YER046W-A_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YER046W-A / YER046W-A

Click on Significant Values for Screen Details ID:SGTC_39|Compound:0986-0283|FD-Score:4.05|P-value:1.02E-5 ID:SGTC_70|Compound:0141-0289|FD-Score:3.62|P-value:7.07E-5 ID:SGTC_127|Compound:0180-0333|FD-Score:3.59|P-value:7.92E-5 ID:SGTC_131|Compound:0141-0277|FD-Score:3.08|P-value:5.96E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:3.41|P-value:1.72E-4 ID:SGTC_181|Compound:1447-1644|FD-Score:4.13|P-value:6.97E-6 ID:SGTC_198|Compound:3454-2873|FD-Score:3.09|P-value:5.93E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:2.98|P-value:8.58E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:3.95|P-value:1.63E-5 ID:SGTC_798|Compound:1287-0182|FD-Score:3.16|P-value:4.54E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:3.56|P-value:9.28E-5 ID:SGTC_893|Compound:0958-0369|FD-Score:-3.04|P-value:6.84E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:3.05|P-value:6.83E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:3.23|P-value:3.47E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:3.03|P-value:7.13E-4 ID:SGTC_1194|Compound:1488-0194|FD-Score:3.08|P-value:6.08E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:-3.11|P-value:5.34E-4 ID:SGTC_1302|Compound:1159-0335|FD-Score:3.91|P-value:1.96E-5 ID:SGTC_1385|Compound:3091-4834|FD-Score:-3.09|P-value:5.69E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:2.96|P-value:9.49E-4 ID:SGTC_1567|Compound:st069303|FD-Score:3.27|P-value:2.99E-4 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:4.27|P-value:3.62E-6 ID:SGTC_1591|Compound:genipin|FD-Score:-3.36|P-value:2.01E-4 ID:SGTC_1784|Compound:st039334|FD-Score:3.58|P-value:8.41E-5 ID:SGTC_1792|Compound:st045773|FD-Score:3.40|P-value:1.78E-4 ID:SGTC_1863|Compound:st057641|FD-Score:3.38|P-value:1.94E-4 ID:SGTC_2165|Compound:5727197|FD-Score:3.12|P-value:5.15E-4 ID:SGTC_2313|Compound:7726885|FD-Score:4.57|P-value:7.76E-7 ID:SGTC_2354|Compound:9060492|FD-Score:3.91|P-value:1.97E-5 ID:SGTC_2373|Compound:9071805|FD-Score:-2.96|P-value:8.99E-4 ID:SGTC_2391|Compound:6285546|FD-Score:3.20|P-value:3.90E-4 ID:SGTC_2414|Compound:st077232|FD-Score:3.84|P-value:2.74E-5 ID:SGTC_2455|Compound:5377712|FD-Score:3.77|P-value:3.65E-5 ID:SGTC_2585|Compound:alliin|FD-Score:-4.80|P-value:2.12E-7 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.85|P-value:2.60E-5 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:-3.40|P-value:1.73E-4 ID:SGTC_2816|Compound:7982706|FD-Score:-3.81|P-value:3.08E-5 ID:SGTC_2975|Compound:9084847|FD-Score:-4.09|P-value:8.33E-6 ID:SGTC_2980|Compound:9014342|FD-Score:-3.55|P-value:9.37E-5 ID:SGTC_3034|Compound:9090421|FD-Score:3.15|P-value:4.72E-4 ID:SGTC_3308|Compound:9128332|FD-Score:-3.16|P-value:4.33E-4 ID:SGTC_39|Compound:0986-0283|FD-Score:4.05|P-value:1.02E-5 ID:SGTC_70|Compound:0141-0289|FD-Score:3.62|P-value:7.07E-5 ID:SGTC_127|Compound:0180-0333|FD-Score:3.59|P-value:7.92E-5 ID:SGTC_131|Compound:0141-0277|FD-Score:3.08|P-value:5.96E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:3.41|P-value:1.72E-4 ID:SGTC_181|Compound:1447-1644|FD-Score:4.13|P-value:6.97E-6 ID:SGTC_198|Compound:3454-2873|FD-Score:3.09|P-value:5.93E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:2.98|P-value:8.58E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:3.95|P-value:1.63E-5 ID:SGTC_798|Compound:1287-0182|FD-Score:3.16|P-value:4.54E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:3.56|P-value:9.28E-5 ID:SGTC_893|Compound:0958-0369|FD-Score:-3.04|P-value:6.84E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:3.05|P-value:6.83E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:3.23|P-value:3.47E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:3.03|P-value:7.13E-4 ID:SGTC_1194|Compound:1488-0194|FD-Score:3.08|P-value:6.08E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:-3.11|P-value:5.34E-4 ID:SGTC_1302|Compound:1159-0335|FD-Score:3.91|P-value:1.96E-5 ID:SGTC_1385|Compound:3091-4834|FD-Score:-3.09|P-value:5.69E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:2.96|P-value:9.49E-4 ID:SGTC_1567|Compound:st069303|FD-Score:3.27|P-value:2.99E-4 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:4.27|P-value:3.62E-6 ID:SGTC_1591|Compound:genipin|FD-Score:-3.36|P-value:2.01E-4 ID:SGTC_1784|Compound:st039334|FD-Score:3.58|P-value:8.41E-5 ID:SGTC_1792|Compound:st045773|FD-Score:3.40|P-value:1.78E-4 ID:SGTC_1863|Compound:st057641|FD-Score:3.38|P-value:1.94E-4 ID:SGTC_2165|Compound:5727197|FD-Score:3.12|P-value:5.15E-4 ID:SGTC_2313|Compound:7726885|FD-Score:4.57|P-value:7.76E-7 ID:SGTC_2354|Compound:9060492|FD-Score:3.91|P-value:1.97E-5 ID:SGTC_2373|Compound:9071805|FD-Score:-2.96|P-value:8.99E-4 ID:SGTC_2391|Compound:6285546|FD-Score:3.20|P-value:3.90E-4 ID:SGTC_2414|Compound:st077232|FD-Score:3.84|P-value:2.74E-5 ID:SGTC_2455|Compound:5377712|FD-Score:3.77|P-value:3.65E-5 ID:SGTC_2585|Compound:alliin|FD-Score:-4.80|P-value:2.12E-7 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.85|P-value:2.60E-5 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:-3.40|P-value:1.73E-4 ID:SGTC_2816|Compound:7982706|FD-Score:-3.81|P-value:3.08E-5 ID:SGTC_2975|Compound:9084847|FD-Score:-4.09|P-value:8.33E-6 ID:SGTC_2980|Compound:9014342|FD-Score:-3.55|P-value:9.37E-5 ID:SGTC_3034|Compound:9090421|FD-Score:3.15|P-value:4.72E-4 ID:SGTC_3308|Compound:9128332|FD-Score:-3.16|P-value:4.33E-4

Top fitness defect scores for YER046W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2313 7726885 4.57 200.0 µM 7.76E-7 RPP1 & pyrimidine depletion 22 2.43E-6
2 SGTC_1585 2',4'-dihydroxychalcone 4.27 10.4 µM 3.62E-6 21 9.85E-6
3 SGTC_181 1447-1644 4.13 8.1 µM 6.97E-6 endomembrane recycling 29 1.79E-5
4 SGTC_39 0986-0283 4.05 58.4 µM 1.02E-5 calcium & mitochondrial duress 34 2.53E-5
5 SGTC_454 lyso-paf C-16 3.95 6.7 µM 1.63E-5 16 3.88E-5
6 SGTC_1302 1159-0335 3.91 255.0 µM 1.96E-5 17 4.57E-5
7 SGTC_2354 9060492 3.91 162.0 µM 1.97E-5 19 4.59E-5
8 SGTC_2621 lithochol-11-enic acid 3.85 100.0 µM 2.60E-5 27 5.92E-5
9 SGTC_2414 st077232 3.84 92.9 µM 2.74E-5 24 6.20E-5
10 SGTC_2455 5377712 3.77 9.8 µM 3.65E-5 24 8.05E-5
11 SGTC_70 0141-0289 3.62 43.3 µM 7.07E-5 mitochondrial stress 199 1.47E-4
12 SGTC_127 0180-0333 3.59 59.1 µM 7.92E-5 mitochondrial response to ROS 58 1.63E-4
13 SGTC_1784 st039334 3.58 36.3 µM 8.41E-5 28 1.72E-4
14 SGTC_887 0885-0007 3.56 9.6 µM 9.28E-5 endomembrane recycling 50 1.88E-4
15 SGTC_140 0062-0056 3.41 502.5 µM 1.72E-4 40 3.29E-4
16 SGTC_1792 st045773 3.40 43.6 µM 1.78E-4 49 3.40E-4
17 SGTC_1863 st057641 3.38 20.1 µM 1.94E-4 34 3.68E-4
18 SGTC_1567 st069303 3.27 68.4 µM 2.99E-4 mitochondrial processes 45 5.46E-4
19 SGTC_1044 1222-0021 3.23 1.8 µM 3.47E-4 heme biosynthesis & mitochondrial translocase 65 6.25E-4
20 SGTC_2391 6285546 3.20 200.0 µM 3.90E-4 48 6.95E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.123 8.67E-13 YMR210W YMR210W hom Putative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification
0.098 1.41E-8 YPL011C TAF3 het TFIID subunit (47 kDa), involved in promoter binding and RNA polymerase II transcription initiation
0.094 5.04E-8 YBR071W YBR071W hom Protein of unknown function found in the cytoplasm and bud neck; mRNA expression may be regulated by the cell cycle and/or cell wall stress; overexpression of YBR071W affects endocytic protein trafficking
0.089 2.44E-7 YDR414C ERD1 hom Predicted membrane protein required for the retention of lumenal endoplasmic reticulum proteins; mutants secrete the endogenous ER protein, BiP (Kar2p)
0.088 3.08E-7 YBR087W RFC5 het Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon
0.088 3.52E-7 YJR069C HAM1 hom Nucleoside triphosphate pyrophosphohydrolase; active against a wide range of substrates including ITP, dITP and XTP; mediates exclusion of noncanonical purines and pyrimadines from deoxyribonucleoside triphosphate pools; mutant is sensitive to the base analog 6-N-hydroxylaminopurine; protein abundance increases in response to DNA replication stress
0.087 5.00E-7 YDL081C RPP1A hom Ribosomal stalk protein P1 alpha, involved in the interaction between translational elongation factors and the ribosome; accumulation of P1 in the cytoplasm is regulated by phosphorylation and interaction with the P2 stalk component
0.084 1.33E-6 YBL065W_d YBL065W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF SEF1/YBL066C; YBL065W is a non-essential gene
0.081 2.71E-6 YGR295C COS6 hom Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
0.078 5.58E-6 YDR065W RRG1 hom Protein of unknown function, required for vacuolar acidification and mitochondrial genome maintenance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.078 6.34E-6 YNL313C EMW1 het Essential conserved protein with a role in cell wall integrity; contains six TPR (tetratricopeptide repeat) domains clustered in the C-terminal region; conditional mutant is suppressed by overexpression of GFA1; protein abundance increases in response to DNA replication stress
0.077 7.00E-6 YDR192C NUP42 hom FG-nucleoporin component of central core of the nuclear pore complex (NPC); also part of the NPC cytoplasmic filaments; contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier and is involved in gene tethering at the nuclear periphery; interacts with Gle1p
0.076 9.49E-6 YLR276C DBP9 het DEAD-box protein required for 27S rRNA processing; exhibits DNA, RNA and DNA/RNA helicase activities; ATPase activity shows preference for DNA over RNA; DNA helicase activity abolished by mutation in RNA-binding domain
0.075 1.38E-5 YBR109C CMD1 het Calmodulin; Ca++ binding protein that regulates Ca++ independent processes (mitosis, bud growth, actin organization, endocytosis, etc.) and Ca++ dependent processes (stress-activated pathways), targets include Nuf1p, Myo2p and calcineurin
0.074 1.60E-5 YIL051C MMF1 het Mitochondrial protein required for transamination of isoleucine but not of valine or leucine; may regulate specificity of branched-chain transaminases Bat1p and Bat2p; interacts genetically with mitochondrial ribosomal protein genes