YEL072W / RMD6

Protein required for sporulation

Zygosity: Homozygous strain
fixedexpanded
Profile for YEL072W / RMD6

Click on Significant Values for Screen Details ID:SGTC_166|Compound:k072-0058|FD-Score:-3.34|P-value:6.15E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:-3.78|P-value:1.27E-4 ID:SGTC_262|Compound:fenpropimorph|FD-Score:-3.33|P-value:6.37E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:-3.32|P-value:6.52E-4 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:3.44|P-value:3.61E-4 ID:SGTC_521|Compound:r062-0005|FD-Score:4.04|P-value:3.56E-5 ID:SGTC_630|Compound:4356-0227|FD-Score:-3.34|P-value:6.14E-4 ID:SGTC_636|Compound:0kpi-0074|FD-Score:3.76|P-value:1.09E-4 ID:SGTC_656|Compound:4090-1979|FD-Score:3.45|P-value:3.48E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:3.14|P-value:9.84E-4 ID:SGTC_918|Compound:glabranin|FD-Score:-4.66|P-value:3.15E-6 ID:SGTC_1340|Compound:1486-1359|FD-Score:-3.24|P-value:8.74E-4 ID:SGTC_1439|Compound:4092-1168|FD-Score:3.65|P-value:1.67E-4 ID:SGTC_1840|Compound:st055363|FD-Score:3.17|P-value:8.93E-4 ID:SGTC_1842|Compound:st055362|FD-Score:3.39|P-value:4.23E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.36|P-value:4.79E-4 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:3.33|P-value:5.19E-4 ID:SGTC_1948|Compound:st076329|FD-Score:-3.48|P-value:3.80E-4 ID:SGTC_1950|Compound:st077106|FD-Score:-3.68|P-value:1.83E-4 ID:SGTC_2010|Compound:4012422|FD-Score:-3.66|P-value:1.94E-4 ID:SGTC_2024|Compound:5144227|FD-Score:-4.21|P-value:2.28E-5 ID:SGTC_2081|Compound:5214970|FD-Score:3.26|P-value:6.68E-4 ID:SGTC_2101|Compound:5377231|FD-Score:-3.30|P-value:7.17E-4 ID:SGTC_2176|Compound:5809774|FD-Score:-3.43|P-value:4.49E-4 ID:SGTC_2368|Compound:9071271|FD-Score:4.16|P-value:2.23E-5 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-3.60|P-value:2.46E-4 ID:SGTC_2414|Compound:st077232|FD-Score:3.85|P-value:7.63E-5 ID:SGTC_2419|Compound:paclitaxel|FD-Score:3.38|P-value:4.43E-4 ID:SGTC_2457|Compound:5731572|FD-Score:3.69|P-value:1.43E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.81|P-value:9.05E-5 ID:SGTC_2695|Compound:st077686|FD-Score:-3.22|P-value:9.36E-4 ID:SGTC_2714|Compound:st079313|FD-Score:3.70|P-value:1.37E-4 ID:SGTC_2807|Compound:7945238|FD-Score:-3.81|P-value:1.13E-4 ID:SGTC_2937|Compound:9044753|FD-Score:3.57|P-value:2.28E-4 ID:SGTC_3022|Compound:9087993|FD-Score:3.28|P-value:6.31E-4 ID:SGTC_3202|Compound:9113761|FD-Score:-4.59|P-value:4.24E-6 ID:SGTC_3210|Compound:9128157|FD-Score:3.76|P-value:1.10E-4 ID:SGTC_3220|Compound:9131269|FD-Score:3.77|P-value:1.04E-4 ID:SGTC_3329|Compound:9141233|FD-Score:-3.49|P-value:3.61E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:-3.34|P-value:6.15E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:-3.78|P-value:1.27E-4 ID:SGTC_262|Compound:fenpropimorph|FD-Score:-3.33|P-value:6.37E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:-3.32|P-value:6.52E-4 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:3.44|P-value:3.61E-4 ID:SGTC_521|Compound:r062-0005|FD-Score:4.04|P-value:3.56E-5 ID:SGTC_630|Compound:4356-0227|FD-Score:-3.34|P-value:6.14E-4 ID:SGTC_636|Compound:0kpi-0074|FD-Score:3.76|P-value:1.09E-4 ID:SGTC_656|Compound:4090-1979|FD-Score:3.45|P-value:3.48E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:3.14|P-value:9.84E-4 ID:SGTC_918|Compound:glabranin|FD-Score:-4.66|P-value:3.15E-6 ID:SGTC_1340|Compound:1486-1359|FD-Score:-3.24|P-value:8.74E-4 ID:SGTC_1439|Compound:4092-1168|FD-Score:3.65|P-value:1.67E-4 ID:SGTC_1840|Compound:st055363|FD-Score:3.17|P-value:8.93E-4 ID:SGTC_1842|Compound:st055362|FD-Score:3.39|P-value:4.23E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.36|P-value:4.79E-4 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:3.33|P-value:5.19E-4 ID:SGTC_1948|Compound:st076329|FD-Score:-3.48|P-value:3.80E-4 ID:SGTC_1950|Compound:st077106|FD-Score:-3.68|P-value:1.83E-4 ID:SGTC_2010|Compound:4012422|FD-Score:-3.66|P-value:1.94E-4 ID:SGTC_2024|Compound:5144227|FD-Score:-4.21|P-value:2.28E-5 ID:SGTC_2081|Compound:5214970|FD-Score:3.26|P-value:6.68E-4 ID:SGTC_2101|Compound:5377231|FD-Score:-3.30|P-value:7.17E-4 ID:SGTC_2176|Compound:5809774|FD-Score:-3.43|P-value:4.49E-4 ID:SGTC_2368|Compound:9071271|FD-Score:4.16|P-value:2.23E-5 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-3.60|P-value:2.46E-4 ID:SGTC_2414|Compound:st077232|FD-Score:3.85|P-value:7.63E-5 ID:SGTC_2419|Compound:paclitaxel|FD-Score:3.38|P-value:4.43E-4 ID:SGTC_2457|Compound:5731572|FD-Score:3.69|P-value:1.43E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.81|P-value:9.05E-5 ID:SGTC_2695|Compound:st077686|FD-Score:-3.22|P-value:9.36E-4 ID:SGTC_2714|Compound:st079313|FD-Score:3.70|P-value:1.37E-4 ID:SGTC_2807|Compound:7945238|FD-Score:-3.81|P-value:1.13E-4 ID:SGTC_2937|Compound:9044753|FD-Score:3.57|P-value:2.28E-4 ID:SGTC_3022|Compound:9087993|FD-Score:3.28|P-value:6.31E-4 ID:SGTC_3202|Compound:9113761|FD-Score:-4.59|P-value:4.24E-6 ID:SGTC_3210|Compound:9128157|FD-Score:3.76|P-value:1.10E-4 ID:SGTC_3220|Compound:9131269|FD-Score:3.77|P-value:1.04E-4 ID:SGTC_3329|Compound:9141233|FD-Score:-3.49|P-value:3.61E-4

Top fitness defect scores for YEL072W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2368 9071271 4.16 200.0 µM 2.23E-5 27 1.61E-5
2 SGTC_521 r062-0005 4.04 13.8 µM 3.56E-5 15 2.62E-5
3 SGTC_2414 st077232 3.85 92.9 µM 7.63E-5 23 5.80E-5
4 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.81 3.7 µM 9.05E-5 93 6.94E-5
5 SGTC_3220 9131269 3.77 49.5 µM 1.04E-4 14 8.04E-5
6 SGTC_636 0kpi-0074 3.76 126.0 µM 1.09E-4 23 8.44E-5
7 SGTC_3210 9128157 3.76 49.5 µM 1.10E-4 53 8.51E-5
8 SGTC_2714 st079313 3.70 56.9 µM 1.37E-4 11 1.07E-4
9 SGTC_2457 5731572 3.69 11.7 µM 1.43E-4 19 1.12E-4
10 SGTC_1439 4092-1168 3.65 46.0 µM 1.67E-4 16 1.31E-4
11 SGTC_2937 9044753 3.57 11.3 µM 2.28E-4 60S ribosome export 49 1.82E-4
12 SGTC_656 4090-1979 3.45 187.0 µM 3.48E-4 34 2.81E-4
13 SGTC_392 N-ethylmaleimide 3.44 8.3 µM 3.61E-4 RNA pol III & RNase P/MRP 28 2.93E-4
14 SGTC_1842 st055362 3.39 61.2 µM 4.23E-4 28 3.45E-4
15 SGTC_2419 paclitaxel 3.38 166.5 µM 4.43E-4 77 3.62E-4
16 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 3.36 70.1 µM 4.79E-4 56 3.93E-4
17 SGTC_1928 4'-methoxychalcone 3.33 40.3 µM 5.19E-4 28 4.27E-4
18 SGTC_3022 9087993 3.28 49.5 µM 6.31E-4 18 5.23E-4
19 SGTC_2081 5214970 3.26 32.3 µM 6.68E-4 52 5.55E-4
