YER004W / FMP52

Protein of unknown function, localized to the mitochondrial outer membrane; induced by treatment with 8-methoxypsoralen and UVA irradiation

Zygosity: Homozygous strain
fixedexpanded
Profile for YER004W / FMP52

Click on Significant Values for Screen Details ID:SGTC_146|Compound:3448-8650|FD-Score:3.81|P-value:1.47E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:-3.30|P-value:7.61E-4 ID:SGTC_424|Compound:splitomicin|FD-Score:-3.99|P-value:6.51E-5 ID:SGTC_531|Compound:3788-1495|FD-Score:3.36|P-value:6.92E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:-3.26|P-value:8.89E-4 ID:SGTC_783|Compound:0848-0141|FD-Score:3.53|P-value:3.96E-4 ID:SGTC_909|Compound:3448-9333|FD-Score:5.10|P-value:5.88E-7 ID:SGTC_916|Compound:4466-0038|FD-Score:-3.61|P-value:2.65E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:3.39|P-value:6.46E-4 ID:SGTC_1063|Compound:disulfiram|FD-Score:3.32|P-value:7.97E-4 ID:SGTC_1173|Compound:0443-0020|FD-Score:3.52|P-value:4.15E-4 ID:SGTC_1174|Compound:0739-0097|FD-Score:3.49|P-value:4.58E-4 ID:SGTC_1302|Compound:1159-0335|FD-Score:3.48|P-value:4.74E-4 ID:SGTC_1365|Compound:1672-3266|FD-Score:3.81|P-value:1.46E-4 ID:SGTC_1508|Compound:1080-0625|FD-Score:-3.86|P-value:1.07E-4 ID:SGTC_1513|Compound:0337-0559|FD-Score:3.93|P-value:9.32E-5 ID:SGTC_1550|Compound:gossypolone|FD-Score:3.88|P-value:1.12E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:5.19|P-value:3.87E-7 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:-4.33|P-value:1.68E-5 ID:SGTC_1924|Compound:st058459|FD-Score:-5.65|P-value:3.10E-8 ID:SGTC_1935|Compound:st074532|FD-Score:-3.45|P-value:4.75E-4 ID:SGTC_1938|Compound:st074717|FD-Score:-3.79|P-value:1.41E-4 ID:SGTC_2051|Compound:5263410|FD-Score:4.85|P-value:1.92E-6 ID:SGTC_2121|Compound:5257820|FD-Score:-4.01|P-value:6.11E-5 ID:SGTC_2176|Compound:5809774|FD-Score:-3.42|P-value:5.17E-4 ID:SGTC_2283|Compound:7944793|FD-Score:5.00|P-value:9.60E-7 ID:SGTC_2284|Compound:7945075|FD-Score:-3.52|P-value:3.62E-4 ID:SGTC_2294|Compound:7971431|FD-Score:3.28|P-value:9.22E-4 ID:SGTC_2349|Compound:9023730|FD-Score:3.91|P-value:1.02E-4 ID:SGTC_2365|Compound:9042475|FD-Score:5.35|P-value:1.73E-7 ID:SGTC_2366|Compound:9070441|FD-Score:4.28|P-value:2.33E-5 ID:SGTC_2479|Compound:5617353|FD-Score:-3.37|P-value:6.13E-4 ID:SGTC_2504|Compound:purpurogallin|FD-Score:-3.70|P-value:1.96E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:3.32|P-value:8.05E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:-4.13|P-value:3.72E-5 ID:SGTC_2687|Compound:chenodiol|FD-Score:-3.37|P-value:6.05E-4 ID:SGTC_2694|Compound:st077685|FD-Score:5.12|P-value:5.52E-7 ID:SGTC_2695|Compound:st077686|FD-Score:6.58|P-value:1.84E-10 ID:SGTC_2696|Compound:st077691|FD-Score:-7.15|P-value:3.90E-12 ID:SGTC_2783|Compound:7738165|FD-Score:8.51|P-value:2.43E-16 ID:SGTC_2808|Compound:7946468|FD-Score:-3.85|P-value:1.10E-4 ID:SGTC_2983|Compound:9022671|FD-Score:-3.28|P-value:8.14E-4 ID:SGTC_3010|Compound:9080089|FD-Score:3.61|P-value:2.97E-4 ID:SGTC_3052|Compound:9092717|FD-Score:6.38|P-value:5.97E-10 ID:SGTC_3126|Compound:9127922|FD-Score:4.18|P-value:3.56E-5 ID:SGTC_3193|Compound:9111931|FD-Score:-3.71|P-value:1.86E-4 ID:SGTC_3278|Compound:9139605|FD-Score:3.72|P-value:2.05E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:3.81|P-value:1.47E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:-3.30|P-value:7.61E-4 ID:SGTC_424|Compound:splitomicin|FD-Score:-3.99|P-value:6.51E-5 ID:SGTC_531|Compound:3788-1495|FD-Score:3.36|P-value:6.92E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:-3.26|P-value:8.89E-4 ID:SGTC_783|Compound:0848-0141|FD-Score:3.53|P-value:3.96E-4 ID:SGTC_909|Compound:3448-9333|FD-Score:5.10|P-value:5.88E-7 ID:SGTC_916|Compound:4466-0038|FD-Score:-3.61|P-value:2.65E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:3.39|P-value:6.46E-4 ID:SGTC_1063|Compound:disulfiram|FD-Score:3.32|P-value:7.97E-4 ID:SGTC_1173|Compound:0443-0020|FD-Score:3.52|P-value:4.15E-4 ID:SGTC_1174|Compound:0739-0097|FD-Score:3.49|P-value:4.58E-4 ID:SGTC_1302|Compound:1159-0335|FD-Score:3.48|P-value:4.74E-4 ID:SGTC_1365|Compound:1672-3266|FD-Score:3.81|P-value:1.46E-4 ID:SGTC_1508|Compound:1080-0625|FD-Score:-3.86|P-value:1.07E-4 ID:SGTC_1513|Compound:0337-0559|FD-Score:3.93|P-value:9.32E-5 ID:SGTC_1550|Compound:gossypolone|FD-Score:3.88|P-value:1.12E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:5.19|P-value:3.87E-7 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:-4.33|P-value:1.68E-5 ID:SGTC_1924|Compound:st058459|FD-Score:-5.65|P-value:3.10E-8 ID:SGTC_1935|Compound:st074532|FD-Score:-3.45|P-value:4.75E-4 ID:SGTC_1938|Compound:st074717|FD-Score:-3.79|P-value:1.41E-4 ID:SGTC_2051|Compound:5263410|FD-Score:4.85|P-value:1.92E-6 ID:SGTC_2121|Compound:5257820|FD-Score:-4.01|P-value:6.11E-5 ID:SGTC_2176|Compound:5809774|FD-Score:-3.42|P-value:5.17E-4 ID:SGTC_2283|Compound:7944793|FD-Score:5.00|P-value:9.60E-7 ID:SGTC_2284|Compound:7945075|FD-Score:-3.52|P-value:3.62E-4 ID:SGTC_2294|Compound:7971431|FD-Score:3.28|P-value:9.22E-4 ID:SGTC_2349|Compound:9023730|FD-Score:3.91|P-value:1.02E-4 ID:SGTC_2365|Compound:9042475|FD-Score:5.35|P-value:1.73E-7 ID:SGTC_2366|Compound:9070441|FD-Score:4.28|P-value:2.33E-5 ID:SGTC_2479|Compound:5617353|FD-Score:-3.37|P-value:6.13E-4 ID:SGTC_2504|Compound:purpurogallin|FD-Score:-3.70|P-value:1.96E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:3.32|P-value:8.05E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:-4.13|P-value:3.72E-5 ID:SGTC_2687|Compound:chenodiol|FD-Score:-3.37|P-value:6.05E-4 ID:SGTC_2694|Compound:st077685|FD-Score:5.12|P-value:5.52E-7 ID:SGTC_2695|Compound:st077686|FD-Score:6.58|P-value:1.84E-10 ID:SGTC_2696|Compound:st077691|FD-Score:-7.15|P-value:3.90E-12 ID:SGTC_2783|Compound:7738165|FD-Score:8.51|P-value:2.43E-16 ID:SGTC_2808|Compound:7946468|FD-Score:-3.85|P-value:1.10E-4 ID:SGTC_2983|Compound:9022671|FD-Score:-3.28|P-value:8.14E-4 ID:SGTC_3010|Compound:9080089|FD-Score:3.61|P-value:2.97E-4 ID:SGTC_3052|Compound:9092717|FD-Score:6.38|P-value:5.97E-10 ID:SGTC_3126|Compound:9127922|FD-Score:4.18|P-value:3.56E-5 ID:SGTC_3193|Compound:9111931|FD-Score:-3.71|P-value:1.86E-4 ID:SGTC_3278|Compound:9139605|FD-Score:3.72|P-value:2.05E-4

Top fitness defect scores for YER004W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2783 7738165 8.51 71.4 µM 2.43E-16 1 8.39E-18
2 SGTC_2695 st077686 6.58 52.0 µM 1.84E-10 6 2.37E-11
3 SGTC_3052 9092717 6.38 49.5 µM 5.97E-10 2 8.62E-11
4 SGTC_2365 9042475 5.35 200.0 µM 1.73E-7 11 4.33E-8
5 SGTC_1564 D-Arginine 5.19 115.0 µM 3.87E-7 14 1.05E-7
6 SGTC_2694 st077685 5.12 81.9 µM 5.52E-7 endomembrane recycling 12 1.54E-7
7 SGTC_909 3448-9333 5.10 149.0 µM 5.88E-7 5 1.66E-7
8 SGTC_2283 7944793 5.00 200.0 µM 9.60E-7 17 2.83E-7
9 SGTC_2051 5263410 4.85 176.0 µM 1.92E-6 10 6.05E-7
10 SGTC_2366 9070441 4.28 60.6 µM 2.33E-5 22 9.35E-6
11 SGTC_3126 9127922 4.18 49.5 µM 3.56E-5 fatty acid desaturase (OLE1) 29 1.49E-5
12 SGTC_1513 0337-0559 3.93 19.0 µM 9.32E-5 18 4.27E-5
13 SGTC_2349 9023730 3.91 187.1 µM 1.02E-4 24 4.69E-5
14 SGTC_1550 gossypolone 3.88 36.6 µM 1.12E-4 14 5.22E-5
15 SGTC_1365 1672-3266 3.81 55.4 µM 1.46E-4 25 6.98E-5
16 SGTC_146 3448-8650 3.81 53.1 µM 1.47E-4 NEO1-PIK1 148 7.01E-5
17 SGTC_3278 9139605 3.72 49.5 µM 2.05E-4 21 1.01E-4
18 SGTC_3010 9080089 3.61 71.4 µM 2.97E-4 23 1.51E-4
19 SGTC_783 0848-0141 3.53 92.7 µM 3.96E-4 RSC & ERG11 21 2.08E-4
20 SGTC_1173 0443-0020 3.52 122.0 µM 4.15E-4 TSC3-RPN4 57 2.19E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.153 5.14E-19 YMR031C EIS1 hom Component of the eisosome required for proper eisosome assembly; similarity to Ykl050cp and Uso1p; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; protein increases in abundance and relocalizes from plasma membrane to cytoplasm upon DNA replication stress
0.135 3.57E-15 YLR084C RAX2 hom N-glycosylated protein involved in the maintenance of bud site selection during bipolar budding; localization requires Rax1p; RAX2 mRNA stability is regulated by Mpt5p
0.135 3.83E-15 YML054C CYB2 hom Cytochrome b2 (L-lactate cytochrome-c oxidoreductase), component of the mitochondrial intermembrane space, required for lactate utilization; expression is repressed by glucose and anaerobic conditions
0.128 1.03E-13 YAL066W_d YAL066W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.120 3.58E-12 YFR057W_p YFR057W_p hom Putative protein of unknown function
0.118 5.87E-12 YER082C UTP7 het Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
0.108 4.08E-10 YBL087C RPL23A hom Ribosomal 60S subunit protein L23A; homologous to mammalian ribosomal protein L23 and bacterial L14; RPL23A has a paralog, RPL23B, that arose from the whole genome duplication
0.101 4.38E-9 YPL041C_p YPL041C_p hom Protein of unknown function involved in maintenance of proper telomere length
0.098 1.16E-8 YDR452W PPN1 hom Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer; relocalizes from vacuole to cytoplasm upon DNA replication stress
0.097 2.01E-8 YNR032W PPG1 hom Putative serine/threonine protein phosphatase of the type 2A-like phosphatase family, required for glycogen accumulation; interacts with Tap42p, which binds to and regulates other protein phosphatases
0.094 5.63E-8 YNL067W-B_p YNL067W-B_p hom Putative protein of unknown function
0.093 6.62E-8 YOR342C YOR342C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; relocalizes from nucleus to cytoplasm upon DNA replication stress; YOR342C has a paralog, YAL037W, that arose from the whole genome duplication
0.092 1.03E-7 YKL132C RMA1 hom Putative dihydrofolate synthetase; has similarity to Fol3p and to E. coli folylpolyglutamate synthetase/dihydrofolate synthetase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.090 1.77E-7 YJL009W_d YJL009W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps CCT8/YJL008C, a verified gene encoding a subunit of the cytosolic chaperonin Cct ring complex
0.090 1.81E-7 YMR080C NAM7 hom ATP-dependent RNA helicase of the SFI superfamily; involved in nonsense mediated mRNA decay; required for efficient translation termination at nonsense codons and targeting of NMD substrates to P-bodies; involved in telomere maintenance; forms cytoplasmic foci upon DNA replication stress