YER046W / SPO73

Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensible for both nuclear divisions during meiosis

Zygosity: Homozygous strain
fixedexpanded
Profile for YER046W / SPO73

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:-3.14|P-value:5.51E-4 ID:SGTC_85|Compound:0868-0259|FD-Score:-2.98|P-value:9.80E-4 ID:SGTC_88|Compound:0180-0332|FD-Score:3.09|P-value:6.34E-4 ID:SGTC_90|Compound:0870-0863|FD-Score:4.79|P-value:2.81E-7 ID:SGTC_94|Compound:0334-0113|FD-Score:-3.53|P-value:1.20E-4 ID:SGTC_96|Compound:0929-0093|FD-Score:3.08|P-value:6.48E-4 ID:SGTC_148|Compound:3253-0744|FD-Score:-3.00|P-value:9.12E-4 ID:SGTC_175|Compound:3793-3120|FD-Score:3.07|P-value:6.64E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:-3.63|P-value:7.94E-5 ID:SGTC_407|Compound:eburnamonine|FD-Score:-3.26|P-value:3.53E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:3.19|P-value:4.35E-4 ID:SGTC_1018|Compound:4259-0013|FD-Score:-4.08|P-value:1.11E-5 ID:SGTC_1022|Compound:4477-0945|FD-Score:-3.59|P-value:9.68E-5 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:3.23|P-value:3.70E-4 ID:SGTC_1194|Compound:1488-0194|FD-Score:3.59|P-value:8.70E-5 ID:SGTC_1203|Compound:3992-3522|FD-Score:7.47|P-value:3.36E-15 ID:SGTC_1270|Compound:0831-1170|FD-Score:3.19|P-value:4.37E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-4.73|P-value:4.37E-7 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.08|P-value:6.98E-4 ID:SGTC_1617|Compound:st002906|FD-Score:4.12|P-value:8.63E-6 ID:SGTC_1619|Compound:st003326|FD-Score:3.24|P-value:3.62E-4 ID:SGTC_1671|Compound:st016596|FD-Score:3.16|P-value:4.80E-4 ID:SGTC_1957|Compound:st077035|FD-Score:-3.25|P-value:3.62E-4 ID:SGTC_2114|Compound:5491910|FD-Score:2.96|P-value:9.79E-4 ID:SGTC_2125|Compound:5246583|FD-Score:3.87|P-value:2.71E-5 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:3.07|P-value:6.59E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:-3.07|P-value:7.05E-4 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:3.63|P-value:7.67E-5 ID:SGTC_2596|Compound:sinensetin|FD-Score:-3.18|P-value:4.73E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:2.99|P-value:8.96E-4 ID:SGTC_2638|Compound:epoxomicin|FD-Score:3.70|P-value:5.56E-5 ID:SGTC_2784|Compound:7567673|FD-Score:3.26|P-value:3.29E-4 ID:SGTC_2788|Compound:5282734|FD-Score:3.80|P-value:3.58E-5 ID:SGTC_3303|Compound:9125618|FD-Score:3.74|P-value:4.64E-5 ID:SGTC_3356|Compound:9151811|FD-Score:3.05|P-value:7.21E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.14|P-value:5.51E-4 ID:SGTC_85|Compound:0868-0259|FD-Score:-2.98|P-value:9.80E-4 ID:SGTC_88|Compound:0180-0332|FD-Score:3.09|P-value:6.34E-4 ID:SGTC_90|Compound:0870-0863|FD-Score:4.79|P-value:2.81E-7 ID:SGTC_94|Compound:0334-0113|FD-Score:-3.53|P-value:1.20E-4 ID:SGTC_96|Compound:0929-0093|FD-Score:3.08|P-value:6.48E-4 ID:SGTC_148|Compound:3253-0744|FD-Score:-3.00|P-value:9.12E-4 ID:SGTC_175|Compound:3793-3120|FD-Score:3.07|P-value:6.64E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:-3.63|P-value:7.94E-5 ID:SGTC_407|Compound:eburnamonine|FD-Score:-3.26|P-value:3.53E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:3.19|P-value:4.35E-4 ID:SGTC_1018|Compound:4259-0013|FD-Score:-4.08|P-value:1.11E-5 ID:SGTC_1022|Compound:4477-0945|FD-Score:-3.59|P-value:9.68E-5 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:3.23|P-value:3.70E-4 ID:SGTC_1194|Compound:1488-0194|FD-Score:3.59|P-value:8.70E-5 ID:SGTC_1203|Compound:3992-3522|FD-Score:7.47|P-value:3.36E-15 ID:SGTC_1270|Compound:0831-1170|FD-Score:3.19|P-value:4.37E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-4.73|P-value:4.37E-7 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.08|P-value:6.98E-4 ID:SGTC_1617|Compound:st002906|FD-Score:4.12|P-value:8.63E-6 ID:SGTC_1619|Compound:st003326|FD-Score:3.24|P-value:3.62E-4 ID:SGTC_1671|Compound:st016596|FD-Score:3.16|P-value:4.80E-4 ID:SGTC_1957|Compound:st077035|FD-Score:-3.25|P-value:3.62E-4 ID:SGTC_2114|Compound:5491910|FD-Score:2.96|P-value:9.79E-4 ID:SGTC_2125|Compound:5246583|FD-Score:3.87|P-value:2.71E-5 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:3.07|P-value:6.59E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:-3.07|P-value:7.05E-4 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:3.63|P-value:7.67E-5 ID:SGTC_2596|Compound:sinensetin|FD-Score:-3.18|P-value:4.73E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:2.99|P-value:8.96E-4 ID:SGTC_2638|Compound:epoxomicin|FD-Score:3.70|P-value:5.56E-5 ID:SGTC_2784|Compound:7567673|FD-Score:3.26|P-value:3.29E-4 ID:SGTC_2788|Compound:5282734|FD-Score:3.80|P-value:3.58E-5 ID:SGTC_3303|Compound:9125618|FD-Score:3.74|P-value:4.64E-5 ID:SGTC_3356|Compound:9151811|FD-Score:3.05|P-value:7.21E-4

