HIPHOP chemogenomics database

YER058W / PET117

Protein required for assembly of cytochrome c oxidase

Zygosity: Homozygous strain

fixedexpanded
Profile for YER058W / PET117

Click on Significant Values for Screen Details

Top fitness defect scores for YER058W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_236	1509-0011	24.60	5.3 µM	1.82E-161		33	1.79E-133
2	SGTC_1635	st007035	16.60	42.4 µM	8.47E-75		29	4.05E-62
3	SGTC_386	1509-0011	15.00	3.1 µM	9.89E-62		20	2.37E-51
4	SGTC_134	0269-0018	13.30	6.9 µM	1.27E-48		25	1.52E-40
5	SGTC_543	3844-1095	5.79	191.0 µM	1.16E-10	ERG2	19	3.59E-9
6	SGTC_168	3970-0862	5.63	530.5 µM	3.47E-10		54	8.92E-9
7	SGTC_2054	5233173	5.03	129.0 µM	1.86E-8	mitochondrial response to ROS	25	2.45E-7
8	SGTC_933	2914-0560	4.83	114.0 µM	6.29E-8		16	6.77E-7
9	SGTC_563	tetrahydrosecaminediol	4.71	614.0 µM	1.33E-7	amide catabolism	8	1.27E-6
10	SGTC_1912	st060209	4.69	90.8 µM	1.48E-7		21	1.38E-6
11	SGTC_819	1013-0258	4.42	27.7 µM	6.67E-7		26	4.85E-6
12	SGTC_1792	st045773	4.24	43.6 µM	1.83E-6		20	1.13E-5
13	SGTC_915	methyl methanesulfonate (MMS)	4.14	110.0 mM	3.06E-6	DNA damage response	35	1.73E-5
14	SGTC_87	0100-0052	3.92	35.5 µM	9.31E-6		107	4.39E-5
15	SGTC_345	1362-0200	3.87	395.0 µM	1.18E-5		20	5.34E-5
16	SGTC_782	0083-0095	3.79	30.5 µM	1.74E-5		33	7.41E-5
17	SGTC_277	nystatin	3.78	15.5 µM	1.89E-5		17	7.96E-5
18	SGTC_761	k216-0224	3.72	480.0 µM	2.47E-5		24	9.96E-5
19	SGTC_34	0469-0683	3.61	81.8 µM	4.22E-5	SWF1 & branched chain AA biosynthesis	36	1.56E-4
20	SGTC_2791	5663188	3.56	71.4 µM	5.16E-5	RPP1 & pyrimidine depletion	35	1.85E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	ORF	Gene	Zygosity	Description
0.718	YJL166W	QCR8	hom	Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.714	YDR230W_d	YDR230W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.697	YPL132W	COX11	hom	Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
0.676	YNR045W	PET494	hom	Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane
0.674	YJL062W-A	COA3	hom	Mitochondrial inner membrane protein that participates in regulation of COX1 translation, Cox1p stabilization, and cytochrome oxidase assembly
0.673	YPL013C	MRPS16	hom	Mitochondrial ribosomal protein of the small subunit
0.667	YPL215W	CBP3	hom	Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.661	YEL059C-A	SOM1	hom	Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.653	YMR035W	IMP2	hom	Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.651	YDR231C	COX20	hom	Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase
0.651	YMR151W_d	YIM2_d	hom	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.649	YHR116W	COX23	hom	Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs
0.648	YJL209W	CBP1	hom	Mitochondrial protein, regulator of COB mRNA stability and translation; interacts with the 5'-untranslated region of the COB mRNA; found in a complex at the inner membrane along with Pet309p; localizes to mitochondrial foci upon DNA replication stress
0.645	YJL022W_d	YJL022W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130
0.644	YDR375C	BCS1	hom	Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases