HIPHOP chemogenomics database

YER112W / LSM4

Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; forms cytoplasmic foci upon DNA replication stress

Zygosity: Heterozygous strain

fixedexpanded
Profile for YER112W / LSM4

Click on Significant Values for Screen Details

Top fitness defect scores for YER112W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value	Screen Clearance
1	SGTC_2567	aureobasidin a	10.40	60.0 nM	8.50E-21		12	9.59E-26	0.08
2	SGTC_1844	rapamycin	10.10	4.0 nM	1.63E-19		10	3.95E-24	0.42
3	SGTC_97	0535-0701	8.08	19.1 µM	3.28E-13	60S ribosome export	4	3.35E-16	2.00
4	SGTC_1818	st052136	7.43	56.3 µM	1.83E-11	NEO1-PIK1	3	5.23E-14	0.55
5	SGTC_584	0986-0246	7.34	15.4 µM	3.23E-11	heme requiring	4	1.07E-13	0.28
6	SGTC_2867	9039098	6.96	71.4 µM	2.85E-10	iron homeostasis	2	1.65E-12	0.88
7	SGTC_1829	berberine	6.91	14.4 µM	3.77E-10	60S ribosome export	6	2.34E-12	2.06
8	SGTC_1592	4',5'-dihydroxyflavone	6.91	8.8 µM	3.98E-10	60S ribosome export	3	2.51E-12	2.36
9	SGTC_765	1319-0117	6.64	244.0 µM	1.69E-9	60S ribosome export	3	1.55E-11	1.39
10	SGTC_184	1494-0393	6.50	24.7 µM	3.71E-9		8	4.14E-11	0.52
11	SGTC_108	0509-0257	6.32	621.1 µM	9.48E-9		5	1.34E-10	0.31
12	SGTC_2257	7960413	6.26	200.0 µM	1.25E-8	NEO1-PIK1	8	1.91E-10	0.00
13	SGTC_3217	9129673	6.06	49.5 µM	3.44E-8		2	6.76E-10	0.76
14	SGTC_3039	9090270	5.92	49.5 µM	6.79E-8	RPP1 & pyrimidine depletion	2	1.58E-9	1.39
15	SGTC_3219	9131112	5.92	49.5 µM	7.02E-8	Golgi	5	1.65E-9	0.28
16	SGTC_2563	tomatine	5.77	8.5 µM	1.44E-7		5	4.08E-9	0.10
17	SGTC_2100	5377183	5.58	190.0 µM	3.44E-7	60S ribosome export	4	1.21E-8	0.61
18	SGTC_3032	9089427	5.53	49.5 µM	4.23E-7	60S ribosome export	2	1.57E-8	1.45
19	SGTC_1786	berberine	5.35	21.6 µM	9.62E-7	60S ribosome export	9	4.39E-8	0.17
20	SGTC_2226	7298446	5.34	200.0 µM	9.98E-7		1	4.60E-8	0.87

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.312	1.08E-76	YLR438C-A	LSM3	het	Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; protein increases in abundance and relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
0.212	2.36E-35	YMR211W	DML1	het	Essential protein involved in mtDNA inheritance, may also function in the partitioning of the mitochondrial organelle or in the segregation of chromosomes, exhibits regions similar to members of a GTPase family
0.188	3.70E-28	YKL004W	AUR1	het	Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance
0.165	7.60E-22	YGL099W	LSG1	het	Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm
0.151	1.83E-18	YPL202C	AFT2	hom	Iron-regulated transcriptional activator; activates genes involved in intracellular iron use and required for iron homeostasis and resistance to oxidative stress; AFT2 has a paralog, AFT1, that arose from the whole genome duplication
0.150	2.84E-18	YNL112W	DBP2	het	ATP-dependent RNA helicase of the DEAD-box protein family; has a strong preference for dsRNA; involved mRNA decay and rRNA processing; may be involved in suppression of transcription from cryptic initiation sites
0.147	1.14E-17	YJR066W	TOR1	hom	PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication
0.137	1.41E-15	YJR013W	GPI14	het	Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M
0.134	5.47E-15	YHR187W	IKI1	hom	Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocin
0.131	2.39E-14	YHR170W	NMD3	het	Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex
0.131	2.51E-14	YKL203C	TOR2	het	PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication
0.129	6.25E-14	YML121W	GTR1	hom	Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB
0.126	2.68E-13	YPL084W	BRO1	hom	Cytoplasmic class E vacuolar protein sorting (VPS) factor that coordinates deubiquitination in the multivesicular body (MVB) pathway by recruiting Doa4p to endosomes
0.125	3.47E-13	YIR008C	PRI1	het	Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
0.122	1.07E-12	YHR186C	KOG1	het	Subunit of TORC1, a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors