YER176W / ECM32

DNA dependent ATPase/DNA helicase belonging to the Dna2p- and Nam7p-like family of helicases that is involved in modulating translation termination; interacts with the translation termination factors, localized to polysomes

Zygosity: Homozygous strain
fixedexpanded
Profile for YER176W / ECM32

Click on Significant Values for Screen Details ID:SGTC_179|Compound:1273-0063|FD-Score:-3.06|P-value:9.65E-4 ID:SGTC_323|Compound:4013-0906|FD-Score:5.78|P-value:1.13E-9 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:-3.30|P-value:4.08E-4 ID:SGTC_405|Compound:ebelactone b|FD-Score:-3.34|P-value:3.42E-4 ID:SGTC_456|Compound:gingerol|FD-Score:-3.05|P-value:9.93E-4 ID:SGTC_661|Compound:1304-0007|FD-Score:4.04|P-value:1.35E-5 ID:SGTC_722|Compound:3534-0461|FD-Score:4.37|P-value:2.91E-6 ID:SGTC_726|Compound:3448-4391|FD-Score:3.05|P-value:7.34E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:3.26|P-value:3.47E-4 ID:SGTC_1244|Compound:0416-0015|FD-Score:5.53|P-value:5.10E-9 ID:SGTC_1389|Compound:3405-0187|FD-Score:4.05|P-value:1.28E-5 ID:SGTC_1513|Compound:0337-0559|FD-Score:-3.71|P-value:7.99E-5 ID:SGTC_1656|Compound:st012921|FD-Score:2.99|P-value:9.18E-4 ID:SGTC_1747|Compound:st037496|FD-Score:4.31|P-value:3.84E-6 ID:SGTC_1766|Compound:st045414|FD-Score:3.76|P-value:4.64E-5 ID:SGTC_1853|Compound:st056710|FD-Score:3.07|P-value:6.98E-4 ID:SGTC_1860|Compound:st056228|FD-Score:3.46|P-value:1.64E-4 ID:SGTC_1868|Compound:st057644|FD-Score:3.30|P-value:2.95E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:3.08|P-value:6.66E-4 ID:SGTC_1943|Compound:st076331|FD-Score:3.32|P-value:2.81E-4 ID:SGTC_2063|Compound:5246145|FD-Score:4.57|P-value:1.08E-6 ID:SGTC_2064|Compound:5220758|FD-Score:3.52|P-value:1.26E-4 ID:SGTC_2071|Compound:5230951|FD-Score:-3.74|P-value:7.14E-5 ID:SGTC_2082|Compound:5219693|FD-Score:-3.41|P-value:2.66E-4 ID:SGTC_2089|Compound:5281248|FD-Score:3.72|P-value:5.62E-5 ID:SGTC_2113|Compound:5491891|FD-Score:3.44|P-value:1.76E-4 ID:SGTC_2117|Compound:5521686|FD-Score:-3.10|P-value:8.19E-4 ID:SGTC_2239|Compound:6685329|FD-Score:3.44|P-value:1.75E-4 ID:SGTC_2285|Compound:7945142|FD-Score:3.12|P-value:5.82E-4 ID:SGTC_2293|Compound:7624732|FD-Score:3.21|P-value:4.18E-4 ID:SGTC_2301|Compound:7769476|FD-Score:6.95|P-value:3.47E-13 ID:SGTC_2385|Compound:9074692|FD-Score:5.62|P-value:2.95E-9 ID:SGTC_2390|Compound:9097792|FD-Score:-3.64|P-value:1.06E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:4.33|P-value:3.48E-6 ID:SGTC_2414|Compound:st077232|FD-Score:3.16|P-value:5.08E-4 ID:SGTC_2492|Compound:derrusnin|FD-Score:3.01|P-value:8.59E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:3.69|P-value:6.30E-5 ID:SGTC_2504|Compound:purpurogallin|FD-Score:-3.08|P-value:8.94E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:-3.62|P-value:1.15E-4 ID:SGTC_2591|Compound:skatole|FD-Score:-4.25|P-value:7.70E-6 ID:SGTC_2705|Compound:st078069|FD-Score:3.39|P-value:2.09E-4 ID:SGTC_2829|Compound:7992743|FD-Score:9.89|P-value:8.88E-25 ID:SGTC_2832|Compound:7992762|FD-Score:10.60|P-value:2.52E-28 ID:SGTC_2833|Compound:9001315|FD-Score:8.55|P-value:5.28E-19 ID:SGTC_2933|Compound:9026794|FD-Score:3.33|P-value:2.67E-4 ID:SGTC_3031|Compound:9088762|FD-Score:-3.22|P-value:5.49E-4 ID:SGTC_3157|Compound:9099274|FD-Score:-3.45|P-value:2.28E-4 ID:SGTC_3204|Compound:9114183|FD-Score:3.26|P-value:3.50E-4 ID:SGTC_3259|Compound:9138485|FD-Score:3.06|P-value:7.30E-4 ID:SGTC_179|Compound:1273-0063|FD-Score:-3.06|P-value:9.65E-4 ID:SGTC_323|Compound:4013-0906|FD-Score:5.78|P-value:1.13E-9 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:-3.30|P-value:4.08E-4 ID:SGTC_405|Compound:ebelactone