YEL038W / UTR4

Protein with sequence similarity to 2,3-diketo-5-methylthiopentyl-1-phosphate enolase-phosphatases, involved in methionine salvage; found in both the cytoplasm and nucleus

Zygosity: Homozygous strain
fixedexpanded
Profile for YEL038W / UTR4

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:2.66|P-value:9.52E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:2.88|P-value:3.78E-4 ID:SGTC_180|Compound:1486-1293|FD-Score:2.71|P-value:7.57E-4 ID:SGTC_306|Compound:1672-3436|FD-Score:3.48|P-value:2.51E-5 ID:SGTC_317|Compound:4495-0002|FD-Score:3.59|P-value:1.44E-5 ID:SGTC_318|Compound:1488-0629|FD-Score:4.24|P-value:3.92E-7 ID:SGTC_326|Compound:k292-0812|FD-Score:-2.77|P-value:7.25E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:2.98|P-value:2.47E-4 ID:SGTC_348|Compound:k064-0012|FD-Score:3.22|P-value:8.44E-5 ID:SGTC_352|Compound:k048-0007|FD-Score:-3.07|P-value:2.11E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:2.71|P-value:7.67E-4 ID:SGTC_381|Compound:3461-2219|FD-Score:-2.93|P-value:3.80E-4 ID:SGTC_417|Compound:st075190|FD-Score:-2.85|P-value:5.44E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:2.90|P-value:3.49E-4 ID:SGTC_455|Compound:paf C-16|FD-Score:3.30|P-value:5.97E-5 ID:SGTC_553|Compound:k007-0256|FD-Score:2.90|P-value:3.51E-4 ID:SGTC_588|Compound:3970-1144|FD-Score:2.68|P-value:8.67E-4 ID:SGTC_624|Compound:k048-0052|FD-Score:-3.12|P-value:1.69E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:3.80|P-value:4.58E-6 ID:SGTC_829|Compound:1635-0120|FD-Score:2.69|P-value:8.25E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:3.01|P-value:2.15E-4 ID:SGTC_1170|Compound:0310-0127|FD-Score:-3.18|P-value:1.29E-4 ID:SGTC_1180|Compound:1193-0155|FD-Score:3.24|P-value:7.95E-5 ID:SGTC_1185|Compound:1319-0113|FD-Score:-4.07|P-value:1.42E-6 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:2.86|P-value:4.18E-4 ID:SGTC_1624|Compound:st003710|FD-Score:2.80|P-value:5.25E-4 ID:SGTC_1670|Compound:st016595|FD-Score:-3.30|P-value:7.29E-5 ID:SGTC_1870|Compound:st057514|FD-Score:-4.02|P-value:1.84E-6 ID:SGTC_1874|Compound:staurosporine|FD-Score:3.95|P-value:2.12E-6 ID:SGTC_1876|Compound:myriocin|FD-Score:2.65|P-value:9.76E-4 ID:SGTC_1939|Compound:st074455|FD-Score:2.81|P-value:5.16E-4 ID:SGTC_2010|Compound:4012422|FD-Score:3.37|P-value:4.18E-5 ID:SGTC_2034|Compound:5197015|FD-Score:2.79|P-value:5.62E-4 ID:SGTC_2391|Compound:6285546|FD-Score:2.72|P-value:7.29E-4 ID:SGTC_2446|Compound:5162541|FD-Score:-3.07|P-value:2.13E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:3.39|P-value:3.81E-5 ID:SGTC_2564|Compound:betulinic acid|FD-Score:3.86|P-value:3.48E-6 ID:SGTC_2602|Compound:kawain|FD-Score:5.01|P-value:2.79E-9 ID:SGTC_2623|Compound:humulene|FD-Score:-3.86|P-value:4.51E-6 ID:SGTC_2657|Compound:nystatin|FD-Score:2.71|P-value:7.75E-4 ID:SGTC_2773|Compound:thioridazine|FD-Score:-3.33|P-value:6.42E-5 ID:SGTC_3221|Compound:9128209|FD-Score:-3.26|P-value:9.11E-5 ID:SGTC_3322|Compound:9139058|FD-Score:3.36|P-value:4.41E-5 ID:SGTC_10|Compound:0279-0212|FD-Score:2.66|P-value:9.52E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:2.88|P-value:3.78E-4 ID:SGTC_180|Compound:1486-1293|FD-Score:2.71|P-value:7.57E-4 ID:SGTC_306|Compound:1672-3436|FD-Score:3.48|P-value:2.51E-5 ID:SGTC_317|Compound:4495-0002|FD-Score:3.59|P-value:1.44E-5 ID:SGTC_318|Compound:1488-0629|FD-Score:4.24|P-value:3.92E-7 ID:SGTC_326|Compound:k292-0812|FD-Score:-2.77|P-value:7.25E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:2.98|P-value:2.47E-4 ID:SGTC_348|Compound:k064-0012|FD-Score:3.22|P-value:8.44E-5 ID:SGTC_352|Compound:k048-0007|FD-Score:-3.07|P-value:2.11E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:2.71|P-value:7.67E-4 ID:SGTC_381|Compound:3461-2219|FD-Score:-2.93|P-value:3.80E-4 ID:SGTC_417|Compound:st075190|FD-Score:-2.85|P-value:5.44E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:2.90|P-value:3.49E-4 ID:SGTC_455|Compound:paf C-16|FD-Score:3.30|P-value:5.97E-5 ID:SGTC_553|Compound:k007-0256|FD-Score:2.90|P-value:3.51E-4 ID:SGTC_588|Compound:3970-1144|FD-Score:2.68|P-value:8.67E-4 ID:SGTC_624|Compound:k048-0052|FD-Score:-3.12|P-value:1.69E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:3.80|P-value:4.58E-6 ID:SGTC_829|Compound:1635-0120|FD-Score:2.69|P-value:8.25E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:3.01|P-value:2.15E-4 ID:SGTC_1170|Compound:0310-0127|FD-Score:-3.18|P-value:1.29E-4 ID:SGTC_1180|Compound:1193-0155|FD-Score:3.24|P-value:7.95E-5 ID:SGTC_1185|Compound:1319-0113|FD-Score:-4.07|P-value:1.42E-6 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:2.86|P-value:4.18E-4 ID:SGTC_1624|Compound:st003710|FD-Score:2.80|P-value:5.25E-4 ID:SGTC_1670|Compound:st016595|FD-Score:-3.30|P-value:7.29E-5 ID:SGTC_1870|Compound:st057514|FD-Score:-4.02|P-value:1.84E-6 ID:SGTC_1874|Compound:staurosporine|FD-Score:3.95|P-value:2.12E-6 ID:SGTC_1876|Compound:myriocin|FD-Score:2.65|P-value:9.76E-4 ID:SGTC_1939|Compound:st074455|FD-Score:2.81|P-value:5.16E-4 ID:SGTC_2010|Compound:4012422|FD-Score:3.37|P-value:4.18E-5 ID:SGTC_2034|Compound:5197015|FD-Score:2.79|P-value:5.62E-4 ID:SGTC_2391|Compound:6285546|FD-Score:2.72|P-value:7.29E-4 ID:SGTC_2446|Compound:5162541|FD-Score:-3.07|P-value:2.13E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:3.39|P-value:3.81E-5 ID:SGTC_2564|Compound:betulinic acid|FD-Score:3.86|P-value:3.48E-6 ID:SGTC_2602|Compound:kawain|FD-Score:5.01|P-value:2.79E-9 ID:SGTC_2623|Compound:humulene|FD-Score:-3.86|P-value:4.51E-6 ID:SGTC_2657|Compound:nystatin|FD-Score:2.71|P-value:7.75E-4 ID:SGTC_2773|Compound:thioridazine|FD-Score:-3.33|P-value:6.42E-5 ID:SGTC_3221|Compound:9128209|FD-Score:-3.26|P-value:9.11E-5 ID:SGTC_3322|Compound:9139058|FD-Score:3.36|P-value:4.41E-5

Top fitness defect scores for YEL038W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2602 kawain 5.01 100.0 µM 2.79E-9 9 2.76E-7
2 SGTC_318 1488-0629 4.24 67.2 µM 3.92E-7 copper-dependent oxidative stress 19 1.12E-5
3 SGTC_1874 staurosporine 3.95 7.6 µM 2.12E-6 cell wall signaling 27 3.99E-5
4 SGTC_2564 betulinic acid 3.86 100.0 µM 3.48E-6 33 5.78E-5
5 SGTC_632 0781-2353 3.80 4.7 µM 4.58E-6 Golgi 49 7.10E-5
6 SGTC_317 4495-0002 3.59 170.0 µM 1.44E-5 15 1.68E-4
7 SGTC_306 1672-3436 3.48 11.6 µM 2.51E-5 Golgi 25 2.55E-4
8 SGTC_2563 tomatine 3.39 8.5 µM 3.81E-5 79 3.49E-4
9 SGTC_2010 4012422 3.37 159.0 µM 4.18E-5 45 3.75E-4
10 SGTC_3322 9139058 3.36 2.1 µM 4.41E-5 cell wall 48 3.90E-4
11 SGTC_455 paf C-16 3.30 10.0 µM 5.97E-5 51 4.89E-4
12 SGTC_1180 1193-0155 3.24 285.0 µM 7.95E-5 43 6.08E-4
13 SGTC_348 k064-0012 3.22 10.7 µM 8.44E-5 60S ribosome export 40 6.36E-4
14 SGTC_1069 diphenylcyclopropenone 3.01 8.5 µM 2.15E-4 70 0.00129
15 SGTC_341 1486-1430 2.98 230.0 µM 2.47E-4 61 0.00143
16 SGTC_430 0958-0115 2.90 16.4 µM 3.49E-4 88 0.00185
17 SGTC_553 k007-0256 2.90 45.7 µM 3.51E-4 heme biosynthesis & mitochondrial translocase 84 0.00186
18 SGTC_127 0180-0333 2.88 59.1 µM 3.78E-4 mitochondrial response to ROS 123 0.00197
19 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 2.86 66.5 µM 4.18E-4 55 0.00213
20 SGTC_1939 st074455 2.81 53.6 µM 5.16E-4 100 0.00249

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.139 5.29E-16 YDL201W TRM8 hom Noncatalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p
0.131 3.04E-14 YGL243W TAD1 hom tRNA-specific adenosine deaminase, deaminates adenosine-37 to inosine in tRNA-Ala
0.127 1.31E-13 YDR299W BFR2 het Essential protein that is a component of 90S preribosomes; may be involved in rRNA processing; multicopy suppressor of sensitivity to Brefeldin A; expression is induced during lag phase and also by cold shock
0.125 3.78E-13 YDR018C_p YDR018C_p hom Probable membrane protein with three predicted transmembrane domains; similar to C. elegans F55A11.5 and maize 1-acyl-glycerol-3-phosphate acyltransferase; YDR018C has a paralog, CST26, that arose from the whole genome duplication
0.119 4.19E-12 YNR032C-A HUB1 hom Ubiquitin-like protein modifier; promotes alternative splicing of SRC1 pre-mRNA; binds non-covalently to the HIND domain of Snu66, may function in modification of Sph1p and Hbt1p, functionally complemented by the human or S. pombe ortholog; mechanism of Hub1p adduct formation not yet clear
0.116 1.81E-11 YBL063W KIP1 hom Kinesin-related motor protein required for mitotic spindle assembly, chromosome segregation, and 2 micron plasmid partitioning; functionally redundant with Cin8p for chromosomal but not plasmid functions
0.108 3.25E-10 YBR050C REG2 hom Regulatory subunit of the Glc7p type-1 protein phosphatase; involved with Reg1p, Glc7p, and Snf1p in regulation of glucose-repressible genes, also involved in glucose-induced proteolysis of maltose permease
0.105 1.12E-9 YFL055W AGP3 hom Low-affinity amino acid permease, may act to supply the cell with amino acids as nitrogen source in nitrogen-poor conditions; transcription is induced under conditions of sulfur limitation; plays a role in regulating Ty1 transposition
0.101 4.06E-9 YBR070C ALG14 het Component of UDP-GlcNAc transferase required for the second step of dolichyl-linked oligosaccharide synthesis; anchors the catalytic subunit Alg13p to the ER membrane; similar to bacterial and human glycosyltransferases
0.097 1.75E-8 YCR088W ABP1 hom Actin-binding protein of the cortical actin cytoskeleton, important for activation of the Arp2/3 complex that plays a key role actin in cytoskeleton organization; phosphorylation within its PRR (Proline-Rich Region), mediated by Cdc28p and Pho85p, protects Abp1p from proteolysis mediated by its own PEST sequences
0.096 2.84E-8 YDL129W YDL129W hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; YDL129W is not an essential gene; relative distribution to the nucleus increases upon DNA replication stress
0.091 1.13E-7 YDR165W TRM82 hom Catalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p
0.091 1.35E-7 YER156C_p YER156C_p hom Putative protein of unknown function; interacts with Hsp82p and copurifies with Ipl1p; expression is copper responsive and downregulated in strains deleted for MAC1, a copper-responsive transcription factor; similarity to mammalian MYG1
0.089 2.18E-7 YOR296W_p YOR296W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; expressed during copper starvation; YOR296W is not an essential gene
0.089 2.50E-7 YJR023C_d YJR023C_d het Putative protein of unknown function; open reading frame overlaps LSM8/YJR022W encoding an essential snRNP protein required for RNA processing and splicing