YER072W / VTC1

Subunit of the vacuolar transporter chaperone (VTC) complex; VTC complex is involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion; also has mRNA binding activity; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YER072W / VTC1

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:5.30|P-value:1.57E-8 ID:SGTC_58|Compound:0957-0393|FD-Score:4.21|P-value:5.64E-6 ID:SGTC_161|Compound:4065-0411|FD-Score:3.87|P-value:2.74E-5 ID:SGTC_175|Compound:3793-3120|FD-Score:-3.46|P-value:1.27E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:-2.93|P-value:9.57E-4 ID:SGTC_180|Compound:1486-1293|FD-Score:3.14|P-value:5.34E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:5.29|P-value:1.65E-8 ID:SGTC_309|Compound:k408-0051|FD-Score:-4.91|P-value:1.06E-7 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:3.24|P-value:3.69E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:5.03|P-value:7.50E-8 ID:SGTC_749|Compound:1000-0129|FD-Score:3.09|P-value:6.43E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:7.53|P-value:1.66E-15 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:5.41|P-value:8.08E-9 ID:SGTC_1232|Compound:0279-0259|FD-Score:-3.19|P-value:3.71E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:5.14|P-value:4.13E-8 ID:SGTC_1316|Compound:1272-0050|FD-Score:3.05|P-value:7.66E-4 ID:SGTC_1489|Compound:4065-0444|FD-Score:3.04|P-value:7.93E-4 ID:SGTC_1499|Compound:4480-0877|FD-Score:3.18|P-value:4.60E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:-3.50|P-value:1.07E-4 ID:SGTC_1604|Compound:st002052|FD-Score:-2.93|P-value:9.67E-4 ID:SGTC_1687|Compound:st020778|FD-Score:3.33|P-value:2.63E-4 ID:SGTC_1717|Compound:st033143|FD-Score:5.44|P-value:6.87E-9 ID:SGTC_1722|Compound:st034304|FD-Score:3.19|P-value:4.54E-4 ID:SGTC_1725|Compound:st036284|FD-Score:4.69|P-value:4.84E-7 ID:SGTC_1742|Compound:st038235|FD-Score:3.20|P-value:4.33E-4 ID:SGTC_1909|Compound:st060837|FD-Score:-3.03|P-value:6.72E-4 ID:SGTC_1917|Compound:st066507|FD-Score:3.61|P-value:8.65E-5 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.55|P-value:1.08E-4 ID:SGTC_1934|Compound:st074720|FD-Score:3.83|P-value:3.29E-5 ID:SGTC_2122|Compound:5258151|FD-Score:3.06|P-value:7.38E-4 ID:SGTC_2309|Compound:7664088|FD-Score:3.55|P-value:1.07E-4 ID:SGTC_2372|Compound:9071633|FD-Score:3.19|P-value:4.54E-4 ID:SGTC_2386|Compound:9075165|FD-Score:3.62|P-value:8.20E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:-4.11|P-value:7.00E-6 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:-3.44|P-value:1.36E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:7.22|P-value:2.13E-14 ID:SGTC_2584|Compound:androsterone|FD-Score:3.37|P-value:2.22E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:3.16|P-value:5.00E-4 ID:SGTC_2694|Compound:st077685|FD-Score:-2.98|P-value:8.06E-4 ID:SGTC_2701|Compound:st077767|FD-Score:-4.06|P-value:8.85E-6 ID:SGTC_2717|Compound:st081029|FD-Score:4.87|P-value:1.88E-7 ID:SGTC_2727|Compound:riluzole|FD-Score:-3.60|P-value:7.10E-5 ID:SGTC_2732|Compound:terfenadine|FD-Score:-3.28|P-value:2.61E-4 ID:SGTC_2740|Compound:felodipine|FD-Score:2.99|P-value:9.40E-4 ID:SGTC_2742|Compound:clothiapine|FD-Score:3.05|P-value:7.55E-4 ID:SGTC_2853|Compound:9015042|FD-Score:-4.35|P-value:2.12E-6 ID:SGTC_2855|Compound:9016525|FD-Score:-3.25|P-value:2.86E-4 ID:SGTC_3167|Compound:9103034|FD-Score:-3.33|P-value:2.08E-4 