YER053C / PIC2

Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Mir1p but less abundant than Mir1p under normal conditions; expression is induced at high temperature

Zygosity: Homozygous strain
fixedexpanded
Profile for YER053C / PIC2

Click on Significant Values for Screen Details ID:SGTC_73|Compound:0327-0325|FD-Score:3.67|P-value:7.08E-6 ID:SGTC_159|Compound:3970-0959|FD-Score:2.89|P-value:3.09E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.08|P-value:1.32E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:3.21|P-value:7.12E-5 ID:SGTC_517|Compound:1365-0151|FD-Score:3.21|P-value:7.19E-5 ID:SGTC_613|Compound:3914-0030|FD-Score:-3.69|P-value:7.82E-6 ID:SGTC_614|Compound:0462-0418|FD-Score:-2.74|P-value:6.75E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:-3.59|P-value:1.34E-5 ID:SGTC_750|Compound:4073-0104|FD-Score:-4.26|P-value:2.92E-7 ID:SGTC_988|Compound:1497-1057|FD-Score:2.67|P-value:7.53E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:2.89|P-value:3.07E-4 ID:SGTC_1146|Compound:3579-1023|FD-Score:3.35|P-value:3.54E-5 ID:SGTC_1177|Compound:0983-0204|FD-Score:2.85|P-value:3.67E-4 ID:SGTC_1208|Compound:2323-2347|FD-Score:2.61|P-value:9.84E-4 ID:SGTC_1209|Compound:2323-2347|FD-Score:2.95|P-value:2.34E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:-3.56|P-value:1.54E-5 ID:SGTC_1375|Compound:2910-0797|FD-Score:2.67|P-value:7.80E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:-4.20|P-value:4.25E-7 ID:SGTC_1457|Compound:k015-0032|FD-Score:-2.84|P-value:4.53E-4 ID:SGTC_1675|Compound:st018485|FD-Score:2.67|P-value:7.56E-4 ID:SGTC_1739|Compound:st037196|FD-Score:3.15|P-value:9.50E-5 ID:SGTC_1892|Compound:st058411|FD-Score:2.69|P-value:6.93E-4 ID:SGTC_1898|Compound:st060199|FD-Score:-3.01|P-value:2.13E-4 ID:SGTC_1914|Compound:st062367|FD-Score:4.57|P-value:3.15E-8 ID:SGTC_2029|Compound:5175081|FD-Score:2.97|P-value:2.12E-4 ID:SGTC_2049|Compound:5262831|FD-Score:2.81|P-value:4.23E-4 ID:SGTC_2255|Compound:7941087|FD-Score:2.74|P-value:5.79E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.44|P-value:2.83E-5 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-3.22|P-value:8.43E-5 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-2.69|P-value:8.51E-4 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:3.16|P-value:9.03E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:-2.69|P-value:8.36E-4 ID:SGTC_2623|Compound:humulene|FD-Score:-2.69|P-value:8.27E-4 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:2.92|P-value:2.64E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:2.96|P-value:2.21E-4 ID:SGTC_2787|Compound:5284540|FD-Score:-5.23|P-value:4.29E-10 ID:SGTC_2791|Compound:5663188|FD-Score:3.37|P-value:3.22E-5 ID:SGTC_2834|Compound:9001755|FD-Score:-2.98|P-value:2.42E-4 ID:SGTC_2851|Compound:9015922|FD-Score:3.68|P-value:6.45E-6 ID:SGTC_2923|Compound:7992654|FD-Score:3.69|P-value:6.21E-6 ID:SGTC_2962|Compound:9082311|FD-Score:3.92|P-value:1.75E-6 ID:SGTC_2964|Compound:9083345|FD-Score:-3.33|P-value:4.82E-5 ID:SGTC_2996|Compound:9066192|FD-Score:4.60|P-value:2.58E-8 ID:SGTC_2998|Compound:9066762|FD-Score:2.67|P-value:7.51E-4 ID:SGTC_3087|Compound:9117406|FD-Score:2.90|P-value:2.88E-4 ID:SGTC_3137|Compound:9097352|FD-Score:3.01|P-value:1.81E-4 ID:SGTC_3225|Compound:9130819|FD-Score:2.67|P-value:7.78E-4 ID:SGTC_3228|Compound:9131799|FD-Score:3.14|P-value:1.01E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:3.67|P-value:7.08E-6 ID:SGTC_159|Compound:3970-0959|FD-Score:2.89|P-value:3.09E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.08|P-value:1.32E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:3.21|P-value:7.12E-5 ID:SGTC_517|Compound:1365-0151|FD-Score:3.21|P-value:7.19E-5 ID:SGTC_613|Compound:3914-0030|FD-Score:-3.69|P-value:7.82E-6 ID:SGTC_614|Compound:0462-0418|FD-Score:-2.74|P-value:6.75E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:-3.59|P-value:1.34E-5 ID:SGTC_750|Compound:4073-0104|FD-Score:-4.26|P-value:2.92E-7 ID:SGTC_988|Compound:1497-1057|FD-Score:2.67|P-value:7.53E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:2.89|P-value:3.07E-4 ID:SGTC_1146|Compound:3579-1023|FD-Score:3.35|P-value:3.54E-5 ID:SGTC_1177|Compound:0983-0204|FD-Score:2.85|P-value:3.67E-4 ID:SGTC_1208|Compound:2323-2347|FD-Score:2.61|P-value:9.84E-4 ID:SGTC_1209|Compound:2323-2347|FD-Score:2.95|P-value:2.34E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:-3.56|P-value:1.54E-5 ID:SGTC_1375|Compound:2910-0797|FD-Score:2.67|P-value:7.80E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:-4.20|P-value:4.25E-7 ID:SGTC_1457|Compound:k015-0032|FD-Score:-2.84|P-value:4.53E-4 ID:SGTC_1675|Compound:st018485|FD-Score:2.67|P-value:7.56E-4 ID:SGTC_1739|Compound:st037196|FD-Score:3.15|P-value:9.50E-5 ID:SGTC_1892|Compound:st058411|FD-Score:2.69|P-value:6.93E-4 ID:SGTC_1898|Compound:st060199|FD-Score:-3.01|P-value:2.13E-4 ID:SGTC_1914|Compound:st062367|FD-Score:4.57|P-value:3.15E-8 ID:SGTC_2029|Compound:5175081|FD-Score:2.97|P-value:2.12E-4 ID:SGTC_2049|Compound:5262831|FD-Score:2.81|P-value:4.23E-4 ID:SGTC_2255|Compound:7941087|FD-Score:2.74|P-value:5.79E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.44|P-value:2.83E-5 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-3.22|P-value:8.43E-5 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-2.69|P-value:8.51E-4 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:3.16|P-value:9.03E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:-2.69|P-value:8.36E-4 ID:SGTC_2623|Compound:humulene|FD-Score:-2.69|P-value:8.27E-4 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:2.92|P-value:2.64E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:2.96|P-value:2.21E-4 ID:SGTC_2787|Compound:5284540|FD-Score:-5.23|P-value:4.29E-10 ID:SGTC_2791|Compound:5663188|FD-Score:3.37|P-value:3.22E-5 ID:SGTC_2834|Compound:9001755|FD-Score:-2.98|P-value:2.42E-4 ID:SGTC_2851|Compound:9015922|FD-Score:3.68|P-value:6.45E-6 ID:SGTC_2923|Compound:7992654|FD-Score:3.69|P-value:6.21E-6 ID:SGTC_2962|Compound:9082311|FD-Score:3.92|P-value:1.75E-6 ID:SGTC_2964|Compound:9083345|FD-Score:-3.33|P-value:4.82E-5 ID:SGTC_2996|Compound:9066192|FD-Score:4.60|P-value:2.58E-8 ID:SGTC_2998|Compound:9066762|FD-Score:2.67|P-value:7.51E-4 ID:SGTC_3087|Compound:9117406|FD-Score:2.90|P-value:2.88E-4 ID:SGTC_3137|Compound:9097352|FD-Score:3.01|P-value:1.81E-4 ID:SGTC_3225|Compound:9130819|FD-Score:2.67|P-value:7.78E-4 ID:SGTC_3228|Compound:9131799|FD-Score:3.14|P-value:1.01E-4

Top fitness defect scores for YER053C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2996 9066192 4.60 71.4 µM 2.58E-8 16 2.08E-6
2 SGTC_1914 st062367 4.57 72.6 µM 3.15E-8 14 2.40E-6
3 SGTC_2962 9082311 3.92 13.2 µM 1.75E-6 23 4.47E-5
4 SGTC_2923 7992654 3.69 58.1 µM 6.21E-6 Golgi 35 1.12E-4
5 SGTC_2851 9015922 3.68 71.4 µM 6.45E-6 52 1.15E-4
6 SGTC_73 0327-0325 3.67 16.2 µM 7.08E-6 DNA damage response 60 1.23E-4
7 SGTC_2791 5663188 3.37 71.4 µM 3.22E-5 RPP1 & pyrimidine depletion 42 3.73E-4
8 SGTC_1146 3579-1023 3.35 7.0 µM 3.54E-5 35 3.99E-4
9 SGTC_515 4092-1064 3.21 102.0 µM 7.12E-5 plasma membrane duress 88 6.65E-4
10 SGTC_517 1365-0151 3.21 113.0 µM 7.19E-5 55 6.71E-4
11 SGTC_2546 rhodinyl acetate 3.16 100.0 µM 9.03E-5 34 7.92E-4
12 SGTC_1739 st037196 3.15 92.5 µM 9.50E-5 56 8.22E-4
13 SGTC_3228 9131799 3.14 49.5 µM 1.01E-4 amide catabolism 26 8.59E-4
14 SGTC_453 enantio-paf c16 3.08 10.0 µM 1.32E-4 236 0.00104
15 SGTC_3137 9097352 3.01 49.5 µM 1.81E-4 90 0.00132
16 SGTC_2029 5175081 2.97 200.0 µM 2.12E-4 67 0.00148
17 SGTC_2757 clomiphene 2.96 4.2 µM 2.21E-4 fatty acid desaturase (OLE1) 99 0.00153
18 SGTC_1209 2323-2347 2.95 50.3 µM 2.34E-4 43 0.00159
19 SGTC_2660 2',4'-dihydroxychalcone 2.92 17.1 µM 2.64E-4 59 0.00174
20 SGTC_3087 9117406 2.90 49.5 µM 2.88E-4 59 0.00185

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.206 1.28E-33 YLR205C HMX1 hom ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
0.203 2.36E-32 YLL046C RNP1 hom Ribonucleoprotein that contains two RNA recognition motifs (RRM)
0.190 1.67E-28 YER060W-A FCY22 hom Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function
0.165 6.62E-22 YMR111C YMR111C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR111C is not an essential gene; forms nuclear foci upon DNA replication stress
0.155 1.37E-19 YGL081W_p YGL081W_p hom Putative protein of unknown function; non-essential gene; interacts genetically with CHS5, a gene involved in chitin biosynthesis
0.155 1.75E-19 YLR016C PML1 hom Subunit of the RES complex, which is required for nuclear retention of unspliced pre-mRNAs; acts in the same pathway as Pml39p and Mlp1p
0.147 1.01E-17 YOR010C TIR2 hom Putative cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; transcription is induced by cold shock and anaerobiosis
0.146 2.12E-17 YML083C YML083C hom Protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions
0.145 3.05E-17 YOL141W PPM2 hom AdoMet-dependent tRNA methyltransferase also involved in methoxycarbonylation; required for the synthesis of wybutosine (yW), a modified guanosine found at the 3'-position adjacent to the anticodon of phe-tRNA; similarity to Ppm1p
0.141 2.01E-16 YER071C_p TDA2_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; null mutant is sensitive to expression of the top1-T722A allele
0.141 2.70E-16 YDR534C FIT1 hom Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
0.133 9.36E-15 YGL243W TAD1 hom tRNA-specific adenosine deaminase, deaminates adenosine-37 to inosine in tRNA-Ala
0.129 5.54E-14 YDL224C WHI4 hom Putative RNA binding protein; regulates the cell size requirement for passage through Start and commitment to cell division; WHI4 has a paralog, WHI3, that arose from the whole genome duplication
0.128 1.24E-13 YMR023C MSS1 hom Mitochondrial protein, forms a heterodimer complex with Mto1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; similar to human GTPBP3
0.114 3.88E-11 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS