YER152C

Protein with 2-aminoadipate transaminase activity; shares amino acid similarity with the aminotransferases Aro8p and Aro9p; YER152C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YER152C / YER152C

Click on Significant Values for Screen Details ID:SGTC_134|Compound:0269-0018|FD-Score:-3.11|P-value:8.45E-4 ID:SGTC_231|Compound:b-estradiol|FD-Score:3.92|P-value:2.25E-5 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:4.22|P-value:5.51E-6 ID:SGTC_334|Compound:1502-1024|FD-Score:3.33|P-value:2.57E-4 ID:SGTC_424|Compound:splitomicin|FD-Score:-3.36|P-value:3.46E-4 ID:SGTC_593|Compound:1203-0218|FD-Score:3.14|P-value:5.11E-4 ID:SGTC_609|Compound:0986-0026|FD-Score:3.02|P-value:7.78E-4 ID:SGTC_618|Compound:k072-0232|FD-Score:3.13|P-value:5.41E-4 ID:SGTC_930|Compound:2810-3379|FD-Score:3.01|P-value:8.06E-4 ID:SGTC_958|Compound:1222-0007|FD-Score:3.66|P-value:6.84E-5 ID:SGTC_980|Compound:1473-0395|FD-Score:-3.33|P-value:3.85E-4 ID:SGTC_1029|Compound:k015-0030|FD-Score:-3.26|P-value:4.89E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:3.12|P-value:5.57E-4 ID:SGTC_1256|Compound:0570-0116|FD-Score:3.02|P-value:7.78E-4 ID:SGTC_1320|Compound:1313-0481|FD-Score:3.16|P-value:4.76E-4 ID:SGTC_1405|Compound:3909-7894|FD-Score:3.64|P-value:7.26E-5 ID:SGTC_1437|Compound:4092-1038|FD-Score:-3.08|P-value:9.36E-4 ID:SGTC_1549|Compound:4'-methoxyflavonol|FD-Score:-3.43|P-value:2.61E-4 ID:SGTC_1554|Compound:st069299|FD-Score:3.50|P-value:1.29E-4 ID:SGTC_1721|Compound:st082152|FD-Score:3.17|P-value:4.56E-4 ID:SGTC_1726|Compound:st035556|FD-Score:3.09|P-value:6.14E-4 ID:SGTC_1743|Compound:st037606|FD-Score:-3.69|P-value:9.43E-5 ID:SGTC_1801|Compound:st050089|FD-Score:3.51|P-value:1.25E-4 ID:SGTC_1921|Compound:5740136|FD-Score:5.07|P-value:7.02E-8 ID:SGTC_1966|Compound:st070145|FD-Score:-3.81|P-value:5.84E-5 ID:SGTC_1993|Compound:st073995|FD-Score:4.96|P-value:1.31E-7 ID:SGTC_2188|Compound:6126565|FD-Score:3.33|P-value:2.53E-4 ID:SGTC_2276|Compound:7947513|FD-Score:3.37|P-value:2.21E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:-5.87|P-value:1.17E-9 ID:SGTC_2411|Compound:st077133|FD-Score:4.32|P-value:3.56E-6 ID:SGTC_2423|Compound:st077119|FD-Score:-3.40|P-value:2.95E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:-4.43|P-value:3.47E-6 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:4.40|P-value:2.40E-6 ID:SGTC_2537|Compound:larixol|FD-Score:-3.81|P-value:5.72E-5 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:-3.06|P-value:0.00100 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:4.15|P-value:7.94E-6 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:-3.49|P-value:2.11E-4 ID:SGTC_2691|Compound:st077356|FD-Score:3.75|P-value:4.56E-5 ID:SGTC_2782|Compound:7736369|FD-Score:-3.36|P-value:3.39E-4 ID:SGTC_2931|Compound:9014674|FD-Score:-4.50|P-value:2.53E-6 ID:SGTC_3034|Compound:9090421|FD-Score:2.96|P-value:9.74E-4 ID:SGTC_3091|Compound:9116372|FD-Score:3.35|P-value:2.31E-4 ID:SGTC_3352|Compound:9151559|FD-Score:4.10|P-value:9.97E-6 ID:SGTC_134|Compound:0269-0018|FD-Score:-3.11|P-value:8.45E-4 ID:SGTC_231|Compound:b-estradiol|FD-Score:3.92|P-value:2.25E-5 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:4.22|P-value:5.51E-6 ID:SGTC_334|Compound:1502-1024|FD-Score:3.33|P-value:2.57E-4 ID:SGTC_424|Compound:splitomicin|FD-Score:-3.36|P-value:3.46E-4 ID:SGTC_593|Compound:1203-0218|FD-Score:3.14|P-value:5.11E-4 ID:SGTC_609|Compound:0986-0026|FD-Score:3.02|P-value:7.78E-4 ID:SGTC_618|Compound:k072-0232|FD-Score:3.13|P-value:5.41E-4 ID:SGTC_930|Compound:2810-3379|FD-Score:3.01|P-value:8.06E-4 ID:SGTC_958|Compound:1222-0007|FD-Score:3.66|P-value:6.84E-5 ID:SGTC_980|Compound:1473-0395|FD-Score:-3.33|P-value:3.85E-4 ID:SGTC_1029|Compound:k015-0030|FD-Score:-3.26|P-value:4.89E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:3.12|P-value:5.57E-4 ID:SGTC_1256|Compound:0570-0116|FD-Score:3.02|P-value:7.78E-4 ID:SGTC_1320|Compound:1313-0481|FD-Score:3.16|P-value:4.76E-4 ID:SGTC_1405|Compound:3909-7894|FD-Score:3.64|P-value:7.26E-5 ID:SGTC_1437|Compound:4092-1038|FD-Score:-3.08|P-value:9.36E-4 ID:SGTC_1549|Compound:4'-methoxyflavonol|FD-Score:-3.43|P-value:2.61E-4 ID:SGTC_1554|Compound:st069299|FD-Score:3.50|P-value:1.29E-4 ID:SGTC_1721|Compound:st082152|FD-Score:3.17|P-value:4.56E-4 ID:SGTC_1726|Compound:st035556|FD-Score:3.09|P-value:6.14E-4 ID:SGTC_1743|Compound:st037606|FD-Score:-3.69|P-value:9.43E-5 ID:SGTC_1801|Compound:st050089|FD-Score:3.51|P-value:1.25E-4 ID:SGTC_1921|Compound:5740136|FD-Score:5.07|P-value:7.02E-8 ID:SGTC_1966|Compound:st070145|FD-Score:-3.81|P-value:5.84E-5 ID:SGTC_1993|Compound:st073995|FD-Score:4.96|P-value:1.31E-7 ID:SGTC_2188|Compound:6126565|FD-Score:3.33|P-value:2.53E-4 ID:SGTC_2276|Compound:7947513|FD-Score:3.37|P-value:2.21E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:-5.87|P-value:1.17E-9 ID:SGTC_2411|Compound:st077133|FD-Score:4.32|P-value:3.56E-6 ID:SGTC_2423|Compound:st077119|FD-Score:-3.40|P-value:2.95E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:-4.43|P-value:3.47E-6 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:4.40|P-value:2.40E-6 ID:SGTC_2537|Compound:larixol|FD-Score:-3.81|P-value:5.72E-5 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:-3.06|P-value:0.00100 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:4.15|P-value:7.94E-6 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:-3.49|P-value:2.11E-4 ID:SGTC_2691|Compound:st077356|FD-Score:3.75|P-value:4.56E-5 ID:SGTC_2782|Compound:7736369|FD-Score:-3.36|P-value:3.39E-4 ID:SGTC_2931|Compound:9014674|FD-Score:-4.50|P-value:2.53E-6 ID:SGTC_3034|Compound:9090421|FD-Score:2.96|P-value:9.74E-4 ID:SGTC_3091|Compound:9116372|FD-Score:3.35|P-value:2.31E-4 ID:SGTC_3352|Compound:9151559|FD-Score:4.10|P-value:9.97E-6

Top fitness defect scores for YER152C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1921 5740136 5.07 50.0 µM 7.02E-8 TRP & mitochondrial translation 32 1.99E-7
2 SGTC_1993 st073995 4.96 70.8 µM 1.31E-7 8 3.59E-7
3 SGTC_2531 methyl deoxycholate 4.40 70.1 µM 2.40E-6 15 5.49E-6
4 SGTC_2411 st077133 4.32 39.9 µM 3.56E-6 RNA pol III & RNase P/MRP 22 7.95E-6
5 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.22 4.6 µM 5.51E-6 heat shock/prefoldin 31 1.20E-5
6 SGTC_2634 4'-methoxyflavone 4.15 100.0 µM 7.94E-6 27 1.69E-5
7 SGTC_3352 9151559 4.10 45.6 µM 9.97E-6 11 2.09E-5
8 SGTC_231 b-estradiol 3.92 524.0 µM 2.25E-5 9 4.49E-5
9 SGTC_2691 st077356 3.75 60.2 µM 4.56E-5 34 8.71E-5
10 SGTC_958 1222-0007 3.66 33.0 µM 6.84E-5 39 1.27E-4
11 SGTC_1405 3909-7894 3.64 12.0 µM 7.26E-5 60S ribosome export 18 1.35E-4
12 SGTC_1801 st050089 3.51 28.4 µM 1.25E-4 NEO1-PIK1 143 2.25E-4