ID:SGTC_3170|Compound:9103054|FD-Score:-2.94|P-value:9.17E-4 ID:SGTC_3311|Compound:9131146|FD-Score:4.70|P-value:4.57E-7 ID:SGTC_3342|Compound:9147791|FD-Score:3.64|P-value:7.63E-5 ID:SGTC_3350|Compound:9150499|FD-Score:3.03|P-value:8.02E-4 ID:SGTC_8|Compound:0354-0001|FD-Score:5.30|P-value:1.57E-8 ID:SGTC_58|Compound:0957-0393|FD-Score:4.21|P-value:5.64E-6 ID:SGTC_161|Compound:4065-0411|FD-Score:3.87|P-value:2.74E-5 ID:SGTC_175|Compound:3793-3120|FD-Score:-3.46|P-value:1.27E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:-2.93|P-value:9.57E-4 ID:SGTC_180|Compound:1486-1293|FD-Score:3.14|P-value:5.34E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:5.29|P-value:1.65E-8 ID:SGTC_309|Compound:k408-0051|FD-Score:-4.91|P-value:1.06E-7 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:3.24|P-value:3.69E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:5.03|P-value:7.50E-8 ID:SGTC_749|Compound:1000-0129|FD-Score:3.09|P-value:6.43E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:7.53|P-value:1.66E-15 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:5.41|P-value:8.08E-9 ID:SGTC_1232|Compound:0279-0259|FD-Score:-3.19|P-value:3.71E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:5.14|P-value:4.13E-8 ID:SGTC_1316|Compound:1272-0050|FD-Score:3.05|P-value:7.66E-4 ID:SGTC_1489|Compound:4065-0444|FD-Score:3.04|P-value:7.93E-4 ID:SGTC_1499|Compound:4480-0877|FD-Score:3.18|P-value:4.60E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:-3.50|P-value:1.07E-4 ID:SGTC_1604|Compound:st002052|FD-Score:-2.93|P-value:9.67E-4 ID:SGTC_1687|Compound:st020778|FD-Score:3.33|P-value:2.63E-4 ID:SGTC_1717|Compound:st033143|FD-Score:5.44|P-value:6.87E-9 ID:SGTC_1722|Compound:st034304|FD-Score:3.19|P-value:4.54E-4 ID:SGTC_1725|Compound:st036284|FD-Score:4.69|P-value:4.84E-7 ID:SGTC_1742|Compound:st038235|FD-Score:3.20|P-value:4.33E-4 ID:SGTC_1909|Compound:st060837|FD-Score:-3.03|P-value:6.72E-4 ID:SGTC_1917|Compound:st066507|FD-Score:3.61|P-value:8.65E-5 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.55|P-value:1.08E-4 ID:SGTC_1934|Compound:st074720|FD-Score:3.83|P-value:3.29E-5 ID:SGTC_2122|Compound:5258151|FD-Score:3.06|P-value:7.38E-4 ID:SGTC_2309|Compound:7664088|FD-Score:3.55|P-value:1.07E-4 ID:SGTC_2372|Compound:9071633|FD-Score:3.19|P-value:4.54E-4 ID:SGTC_2386|Compound:9075165|FD-Score:3.62|P-value:8.20E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:-4.11|P-value:7.00E-6 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:-3.44|P-value:1.36E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:7.22|P-value:2.13E-14 ID:SGTC_2584|Compound:androsterone|FD-Score:3.37|P-value:2.22E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:3.16|P-value:5.00E-4 ID:SGTC_2694|Compound:st077685|FD-Score:-2.98|P-value:8.06E-4 ID:SGTC_2701|Compound:st077767|FD-Score:-4.06|P-value:8.85E-6 ID:SGTC_2717|Compound:st081029|FD-Score:4.87|P-value:1.88E-7 ID:SGTC_2727|Compound:riluzole|FD-Score:-3.60|P-value:7.10E-5 ID:SGTC_2732|Compound:terfenadine|FD-Score:-3.28|P-value:2.61E-4 ID:SGTC_2740|Compound:felodipine|FD-Score:2.99|P-value:9.40E-4 ID:SGTC_2742|Compound:clothiapine|FD-Score:3.05|P-value:7.55E-4 ID:SGTC_2853|Compound:9015042|FD-Score:-4.35|P-value:2.12E-6 ID:SGTC_2855|Compound:9016525|FD-Score:-3.25|P-value:2.86E-4 ID:SGTC_3167|Compound:9103034|FD-Score:-3.33|P-value:2.08E-4 ID:SGTC_3170|Compound:9103054|FD-Score:-2.94|P-value:9.17E-4 ID:SGTC_3311|Compound:9131146|FD-Score:4.70|P-value:4.57E-7 ID:SGTC_3342|Compound:9147791|FD-Score:3.64|P-value:7.63E-5 ID:SGTC_3350|Compound:9150499|FD-Score:3.03|P-value:8.02E-4

