compound:1319-0216|FD-Score:3.84|P-value:4.29E-5 ID:SGTC_1206|Compound:3978-0017|FD-Score:4.09|P-value:1.42E-5 ID:SGTC_1215|Compound:3852-0577|FD-Score:3.03|P-value:9.38E-4 ID:SGTC_1390|Compound:3413-2614|FD-Score:5.69|P-value:2.98E-9 ID:SGTC_1419|Compound:3993-2473|FD-Score:3.26|P-value:4.19E-4 ID:SGTC_1473|Compound:k844-0725|FD-Score:4.89|P-value:2.83E-7 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:3.49|P-value:1.79E-4 ID:SGTC_1547|Compound:harmine|FD-Score:3.39|P-value:2.56E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:4.01|P-value:2.03E-5 ID:SGTC_1573|Compound:oleylamine|FD-Score:3.24|P-value:4.45E-4 ID:SGTC_1583|Compound:clindamycin|FD-Score:3.59|P-value:1.20E-4 ID:SGTC_1645|Compound:Cervolide|FD-Score:3.31|P-value:3.48E-4 ID:SGTC_1651|Compound:st011928|FD-Score:5.42|P-value:1.50E-8 ID:SGTC_1733|Compound:st037357|FD-Score:3.07|P-value:8.36E-4 ID:SGTC_1765|Compound:st044815|FD-Score:4.57|P-value:1.51E-6 ID:SGTC_1819|Compound:st053448|FD-Score:3.69|P-value:7.81E-5 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:3.15|P-value:6.12E-4 ID:SGTC_1915|Compound:st067105|FD-Score:3.34|P-value:3.17E-4 ID:SGTC_1954|Compound:st077032|FD-Score:4.59|P-value:1.32E-6 ID:SGTC_1961|Compound:st076550|FD-Score:-3.18|P-value:6.52E-4 ID:SGTC_2147|Compound:5545932|FD-Score:3.36|P-value:2.89E-4 ID:SGTC_2260|Compound:7964312|FD-Score:3.02|P-value:9.72E-4 ID:SGTC_2393|Compound:9031399|FD-Score:-3.66|P-value:1.07E-4 ID:SGTC_2394|Compound:5221648|FD-Score:-3.52|P-value:1.82E-4 ID:SGTC_2468|Compound:5987765|FD-Score:3.66|P-value:8.80E-5 ID:SGTC_2515|Compound:chrysin|FD-Score:3.47|P-value:1.93E-4 ID:SGTC_2532|Compound:xanthone|FD-Score:3.06|P-value:8.67E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:5.14|P-value:7.53E-8 ID:SGTC_2767|Compound:sibutramine|FD-Score:3.19|P-value:5.36E-4 ID:SGTC_2798|Compound:7813637|FD-Score:-3.07|P-value:9.63E-4 ID:SGTC_2800|Compound:7887935|FD-Score:-3.28|P-value:4.62E-4 ID:SGTC_2818|Compound:7996756|FD-Score:3.38|P-value:2.72E-4 ID:SGTC_2851|Compound:9015922|FD-Score:3.09|P-value:7.72E-4 ID:SGTC_2925|Compound:9010536|FD-Score:-3.58|P-value:1.49E-4 ID:SGTC_2943|Compound:9068529|FD-Score:4.15|P-value:1.09E-5 ID:SGTC_3002|Compound:9075603|FD-Score:4.15|P-value:1.08E-5 ID:SGTC_3009|Compound:9080819|FD-Score:3.46|P-value:1.94E-4 ID:SGTC_3010|Compound:9080089|FD-Score:3.11|P-value:7.28E-4 ID:SGTC_3103|Compound:9120822|FD-Score:4.29|P-value:5.72E-6 ID:SGTC_3201|Compound:9113999|FD-Score:4.66|P-value:9.42E-7

Top fitness defect scores for YDR538W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_785 1270-0111 6.21 65.3 µM 1.11E-10 1 2.60E-10
2 SGTC_1002 4049-0206 5.71 172.0 µM 2.74E-9 7 5.70E-9
3 SGTC_1390 3413-2614 5.69 145.0 µM 2.98E-9 fatty acid desaturase (OLE1) 5 6.18E-9
4 SGTC_523 1934-0222 5.46 13.7 µM 1.22E-8 11 2.40E-8
5 SGTC_1651 st011928 5.42 86.1 µM 1.50E-8 RSC complex & mRNA processing 4 2.93E-8
6 SGTC_2565 isoliquiritigenin 5.14 100.0 µM 7.53E-8 17 1.39E-7
7 SGTC_359 0081-0058 4.94 15.9 µM 2.18E-7 60S ribosome export 20 3.85E-7
8 SGTC_1473 k844-0725 4.89 134.0 µM 2.83E-7 4 4.94E-7
9 SGTC_3201 9113999 4.66 49.5 µM 9.42E-7 21 1.58E-6
10 SGTC_1954 st077032 4.59 68.9 µM 1.32E-6 9 2.18E-6
11 SGTC_1765 st044815 4.57 90.4 µM 1.51E-6 13 2.48E-6
