HIPHOP chemogenomics database

YER050C / RSM18

Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein

Zygosity: Homozygous strain

fixedexpanded
Profile for YER050C / RSM18

Click on Significant Values for Screen Details

Top fitness defect scores for YER050C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_310	1273-0058	15.60	1.1 µM	1.87E-38	mitochondrial stress	6	2.50E-55
2	SGTC_236	1509-0011	10.00	5.3 µM	4.71E-17		193	5.08E-24
3	SGTC_173	1273-0061	8.89	2.7 µM	9.01E-14	mitochondrial stress	51	3.10E-19
4	SGTC_275	trichlorophene	8.32	5.7 µM	2.75E-12	mitochondrial stress	69	4.50E-17
5	SGTC_1742	st038235	7.31	28.9 µM	6.82E-10	mitochondrial stress	24	1.36E-13
6	SGTC_2250	alverine citrate	6.42	130.0 µM	5.00E-8		43	6.90E-11
7	SGTC_314	1671-0008	5.76	2.7 µM	8.56E-7		6	4.19E-9
8	SGTC_1623	st003709	5.64	20.3 µM	1.37E-6	calcium & mitochondrial duress	14	8.26E-9
9	SGTC_2283	7944793	5.45	200.0 µM	2.98E-6		12	2.53E-8
10	SGTC_118	0083-0097	5.39	135.3 µM	3.75E-6	translation	42	3.53E-8
11	SGTC_119	0121-0043	4.98	24.8 µM	1.70E-5	mitochondrial stress	55	3.10E-7
12	SGTC_704	1310-0270	4.77	142.0 µM	3.57E-5		19	9.04E-7
13	SGTC_1319	1306-0155	4.63	43.7 µM	5.79E-5		10	1.81E-6
14	SGTC_10	0279-0212	4.50	42.6 µM	8.87E-5	TRP & mitochondrial translation	95	3.33E-6
15	SGTC_1624	st003710	4.41	6.2 µM	1.22E-4	calcium & mitochondrial duress	30	5.26E-6
16	SGTC_63	0099-0242	4.24	26.7 µM	2.10E-4	mitochondrial stress	78	1.14E-5
17	SGTC_1900	st060200	4.23	72.8 µM	2.15E-4		17	1.18E-5
18	SGTC_421	streptovitacin	4.15	30.0 mM	2.72E-4		19	1.66E-5
19	SGTC_2540	epiandrosterone	4.08	100.0 µM	3.34E-4		54	2.22E-5
20	SGTC_1722	st034304	4.08	3.6 µM	3.40E-4	mitochondrial processes	21	2.28E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.520	4.82E-232	YPL040C	ISM1	hom	Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
0.518	2.19E-229	YDR194C	MSS116	hom	DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing
0.514	8.89E-226	YNL177C	MRPL22	hom	Mitochondrial ribosomal protein of the large subunit
0.512	8.01E-224	YNL081C	SWS2	hom	Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency
0.499	7.68E-211	YLR069C	MEF1	hom	Mitochondrial elongation factor involved in translational elongation
0.495	8.92E-207	YDR298C	ATP5	hom	Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated
0.495	1.17E-205	YMR287C	DSS1	hom	3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.494	2.13E-206	YMR228W	MTF1	hom	Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.491	7.01E-203	YPL183W-A	RTC6	hom	Protein involved in translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein; protein abundance increases in response to DNA replication stress
0.490	2.16E-202	YML061C	PIF1	hom	DNA helicase; exists in a nuclear form that acts as a catalytic inhibitor of telomerase; and as a mitochondrial form involved in repair and recombination of mitochondrial DNA; mutations affect zinc and iron homeostasis; regulated by Rad53p-dependent phosphorylation in rho0 cells
0.489	2.60E-201	YLR149C	YLR149C	hom	Protein of unknown function; overexpression causes a cell cycle delay or arrest; null mutation results in a decrease in plasma membrane electron transport; YLR149C is not an essential gene; protein abundance increases in response to DNA replication stress
0.487	1.96E-199	YGR215W	RSM27	hom	Mitochondrial ribosomal protein of the small subunit
0.481	1.09E-193	YGR165W	MRPS35	hom	Mitochondrial ribosomal protein of the small subunit; null mutant does not grow on glycerol, is sensitive to 2,4-dichlorophenol, and accumulates large lipid droplets
0.475	9.29E-189	YDR462W	MRPL28	hom	Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.475	4.80E-187	YDR322W	MRPL35	hom	Mitochondrial ribosomal protein of the large subunit