HIPHOP chemogenomics database
YER139C / RTR1 
CTD phosphatase; dephosphorylates S5-P in the C-terminal domain of Rpo21p; has a cysteine-rich motif required for function and conserved in eukaryotes; shuttles between the nucleus and cytoplasm; RTR1 has a paralog, RTR2, that arose from the whole genome duplication
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YER139C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.141 | 1.95E-16 | YDL134C | PPH21 | hom | Catalytic subunit of protein phosphatase 2A (PP2A); functionally redundant with Pph22p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; forms nuclear foci upon DNA replication stress; PPH21 has a paralog, PPH22, that arose from the whole genome duplication |
| 0.103 | 2.21E-9 | YOR029W_d | YOR029W_d | hom | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
| 0.096 | 2.85E-8 | YNL150W_d | YNL150W_d | het | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; extensive overlap with PGA2/YNL149C, an uncharacterized gene with a proposed role in protein trafficking |
| 0.093 | 7.06E-8 | YMR016C | SOK2 | hom | Nuclear protein that negatively regulates pseudohyphal differentiation; plays a regulatory role in the cyclic AMP (cAMP)-dependent protein kinase (PKA) signal transduction pathway; SOK2 has a paralog, PHD1, that arose from the whole genome duplication |
| 0.089 | 2.62E-7 | YNL196C_p | SLZ1_p | hom | Sporulation-specific protein with a leucine zipper motif |
| 0.087 | 4.48E-7 | YGR266W | YGR266W | hom | Protein of unknown function; predicted to contain a single transmembrane domain; mutant has increased aneuploidy tolerance; localized to both the mitochondrial outer membrane and the plasma membrane; protein abundance increases in response to DNA replication stress |
| 0.085 | 7.83E-7 | YJR061W_p | YJR061W_p | hom | Putative protein of unknown function; non-essential gene; transcription repressed by Rm101p; YJR061W has a paralog, MNN4, that arose from the whole genome duplication |
| 0.082 | 1.73E-6 | YBR070C | ALG14 | het | Component of UDP-GlcNAc transferase required for the second step of dolichyl-linked oligosaccharide synthesis; anchors the catalytic subunit Alg13p to the ER membrane; similar to bacterial and human glycosyltransferases |
| 0.082 | 2.25E-6 | YBR146W | MRPS9 | hom | Mitochondrial ribosomal protein of the small subunit |
| 0.081 | 2.33E-6 | YEL020C_p | YEL020C_p | hom | Protein of unknown function with low sequence identity to Pdc1p; mRNA identified as translated by ribosome profiling data |
| 0.081 | 2.34E-6 | YBR254C | TRS20 | het | One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; mutations in the human homolog cause the spondyloepiphyseal dysplasia tarda (SEDL) disorder |
| 0.081 | 2.91E-6 | YPL011C | TAF3 | het | TFIID subunit (47 kDa), involved in promoter binding and RNA polymerase II transcription initiation |
| 0.079 | 4.35E-6 | YJL203W | PRP21 | het | Subunit of the SF3a splicing factor complex, required for spliceosome assembly |
| 0.079 | 4.49E-6 | YHR140W_p | YHR140W_p | hom | Putative integral membrane protein of unknown function |
| 0.079 | 4.67E-6 | YBR024W | SCO2 | hom | Protein anchored to mitochondrial inner membrane; may have a redundant function with Sco1p in delivery of copper to cytochrome c oxidase; interacts with Cox2p; SCO2 has a paralog, SCO1, that arose from the whole genome duplication |