HIPHOP chemogenomics database
YER150W / SPI1 
GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; similar to Sed1p
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YER150W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.114 | 3.99E-11 | YDL179W | PCL9 | hom | Cyclin, forms a functional kinase complex with Pho85p cyclin-dependent kinase (Cdk), expressed in late M/early G1 phase, activated by Swi5p |
| 0.100 | 5.77E-9 | YJL213W | YJL213W | hom | Protein of unknown function that may interact with ribosomes; periodically expressed during the yeast metabolic cycle; phosphorylated in vitro by the mitotic exit network (MEN) kinase complex, Dbf2p/Mob1p |
| 0.099 | 8.15E-9 | YOR137C | SIA1 | hom | Protein of unassigned function involved in activation of the Pma1p plasma membrane H+-ATPase by glucose |
| 0.091 | 1.44E-7 | YOR288C | MPD1 | hom | Member of the protein disulfide isomerase (PDI) family; interacts with and inhibits the chaperone activity of Cne1p; MPD1 overexpression in a pdi1 null mutant suppresses defects in Pdi1p functions such as carboxypeptidase Y maturation |
| 0.088 | 2.88E-7 | YKL004W | AUR1 | het | Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance |
| 0.087 | 4.78E-7 | YOL038C-A_p | YOL038C-A_p | hom | Putative protein of unknown function; identified by SAGE analysis |
| 0.079 | 4.42E-6 | YBR022W | POA1 | hom | Phosphatase that is highly specific for ADP-ribose 1''-phosphate, a tRNA splicing metabolite; may have a role in regulation of tRNA splicing |
| 0.078 | 5.63E-6 | YDL141W | BPL1 | het | Biotin:apoprotein ligase, covalently modifies proteins with the addition of biotin, required for acetyl-CoA carboxylase (Acc1p) holoenzyme formation |
| 0.078 | 6.23E-6 | YEL065W | SIT1 | hom | Ferrioxamine B transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; transcription is induced during iron deprivation and diauxic shift; potentially phosphorylated by Cdc28p |
| 0.076 | 9.50E-6 | YDR340W_d | YDR340W_d | hom | Putative protein of unknown function |
| 0.076 | 1.07E-5 | YKL011C | CCE1 | hom | Mitochondrial cruciform cutting endonuclease, cleaves Holliday junctions formed during recombination of mitochondrial DNA |
| 0.076 | 1.07E-5 | YLR175W | CBF5 | het | Pseudouridine synthase catalytic subunit of box H/ACA small nucleolar ribonucleoprotein particles (snoRNPs), acts on both large and small rRNAs and on snRNA U2; mutations in human ortholog dyskerin cause the disorder dyskeratosis congenita |
| 0.075 | 1.33E-5 | YDR338C_p | YDR338C_p | hom | Putative protein of unknown function, member of the multi-drug and toxin extrusion (MATE) family of the multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily |
| 0.074 | 1.68E-5 | YOR333C_d | YOR333C_d | hom | Dubious open reading frame, unlikely to encode a functional protein; overlaps 5' end of MRS2 gene required for respiratory growth |
| 0.074 | 1.89E-5 | YJL064W_d | YJL064W_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YJL065C/DLS1 |