b|FD-Score:-3.34|P-value:3.42E-4 ID:SGTC_456|Compound:gingerol|FD-Score:-3.05|P-value:9.93E-4 ID:SGTC_661|Compound:1304-0007|FD-Score:4.04|P-value:1.35E-5 ID:SGTC_722|Compound:3534-0461|FD-Score:4.37|P-value:2.91E-6 ID:SGTC_726|Compound:3448-4391|FD-Score:3.05|P-value:7.34E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:3.26|P-value:3.47E-4 ID:SGTC_1244|Compound:0416-0015|FD-Score:5.53|P-value:5.10E-9 ID:SGTC_1389|Compound:3405-0187|FD-Score:4.05|P-value:1.28E-5 ID:SGTC_1513|Compound:0337-0559|FD-Score:-3.71|P-value:7.99E-5 ID:SGTC_1656|Compound:st012921|FD-Score:2.99|P-value:9.18E-4 ID:SGTC_1747|Compound:st037496|FD-Score:4.31|P-value:3.84E-6 ID:SGTC_1766|Compound:st045414|FD-Score:3.76|P-value:4.64E-5 ID:SGTC_1853|Compound:st056710|FD-Score:3.07|P-value:6.98E-4 ID:SGTC_1860|Compound:st056228|FD-Score:3.46|P-value:1.64E-4 ID:SGTC_1868|Compound:st057644|FD-Score:3.30|P-value:2.95E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:3.08|P-value:6.66E-4 ID:SGTC_1943|Compound:st076331|FD-Score:3.32|P-value:2.81E-4 ID:SGTC_2063|Compound:5246145|FD-Score:4.57|P-value:1.08E-6 ID:SGTC_2064|Compound:5220758|FD-Score:3.52|P-value:1.26E-4 ID:SGTC_2071|Compound:5230951|FD-Score:-3.74|P-value:7.14E-5 ID:SGTC_2082|Compound:5219693|FD-Score:-3.41|P-value:2.66E-4 ID:SGTC_2089|Compound:5281248|FD-Score:3.72|P-value:5.62E-5 ID:SGTC_2113|Compound:5491891|FD-Score:3.44|P-value:1.76E-4 ID:SGTC_2117|Compound:5521686|FD-Score:-3.10|P-value:8.19E-4 ID:SGTC_2239|Compound:6685329|FD-Score:3.44|P-value:1.75E-4 ID:SGTC_2285|Compound:7945142|FD-Score:3.12|P-value:5.82E-4 ID:SGTC_2293|Compound:7624732|FD-Score:3.21|P-value:4.18E-4 ID:SGTC_2301|Compound:7769476|FD-Score:6.95|P-value:3.47E-13 ID:SGTC_2385|Compound:9074692|FD-Score:5.62|P-value:2.95E-9 ID:SGTC_2390|Compound:9097792|FD-Score:-3.64|P-value:1.06E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:4.33|P-value:3.48E-6 ID:SGTC_2414|Compound:st077232|FD-Score:3.16|P-value:5.08E-4 ID:SGTC_2492|Compound:derrusnin|FD-Score:3.01|P-value:8.59E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:3.69|P-value:6.30E-5 ID:SGTC_2504|Compound:purpurogallin|FD-Score:-3.08|P-value:8.94E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:-3.62|P-value:1.15E-4 ID:SGTC_2591|Compound:skatole|FD-Score:-4.25|P-value:7.70E-6 ID:SGTC_2705|Compound:st078069|FD-Score:3.39|P-value:2.09E-4 ID:SGTC_2829|Compound:7992743|FD-Score:9.89|P-value:8.88E-25 ID:SGTC_2832|Compound:7992762|FD-Score:10.60|P-value:2.52E-28 ID:SGTC_2833|Compound:9001315|FD-Score:8.55|P-value:5.28E-19 ID:SGTC_2933|Compound:9026794|FD-Score:3.33|P-value:2.67E-4 ID:SGTC_3031|Compound:9088762|FD-Score:-3.22|P-value:5.49E-4 ID:SGTC_3157|Compound:9099274|FD-Score:-3.45|P-value:2.28E-4 ID:SGTC_3204|Compound:9114183|FD-Score:3.26|P-value:3.50E-4 ID:SGTC_3259|Compound:9138485|FD-Score:3.06|P-value:7.30E-4

Top fitness defect scores for YER176W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2832 7992762 10.60 52.0 µM 2.52E-28 1 1.00E-26
2 SGTC_2829 7992743 9.89 58.4 µM 8.88E-25 1 2.23E-23
3 SGTC_2833 9001315 8.55 45.5 µM 5.28E-19 amide catabolism 4 6.21E-18
4 SGTC_2301 7769476 6.95 200.0 µM 3.47E-13 6 1.89E-12
5 SGTC_323 4013-0906 5.78 34.3 µM 1.13E-9 ERG2 2 3.84E-9
6 SGTC_2385 9074692 5.62 200.0 µM 2.95E-9 15 9.47E-9
7 SGTC_1244 0416-0015 5.53 52.5 µM 5.10E-9 ERG2 8 1.59E-8
8 SGTC_2063 5246145 4.57 200.0 µM 1.08E-6 14 2.46E-6
9 SGTC_722 3534-0461 4.37 190.0 µM 2.91E-6 PDR1 25 6.23E-6
10 SGTC_2410 aloe-emodin-8-o-glycoside 4.33 46.3 µM 3.48E-6 mitochondrial processes 20 7.37E-6
11 SGTC_1747 st037496 4.31 66.6 µM 3.84E-6 11 8.08E-6
12 SGTC_1389 3405-0187 4.05 19.0 µM 1.28E-5 12 2.51E-5
13 SGTC_661 1304-0007 4.04 33.6 µM 1.35E-5 19 2.64E-5
14 SGTC_1766 st045414 3.76 44.8 µM 4.64E-5 RPP1 & pyrimidine depletion 29 8.41E-5
15 SGTC_2089 5281248 3.72 129.7 µM 5.62E-5 superoxide 29 1.01E-4
16 SGTC_2500 5-alpha-androstan-3,17-dione 3.69 61.4 µM 6.30E-5 47 1.12E-4
17 SGTC_2064 5220758 3.52 200.0 µM 1.26E-4 53 2.15E-4
18 SGTC_1860 st056228 3.46 74.6 µM 1.64E-4 35 2.75E-4
19 SGTC_2239 6685329 3.44 187.6 µM 1.75E-4 51 2.93E-4
20 SGTC_2113 5491891 3.44 107.0 µM 1.76E-4 TSC3-RPN4 42 2.95E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.161 6.49E-21 YNR028W CPR8 hom Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; similarity to Cpr4p suggests a potential role in the secretory pathway
0.138 9.12E-16 YJR035W RAD26 hom Protein involved in transcription-coupled nucleotide excision repair of UV-induced DNA lesions; recruitment to DNA lesions is dependent on an elongating RNA polymerase II; homolog of human CSB protein
0.116 1.86E-11 YGR034W RPL26B hom Ribosomal 60S subunit protein L26B; binds to 5.8S rRNA; homologous to mammalian ribosomal protein L26 and bacterial L24; RPL26B has a paralog, RPL26A, that arose from the whole genome duplication
0.106 7.14E-10 YLR098C CHA4 hom DNA binding transcriptional activator, mediates serine/threonine activation of the catabolic L-serine (L-threonine) deaminase (CHA1); Zinc-finger protein with Zn[2]-Cys[6] fungal-type binuclear cluster domain
0.102 3.10E-9 YDL166C FAP7 het Essential NTPase required for small ribosome subunit synthesis, mediates processing of the 20S pre-rRNA at site D in the cytoplasm but associates only transiently with 43S preribosomes via Rps14p, may be the endonuclease for site D
0.101 5.37E-9 YOL044W PEX15 hom Phosphorylated tail-anchored type II integral peroxisomal membrane protein required for peroxisome biogenesis, cells lacking Pex15p mislocalize peroxisomal matrix proteins to cytosol, overexpression results in impaired peroxisome assembly
0.100 6.95E-9 YOR011W AUS1 hom Plasma membrane sterol transporter of the ATP-binding cassette family; required, along with Pdr11p, for uptake of exogenous sterols and their incorporation into the plasma membrane; activity is stimulated by phosphatidylserine; sterol uptake is required for anaerobic growth because sterol biosynthesis requires oxygen
0.097 1.69E-8 YER116C SLX8 hom Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex; stimulated by prior attachment of SUMO to the substrate; contains a C-terminal RING domain; forms nuclear foci upon DNA replication stress
0.094 4.30E-8 YJL044C GYP6 hom GTPase-activating protein (GAP) for the yeast Rab family member, Ypt6p; involved in vesicle mediated protein transport
0.092 9.15E-8 YJL071W ARG2 hom Acetylglutamate synthase (glutamate N-acetyltransferase), mitochondrial enzyme that catalyzes the first step in the biosynthesis of the arginine precursor ornithine; forms a complex with Arg5,6p
0.087 4.81E-7 YDR459C PFA5 hom Palmitoyltransferase with autoacylation activity; likely functions in pathway(s) outside Ras; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain
0.086 6.79E-7 YKR004C ECM9 het Non-essential protein of unknown function
0.082 2.27E-6 YPR093C ASR1 hom Ubiquitin ligase that modifies and regulates RNA Pol II; involved in a putative alcohol-responsive signaling pathway; accumulates in the nucleus under alcohol stress; contains a Ring/PHD finger domain similar to the mammalian rA9 protein
0.081 2.28E-6 YER003C PMI40 het Mannose-6-phosphate isomerase, catalyzes the interconversion of fructose-6-P and mannose-6-P; required for early steps in protein mannosylation
0.080 4.01E-6 YLR080W EMP46 hom Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport