YFL040W_p

Putative transporter, member of the sugar porter family; YFL040W is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YFL040W / YFL040W

Click on Significant Values for Screen Details ID:SGTC_281|Compound:1672-3440|FD-Score:3.29|P-value:2.26E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:3.06|P-value:5.45E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:4.25|P-value:2.73E-6 ID:SGTC_701|Compound:4424-0219|FD-Score:3.18|P-value:3.40E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:3.10|P-value:4.69E-4 ID:SGTC_762|Compound:1165-0429|FD-Score:3.10|P-value:4.77E-4 ID:SGTC_936|Compound:3005-4620|FD-Score:3.73|P-value:3.39E-5 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.88|P-value:1.72E-5 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.67|P-value:4.38E-5 ID:SGTC_1270|Compound:0831-1170|FD-Score:3.25|P-value:2.60E-4 ID:SGTC_1452|Compound:4194-0072|FD-Score:3.28|P-value:2.30E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-5.06|P-value:2.39E-8 ID:SGTC_1737|Compound:st035557|FD-Score:-4.07|P-value:5.66E-6 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:-2.89|P-value:8.95E-4 ID:SGTC_2036|Compound:5160441|FD-Score:3.77|P-value:2.85E-5 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:3.18|P-value:3.42E-4 ID:SGTC_2315|Compound:7733312|FD-Score:-3.86|P-value:1.57E-5 ID:SGTC_2342|Compound:7990637|FD-Score:2.92|P-value:9.12E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:3.14|P-value:4.03E-4 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:3.20|P-value:3.15E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:-3.47|P-value:9.01E-5 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:2.93|P-value:9.00E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:5.51|P-value:1.89E-9 ID:SGTC_2700|Compound:st077718|FD-Score:-2.96|P-value:6.90E-4 ID:SGTC_2722|Compound:naftopidil|FD-Score:3.13|P-value:4.19E-4 ID:SGTC_2773|Compound:thioridazine|FD-Score:-3.51|P-value:7.67E-5 ID:SGTC_2832|Compound:7992762|FD-Score:-3.53|P-value:7.00E-5 ID:SGTC_2848|Compound:9016370|FD-Score:-2.88|P-value:9.33E-4 ID:SGTC_2853|Compound:9015042|FD-Score:-3.59|P-value:5.22E-5 ID:SGTC_2881|Compound:9058953|FD-Score:-4.37|P-value:1.21E-6 ID:SGTC_2889|Compound:9059656|FD-Score:4.56|P-value:5.40E-7 ID:SGTC_2894|Compound:9048625|FD-Score:3.89|P-value:1.63E-5 ID:SGTC_2895|Compound:9054447|FD-Score:4.61|P-value:4.22E-7 ID:SGTC_2898|Compound:9056270|FD-Score:3.20|P-value:3.16E-4 ID:SGTC_2917|Compound:7979103|FD-Score:3.06|P-value:5.44E-4 ID:SGTC_2959|Compound:9079155|FD-Score:3.01|P-value:6.57E-4 ID:SGTC_2993|Compound:9054257|FD-Score:-3.10|P-value:3.97E-4 ID:SGTC_3012|Compound:9080433|FD-Score:3.13|P-value:4.18E-4 ID:SGTC_3108|Compound:9121785|FD-Score:3.07|P-value:5.19E-4 ID:SGTC_3159|Compound:9100096|FD-Score:-3.40|P-value:1.22E-4 ID:SGTC_3210|Compound:9128157|FD-Score:-6.13|P-value:2.08E-11 ID:SGTC_3242|Compound:9133940|FD-Score:2.94|P-value:8.74E-4 ID:SGTC_3264|Compound:9137442|FD-Score:3.00|P-value:6.97E-4 ID:SGTC_281|Compound:1672-3440|FD-Score:3.29|P-value:2.26E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:3.06|P-value:5.45E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:4.25|P-value:2.73E-6 ID:SGTC_701|Compound:4424-0219|FD-Score:3.18|P-value:3.40E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:3.10|P-value:4.69E-4 ID:SGTC_762|Compound:1165-0429|FD-Score:3.10|P-value:4.77E-4 ID:SGTC_936|Compound:3005-4620|FD-Score:3.73|P-value:3.39E-5 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.88|P-value:1.72E-5 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.67|P-value:4.38E-5 ID:SGTC_1270|Compound:0831-1170|FD-Score:3.25|P-value:2.60E-4 ID:SGTC_1452|Compound:4194-0072|FD-Score:3.28|P-value:2.30E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-5.06|P-value:2.39E-8 ID:SGTC_1737|Compound:st035557|FD-Score:-4.07|P-value:5.66E-6 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:-2.89|P-value:8.95E-4 ID:SGTC_2036|Compound:5160441|FD-Score:3.77|P-value:2.85E-5 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:3.18|P-value:3.42E-4 ID:SGTC_2315|Compound:7733312|FD-Score:-3.86|P-value:1.57E-5 ID:SGTC_2342|Compound:7990637|FD-Score:2.92|P-value:9.12E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:3.14|P-value:4.03E-4 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:3.20|P-value:3.15E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:-3.47|P-value:9.01E-5 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:2.93|P-value:9.00E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:5.51|P-value:1.89E-9 ID:SGTC_2700|Compound:st077718|FD-Score:-2.96|P-value:6.90E-4 ID:SGTC_2722|Compound:naftopidil|FD-Score:3.13|P-value:4.19E-4 ID:SGTC_2773|Compound:thioridazine|FD-Score:-3.51|P-value:7.67E-5 ID:SGTC_2832|Compound:7992762|FD-Score:-3.53|P-value:7.00E-5 ID:SGTC_2848|Compound:9016370|FD-Score:-2.88|P-value:9.33E-4 ID:SGTC_2853|Compound:9015042|FD-Score:-3.59|P-value:5.22E-5 ID:SGTC_2881|Compound:9058953|FD-Score:-4.37|P-value:1.21E-6 ID:SGTC_2889|Compound:9059656|FD-Score:4.56|P-value:5.40E-7 ID:SGTC_2894|Compound:9048625|FD-Score:3.89|P-value:1.63E-5 ID:SGTC_2895|Compound:9054447|FD-Score:4.61|P-value:4.22E-7 ID:SGTC_2898|Compound:9056270|FD-Score:3.20|P-value:3.16E-4 ID:SGTC_2917|Compound:7979103|FD-Score:3.06|P-value:5.44E-4 ID:SGTC_2959|Compound:9079155|FD-Score:3.01|P-value:6.57E-4 ID:SGTC_2993|Compound:9054257|FD-Score:-3.10|P-value:3.97E-4 ID:SGTC_3012|Compound:9080433|FD-Score:3.13|P-value:4.18E-4 ID:SGTC_3108|Compound:9121785|FD-Score:3.07|P-value:5.19E-4 ID:SGTC_3159|Compound:9100096|FD-Score:-3.40|P-value:1.22E-4 ID:SGTC_3210|Compound:9128157|FD-Score:-6.13|P-value:2.08E-11 ID:SGTC_3242|Compound:9133940|FD-Score:2.94|P-value:8.74E-4 ID:SGTC_3264|Compound:9137442|FD-Score:3.00|P-value:6.97E-4

Top fitness defect scores for YFL040W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2636 apigenin dimethyl ether 5.51 100.0 µM 1.89E-9 13 1.81E-8
2 SGTC_2895 9054447 4.61 58.4 µM 4.22E-7 3 2.04E-6
3 SGTC_2889 9059656 4.56 52.0 µM 5.40E-7 3 2.53E-6
4 SGTC_366 0181-0206 4.25 4.3 µM 2.73E-6 Golgi 31 1.05E-5
5 SGTC_2894 9048625 3.89 32.5 µM 1.63E-5 12 5.04E-5
6 SGTC_1083 didemethylchlorpromazine sulfoxide 3.88 707.4 nM 1.72E-5 redox potentiating 87 5.28E-5
7 SGTC_2036 5160441 3.77 105.0 µM 2.85E-5 NEO1 88 8.20E-5
8 SGTC_936 3005-4620 3.73 401.0 µM 3.39E-5 30 9.57E-5
9 SGTC_1132 3456-3614 3.67 2.5 µM 4.38E-5 tubulin folding & SWR complex 66 1.20E-4
10 SGTC_281 1672-3440 3.29 14.9 µM 2.26E-4 Golgi 17 5.07E-4
11 SGTC_1452 4194-0072 3.28 190.0 µM 2.30E-4 36 5.14E-4
12 SGTC_1270 0831-1170 3.25 17.3 µM 2.60E-4 30 5.72E-4
13 SGTC_2598 perillyl alcohol 3.20 100.0 µM 3.15E-4 67 6.78E-4
14 SGTC_2898 9056270 3.20 58.4 µM 3.16E-4 14 6.80E-4
15 SGTC_701 4424-0219 3.18 185.0 µM 3.40E-4 calcium & mitochondrial duress 43 7.26E-4
16 SGTC_2042 p-Dimethylaminoacetophenone 3.18 200.0 µM 3.42E-4 48 7.28E-4
17 SGTC_2563 tomatine 3.14 8.5 µM 4.03E-4 95 8.43E-4
18 SGTC_3012 9080433 3.13 71.4 µM 4.18E-4 35 8.69E-4
19 SGTC_2722 naftopidil 3.13 47.2 µM 4.19E-4 28 8.71E-4
20 SGTC_758 0868-0029 3.10 16.0 µM 4.69E-4 25 9.62E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.172 1.63E-23 YGL109W_d YGL109W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized gene YGL108C
0.154 2.89E-19 YPL251W_d YPL251W_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified, essential gene YAH1/YPL252C
0.149 6.14E-18 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.142 1.82E-16 YGR244C LSC2 hom Beta subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate
0.140 6.02E-16 YCL026C-A FRM2 hom Type II nitroreductase, using NADH as reductant; mutants are defective in fatty acid mediated repression of genes involved in fatty acid biosynthesis indicative of a role in lipid signaling; involved in the oxidative stress response; transcription induction by cadmium and selenite indicates a possible role in the metal stress response; expression induced in cells treated with the mycotoxin patulin
0.132 1.94E-14 YDR107C TMN2 hom Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn3p; member of the evolutionarily conserved Transmembrane Nine family of proteins with nine membrane-spanning segments
0.132 2.04E-14 YFL014W HSP12 hom Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension
0.129 8.77E-14 YPL252C YAH1 het Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin
0.125 4.19E-13 YOR301W RAX1 hom Protein involved in bud site selection during bipolar budding; localization requires Rax2p; has similarity to members of the insulin-related peptide superfamily
0.123 7.94E-13 YKL185W ASH1 hom Zinc-finger inhibitor of HO transcription; mRNA is localized and translated in the distal tip of anaphase cells, resulting in accumulation of Ash1p in daughter cell nuclei and inhibition of HO expression; potential Cdc28p substrate
0.123 9.90E-13 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.120 3.33E-12 YDL222C FMP45 hom Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C
0.119 5.98E-12 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.118 6.81E-12 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.115 2.46E-11 YDR431W_d YDR431W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data