12 SGTC_762 1165-0429 4.54 115.0 µM 1.74E-6 TSC3-RPN4 8 2.85E-6
13 SGTC_530 4358-1714 4.40 28.0 µM 3.42E-6 34 5.45E-6
14 SGTC_199 4063-0024 4.33 41.6 µM 4.79E-6 3 7.54E-6
15 SGTC_3103 9120822 4.29 49.5 µM 5.72E-6 8 8.94E-6
16 SGTC_3002 9075603 4.15 71.4 µM 1.08E-5 19 1.64E-5
17 SGTC_2943 9068529 4.15 45.3 µM 1.09E-5 14 1.67E-5
18 SGTC_1206 3978-0017 4.09 132.0 µM 1.42E-5 ERG2 31 2.14E-5
19 SGTC_1564 D-Arginine 4.01 115.0 µM 2.03E-5 25 3.03E-5
20 SGTC_1186 1319-0216 3.84 26.0 µM 4.29E-5 19 6.21E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.101 4.54E-9 YPL216W_p YPL216W_p hom Putative protein of unknown function; YPL216W is not an essential gene
0.095 3.70E-8 YJL208C NUC1 hom Major mitochondrial nuclease, has RNAse and DNA endo- and exonucleolytic activities; has roles in mitochondrial recombination, apoptosis and maintenance of polyploidy
0.094 4.29E-8 YMR311C GLC8 hom Regulatory subunit of protein phosphatase 1 (Glc7p); involved in glycogen metabolism and chromosome segregation; proposed to regulate Glc7p activity via conformational alteration; ortholog of the mammalian protein phosphatase inhibitor 2; protein abundance increases in response to DNA replication stress
0.089 2.26E-7 YLR402W_d YLR402W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.086 6.10E-7 YMR082C_d YMR082C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.086 6.67E-7 YER103W SSA4 hom Heat shock protein that is highly induced upon stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the HSP70 family; cytoplasmic protein that concentrates in nuclei upon starvation; SSA4 has a paralog, SSA3, that arose from the whole genome duplication
0.083 1.45E-6 YOL113W SKM1 hom Member of the PAK family of serine/threonine protein kinases with similarity to Ste20p and Cla4p; involved in down-regulation of sterol uptake; proposed to be a downstream effector of Cdc42p during polarized growth
0.081 2.55E-6 YIL120W QDR1 hom Multidrug transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; required for resistance to quinidine, ketoconazole, fluconazole, and barban; QDR1 has a paralog, AQR1, that arose from the whole genome duplication
0.080 3.29E-6 YOR149C SMP3 het Alpha 1,2-mannosyltransferase involved in glycosyl phosphatidyl inositol (GPI) biosynthesis; required for addition of the fourth, side branching mannose to the GPI core structure
0.078 5.50E-6 YKL006C-A SFT1 het Intra-Golgi v-SNARE, required for transport of proteins between an early and a later Golgi compartment
0.078 6.75E-6 YHL016C DUR3 hom Plasma membrane transporter for both urea and polyamines, expression is highly sensitive to nitrogen catabolite repression and induced by allophanate, the last intermediate of the allantoin degradative pathway
0.076 1.12E-5 YDR225W HTA1 hom Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical subtypes (see also HTA2); DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p
0.072 3.13E-5 YNR066C_p YNR066C_p hom Putative membrane-localized protein of unknown function
0.072 3.23E-5 YHR024C MAS2 het Larger subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins
0.071 4.34E-5 YIL026C IRR1 het Subunit of the cohesin complex, which is required for sister chromatid cohesion during mitosis and meiosis and interacts with centromeres and chromosome arms, essential for viability