YFL021W / GAT1

Transcriptional activator of genes involved in nitrogen catabolite repression; contains a GATA-1-type zinc finger DNA-binding motif; activity and localization regulated by nitrogen limitation and Ure2p

Zygosity: Homozygous strain
fixedexpanded
Profile for YFL021W / GAT1

Click on Significant Values for Screen Details ID:SGTC_69|Compound:0096-0274|FD-Score:2.96|P-value:4.18E-4 ID:SGTC_218|Compound:alverine citrate|FD-Score:3.33|P-value:8.41E-5 ID:SGTC_232|Compound:clozapine|FD-Score:3.54|P-value:3.15E-5 ID:SGTC_258|Compound:haloperidol|FD-Score:-2.84|P-value:7.51E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:-2.91|P-value:5.71E-4 ID:SGTC_371|Compound:0195-0006|FD-Score:-2.85|P-value:7.21E-4 ID:SGTC_408|Compound:cantharidin|FD-Score:2.90|P-value:5.37E-4 ID:SGTC_443|Compound:clozapine|FD-Score:3.05|P-value:2.83E-4 ID:SGTC_687|Compound:k029-0044|FD-Score:3.41|P-value:6.00E-5 ID:SGTC_716|Compound:1683-5115|FD-Score:2.83|P-value:7.00E-4 ID:SGTC_1031|Compound:k035-0009|FD-Score:3.10|P-value:2.30E-4 ID:SGTC_1034|Compound:k072-0165|FD-Score:2.91|P-value:4.97E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:-2.83|P-value:7.68E-4 ID:SGTC_1038|Compound:k292-0204|FD-Score:-3.23|P-value:1.48E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-3.65|P-value:2.20E-5 ID:SGTC_1985|Compound:st071382|FD-Score:-3.25|P-value:1.39E-4 ID:SGTC_2031|Compound:5180455|FD-Score:-3.02|P-value:3.63E-4 ID:SGTC_2046|Compound:4110841|FD-Score:4.15|P-value:1.40E-6 ID:SGTC_2311|Compound:7694451|FD-Score:2.74|P-value:9.97E-4 ID:SGTC_2364|Compound:9055074|FD-Score:-2.93|P-value:5.15E-4 ID:SGTC_2485|Compound:5633444|FD-Score:-4.18|P-value:1.42E-6 ID:SGTC_2679|Compound:rapamycin|FD-Score:-3.29|P-value:1.12E-4 ID:SGTC_2714|Compound:st079313|FD-Score:-2.83|P-value:7.77E-4 ID:SGTC_3212|Compound:9128307|FD-Score:-3.41|P-value:6.55E-5 ID:SGTC_3327|Compound:9140648|FD-Score:2.89|P-value:5.46E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:2.96|P-value:4.18E-4 ID:SGTC_218|Compound:alverine citrate|FD-Score:3.33|P-value:8.41E-5 ID:SGTC_232|Compound:clozapine|FD-Score:3.54|P-value:3.15E-5 ID:SGTC_258|Compound:haloperidol|FD-Score:-2.84|P-value:7.51E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:-2.91|P-value:5.71E-4 ID:SGTC_371|Compound:0195-0006|FD-Score:-2.85|P-value:7.21E-4 ID:SGTC_408|Compound:cantharidin|FD-Score:2.90|P-value:5.37E-4 ID:SGTC_443|Compound:clozapine|FD-Score:3.05|P-value:2.83E-4 ID:SGTC_687|Compound:k029-0044|FD-Score:3.41|P-value:6.00E-5 ID:SGTC_716|Compound:1683-5115|FD-Score:2.83|P-value:7.00E-4 ID:SGTC_1031|Compound:k035-0009|FD-Score:3.10|P-value:2.30E-4 ID:SGTC_1034|Compound:k072-0165|FD-Score:2.91|P-value:4.97E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:-2.83|P-value:7.68E-4 ID:SGTC_1038|Compound:k292-0204|FD-Score:-3.23|P-value:1.48E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-3.65|P-value:2.20E-5 ID:SGTC_1985|Compound:st071382|FD-Score:-3.25|P-value:1.39E-4 ID:SGTC_2031|Compound:5180455|FD-Score:-3.02|P-value:3.63E-4 ID:SGTC_2046|Compound:4110841|FD-Score:4.15|P-value:1.40E-6 ID:SGTC_2311|Compound:7694451|FD-Score:2.74|P-value:9.97E-4 ID:SGTC_2364|Compound:9055074|FD-Score:-2.93|P-value:5.15E-4 ID:SGTC_2485|Compound:5633444|FD-Score:-4.18|P-value:1.42E-6 ID:SGTC_2679|Compound:rapamycin|FD-Score:-3.29|P-value:1.12E-4 ID:SGTC_2714|Compound:st079313|FD-Score:-2.83|P-value:7.77E-4 ID:SGTC_3212|Compound:9128307|FD-Score:-3.41|P-value:6.55E-5 ID:SGTC_3327|Compound:9140648|FD-Score:2.89|P-value:5.46E-4

