YER058W / PET117

Protein required for assembly of cytochrome c oxidase

Zygosity: Homozygous strain
fixedexpanded
Profile for YER058W / PET117

Click on Significant Values for Screen Details ID:SGTC_34|Compound:0469-0683|FD-Score:3.61|P-value:4.22E-5 ID:SGTC_87|Compound:0100-0052|FD-Score:3.92|P-value:9.31E-6 ID:SGTC_127|Compound:0180-0333|FD-Score:3.53|P-value:5.83E-5 ID:SGTC_134|Compound:0269-0018|FD-Score:13.30|P-value:1.27E-48 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.01|P-value:3.79E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:5.63|P-value:3.47E-10 ID:SGTC_214|Compound:4373-3496|FD-Score:3.23|P-value:2.17E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:24.60|P-value:1.82E-161 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:-4.09|P-value:2.59E-6 ID:SGTC_266|Compound:formosanin C|FD-Score:3.16|P-value:2.90E-4 ID:SGTC_277|Compound:nystatin|FD-Score:3.78|P-value:1.89E-5 ID:SGTC_341|Compound:1486-1430|FD-Score:2.98|P-value:5.92E-4 ID:SGTC_345|Compound:1362-0200|FD-Score:3.87|P-value:1.18E-5 ID:SGTC_386|Compound:1509-0011|FD-Score:15.00|P-value:9.89E-62 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:3.24|P-value:2.05E-4 ID:SGTC_511|Compound:blebbistatin|FD-Score:-3.30|P-value:1.15E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:-3.24|P-value:1.43E-4 ID:SGTC_519|Compound:k048-0011|FD-Score:3.06|P-value:4.33E-4 ID:SGTC_543|Compound:3844-1095|FD-Score:5.79|P-value:1.16E-10 ID:SGTC_548|Compound:1436-0017|FD-Score:-3.73|P-value:1.57E-5 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:4.71|P-value:1.33E-7 ID:SGTC_704|Compound:1310-0270|FD-Score:3.54|P-value:5.75E-5 ID:SGTC_723|Compound:4182-0001|FD-Score:-3.41|P-value:6.84E-5 ID:SGTC_761|Compound:k216-0224|FD-Score:3.72|P-value:2.47E-5 ID:SGTC_771|Compound:0250-0039|FD-Score:-3.80|P-value:1.09E-5 ID:SGTC_782|Compound:0083-0095|FD-Score:3.79|P-value:1.74E-5 ID:SGTC_819|Compound:1013-0258|FD-Score:4.42|P-value:6.67E-7 ID:SGTC_832|Compound:4083-0019|FD-Score:2.95|P-value:6.64E-4 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:4.14|P-value:3.06E-6 ID:SGTC_933|Compound:2914-0560|FD-Score:4.83|P-value:6.29E-8 ID:SGTC_1011|Compound:4112-3381|FD-Score:3.27|P-value:1.84E-4 ID:SGTC_1022|Compound:4477-0945|FD-Score:3.27|P-value:1.81E-4 ID:SGTC_1043|Compound:0916-0009|FD-Score:3.04|P-value:4.72E-4 ID:SGTC_1072|Compound:oxiconazole|FD-Score:3.07|P-value:4.10E-4 ID:SGTC_1173|Compound:0443-0020|FD-Score:2.98|P-value:5.90E-4 ID:SGTC_1289|Compound:0976-0073|FD-Score:-2.95|P-value:4.73E-4 ID:SGTC_1372|Compound:2752-0194|FD-Score:3.10|P-value:3.71E-4 ID:SGTC_1375|Compound:2910-0797|FD-Score:3.16|P-value:2.92E-4 ID:SGTC_1382|Compound:3002-2117|FD-Score:-3.07|P-value:2.96E-4 ID:SGTC_1475|Compound:4092-1048|FD-Score:3.40|P-value:1.04E-4 ID:SGTC_1635|Compound:st007035|FD-Score:16.60|P-value:8.47E-75 ID:SGTC_1695|Compound:st026914|FD-Score:3.33|P-value:1.45E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-2.88|P-value:6.21E-4 