YFL020C / PAU5

Member of the seripauperin multigene family encoded mainly in subtelomeric regions; induced during alcoholic fermentation; induced by low temperature and also by anaerobic conditions; negatively regulated by oxygen and repressed by heme

Zygosity: Homozygous strain
fixedexpanded
Profile for YFL020C / PAU5

Click on Significant Values for Screen Details ID:SGTC_92|Compound:0063-0024|FD-Score:-3.78|P-value:1.70E-5 ID:SGTC_148|Compound:3253-0744|FD-Score:-3.79|P-value:1.64E-5 ID:SGTC_394|Compound:menadione|FD-Score:2.93|P-value:6.73E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:3.78|P-value:1.80E-5 ID:SGTC_736|Compound:0958-0254|FD-Score:3.08|P-value:3.84E-4 ID:SGTC_798|Compound:1287-0182|FD-Score:3.44|P-value:8.56E-5 ID:SGTC_802|Compound:4112-3352|FD-Score:3.88|P-value:1.11E-5 ID:SGTC_1017|Compound:4239-0030|FD-Score:-3.31|P-value:1.41E-4 ID:SGTC_1186|Compound:1319-0216|FD-Score:3.30|P-value:1.53E-4 ID:SGTC_1187|Compound:1391-0724|FD-Score:3.74|P-value:2.16E-5 ID:SGTC_1195|Compound:1502-0147|FD-Score:2.90|P-value:7.64E-4 ID:SGTC_1207|Compound:2099-0101|FD-Score:-2.92|P-value:6.90E-4 ID:SGTC_1228|Compound:0124-0032|FD-Score:-2.91|P-value:6.98E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:3.47|P-value:7.40E-5 ID:SGTC_1245|Compound:0418-0076|FD-Score:5.18|P-value:7.34E-9 ID:SGTC_1256|Compound:0570-0116|FD-Score:-2.90|P-value:7.26E-4 ID:SGTC_1274|Compound:0865-0114|FD-Score:2.91|P-value:7.19E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.09|P-value:3.55E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:3.11|P-value:3.40E-4 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:3.10|P-value:3.43E-4 ID:SGTC_1752|Compound:st044819|FD-Score:-3.13|P-value:2.98E-4 ID:SGTC_1764|Compound:st044502|FD-Score:-4.18|P-value:2.31E-6 ID:SGTC_1769|Compound:st044406|FD-Score:4.26|P-value:1.57E-6 ID:SGTC_1792|Compound:st045773|FD-Score:-3.29|P-value:1.54E-4 ID:SGTC_1798|Compound:st045719|FD-Score:3.21|P-value:2.24E-4 ID:SGTC_1801|Compound:st050089|FD-Score:2.93|P-value:6.64E-4 ID:SGTC_1837|Compound:st055472|FD-Score:3.08|P-value:3.80E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:2.95|P-value:6.28E-4 ID:SGTC_1970|Compound:st070122|FD-Score:2.89|P-value:7.89E-4 ID:SGTC_2023|Compound:5144124|FD-Score:-3.61|P-value:3.87E-5 ID:SGTC_2048|Compound:5246248|FD-Score:3.11|P-value:3.39E-4 ID:SGTC_2693|Compound:st077581|FD-Score:2.87|P-value:8.38E-4 ID:SGTC_2810|Compound:7959871|FD-Score:3.99|P-value:6.35E-6 ID:SGTC_2876|Compound:9059903|FD-Score:3.20|P-value:2.37E-4 ID:SGTC_2930|Compound:9013230|FD-Score:3.10|P-value:3.47E-4 ID:SGTC_2969|Compound:9091408|FD-Score:-3.63|P-value:3.40E-5 ID:SGTC_2991|Compound:9074669|FD-Score:3.64|P-value:3.45E-5 ID:SGTC_3080|Compound:9117754|FD-Score:3.68|P-value:2.78E-5 ID:SGTC_92|Compound:0063-0024|FD-Score:-3.78|P-value:1.70E-5 ID:SGTC_148|Compound:3253-0744|FD-Score:-3.79|P-value:1.64E-5 ID:SGTC_394|Compound:menadione|FD-Score:2.93|P-value:6.73E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:3.78|P-value:1.80E-5 ID:SGTC_736|Compound:0958-0254|FD-Score:3.08|P-value:3.84E-4 ID:SGTC_798|Compound:1287-0182|FD-Score:3.44|P-value:8.56E-5 ID:SGTC_802|Compound:4112-3352|FD-Score:3.88|P-value:1.11E-5 ID:SGTC_1017|Compound:4239-0030|FD-Score:-3.31|P-value:1.41E-4 ID:SGTC_1186|Compound:1319-0216|FD-Score:3.30|P-value:1.53E-4 ID:SGTC_1187|Compound:1391-0724|FD-Score:3.74|P-value:2.16E-5 ID:SGTC_1195|Compound:1502-0147|FD-Score:2.90|P-value:7.64E-4 ID:SGTC_1207|Compound:2099-0101|FD-Score:-2.92|P-value:6.90E-4 ID:SGTC_1228|Compound:0124-0032|FD-Score:-2.91|P-value:6.98E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:3.47|P-value:7.40E-5 ID:SGTC_1245|Compound:0418-0076|FD-Score:5.18|P-value:7.34E-9 ID:SGTC_1256|Compound:0570-0116|FD-Score:-2.90|P-value:7.26E-4 ID:SGTC_1274|Compound:0865-0114|FD-Score:2.91|P-value:7.19E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.09|P-value:3.55E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:3.11|P-value:3.40E-4 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:3.10|P-value:3.43E-4 ID:SGTC_1752|Compound:st044819|FD-Score:-3.13|P-value:2.98E-4 ID:SGTC_1764|Compound:st044502|FD-Score:-4.18|P-value:2.31E-6 ID:SGTC_1769|Compound:st044406|FD-Score:4.26|P-value:1.57E-6 ID:SGTC_1792|Compound:st045773|FD-Score:-3.29|P-value:1.54E-4 ID:SGTC_1798|Compound:st045719|FD-Score:3.21|P-value:2.24E-4 ID:SGTC_1801|Compound:st050089|FD-Score:2.93|P-value:6.64E-4 ID:SGTC_1837|Compound:st055472|FD-Score:3.08|P-value:3.80E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:2.95|P-value:6.28E-4 ID:SGTC_1970|Compound:st070122|FD-Score:2.89|P-value:7.89E-4 ID:SGTC_2023|Compound:5144124|FD-Score:-3.61|P-value:3.87E-5 ID:SGTC_2048|Compound:5246248|FD-Score:3.11|P-value:3.39E-4 ID:SGTC_2693|Compound:st077581|FD-Score:2.87|P-value:8.38E-4 ID:SGTC_2810|Compound:7959871|FD-Score:3.99|P-value:6.35E-6 ID:SGTC_2876|Compound:9059903|FD-Score:3.20|P-value:2.37E-4 ID:SGTC_2930|Compound:9013230|FD-Score:3.10|P-value:3.47E-4 ID:SGTC_2969|Compound:9091408|FD-Score:-3.63|P-value:3.40E-5 ID:SGTC_2991|Compound:9074669|FD-Score:3.64|P-value:3.45E-5 ID:SGTC_3080|Compound:9117754|FD-Score:3.68|P-value:2.78E-5