Top fitness defect scores for YFL021W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2046 4110841 4.15 106.0 µM 1.40E-6 iron homeostasis 24 1.64E-5
2 SGTC_232 clozapine 3.54 119.0 µM 3.15E-5 NEO1 82 1.96E-4
3 SGTC_687 k029-0044 3.41 34.9 µM 6.00E-5 PDR1 32 3.28E-4
4 SGTC_218 alverine citrate 3.33 93.8 µM 8.41E-5 fatty acid desaturase (OLE1) 49 4.30E-4
5 SGTC_1031 k035-0009 3.10 16.0 µM 2.30E-4 70 9.61E-4
6 SGTC_443 clozapine 3.05 122.0 µM 2.83E-4 NEO1-PIK1 24 0.00113
7 SGTC_69 0096-0274 2.96 206.7 µM 4.18E-4 mitochondrial processes 113 0.00155
8 SGTC_1034 k072-0165 2.91 12.7 µM 4.97E-4 Golgi 74 0.00178
9 SGTC_408 cantharidin 2.90 100.0 µM 5.37E-4 cell wall signaling 75 0.00189
10 SGTC_3327 9140648 2.89 26.9 µM 5.46E-4 43 0.00192
11 SGTC_716 1683-5115 2.83 658.0 µM 7.00E-4 83 0.00234
12 SGTC_2311 7694451 2.74 200.0 µM 9.97E-4 87 0.00311
13 SGTC_775 4577-0580 2.72 57.3 µM 0.00107 55 0.00330
14 SGTC_2 0422-0095 2.71 29.0 µM 0.00110 redox potentiating 29 0.00336
15 SGTC_1445 4239-0156 2.69 97.7 µM 0.00118 103 0.00357
16 SGTC_2354 9060492 2.67 162.0 µM 0.00127 98 0.00377
17 SGTC_358 0075-0058 2.64 9.4 µM 0.00142 185 0.00413
18 SGTC_1832 st054113 2.64 55.0 µM 0.00142 50 0.00414
19 SGTC_3329 9141233 2.64 27.6 µM 0.00145 81 0.00420
20 SGTC_362 0310-0100 2.62 9.0 µM 0.00153 RPP1 & pyrimidine depletion 128 0.00439

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.239 5.96E-45 YNL135C FPR1 hom Peptidyl-prolyl cis-trans isomerase (PPIase), binds to the drugs FK506 and rapamycin; also binds to the nonhistone chromatin binding protein Hmo1p and may regulate its assembly or function
0.160 1.23E-20 YGR129W SYF2 hom Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; isy1 syf2 cells have defective spindles activiating cell cycle arrest
0.123 8.89E-13 YLR444C_d YLR444C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.118 7.00E-12 YPL139C UME1 hom Negative regulator of meiosis, required for repression of a subset of meiotic genes during vegetative growth, binding of histone deacetylase Rpd3p required for activity, contains a NEE box and a WD repeat motif; homologous with Wtm1p, Wtm2p
0.117 9.46E-12 YJL102W MEF2 hom Mitochondrial elongation factor involved in translational elongation
0.115 2.33E-11 YJR016C ILV3 het Dihydroxyacid dehydratase, catalyzes third step in the common pathway leading to biosynthesis of branched-chain amino acids
0.113 4.94E-11 YIL153W RRD1 hom Peptidyl-prolyl cis/trans-isomerase; activator of the phosphotyrosyl phosphatase activity of PP2A; involved in G1 phase progression, microtubule dynamics, bud morphogenesis and DNA repair; required for rapid reduction of Sgs1p levels in response to rapamycin; subunit of the Tap42p-Sit4p-Rrd1p complex; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress
0.110 1.65E-10 YDR258C HSP78 hom Oligomeric mitochondrial matrix chaperone that cooperates with Ssc1p in mitochondrial thermotolerance after heat shock; able to prevent the aggregation of misfolded proteins as well as resolubilize protein aggregates
0.108 3.12E-10 YPR123C_d YPR123C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially/completely overlaps the verified ORF CTR
0.105 9.45E-10 YMR073C IRC21 hom Putative protein of unknown function; may be involved in resistance to carboplatin and cisplatin; null mutant displays increase in spontaneous Rad52p foci; contains a lipid-binding domain and binds cardiolipin in a large-scale study
0.103 2.13E-9 YDR140W MTQ2 hom S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; subunit of complex with Trm112p that methylates translation release factor Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; similar to E.coli PrmC
0.096 2.29E-8 YER157W COG3 het Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.096 2.78E-8 YMR096W SNZ1 hom Protein involved in vitamin B6 biosynthesis; member of a stationary phase-induced gene family; coregulated with SNO1; interacts with Sno1p and with Yhr198p, perhaps as a multiprotein complex containing other Snz and Sno proteins
0.096 2.83E-8 YNL199C GCR2 hom Transcriptional activator of genes involved in glycolysis; interacts and functions with the DNA-binding protein Gcr1p
0.096 2.86E-8 YER040W GLN3 hom Transcriptional activator of genes regulated by nitrogen catabolite repression (NCR), localization and activity regulated by quality of nitrogen source