ID:SGTC_1792|Compound:st045773|FD-Score:4.24|P-value:1.83E-6 ID:SGTC_1848|Compound:st056003|FD-Score:3.09|P-value:3.89E-4 ID:SGTC_1878|Compound:temozolomide|FD-Score:3.21|P-value:2.39E-4 ID:SGTC_1912|Compound:st060209|FD-Score:4.69|P-value:1.48E-7 ID:SGTC_1932|Compound:st074806|FD-Score:3.16|P-value:2.85E-4 ID:SGTC_2051|Compound:5263410|FD-Score:-4.70|P-value:8.11E-8 ID:SGTC_2054|Compound:5233173|FD-Score:5.03|P-value:1.86E-8 ID:SGTC_2075|Compound:5212009|FD-Score:3.32|P-value:1.52E-4 ID:SGTC_2301|Compound:7769476|FD-Score:2.98|P-value:5.92E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:2.91|P-value:7.84E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-3.99|P-value:4.41E-6 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:-3.23|P-value:1.55E-4 ID:SGTC_2444|Compound:5485484|FD-Score:3.27|P-value:1.84E-4 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:-3.32|P-value:1.05E-4 ID:SGTC_2528|Compound:xanthyletin|FD-Score:-2.82|P-value:7.99E-4 ID:SGTC_2784|Compound:7567673|FD-Score:-3.35|P-value:8.98E-5 ID:SGTC_2786|Compound:7743617|FD-Score:-3.47|P-value:5.29E-5 ID:SGTC_2791|Compound:5663188|FD-Score:3.56|P-value:5.16E-5 ID:SGTC_2854|Compound:9024559|FD-Score:-3.37|P-value:8.33E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-3.11|P-value:2.50E-4 ID:SGTC_2897|Compound:9048598|FD-Score:-2.81|P-value:8.19E-4 ID:SGTC_3116|Compound:9124943|FD-Score:3.53|P-value:5.83E-5 ID:SGTC_3192|Compound:9110362|FD-Score:-3.25|P-value:1.37E-4 ID:SGTC_3324|Compound:9138759|FD-Score:3.34|P-value:1.39E-4 ID:SGTC_3327|Compound:9140648|FD-Score:3.37|P-value:1.19E-4 ID:SGTC_34|Compound:0469-0683|FD-Score:3.61|P-value:4.22E-5 ID:SGTC_87|Compound:0100-0052|FD-Score:3.92|P-value:9.31E-6 ID:SGTC_127|Compound:0180-0333|FD-Score:3.53|P-value:5.83E-5 ID:SGTC_134|Compound:0269-0018|FD-Score:13.30|P-value:1.27E-48 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.01|P-value:3.79E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:5.63|P-value:3.47E-10 ID:SGTC_214|Compound:4373-3496|FD-Score:3.23|P-value:2.17E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:24.60|P-value:1.82E-161 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:-4.09|P-value:2.59E-6 ID:SGTC_266|Compound:formosanin C|FD-Score:3.16|P-value:2.90E-4 ID:SGTC_277|Compound:nystatin|FD-Score:3.78|P-value:1.89E-5 ID:SGTC_341|Compound:1486-1430|FD-Score:2.98|P-value:5.92E-4 ID:SGTC_345|Compound:1362-0200|FD-Score:3.87|P-value:1.18E-5 ID:SGTC_386|Compound:1509-0011|FD-Score:15.00|P-value:9.89E-62 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:3.24|P-value:2.05E-4 ID:SGTC_511|Compound:blebbistatin|FD-Score:-3.30|P-value:1.15E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:-3.24|P-value:1.43E-4 ID:SGTC_519|Compound:k048-0011|FD-Score:3.06|P-value:4.33E-4 ID:SGTC_543|Compound:3844-1095|FD-Score:5.79|P-value:1.16E-10 