YEL056W / HAT2

Subunit of the Hat1p-Hat2p histone acetyltransferase complex; required for high affinity binding of the complex to free histone H4, thereby enhancing Hat1p activity; similar to human RbAp46 and 48; has a role in telomeric silencing

Zygosity: Homozygous strain
fixedexpanded
Profile for YEL056W / HAT2

Click on Significant Values for Screen Details ID:SGTC_301|Compound:4119-0100|FD-Score:-2.94|P-value:6.91E-4 ID:SGTC_337|Compound:1315-0038|FD-Score:3.73|P-value:2.26E-5 ID:SGTC_378|Compound:3970-0959|FD-Score:3.79|P-value:1.72E-5 ID:SGTC_393|Compound:acivicin|FD-Score:3.06|P-value:3.99E-4 ID:SGTC_417|Compound:st075190|FD-Score:3.06|P-value:4.04E-4 ID:SGTC_621|Compound:3584-0052|FD-Score:3.02|P-value:4.73E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:3.25|P-value:1.88E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:-2.96|P-value:6.40E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.07|P-value:4.18E-4 ID:SGTC_776|Compound:4476-4378|FD-Score:-2.90|P-value:8.09E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:2.97|P-value:5.77E-4 ID:SGTC_838|Compound:0109-0203|FD-Score:2.98|P-value:5.44E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:-3.28|P-value:1.78E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:3.20|P-value:2.32E-4 ID:SGTC_1017|Compound:4239-0030|FD-Score:2.99|P-value:5.41E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-2.85|P-value:9.84E-4 ID:SGTC_1191|Compound:1487-1166|FD-Score:3.73|P-value:2.27E-5 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.31|P-value:1.61E-4 ID:SGTC_1488|Compound:4013-0813|FD-Score:-2.89|P-value:8.28E-4 ID:SGTC_1550|Compound:gossypolone|FD-Score:-3.10|P-value:3.73E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.57|P-value:4.73E-5 ID:SGTC_1968|Compound:st069590|FD-Score:3.09|P-value:3.63E-4 ID:SGTC_2365|Compound:9042475|FD-Score:3.39|P-value:1.02E-4 ID:SGTC_2484|Compound:5809818|FD-Score:-3.38|P-value:1.18E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:3.76|P-value:1.95E-5 ID:SGTC_2561|Compound:acetosyringone|FD-Score:-3.40|P-value:1.07E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:-3.05|P-value:4.63E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.43|P-value:8.69E-5 ID:SGTC_2623|Compound:humulene|FD-Score:5.64|P-value:3.61E-10 ID:SGTC_2625|Compound:euphol|FD-Score:3.44|P-value:8.46E-5 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:-5.23|P-value:6.08E-9 ID:SGTC_2628|Compound:lathosterol|FD-Score:3.73|P-value:2.22E-5 ID:SGTC_2822|Compound:7994718|FD-Score:3.89|P-value:1.07E-5 ID:SGTC_2949|Compound:9072542|FD-Score:3.87|P-value:1.16E-5 ID:SGTC_3076|Compound:9116187|FD-Score:-3.28|P-value:1.83E-4 ID:SGTC_3216|Compound:9129716|FD-Score:-5.69|P-value:2.78E-10 ID:SGTC_3217|Compound:9129673|FD-Score:-3.78|P-value:1.93E-5 ID:SGTC_3223|Compound:9129970|FD-Score:4.22|P-value:1.97E-6 ID:SGTC_3328|Compound:9140624|FD-Score:3.16|P-value:2.68E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:-2.94|P-value:6.91E-4 ID:SGTC_337|Compound:1315-0038|FD-Score:3.73|P-value:2.26E-5 ID:SGTC_378|Compound:3970-0959|FD-Score:3.79|P-value:1.72E-5 ID:SGTC_393|Compound:acivicin|FD-Score:3.06|P-value:3.99E-4 ID:SGTC_417|Compound:st075190|FD-Score:3.06|P-value:4.04E-4 ID:SGTC_621|Compound:3584-0052|FD-Score:3.02|P-value:4.73E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:3.25|P-value:1.88E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:-2.96|P-value:6.40E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.07|P-value:4.18E-4 ID:SGTC_776|Compound:4476-4378|FD-Score:-2.90|P-value:8.09E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:2.97|P-value:5.77E-4 ID:SGTC_838|Compound:0109-0203|FD-Score:2.98|P-value:5.44E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:-3.28|P-value:1.78E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:3.20|P-value:2.32E-4 ID:SGTC_1017|Compound:4239-0030|FD-Score:2.99|P-value:5.41E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-2.85|P-value:9.84E-4 ID:SGTC_1191|Compound:1487-1166|FD-Score:3.73|P-value:2.27E-5 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.31|P-value:1.61E-4 ID:SGTC_1488|Compound:4013-0813|FD-Score:-2.89|P-value:8.28E-4 ID:SGTC_1550|Compound:gossypolone|FD-Score:-3.10|P-value:3.73E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.57|P-value:4.73E-5 ID:SGTC_1968|Compound:st069590|FD-Score:3.09|P-value:3.63E-4 ID:SGTC_2365|Compound:9042475|FD-Score:3.39|P-value:1.02E-4 ID:SGTC_2484|Compound:5809818|FD-Score:-3.38|P-value:1.18E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:3.76|P-value:1.95E-5 ID:SGTC_2561|Compound:acetosyringone|FD-Score:-3.40|P-value:1.07E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:-3.05|P-value:4.63E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.43|P-value:8.69E-5 ID:SGTC_2623|Compound:humulene|FD-Score:5.64|P-value:3.61E-10 ID:SGTC_2625|Compound:euphol|FD-Score:3.44|P-value:8.46E-5 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:-5.23|P-value:6.08E-9 ID:SGTC_2628|Compound:lathosterol|FD-Score:3.73|P-value:2.22E-5 ID:SGTC_2822|Compound:7994718|FD-Score:3.89|P-value:1.07E-5 ID:SGTC_2949|Compound:9072542|FD-Score:3.87|P-value:1.16E-5 ID:SGTC_3076|Compound:9116187|FD-Score:-3.28|P-value:1.83E-4 ID:SGTC_3216|Compound:9129716|FD-Score:-5.69|P-value:2.78E-10 ID:SGTC_3217|Compound:9129673|FD-Score:-3.78|P-value:1.93E-5 ID:SGTC_3223|Compound:9129970|FD-Score:4.22|P-value:1.97E-6 ID:SGTC_3328|Compound:9140624|FD-Score:3.16|P-value:2.68E-4

Top fitness defect scores for YEL056W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2623 humulene 5.64 100.0 µM 3.61E-10 5 8.65E-9
2 SGTC_3223 9129970 4.22 49.5 µM 1.97E-6 18 1.23E-5
3 SGTC_2822 7994718 3.89 71.4 µM 1.07E-5 19 5.10E-5
4 SGTC_2949 9072542 3.87 2.2 µM 1.16E-5 TSC3-RPN4 39 5.47E-5
5 SGTC_378 3970-0959 3.79 8.3 µM 1.72E-5 20 7.65E-5
6 SGTC_2540 epiandrosterone 3.76 100.0 µM 1.95E-5 65 8.51E-5
7 SGTC_2628 lathosterol 3.73 100.0 µM 2.22E-5 36 9.48E-5
8 SGTC_337 1315-0038 3.73 354.0 µM 2.26E-5 amide catabolism 29 9.61E-5
9 SGTC_1191 1487-1166 3.73 10.6 µM 2.27E-5 azole & statin 38 9.68E-5
10 SGTC_1679 4130-1276 3.57 6.7 µM 4.73E-5 Golgi 85 1.80E-4
11 SGTC_2625 euphol 3.44 100.0 µM 8.46E-5 50 2.94E-4
12 SGTC_2621 lithochol-11-enic acid 3.43 100.0 µM 8.69E-5 44 3.01E-4
13 SGTC_2365 9042475 3.39 200.0 µM 1.02E-4 66 3.44E-4
14 SGTC_673 1082-0474 3.25 110.0 µM 1.88E-4 RSC complex & mRNA processing 101 5.77E-4
15 SGTC_874 0599-0792 3.20 117.0 µM 2.32E-4 63 6.90E-4
16 SGTC_3328 9140624 3.16 29.0 µM 2.68E-4 39 7.80E-4
17 SGTC_1968 st069590 3.09 43.6 µM 3.63E-4 38 0.00101
18 SGTC_393 acivicin 3.06 6.2 µM 3.99E-4 42 0.00109
19 SGTC_417 st075190 3.06 100.0 µM 4.04E-4 45 0.00111
20 SGTC_621 3584-0052 3.02 32.1 µM 4.73E-4 57 0.00126

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.209 2.27E-34 YDR382W RPP2B hom Ribosomal protein P2 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm
0.145 3.56E-17 YGR069W_d YGR069W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.138 9.43E-16 YIL130W ASG1 hom Zinc cluster protein proposed to function as a transcriptional regulator involved in the stress response; null mutants have a respiratory deficiency, calcofluor white sensitivity and slightly increased cycloheximide resistance
0.136 2.32E-15 YKL132C RMA1 hom Putative dihydrofolate synthetase; has similarity to Fol3p and to E. coli folylpolyglutamate synthetase/dihydrofolate synthetase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.122 1.17E-12 YPL140C MKK2 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk1p; MKK2 has a paralog, MKK1, that arose from the whole genome duplication
0.119 4.90E-12 YFR042W KEG1 het Integral membrane protein of the ER; physically interacts with Kre6p; has a role in the synthesis of beta-1,6-glucan in the cell wall; required for cell viability
0.113 4.77E-11 YMR079W SEC14 het Phosphatidylinositol/phosphatidylcholine transfer protein; involved in regulating PtdIns, PtdCho, and ceramide metabolism, products of which regulate intracellular transport and UPR; has a role in localization of lipid raft proteins; functionally homologous to mammalian PITPs
0.107 4.36E-10 YER063W THO1 hom Conserved nuclear RNA-binding protein; specifically binds to transcribed chromatin in a THO- and RNA-dependent manner, genetically interacts with shuttling hnRNP NAB2; overproduction suppresses transcriptional defect caused by hpr1 mutation
0.098 1.33E-8 YEL060C PRB1 hom Vacuolar proteinase B (yscB); serine protease of the subtilisin family; involved in protein degradation in the vacuole and required for full protein degradation during sporulation; activity inhibited by Pbi2p; protein abundance increases in response to DNA replication stress
0.095 3.81E-8 YBL003C HTA2 hom Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical (see also HTA1) subtypes; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p
0.094 4.29E-8 YPL107W_p YPL107W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YPL107W is not an essential gene
0.094 4.41E-8 YLR294C_d YLR294C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene ATP14
0.093 7.48E-8 YCL022C_d YCL022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene KCC4/YCL024W
0.092 1.11E-7 YGR053C_p YGR053C_p hom Putative protein of unknown function
0.091 1.19E-7 YOL077W-A ATP19 hom Subunit k of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; associated only with the dimeric form of ATP synthase