YER044C / ERG28

Endoplasmic reticulum membrane protein, may facilitate protein-protein interactions between the Erg26p dehydrogenase and the Erg27p 3-ketoreductase and/or tether these enzymes to the ER, also interacts with Erg6p

Zygosity: Homozygous strain
fixedexpanded
Profile for YER044C / ERG28

Click on Significant Values for Screen Details ID:SGTC_116|Compound:0155-0182|FD-Score:-3.92|P-value:7.59E-5 ID:SGTC_119|Compound:0121-0043|FD-Score:3.68|P-value:1.96E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:-3.61|P-value:2.44E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:3.48|P-value:4.07E-4 ID:SGTC_567|Compound:1080-0542|FD-Score:-3.84|P-value:1.02E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:3.25|P-value:8.81E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:-5.22|P-value:2.22E-7 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:3.24|P-value:9.23E-4 ID:SGTC_1153|Compound:4055-0057|FD-Score:3.24|P-value:9.01E-4 ID:SGTC_1227|Compound:3909-8010|FD-Score:-3.55|P-value:3.00E-4 ID:SGTC_1271|Compound:0832-2808|FD-Score:-5.01|P-value:6.52E-7 ID:SGTC_1274|Compound:0865-0114|FD-Score:-4.16|P-value:2.88E-5 ID:SGTC_1276|Compound:0871-0068|FD-Score:-7.52|P-value:1.86E-13 ID:SGTC_1289|Compound:0976-0073|FD-Score:-4.32|P-value:1.48E-5 ID:SGTC_1661|Compound:st013063|FD-Score:3.27|P-value:8.24E-4 ID:SGTC_1672|Compound:st016598|FD-Score:3.40|P-value:5.34E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-3.23|P-value:8.83E-4 ID:SGTC_1708|Compound:st033234|FD-Score:3.26|P-value:8.62E-4 ID:SGTC_1764|Compound:st044502|FD-Score:-3.58|P-value:2.62E-4 ID:SGTC_1830|Compound:st055982|FD-Score:3.29|P-value:7.81E-4 ID:SGTC_1884|Compound:5633444|FD-Score:-3.47|P-value:4.00E-4 ID:SGTC_1923|Compound:st058458|FD-Score:3.52|P-value:3.51E-4 ID:SGTC_2075|Compound:5212009|FD-Score:-3.73|P-value:1.56E-4 ID:SGTC_2138|Compound:5575593|FD-Score:-4.03|P-value:4.88E-5 ID:SGTC_2141|Compound:5621638|FD-Score:3.25|P-value:8.66E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-3.70|P-value:1.75E-4 ID:SGTC_2243|Compound:6634756|FD-Score:-3.40|P-value:5.09E-4 ID:SGTC_2310|Compound:7668677|FD-Score:3.67|P-value:2.05E-4 ID:SGTC_2315|Compound:7733312|FD-Score:3.31|P-value:7.11E-4 ID:SGTC_2486|Compound:5283202|FD-Score:3.51|P-value:3.58E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:3.47|P-value:4.18E-4 ID:SGTC_2971|Compound:9092186|FD-Score:-3.57|P-value:2.79E-4 ID:SGTC_3140|Compound:9094243|FD-Score:3.43|P-value:4.79E-4 ID:SGTC_3143|Compound:9086658|FD-Score:-3.80|P-value:1.18E-4 ID:SGTC_3219|Compound:9131112|FD-Score:-3.61|P-value:2.39E-4 ID:SGTC_3245|Compound:9134821|FD-Score:3.23|P-value:9.30E-4 ID:SGTC_3341|Compound:9147222|FD-Score:-3.30|P-value:7.07E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-3.92|P-value:7.59E-5 ID:SGTC_119|Compound:0121-0043|FD-Score:3.68|P-value:1.96E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:-3.61|P-value:2.44E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:3.48|P-value:4.07E-4 ID:SGTC_567|Compound:1080-0542|FD-Score:-3.84|P-value:1.02E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:3.25|P-value:8.81E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:-5.22|P-value:2.22E-7 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:3.24|P-value:9.23E-4 ID:SGTC_1153|Compound:4055-0057|FD-Score:3.24|P-value:9.01E-4 ID:SGTC_1227|Compound:3909-8010|FD-Score:-3.55|P-value:3.00E-4 ID:SGTC_1271|Compound:0832-2808|FD-Score:-5.01|P-value:6.52E-7 ID:SGTC_1274|Compound:0865-0114|FD-Score:-4.16|P-value:2.88E-5 ID:SGTC_1276|Compound:0871-0068|FD-Score:-7.52|P-value:1.86E-13 ID:SGTC_1289|Compound:0976-0073|FD-Score:-4.32|P-value:1.48E-5 ID:SGTC_1661|Compound:st013063|FD-Score:3.27|P-value:8.24E-4 ID:SGTC_1672|Compound:st016598|FD-Score:3.40|P-value:5.34E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-3.23|P-value:8.83E-4 ID:SGTC_1708|Compound:st033234|FD-Score:3.26|P-value:8.62E-4 ID:SGTC_1764|Compound:st044502|FD-Score:-3.58|P-value:2.62E-4 ID:SGTC_1830|Compound:st055982|FD-Score:3.29|P-value:7.81E-4 ID:SGTC_1884|Compound:5633444|FD-Score:-3.47|P-value:4.00E-4 ID:SGTC_1923|Compound:st058458|FD-Score:3.52|P-value:3.51E-4 ID:SGTC_2075|Compound:5212009|FD-Score:-3.73|P-value:1.56E-4 ID:SGTC_2138|Compound:5575593|FD-Score:-4.03|P-value:4.88E-5 ID:SGTC_2141|Compound:5621638|FD-Score:3.25|P-value:8.66E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-3.70|P-value:1.75E-4 ID:SGTC_2243|Compound:6634756|FD-Score:-3.40|P-value:5.09E-4 ID:SGTC_2310|Compound:7668677|FD-Score:3.67|P-value:2.05E-4 ID:SGTC_2315|Compound:7733312|FD-Score:3.31|P-value:7.11E-4 ID:SGTC_2486|Compound:5283202|FD-Score:3.51|P-value:3.58E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:3.47|P-value:4.18E-4 ID:SGTC_2971|Compound:9092186|FD-Score:-3.57|P-value:2.79E-4 ID:SGTC_3140|Compound:9094243|FD-Score:3.43|P-value:4.79E-4 ID:SGTC_3143|Compound:9086658|FD-Score:-3.80|P-value:1.18E-4 ID:SGTC_3219|Compound:9131112|FD-Score:-3.61|P-value:2.39E-4 ID:SGTC_3245|Compound:9134821|FD-Score:3.23|P-value:9.30E-4 ID:SGTC_3341|Compound:9147222|FD-Score:-3.30|P-value:7.07E-4

Top fitness defect scores for YER044C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_119 0121-0043 3.68 24.8 µM 1.96E-4 mitochondrial stress 135 1.15E-4
2 SGTC_2310 7668677 3.67 200.0 µM 2.05E-4 42 1.21E-4
3 SGTC_1923 st058458 3.52 19.1 µM 3.51E-4 49 2.16E-4
4 SGTC_2486 5283202 3.51 22.4 µM 3.58E-4 51 2.20E-4
5 SGTC_432 NS 1619 3.48 61.3 µM 4.07E-4 43 2.53E-4
6 SGTC_2610 ononetin 3.47 44.2 µM 4.18E-4 63 2.61E-4
7 SGTC_3140 9094243 3.43 49.5 µM 4.79E-4 47 3.01E-4
8 SGTC_1672 st016598 3.40 6.5 µM 5.34E-4 endomembrane recycling 91 3.38E-4
9 SGTC_2315 7733312 3.31 200.0 µM 7.11E-4 46 4.60E-4
10 SGTC_1830 st055982 3.29 50.3 µM 7.81E-4 47 5.09E-4
11 SGTC_1661 st013063 3.27 9.7 µM 8.24E-4 46 5.38E-4
12 SGTC_1708 st033234 3.26 31.8 µM 8.62E-4 34 5.65E-4
13 SGTC_2141 5621638 3.25 7.7 µM 8.66E-4 tubulin folding & SWR complex 52 5.68E-4
14 SGTC_908 3448-7491 3.25 47.7 µM 8.81E-4 mitochondrial stress 180 5.78E-4
15 SGTC_1153 4055-0057 3.24 267.0 µM 9.01E-4 60 5.92E-4
16 SGTC_915 methyl methanesulfonate (MMS) 3.24 110.0 mM 9.23E-4 DNA damage response 70 6.08E-4
17 SGTC_3245 9134821 3.23 49.5 µM 9.30E-4 42 6.13E-4
18 SGTC_2078 5212016 3.19 200.0 µM 0.00106 60S ribosome export 33 7.05E-4
19 SGTC_1931 st074438 3.18 57.1 µM 0.00109 43 7.24E-4
20 SGTC_365 0121-0052 3.18 13.6 µM 0.00110 mitochondrial response to ROS 113 7.35E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.100 5.69E-9 YDL153C SAS10 het Essential subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit; disrupts silencing when overproduced; mutant has increased aneuploidy tolerance
0.088 2.89E-7 YHR192W LNP1 hom Lunapark family member involved in ER network formation; localizes to ER junctions and this localization is regulated by the yeast atlastin ortholog Sey1p; interacts with the reticulon protein Rtn1p; induced in response to the DNA-damaging agent MMS
0.080 3.08E-6 YDR249C_p YDR249C_p hom Putative protein of unknown function
0.080 3.77E-6 YJR034W PET191 hom Protein required for assembly of cytochrome c oxidase; exists as an oligomer; described as both an integral mitochondrial inner membrane protein facing the intermembrane space (IMS) and as a soluble IMS protein; contains a twin Cx9C motif; imported into the IMS via the MIA import machinery
0.078 6.60E-6 YMR112C MED11 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential protein
0.074 1.63E-5 YDL045W-A MRP10 hom Mitochondrial ribosomal protein of the small subunit; contains twin cysteine-x9-cysteine motifs
0.074 1.90E-5 YIL161W_p YIL161W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; mRNA is enriched in Scp160p-associated mRNPs; YIL161W is a non-essential gene
0.074 1.91E-5 YBR146W MRPS9 hom Mitochondrial ribosomal protein of the small subunit
0.073 2.27E-5 YPR050C_d YPR050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MAK3/YPR051W
0.071 3.71E-5 YGR253C PUP2 het Alpha 5 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit zeta
0.071 3.70E-5 YHR143W-A RPC10 het RNA polymerase subunit ABC10-alpha, found in RNA pol I, II, and III; relocalizes from nucleolus to cytoplasm upon DNA replication stress
0.071 4.24E-5 YML025C YML6 het Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins
0.067 1.02E-4 YDR074W TPS2 hom Phosphatase subunit of the trehalose-6-P synthase/phosphatase complex; involved in synthesis of the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway; protein abundance increases in response to DNA replication stress
0.067 1.03E-4 YJL174W KRE9 het Glycoprotein involved in cell wall beta-glucan assembly; null mutation leads to severe growth defects, aberrant multibudded morphology, and mating defects
0.067 1.05E-4 YJL063C MRPL8 hom Mitochondrial ribosomal protein of the large subunit