ID:SGTC_548|Compound:1436-0017|FD-Score:-3.73|P-value:1.57E-5 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:4.71|P-value:1.33E-7 ID:SGTC_704|Compound:1310-0270|FD-Score:3.54|P-value:5.75E-5 ID:SGTC_723|Compound:4182-0001|FD-Score:-3.41|P-value:6.84E-5 ID:SGTC_761|Compound:k216-0224|FD-Score:3.72|P-value:2.47E-5 ID:SGTC_771|Compound:0250-0039|FD-Score:-3.80|P-value:1.09E-5 ID:SGTC_782|Compound:0083-0095|FD-Score:3.79|P-value:1.74E-5 ID:SGTC_819|Compound:1013-0258|FD-Score:4.42|P-value:6.67E-7 ID:SGTC_832|Compound:4083-0019|FD-Score:2.95|P-value:6.64E-4 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:4.14|P-value:3.06E-6 ID:SGTC_933|Compound:2914-0560|FD-Score:4.83|P-value:6.29E-8 ID:SGTC_1011|Compound:4112-3381|FD-Score:3.27|P-value:1.84E-4 ID:SGTC_1022|Compound:4477-0945|FD-Score:3.27|P-value:1.81E-4 ID:SGTC_1043|Compound:0916-0009|FD-Score:3.04|P-value:4.72E-4 ID:SGTC_1072|Compound:oxiconazole|FD-Score:3.07|P-value:4.10E-4 ID:SGTC_1173|Compound:0443-0020|FD-Score:2.98|P-value:5.90E-4 ID:SGTC_1289|Compound:0976-0073|FD-Score:-2.95|P-value:4.73E-4 ID:SGTC_1372|Compound:2752-0194|FD-Score:3.10|P-value:3.71E-4 ID:SGTC_1375|Compound:2910-0797|FD-Score:3.16|P-value:2.92E-4 ID:SGTC_1382|Compound:3002-2117|FD-Score:-3.07|P-value:2.96E-4 ID:SGTC_1475|Compound:4092-1048|FD-Score:3.40|P-value:1.04E-4 ID:SGTC_1635|Compound:st007035|FD-Score:16.60|P-value:8.47E-75 ID:SGTC_1695|Compound:st026914|FD-Score:3.33|P-value:1.45E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-2.88|P-value:6.21E-4 ID:SGTC_1792|Compound:st045773|FD-Score:4.24|P-value:1.83E-6 ID:SGTC_1848|Compound:st056003|FD-Score:3.09|P-value:3.89E-4 ID:SGTC_1878|Compound:temozolomide|FD-Score:3.21|P-value:2.39E-4 ID:SGTC_1912|Compound:st060209|FD-Score:4.69|P-value:1.48E-7 ID:SGTC_1932|Compound:st074806|FD-Score:3.16|P-value:2.85E-4 ID:SGTC_2051|Compound:5263410|FD-Score:-4.70|P-value:8.11E-8 ID:SGTC_2054|Compound:5233173|FD-Score:5.03|P-value:1.86E-8 ID:SGTC_2075|Compound:5212009|FD-Score:3.32|P-value:1.52E-4 ID:SGTC_2301|Compound:7769476|FD-Score:2.98|P-value:5.92E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:2.91|P-value:7.84E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-3.99|P-value:4.41E-6 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:-3.23|P-value:1.55E-4 ID:SGTC_2444|Compound:5485484|FD-Score:3.27|P-value:1.84E-4 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:-3.32|P-value:1.05E-4 ID:SGTC_2528|Compound:xanthyletin|FD-Score:-2.82|P-value:7.99E-4 ID:SGTC_2784|Compound:7567673|FD-Score:-3.35|P-value:8.98E-5 ID:SGTC_2786|Compound:7743617|FD-Score:-3.47|P-value:5.29E-5 ID:SGTC_2791|Compound:5663188|FD-Score:3.56|P-value:5.16E-5 ID:SGTC_2854|Compound:9024559|FD-Score:-3.37|P-value:8.33E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-3.11|P-value:2.50E-4 ID:SGTC_2897|Compound:9048598|FD-Score:-2.81|P-value:8.19E-4 ID:SGTC_3116|Compound:9124943|FD-Score:3.53|P-value:5.83E-5 ID:SGTC_3192|Compound:9110362|FD-Score:-3.25|P-value:1.37E-4 ID:SGTC_3324|Compound:9138759|FD-Score:3.34|P-value:1.39E-4 ID:SGTC_3327|Compound:9140648|FD-Score:3.37|P-value:1.19E-4

Top fitness defect scores for YER058W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 24.60 5.3 µM 1.82E-161 33 1.79E-133
2 SGTC_1635 st007035 16.60 42.4 µM 8.47E-75 29 4.05E-62
3 SGTC_386 1509-0011 15.00 3.1 µM 9.89E-62 20 2.37E-51
4 SGTC_134 0269-0018 13.30 6.9 µM 1.27E-48 25 1.52E-40
5 SGTC_543 3844-1095 5.79 191.0 µM 1.16E-10 ERG2 19 3.59E-9
6 SGTC_168 3970-0862 5.63 530.5 µM 3.47E-10 54 8.92E-9
7 SGTC_2054 5233173 5.03 129.0 µM 1.86E-8 mitochondrial response to ROS 25 2.45E-7
8 SGTC_933 2914-0560 4.83 114.0 µM 6.29E-8 16 6.77E-7
9 SGTC_563 tetrahydrosecaminediol 4.71 614.0 µM 1.33E-7 amide catabolism 8 1.27E-6
10 SGTC_1912 st060209 4.69 90.8 µM 1.48E-7 21 1.38E-6
11 SGTC_819 1013-0258 4.42 27.7 µM 6.67E-7 26 4.85E-6
12 SGTC_1792 st045773 4.24 43.6 µM 1.83E-6 20 1.13E-5
13 SGTC_915 methyl methanesulfonate (MMS) 4.14 110.0 mM 3.06E-6 DNA damage response 35 1.73E-5
14 SGTC_87 0100-0052 3.92 35.5 µM 9.31E-6 107 4.39E-5
15 SGTC_345 1362-0200 3.87 395.0 µM 1.18E-5 20 5.34E-5
16 SGTC_782 0083-0095 3.79 30.5 µM 1.74E-5 33 7.41E-5
17 SGTC_277 nystatin 3.78 15.5 µM 1.89E-5 17 7.96E-5
18 SGTC_761 k216-0224 3.72 480.0 µM 2.47E-5 24 9.96E-5
19 SGTC_34 0469-0683 3.61 81.8 µM 4.22E-5 SWF1 & branched chain AA biosynthesis 36 1.56E-4
20 SGTC_2791 5663188 3.56 71.4 µM 5.16E-5 RPP1 & pyrimidine depletion 35 1.85E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.718 0 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.714 0 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.697 0 YPL132W COX11 hom Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
0.676 0 YNR045W PET494 hom Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane
0.674 0 YJL062W-A COA3 hom Mitochondrial inner membrane protein that participates in regulation of COX1 translation, Cox1p stabilization, and cytochrome oxidase assembly
0.673 0 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.667 0 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.661 0 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.653 0 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.651 0 YDR231C COX20 hom Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase
0.651 0 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.649 0 YHR116W COX23 hom Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs
0.648 0 YJL209W CBP1 hom Mitochondrial protein, regulator of COB mRNA stability and translation; interacts with the 5'-untranslated region of the COB mRNA; found in a complex at the inner membrane along with Pet309p; localizes to mitochondrial foci upon DNA replication stress
0.645 0 YJL022W_d YJL022W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130
0.644 0 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases