Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YER050C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.520 | 4.82E-232 | YPL040C | ISM1 | hom | Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth |
0.518 | 2.19E-229 | YDR194C | MSS116 | hom | DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing |
0.514 | 8.89E-226 | YNL177C | MRPL22 | hom | Mitochondrial ribosomal protein of the large subunit |
0.512 | 8.01E-224 | YNL081C | SWS2 | hom | Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency |
0.499 | 7.68E-211 | YLR069C | MEF1 | hom | Mitochondrial elongation factor involved in translational elongation |
0.495 | 8.92E-207 | YDR298C | ATP5 | hom | Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated |
0.495 | 1.17E-205 | YMR287C | DSS1 | hom | 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs |
0.494 | 2.13E-206 | YMR228W | MTF1 | hom | Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation |
0.491 | 7.01E-203 | YPL183W-A | RTC6 | hom | Protein involved in translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein; protein abundance increases in response to DNA replication stress |
0.490 | 2.16E-202 | YML061C | PIF1 | hom | DNA helicase; exists in a nuclear form that acts as a catalytic inhibitor of telomerase; and as a mitochondrial form involved in repair and recombination of mitochondrial DNA; mutations affect zinc and iron homeostasis; regulated by Rad53p-dependent phosphorylation in rho0 cells |
0.489 | 2.60E-201 | YLR149C | YLR149C | hom | Protein of unknown function; overexpression causes a cell cycle delay or arrest; null mutation results in a decrease in plasma membrane electron transport; YLR149C is not an essential gene; protein abundance increases in response to DNA replication stress |
0.487 | 1.96E-199 | YGR215W | RSM27 | hom | Mitochondrial ribosomal protein of the small subunit |
0.481 | 1.09E-193 | YGR165W | MRPS35 | hom | Mitochondrial ribosomal protein of the small subunit; null mutant does not grow on glycerol, is sensitive to 2,4-dichlorophenol, and accumulates large lipid droplets |
0.475 | 9.29E-189 | YDR462W | MRPL28 | hom | Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress |
0.475 | 4.80E-187 | YDR322W | MRPL35 | hom | Mitochondrial ribosomal protein of the large subunit |