Top fitness defect scores for YER046W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1203 3992-3522 7.47 103.0 µM 3.36E-15 3 4.06E-14
2 SGTC_90 0870-0863 4.79 4.6 µM 2.81E-7 28 8.14E-7
3 SGTC_1617 st002906 4.12 78.0 µM 8.63E-6 25 1.92E-5
4 SGTC_2125 5246583 3.87 200.0 µM 2.71E-5 tubulin folding & SWR complex 46 5.54E-5
5 SGTC_2788 5282734 3.80 71.4 µM 3.58E-5 56 7.14E-5
6 SGTC_3303 9125618 3.74 40.6 µM 4.64E-5 55 9.08E-5
7 SGTC_2638 epoxomicin 3.70 18.0 µM 5.56E-5 42 1.07E-4
8 SGTC_2574 2',4'-dihydroxychalcone 3.63 14.6 µM 7.67E-5 31 1.44E-4
9 SGTC_1194 1488-0194 3.59 225.0 µM 8.70E-5 43 1.62E-4
10 SGTC_2784 7567673 3.26 72.7 µM 3.29E-4 iron homeostasis 57 5.55E-4
11 SGTC_1619 st003326 3.24 88.7 µM 3.62E-4 60S ribosome export 38 6.06E-4
12 SGTC_1071 trifluoperazine 3.23 6.3 µM 3.70E-4 51 6.19E-4
13 SGTC_527 4476-4215 3.19 268.0 µM 4.35E-4 PDR1 70 7.17E-4
14 SGTC_1270 0831-1170 3.19 17.3 µM 4.37E-4 34 7.20E-4
15 SGTC_1671 st016596 3.16 74.5 µM 4.80E-4 41 7.86E-4
16 SGTC_88 0180-0332 3.09 8.7 µM 6.34E-4 58 0.00102
17 SGTC_96 0929-0093 3.08 37.3 µM 6.48E-4 calcium & mitochondrial duress 43 0.00104
18 SGTC_2420 aureobasidin a 3.07 50.0 nM 6.59E-4 90 0.00105
19 SGTC_175 3793-3120 3.07 23.7 µM 6.64E-4 47 0.00106
20 SGTC_3356 9151811 3.05 4.5 µM 7.21E-4 cell wall 56 0.00114

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.161 7.35E-21 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.158 4.74E-20 YDL222C FMP45 hom Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C
0.152 7.13E-19 YER051W JHD1 hom JmjC domain family histone demethylase specific for H3-K36, similar to proteins found in human, mouse, drosophila, X. laevis, C. elegans, and S. pombe
0.151 1.77E-18 YDR308C SRB7 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; target of the global repressor Tup1p
0.136 2.54E-15 YGR206W MVB12 hom ESCRT-I subunit required to stabilize oligomers of the ESCRT-I core complex (Stp22p, Vps28p, Srn2p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; deletion mutant is sensitive to rapamycin and nystatin
0.136 2.65E-15 YNL253W TEX1 hom Protein involved in mRNA export, component of the transcription export (TREX) complex
0.131 2.57E-14 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.130 3.38E-14 YOR152C_p YOR152C_p hom Putative protein of unknown function; YOR152C is not an essential gene
0.130 3.62E-14 YGR172C YIP1 het Integral membrane protein required for the biogenesis of ER-derived COPII transport vesicles; interacts with Yif1p and Yos1p; localizes to the Golgi, the ER, and COPII vesicles; homolog of human YIPF4
0.127 1.31E-13 YIL010W DOT5 hom Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth
0.126 2.42E-13 YOL032W OPI10 hom Protein with a possible role in phospholipid biosynthesis; null mutant displays an inositol-excreting phenotype that is suppressed by exogenous choline; protein abundance increases in response to DNA replication stress
0.126 2.64E-13 YDR530C APA2 hom Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase II; AP4A phosphorylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; APA2 has a paralog, APA1, that arose from the whole genome duplication
0.125 4.21E-13 YJR078W BNA2 hom Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase, required for de novo biosynthesis of NAD from tryptophan via kynurenine; interacts genetically with telomere capping gene CDC13; regulated by Hst1p and Aftp
0.121 1.77E-12 YPL137C GIP3 hom Cytoplasmic protein that regulates protein phosphatase 1 Glc7p; overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; may interact with ribosomes, based on co-purification experiments; GIP3 has a paralog, HER1, that arose from the whole genome duplication
0.119 4.41E-12 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p