YEL066W / HPA3

D-Amino acid N-acetyltransferase, catalyzes N-acetylation of D-amino acids through ordered bi-bi mechanism in which acetyl-CoA is first substrate bound and CoA is last product liberated; similar to Hpa2p, acetylates histones weakly in vitro

Zygosity: Homozygous strain
fixedexpanded
Profile for YEL066W / HPA3

Click on Significant Values for Screen Details ID:SGTC_67|Compound:0335-0847|FD-Score:3.49|P-value:1.88E-5 ID:SGTC_333|Compound:3486-0131|FD-Score:3.24|P-value:6.47E-5 ID:SGTC_337|Compound:1315-0038|FD-Score:2.61|P-value:9.65E-4 ID:SGTC_499|Compound:genistein|FD-Score:-2.75|P-value:9.09E-4 ID:SGTC_627|Compound:1391-0720|FD-Score:-4.53|P-value:1.15E-7 ID:SGTC_632|Compound:0781-2353|FD-Score:2.79|P-value:4.68E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:3.26|P-value:5.85E-5 ID:SGTC_640|Compound:3381-0960|FD-Score:-3.20|P-value:1.36E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:2.72|P-value:6.30E-4 ID:SGTC_761|Compound:k216-0224|FD-Score:-3.13|P-value:1.93E-4 ID:SGTC_779|Compound:1360-0071|FD-Score:2.94|P-value:2.49E-4 ID:SGTC_801|Compound:0866-0028|FD-Score:2.77|P-value:5.00E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:3.29|P-value:5.03E-5 ID:SGTC_911|Compound:3456-4043|FD-Score:3.16|P-value:9.50E-5 ID:SGTC_917|Compound:harmaline|FD-Score:-2.90|P-value:5.03E-4 ID:SGTC_993|Compound:3909-8757|FD-Score:-4.62|P-value:6.22E-8 ID:SGTC_1009|Compound:4106-0057|FD-Score:3.89|P-value:2.32E-6 ID:SGTC_1052|Compound:3253-3998|FD-Score:-2.98|P-value:3.69E-4 ID:SGTC_1061|Compound:3448-9325|FD-Score:3.28|P-value:5.37E-5 ID:SGTC_1118|Compound:chelidonine|FD-Score:3.16|P-value:9.52E-5 ID:SGTC_1296|Compound:1068-0102|FD-Score:2.93|P-value:2.61E-4 ID:SGTC_1327|Compound:1436-0082|FD-Score:3.15|P-value:9.96E-5 ID:SGTC_1375|Compound:2910-0797|FD-Score:2.63|P-value:9.13E-4 ID:SGTC_1440|Compound:4100-1550|FD-Score:-2.89|P-value:5.26E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-4.40|P-value:2.51E-7 ID:SGTC_1527|Compound:coumarin|FD-Score:3.33|P-value:4.08E-5 ID:SGTC_1602|Compound:st001878|FD-Score:2.61|P-value:9.78E-4 ID:SGTC_1683|Compound:st010134|FD-Score:2.78|P-value:4.84E-4 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:3.34|P-value:3.92E-5 ID:SGTC_2057|Compound:5236571|FD-Score:3.34|P-value:4.07E-5 ID:SGTC_2120|Compound:5538279|FD-Score:-3.21|P-value:1.33E-4 ID:SGTC_2302|Compound:7771753|FD-Score:4.37|P-value:1.37E-7 ID:SGTC_2329|Compound:6138490|FD-Score:2.76|P-value:5.39E-4 ID:SGTC_2394|Compound:5221648|FD-Score:-2.94|P-value:4.22E-4 ID:SGTC_2404|Compound:5161160|FD-Score:-3.08|P-value:2.32E-4 ID:SGTC_2694|Compound:st077685|FD-Score:-4.48|P-value:1.58E-7 ID:SGTC_2754|Compound:granisetron|FD-Score:-3.27|P-value:1.01E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:-4.65|P-value:5.38E-8 ID:SGTC_2777|Compound:climbazole|FD-Score:2.62|P-value:9.37E-4 ID:SGTC_2957|Compound:9076800|FD-Score:-3.64|P-value:1.73E-5 ID:SGTC_3007|Compound:9078383|FD-Score:2.96|P-value:2.30E-4 ID:SGTC_3201|Compound:9113999|FD-Score:-3.83|P-value:6.32E-6 ID:SGTC_67|Compound:0335-0847|FD-Score:3.49|P-value:1.88E-5 ID:SGTC_333|Compound:3486-0131|FD-Score:3.24|P-value:6.47E-5 ID:SGTC_337|Compound:1315-0038|FD-Score:2.61|P-value:9.65E-4 ID:SGTC_499|Compound:genistein|FD-Score:-2.75|P-value:9.09E-4 ID:SGTC_627|Compound:1391-0720|FD-Score:-4.53|P-value:1.15E-7 ID:SGTC_632|Compound:0781-2353|FD-Score:2.79|P-value:4.68E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:3.26|P-value:5.85E-5 ID:SGTC_640|Compound:3381-0960|FD-Score:-3.20|P-value:1.36E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:2.72|P-value:6.30E-4 ID:SGTC_761|Compound:k216-0224|FD-Score:-3.13|P-value:1.93E-4 ID:SGTC_779|Compound:1360-0071|FD-Score:2.94|P-value:2.49E-4 ID:SGTC_801|Compound:0866-0028|FD-Score:2.77|P-value:5.00E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:3.29|P-value:5.03E-5 ID:SGTC_911|Compound:3456-4043|FD-Score:3.16|P-value:9.50E-5 ID:SGTC_917|Compound:harmaline|FD-Score:-2.90|P-value:5.03E-4 ID:SGTC_993|Compound:3909-8757|FD-Score:-4.62|P-value:6.22E-8 ID:SGTC_1009|Compound:4106-0057|FD-Score:3.89|P-value:2.32E-6 ID:SGTC_1052|Compound:3253-3998|FD-Score:-2.98|P-value:3.69E-4 ID:SGTC_1061|Compound:3448-9325|FD-Score:3.28|P-value:5.37E-5 ID:SGTC_1118|Compound:chelidonine|FD-Score:3.16|P-value:9.52E-5 ID:SGTC_1296|Compound:1068-0102|FD-Score:2.93|P-value:2.61E-4 ID:SGTC_1327|Compound:1436-0082|FD-Score:3.15|P-value:9.96E-5 ID:SGTC_1375|Compound:2910-0797|FD-Score:2.63|P-value:9.13E-4 ID:SGTC_1440|Compound:4100-1550|FD-Score:-2.89|P-value:5.26E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-4.40|P-value:2.51E-7 ID:SGTC_1527|Compound:coumarin|FD-Score:3.33|P-value:4.08E-5 ID:SGTC_1602|Compound:st001878|FD-Score:2.61|P-value:9.78E-4 ID:SGTC_1683|Compound:st010134|FD-Score:2.78|P-value:4.84E-4 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:3.34|P-value:3.92E-5 ID:SGTC_2057|Compound:5236571|FD-Score:3.34|P-value:4.07E-5 ID:SGTC_2120|Compound:5538279|FD-Score:-3.21|P-value:1.33E-4 ID:SGTC_2302|Compound:7771753|FD-Score:4.37|P-value:1.37E-7 ID:SGTC_2329|Compound:6138490|FD-Score:2.76|P-value:5.39E-4 ID:SGTC_2394|Compound:5221648|FD-Score:-2.94|P-value:4.22E-4 ID:SGTC_2404|Compound:5161160|FD-Score:-3.08|P-value:2.32E-4 ID:SGTC_2694|Compound:st077685|FD-Score:-4.48|P-value:1.58E-7 ID:SGTC_2754|Compound:granisetron|FD-Score:-3.27|P-value:1.01E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:-4.65|P-value:5.38E-8 ID:SGTC_2777|Compound:climbazole|FD-Score:2.62|P-value:9.37E-4 ID:SGTC_2957|Compound:9076800|FD-Score:-3.64|P-value:1.73E-5 ID:SGTC_3007|Compound:9078383|FD-Score:2.96|P-value:2.30E-4 ID:SGTC_3201|Compound:9113999|FD-Score:-3.83|P-value:6.32E-6

Top fitness defect scores for YEL066W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2302 7771753 4.37 200.0 µM 1.37E-7 33 6.19E-6
2 SGTC_1009 4106-0057 3.89 9.9 µM 2.32E-6 12 5.06E-5
3 SGTC_67 0335-0847 3.49 266.0 µM 1.88E-5 ubiquinone biosynthesis & proteasome 143 2.40E-4
4 SGTC_1823 3-hydroxy-2-naphthoic acid 3.34 106.0 µM 3.92E-5 33 4.14E-4
5 SGTC_2057 5236571 3.34 38.3 µM 4.07E-5 RPP1 & pyrimidine depletion 62 4.26E-4
6 SGTC_1527 coumarin 3.33 137.0 µM 4.08E-5 47 4.27E-4
7 SGTC_807 1315-0151 3.29 48.0 µM 5.03E-5 51 4.99E-4
8 SGTC_1061 3448-9325 3.28 110.0 µM 5.37E-5 41 5.24E-4
9 SGTC_637 1181-0519 3.26 7.3 µM 5.85E-5 fatty acid desaturase (OLE1) 141 5.58E-4
10 SGTC_333 3486-0131 3.24 40.1 µM 6.47E-5 amide catabolism 27 6.02E-4
11 SGTC_911 3456-4043 3.16 236.0 µM 9.50E-5 mitochondrial processes 61 8.01E-4
12 SGTC_1118 chelidonine 3.16 707.5 nM 9.52E-5 48 8.02E-4
13 SGTC_1327 1436-0082 3.15 2.2 µM 9.96E-5 51 8.30E-4
14 SGTC_3007 9078383 2.96 71.4 µM 2.30E-4 56 0.00155
15 SGTC_779 1360-0071 2.94 233.0 µM 2.49E-4 fatty acid desaturase (OLE1) 83 0.00164
16 SGTC_1296 1068-0102 2.93 11.9 µM 2.61E-4 32 0.00170
17 SGTC_632 0781-2353 2.79 4.7 µM 4.68E-4 Golgi 104 0.00263
18 SGTC_1683 st010134 2.78 710.0 nM 4.84E-4 101 0.00270
19 SGTC_801 0866-0028 2.77 10.1 µM 5.00E-4 110 0.00276
20 SGTC_2329 6138490 2.76 200.0 µM 5.39E-4 109 0.00292

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.160 1.02E-20 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.152 8.20E-19 YJR058C APS2 hom Small subunit of the clathrin-associated adaptor complex AP-2, which is involved in protein sorting at the plasma membrane; related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex
0.147 1.29E-17 YBR263W SHM1 hom Mitochondrial serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis; reverse reaction generates serine
0.145 3.29E-17 YBR241C_p YBR241C_p hom Putative transporter, member of the sugar porter family; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar membrane; YBR241C is not an essential gene
0.132 1.46E-14 YJL152W_d YJL152W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.129 6.82E-14 YOR019W YOR019W hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments
0.128 1.09E-13 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.127 1.76E-13 YCL026C-A FRM2 hom Type II nitroreductase, using NADH as reductant; mutants are defective in fatty acid mediated repression of genes involved in fatty acid biosynthesis indicative of a role in lipid signaling; involved in the oxidative stress response; transcription induction by cadmium and selenite indicates a possible role in the metal stress response; expression induced in cells treated with the mycotoxin patulin
0.118 6.35E-12 YOR105W_p YOR105W_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.117 1.20E-11 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.116 1.55E-11 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.115 2.54E-11 YDR312W SSF2 hom Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication
0.115 2.80E-11 YMR322C_p SNO4_p hom Possible chaperone and cysteine protease, similar to bacterial Hsp31 and yeast Hsp31p, Hsp32p, and Hsp33p; DJ-1/ThiJ/PfpI superfamily member; predicted involvement in pyridoxine metabolism; induced by mild heat stress and copper deprivation
0.114 3.29E-11 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.113 4.44E-11 YIL147C SLN1 het Histidine kinase osmosensor that regulates a MAP kinase cascade; transmembrane protein with an intracellular kinase domain that signals to Ypd1p and Ssk1p, thereby forming a phosphorelay system similar to bacterial two-component regulators