20 SGTC_1840 st055363 3.17 71.0 µM 8.93E-4 41 7.50E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.162 3.52E-21 YML053C_p YML053C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; overexpression causes a cell cycle delay or arrest; YML053C is not an essential gene
0.132 1.77E-14 YFL042C_p YFL042C_p hom Putative protein of unknown function; YFL042C is not an essential gene
0.123 8.33E-13 YGL156W AMS1 hom Vacuolar alpha mannosidase, involved in free oligosaccharide (fOS) degradation; delivered to the vacuole in a novel pathway separate from the secretory pathway
0.114 3.24E-11 YOR220W RCN2 hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; phosphorylated in response to alpha factor; protein abundance increases in response to DNA replication stress
0.112 6.51E-11 YAL005C SSA1 hom ATPase involved in protein folding and NLS-directed nuclear transport; member of HSP70 family; forms chaperone complex with Ydj1p; localized to nucleus, cytoplasm, and cell wall; 98% identical with paralog Ssa2p, but subtle differences between the two proteins provide functional specificity with respect to propagation of yeast [URE3] prions and vacuolar-mediated degradations of gluconeogenesis enzymes; general targeting factor of Hsp104p to prion fibrils
0.100 7.01E-9 YGL152C_d YGL152C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF PEX14/YGL153W
0.095 3.65E-8 YMR244C-A COA6 hom Protein involved in cytochrome c oxidase assembly; also required for efficient formation of respiratory supercomplexes comprised of Complexes III and IV; localizes to the mitochondrial intermembrane space; has a human homolog; transcription is induced in response to the DNA-damaging agent MMS; protein abundance increases in response to DNA replication stress
0.092 8.32E-8 YLR421C RPN13 hom Subunit of the 19S regulatory particle of the 26S proteasome lid; acts as a ubiquitin receptor for the proteasome; null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; protein abundance increases in response to DNA replication stress
0.090 1.63E-7 YKL117W SBA1 hom Co-chaperone that binds to and regulates Hsp90 family chaperones; important for pp60v-src activity in yeast; homologous to the mammalian p23 proteins, and like p23 can regulate telomerase activity; protein abundance increases in response to DNA replication stress
0.088 3.55E-7 YKL164C PIR1 hom O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle; PIR1 has a paralog, YJL160C, that arose from the whole genome duplication
0.087 4.61E-7 YLR137W RKM5 hom Protein lysine methyltransferase; monomethylates Lys-46 of the ribosomal large subunit Rpl1a/Rpl1b; member of the seven beta-strand methyltransferase superfamily; orthologs only found among fungal species
0.086 5.24E-7 YDR222W_p YDR222W_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.086 5.33E-7 YLR254C NDL1 hom Homolog of nuclear distribution factor NudE, NUDEL; interacts with Pac1p and regulates dynein targeting to microtubule plus ends
0.085 7.25E-7 YBR052C RFS1 hom Protein of unknown function; member of a flavodoxin-like fold protein family that includes Pst2p and Ycp4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; RFS1 has a paralog, PST2, that arose from the whole genome duplication
0.083 1.46E-6 YGL231C EMC4 hom Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm ZK616.6/EMC-4, fly CG11137, human TMM85