13 SGTC_1554 st069299 3.50 38.7 µM 1.29E-4 34 2.31E-4
14 SGTC_2276 7947513 3.37 42.1 µM 2.21E-4 40 3.82E-4
15 SGTC_3091 9116372 3.35 49.5 µM 2.31E-4 31 4.00E-4
16 SGTC_2188 6126565 3.33 140.7 µM 2.53E-4 mitochondrial processes 27 4.34E-4
17 SGTC_334 1502-1024 3.33 68.5 µM 2.57E-4 26 4.41E-4
18 SGTC_1721 st082152 3.17 9.3 µM 4.56E-4 60S ribosome export 50 7.54E-4
19 SGTC_1320 1313-0481 3.16 95.3 µM 4.76E-4 47 7.86E-4
20 SGTC_593 1203-0218 3.14 61.7 µM 5.11E-4 33 8.39E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.119 4.93E-12 YER085C_p YER085C_p hom Putative protein of unknown function
0.104 1.73E-9 YDR461W MFA1 hom Mating pheromone a-factor, made by a cells; interacts with alpha cells to induce cell cycle arrest and other responses leading to mating; biogenesis involves C-terminal modification, N-terminal proteolysis, and export; also encoded by MFA2
0.104 1.80E-9 YPL201C YIG1 hom Protein that interacts with glycerol 3-phosphatase and plays a role in anaerobic glycerol production; localizes to the nucleus and cytosol
0.099 9.34E-9 YNL221C POP1 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P
0.097 1.87E-8 YOR260W GCD1 het Gamma subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
0.095 3.90E-8 YER045C ACA1 hom ATF/CREB family basic leucine zipper (bZIP) transcription factor; binds as a homodimer to the ATF/CREB consensus sequence TGACGTCA; important for carbon source utilization; target genes include GRE2 and COS8; ACA1 has a paralog, CST6, that arose from the whole genome duplication
0.089 2.17E-7 YGR121C MEP1 hom Ammonium permease; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation
0.086 5.93E-7 YEL065W SIT1 hom Ferrioxamine B transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; transcription is induced during iron deprivation and diauxic shift; potentially phosphorylated by Cdc28p
0.086 6.89E-7 YOR038C HIR2 hom Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; recruits Swi-Snf complexes to histone gene promoters; promotes heterochromatic gene silencing with Asf1p
0.085 7.44E-7 YEL052W AFG1 hom Conserved protein that may act as a chaperone in the degradation of misfolded or unassembled cytochrome c oxidase subunits; localized to matrix face of the mitochondrial inner membrane; member of the AAA family but lacks a protease domain
0.085 8.96E-7 YJL212C OPT1 hom Proton-coupled oligopeptide transporter of the plasma membrane; also transports glutathione and phytochelatin; member of the OPT family
0.084 1.09E-6 YDR093W DNF2 hom Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase
0.084 1.22E-6 YML030W RCF1 hom Cytochrome c oxidase subunit; required for assembly of the Complex III-Complex IV supercomplex, and for assembly of Cox13p and Rcf2p into cytochrome c oxidase; similar to Rcf2p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; required for growth under hypoxic conditions; member of the hypoxia induced gene family; C. elegans and human orthologs are functional in yeast
0.083 1.53E-6 YMR326C_d YMR326C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the telomere on the right arm of chromosome 13
0.081 2.74E-6 YOR077W RTS2 het Basic zinc-finger protein, similar to human and mouse Kin17 proteins which are chromatin-associated proteins involved in UV response and DNA replication