Top fitness defect scores for YER072W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_916 4466-0038 7.53 42.0 nM 1.66E-15 cell wall 13 2.49E-14
2 SGTC_2582 agaric acid 7.22 100.0 µM 2.13E-14 redox potentiating 121 2.55E-13
3 SGTC_1717 st033143 5.44 58.0 µM 6.87E-9 19 2.73E-8
4 SGTC_1135 dihydrocapsaicin 5.41 536.7 nM 8.08E-9 9 3.17E-8
5 SGTC_8 0354-0001 5.30 70.0 µM 1.57E-8 35 5.83E-8
6 SGTC_304 1310-0298 5.29 97.0 µM 1.65E-8 cell wall 27 6.10E-8
7 SGTC_1263 0774-1208 5.14 64.8 µM 4.13E-8 21 1.41E-7
8 SGTC_453 enantio-paf c16 5.03 10.0 µM 7.50E-8 86 2.44E-7
9 SGTC_2717 st081029 4.87 62.3 µM 1.88E-7 6 5.66E-7
10 SGTC_3311 9131146 4.70 2.9 µM 4.57E-7 cell wall 91 1.27E-6
11 SGTC_1725 st036284 4.69 20.6 µM 4.84E-7 19 1.34E-6
12 SGTC_58 0957-0393 4.21 9.0 µM 5.64E-6 cell wall 354 1.27E-5
13 SGTC_161 4065-0411 3.87 162.2 µM 2.74E-5 65 5.43E-5
14 SGTC_1934 st074720 3.83 32.6 µM 3.29E-5 62 6.42E-5
15 SGTC_3342 9147791 3.64 14.5 µM 7.63E-5 24 1.39E-4
16 SGTC_2386 9075165 3.62 157.4 µM 8.20E-5 14 1.48E-4
17 SGTC_1917 st066507 3.61 28.5 µM 8.65E-5 Golgi 53 1.56E-4
18 SGTC_2309 7664088 3.55 163.9 µM 1.07E-4 55 1.89E-4
19 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 3.55 70.1 µM 1.08E-4 44 1.91E-4
20 SGTC_2584 androsterone 3.37 48.7 µM 2.22E-4 cell wall 171 3.71E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.305 6.47E-73 YMR124W_p YMR124W_p hom Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization
0.273 1.50E-58 YJR142W_p YJR142W_p hom Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member
0.266 2.25E-55 YEL007W MIT1 hom Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1
0.253 2.42E-50 YML101C-A_d YML101C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.251 2.20E-49 YNL106C INP52 hom Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.248 2.09E-48 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.230 2.00E-41 YML117W NAB6 hom Putative RNA-binding protein that associates with mRNAs encoding cell wall proteins in high-throughput studies; deletion mutants display increased sensitivity to some cell wall disrupting agents; expression negatively regulated by cAMP
0.228 6.74E-41 YGL178W MPT5 hom mRNA-binding protein of the PUF family; binds to the 3' UTR of specific mRNAs, including those involved in mating type switching, cell wall integrity, chronological lifespan, chromatin modification, and spindle pole body architecture; recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity
0.221 3.06E-38 YBR134W_d YBR134W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.220 6.75E-38 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.205 4.26E-33 YJL099W CHS6 hom Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication
0.204 9.72E-33 YLL032C YLL032C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
0.203 1.56E-32 YDR435C PPM1 hom Carboxyl methyltransferase, methylates the C terminus of the protein phosphatase 2A catalytic subunit (Pph21p or Pph22p), which is important for complex formation with regulatory subunits
0.203 2.43E-32 YNL215W IES2 hom Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress
0.202 2.62E-32 YPL115C BEM3 hom Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly