YEL016C / NPP2

Nucleotide pyrophosphatase/phosphodiesterase; mediates extracellular nucleotide phosphate hydrolysis along with Npp1p and Pho5p; activity and expression enhanced during conditions of phosphate starvation; NPP2 has a paralog, NPP1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YEL016C / NPP2

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:3.30|P-value:5.76E-4 ID:SGTC_12|Compound:0849-0099|FD-Score:3.20|P-value:8.11E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:3.34|P-value:5.10E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:3.57|P-value:2.22E-4 ID:SGTC_433|Compound:pimozide|FD-Score:-3.25|P-value:6.57E-4 ID:SGTC_495|Compound:decylubiquinone|FD-Score:-3.65|P-value:1.57E-4 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:-3.34|P-value:4.74E-4 ID:SGTC_724|Compound:3910-0327|FD-Score:3.20|P-value:8.17E-4 ID:SGTC_741|Compound:4582-0002|FD-Score:3.39|P-value:4.30E-4 ID:SGTC_1102|Compound:cgs 12066b|FD-Score:3.32|P-value:5.42E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.66|P-value:1.47E-4 ID:SGTC_1108|Compound:betulinic acid|FD-Score:3.22|P-value:7.80E-4 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:-4.08|P-value:2.71E-5 ID:SGTC_1168|Compound:k815-0004|FD-Score:3.75|P-value:1.14E-4 ID:SGTC_1181|Compound:1222-0449|FD-Score:3.81|P-value:8.92E-5 ID:SGTC_1415|Compound:3966-0071|FD-Score:-4.01|P-value:3.62E-5 ID:SGTC_1418|Compound:3966-3099|FD-Score:3.98|P-value:4.53E-5 ID:SGTC_1615|Compound:st002656|FD-Score:-3.15|P-value:9.10E-4 ID:SGTC_1768|Compound:st044301|FD-Score:-3.33|P-value:4.95E-4 ID:SGTC_1769|Compound:st044406|FD-Score:-5.24|P-value:1.12E-7 ID:SGTC_1773|Compound:st048542|FD-Score:-4.85|P-value:8.26E-7 ID:SGTC_1777|Compound:st045864|FD-Score:4.00|P-value:4.17E-5 ID:SGTC_1789|Compound:tunicamycin|FD-Score:-4.53|P-value:3.87E-6 ID:SGTC_1792|Compound:st045773|FD-Score:-4.72|P-value:1.57E-6 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:3.84|P-value:7.84E-5 ID:SGTC_1953|Compound:st076800|FD-Score:3.56|P-value:2.33E-4 ID:SGTC_1956|Compound:st077085|FD-Score:3.48|P-value:3.14E-4 ID:SGTC_2000|Compound:st075254|FD-Score:-3.81|P-value:8.12E-5 ID:SGTC_2032|Compound:5185112|FD-Score:-3.41|P-value:3.70E-4 ID:SGTC_2084|Compound:5306078|FD-Score:-4.17|P-value:1.85E-5 ID:SGTC_2199|Compound:6590217|FD-Score:-3.23|P-value:6.96E-4 ID:SGTC_2259|Compound:7964009|FD-Score:3.20|P-value:8.27E-4 ID:SGTC_2262|Compound:9014885|FD-Score:-3.59|P-value:1.95E-4 ID:SGTC_2367|Compound:9070478|FD-Score:-3.39|P-value:3.96E-4 ID:SGTC_2368|Compound:9071271|FD-Score:3.54|P-value:2.46E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.26|P-value:6.76E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:5.04|P-value:3.43E-7 ID:SGTC_2618|Compound:avocadyne|FD-Score:3.27|P-value:6.39E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:-4.26|P-value:1.27E-5 ID:SGTC_2761|Compound:levamisole|FD-Score:5.03|P-value:3.67E-7 ID:SGTC_3147|Compound:9097027|FD-Score:3.96|P-value:4.82E-5 ID:SGTC_3156|Compound:9099931|FD-Score:4.59|P-value:3.06E-6 ID:SGTC_6|Compound:0844-0013|FD-Score:3.30|P-value:5.76E-4 ID:SGTC_12|Compound:0849-0099|FD-Score:3.20|P-value:8.11E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:3.34|P-value:5.10E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:3.57|P-value:2.22E-4 ID:SGTC_433|Compound:pimozide|FD-Score:-3.25|P-value:6.57E-4 ID:SGTC_495|Compound:decylubiquinone|FD-Score:-3.65|P-value:1.57E-4 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:-3.34|P-value:4.74E-4 ID:SGTC_724|Compound:3910-0327|FD-Score:3.20|P-value:8.17E-4 ID:SGTC_741|Compound:4582-0002|FD-Score:3.39|P-value:4.30E-4 ID:SGTC_1102|Compound:cgs 12066b|FD-Score:3.32|P-value:5.42E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.66|P-value:1.47E-4 ID:SGTC_1108|Compound:betulinic acid|FD-Score:3.22|P-value:7.80E-4 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:-4.08|P-value:2.71E-5 ID:SGTC_1168|Compound:k815-0004|FD-Score:3.75|P-value:1.14E-4 ID:SGTC_1181|Compound:1222-0449|FD-Score:3.81|P-value:8.92E-5 ID:SGTC_1415|Compound:3966-0071|FD-Score:-4.01|P-value:3.62E-5 ID:SGTC_1418|Compound:3966-3099|FD-Score:3.98|P-value:4.53E-5 ID:SGTC_1615|Compound:st002656|FD-Score:-3.15|P-value:9.10E-4 ID:SGTC_1768|Compound:st044301|FD-Score:-3.33|P-value:4.95E-4 ID:SGTC_1769|Compound:st044406|FD-Score:-5.24|P-value:1.12E-7 ID:SGTC_1773|Compound:st048542|FD-Score:-4.85|P-value:8.26E-7 ID:SGTC_1777|Compound:st045864|FD-Score:4.00|P-value:4.17E-5 ID:SGTC_1789|Compound:tunicamycin|FD-Score:-4.53|P-value:3.87E-6 ID:SGTC_1792|Compound:st045773|FD-Score:-4.72|P-value:1.57E-6 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:3.84|P-value:7.84E-5 ID:SGTC_1953|Compound:st076800|FD-Score:3.56|P-value:2.33E-4 ID:SGTC_1956|Compound:st077085|FD-Score:3.48|P-value:3.14E-4 ID:SGTC_2000|Compound:st075254|FD-Score:-3.81|P-value:8.12E-5 ID:SGTC_2032|Compound:5185112|FD-Score:-3.41|P-value:3.70E-4 ID:SGTC_2084|Compound:5306078|FD-Score:-4.17|P-value:1.85E-5 ID:SGTC_2199|Compound:6590217|FD-Score:-3.23|P-value:6.96E-4 ID:SGTC_2259|Compound:7964009|FD-Score:3.20|P-value:8.27E-4 ID:SGTC_2262|Compound:9014885|FD-Score:-3.59|P-value:1.95E-4 ID:SGTC_2367|Compound:9070478|FD-Score:-3.39|P-value:3.96E-4 ID:SGTC_2368|Compound:9071271|FD-Score:3.54|P-value:2.46E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.26|P-value:6.76E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:5.04|P-value:3.43E-7 ID:SGTC_2618|Compound:avocadyne|FD-Score:3.27|P-value:6.39E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:-4.26|P-value:1.27E-5 ID:SGTC_2761|Compound:levamisole|FD-Score:5.03|P-value:3.67E-7 ID:SGTC_3147|Compound:9097027|FD-Score:3.96|P-value:4.82E-5 ID:SGTC_3156|Compound:9099931|FD-Score:4.59|P-value:3.06E-6

Top fitness defect scores for YEL016C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2568 diosmetin 5.04 100.0 µM 3.43E-7 8 2.29E-7
2 SGTC_2761 levamisole 5.03 97.9 µM 3.67E-7 4 2.46E-7
3 SGTC_3156 9099931 4.59 49.5 µM 3.06E-6 2 2.18E-6
4 SGTC_1777 st045864 4.00 34.8 µM 4.17E-5 9 3.20E-5
5 SGTC_1418 3966-3099 3.98 2.4 µM 4.53E-5 16 3.48E-5
6 SGTC_3147 9097027 3.96 49.5 µM 4.82E-5 24 3.72E-5
7 SGTC_1951 sophoraflavanone G 3.84 9.2 µM 7.84E-5 RNA processing & uracil transport 25 6.12E-5
8 SGTC_1181 1222-0449 3.81 220.0 µM 8.92E-5 30 6.99E-5
9 SGTC_1168 k815-0004 3.75 80.5 µM 1.14E-4 DNA damage response 21 8.96E-5
10 SGTC_426 0988-0037 3.57 14.6 µM 2.22E-4 ERAD & cell cycle 48 1.78E-4
11 SGTC_1953 st076800 3.56 12.1 µM 2.33E-4 59 1.88E-4
12 SGTC_2368 9071271 3.54 200.0 µM 2.46E-4 52 1.99E-4
13 SGTC_1956 st077085 3.48 54.0 µM 3.14E-4 31 2.55E-4
14 SGTC_741 4582-0002 3.39 126.0 µM 4.30E-4 27 3.52E-4
15 SGTC_423 5-fluorouracil 3.34 457.0 µM 5.10E-4 exosome 43 4.20E-4
16 SGTC_1102 cgs 12066b 3.32 26.1 µM 5.42E-4 endomembrane recycling 18 4.47E-4
17 SGTC_6 0844-0013 3.30 19.8 µM 5.76E-4 162 4.76E-4
18 SGTC_2618 avocadyne 3.27 43.4 µM 6.39E-4 55 5.30E-4
19 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.26 3.7 µM 6.76E-4 157 5.62E-4
20 SGTC_1108 betulinic acid 3.22 729.1 nM 7.80E-4 34 6.51E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.179 1.25E-25 YDL049C KNH1 hom Protein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistance
0.177 6.21E-25 YER067C-A_d YER067C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W
0.171 1.82E-23 YKL205W LOS1 hom Nuclear pore protein involved in nuclear export of pre-tRNA and in re-export of mature tRNAs after their retrograde import from the cytoplasm
0.166 4.27E-22 YDL039C PRM7 hom Pheromone-regulated protein, predicted to have one transmembrane segment; promoter contains Gcn4p binding elements
0.150 3.10E-18 YOR155C ISN1 hom Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, does not show similarity to known 5'-nucleotidases from other organisms
0.137 1.46E-15 YDL018C ERP3 hom Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport
0.130 3.91E-14 YDR051C DET1 hom Acid phosphatase involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane; deletion confers sensitivity to nickel
0.124 5.98E-13 YBL086C_p YBL086C_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.123 8.42E-13 YBL015W ACH1 hom Protein with CoA transferase activity, particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
0.122 1.44E-12 YMR173W DDR48 hom DNA damage-responsive protein; expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS; protein abundance increases in response to DNA replication stress
0.119 4.92E-12 YGL017W ATE1 hom Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway
0.119 4.96E-12 YLR288C MEC3 hom DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1
0.118 7.01E-12 YGR236C SPG1 hom Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.115 2.87E-11 YLR283W_p YLR283W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR283W is not an essential gene
0.111 1.30E-10 YGR189C CRH1 hom Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar and functionally redundant to Utr2; localizes to sites of polarized growth; expression induced by cell wall stress