Top fitness defect scores for YFL020C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1245 0418-0076 5.18 17.2 µM 7.34E-9 ERG2 9 1.13E-7
2 SGTC_1769 st044406 4.26 64.4 µM 1.57E-6 7 1.02E-5
3 SGTC_2810 7959871 3.99 45.5 µM 6.35E-6 copper-dependent oxidative stress 38 3.31E-5
4 SGTC_802 4112-3352 3.88 742.0 µM 1.11E-5 26 5.28E-5
5 SGTC_669 0108-0021 3.78 26.2 µM 1.80E-5 fatty acid desaturase (OLE1) 89 7.96E-5
6 SGTC_1187 1391-0724 3.74 117.0 µM 2.16E-5 amide catabolism 21 9.25E-5
7 SGTC_3080 9117754 3.68 49.5 µM 2.78E-5 24 1.15E-4
8 SGTC_2991 9074669 3.64 71.4 µM 3.45E-5 azole & statin 78 1.37E-4
9 SGTC_1240 0356-0016 3.47 42.1 µM 7.40E-5 mitochondrial response to ROS 50 2.62E-4
10 SGTC_798 1287-0182 3.44 476.0 µM 8.56E-5 38 2.96E-4
11 SGTC_1186 1319-0216 3.30 26.0 µM 1.53E-4 40 4.84E-4
12 SGTC_1798 st045719 3.21 61.0 µM 2.24E-4 23 6.66E-4
13 SGTC_2876 9059903 3.20 26.0 µM 2.37E-4 36 6.98E-4
14 SGTC_2048 5246248 3.11 200.0 µM 3.39E-4 22 9.45E-4
15 SGTC_1520 flindersine 3.11 88.0 µM 3.40E-4 67 9.48E-4
16 SGTC_1584 6-fluoro-dl-tryptophan 3.10 90.0 µM 3.43E-4 mitochondrial processes 50 9.55E-4
17 SGTC_2930 9013230 3.10 14.9 µM 3.47E-4 heme biosynthesis & mitochondrial translocase 83 9.64E-4
18 SGTC_1837 st055472 3.08 66.5 µM 3.80E-4 52 0.00104
19 SGTC_736 0958-0254 3.08 92.6 µM 3.84E-4 Golgi 77 0.00105
20 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 2.95 70.1 µM 6.28E-4 93 0.00159

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.147 9.54E-18 YMR104C YPK2 hom Protein kinase with similarity to serine/threonine protein kinase Ypk1p; functionally redundant with YPK1 at the genetic level; participates in a signaling pathway required for optimal cell wall integrity; homolog of mammalian kinase SGK; YPK2 has a paralog, YPK1, that arose from the whole genome duplication
0.137 2.15E-15 YDR098C GRX3 hom Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage; evidence exists indicating that the translation start site is not Met1 as currently annotated, but rather Met36
0.119 3.77E-12 YER093C-A AIM11 hom Protein of unknown function; null mutant is viable but shows increased loss of mitochondrial genome and synthetic interaction with prohibitin (phb1); contains an intron; YER093C-A has a paralog, YBL059W, that arose from the whole genome duplication
0.117 1.32E-11 YMR094W CTF13 het Subunit of the CBF3 complex, which binds to the CDE III element of centromeres, bending the DNA upon binding, and may be involved in sister chromatid cohesion during mitosis
0.105 1.22E-9 YFL049W SWP82 hom Member of the SWI/SNF chromatin remodeling complex; has an as yet unidentified role in the complex; has identifiable counterparts in closely related yeast species; abundantly expressed in many growth conditions; paralog of Npl6p; relocates to the cytosol under hypoxic conditions
0.103 1.92E-9 YDR097C MSH6 hom Protein required for mismatch repair in mitosis and meiosis, forms a complex with Msh2p to repair both single-base & insertion-deletion mispairs; also involved in interstrand cross-link repair; potentially phosphorylated by Cdc28p
0.103 2.58E-9 YDL133C-A RPL41B hom Ribosomal 60S subunit protein L41B; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41B has a paralog, RPL41A, that arose from the whole genome duplication
0.100 5.87E-9 YKL006C-A SFT1 het Intra-Golgi v-SNARE, required for transport of proteins between an early and a later Golgi compartment
0.099 8.29E-9 YGL037C PNC1 hom Nicotinamidase that converts nicotinamide to nicotinic acid; part of the NAD(+) salvage pathway; required for life span extension by calorie restriction; PNC1 expression responds to all known stimuli that extend replicative life span; protein increases in abundance and relative distribution to cytoplasmic foci decreases upon DNA replication stress
0.098 1.15E-8 YOR354C MSC6 hom Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.098 1.28E-8 YNL209W SSB2 hom Cytoplasmic ATPase that is a ribosome-associated molecular chaperone; functions with J-protein partner Zuo1p; may be involved in the folding of newly-synthesized polypeptide chains; member of the HSP70 family; SSB2 has a paralog, SSB1, that arose from the whole genome duplication
0.095 3.58E-8 YIL042C PKP1 hom Mitochondrial protein kinase involved in negative regulation of pyruvate dehydrogenase complex activity by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp2p and phosphatases Ptc5p and Ptc6p
0.092 1.06E-7 YOL091W SPO21 hom Component of the meiotic outer plaque of the spindle pole body, involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation
0.090 1.56E-7 YDR246W TRS23 het One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic; human homolog is TRAPPC4
0.089 2.18E-7 YER180C ISC10 hom Protein required for sporulation, transcript is induced 7.5 hours after induction of meiosis, expected to play significant role in the formation of reproductive cells