YFL051C_p

Putative protein of unknown function; YFL051C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YFL051C / YFL051C

Click on Significant Values for Screen Details ID:SGTC_45|Compound:0kpi-0036|FD-Score:-3.06|P-value:5.71E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:3.12|P-value:3.32E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:5.00|P-value:2.89E-8 ID:SGTC_195|Compound:4234-0266|FD-Score:-2.96|P-value:8.21E-4 ID:SGTC_298|Compound:1391-0729|FD-Score:2.85|P-value:9.45E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:5.38|P-value:2.72E-9 ID:SGTC_400|Compound:oxethazaine|FD-Score:3.92|P-value:1.03E-5 ID:SGTC_407|Compound:eburnamonine|FD-Score:-4.35|P-value:1.75E-6 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:-3.12|P-value:4.50E-4 ID:SGTC_476|Compound:mead acid|FD-Score:-3.28|P-value:2.42E-4 ID:SGTC_500|Compound:h-89|FD-Score:3.51|P-value:6.70E-5 ID:SGTC_538|Compound:2922-0838|FD-Score:5.87|P-value:9.87E-11 ID:SGTC_939|Compound:1165-0479|FD-Score:3.60|P-value:4.53E-5 ID:SGTC_941|Compound:3237-0776|FD-Score:3.31|P-value:1.55E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:4.18|P-value:2.80E-6 ID:SGTC_1119|Compound:parthenolide|FD-Score:2.89|P-value:7.95E-4 ID:SGTC_1191|Compound:1487-1166|FD-Score:3.01|P-value:5.16E-4 ID:SGTC_1197|Compound:1601-0112|FD-Score:-2.92|P-value:9.76E-4 ID:SGTC_1201|Compound:1889-3372|FD-Score:4.11|P-value:3.99E-6 ID:SGTC_1251|Compound:0490-5699|FD-Score:3.44|P-value:8.84E-5 ID:SGTC_1383|Compound:3049-0032|FD-Score:3.03|P-value:4.83E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-4.76|P-value:1.85E-7 ID:SGTC_1463|Compound:k081-0032|FD-Score:-5.93|P-value:1.09E-10 ID:SGTC_1518|Compound:st038567|FD-Score:-3.02|P-value:6.57E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:3.03|P-value:4.76E-4 ID:SGTC_1611|Compound:st001856|FD-Score:3.90|P-value:1.12E-5 ID:SGTC_1623|Compound:st003709|FD-Score:-3.07|P-value:5.44E-4 ID:SGTC_1741|Compound:st038134|FD-Score:4.65|P-value:2.22E-7 ID:SGTC_1773|Compound:st048542|FD-Score:2.84|P-value:9.61E-4 ID:SGTC_1843|Compound:st055809|FD-Score:2.86|P-value:8.84E-4 ID:SGTC_1960|Compound:st011366|FD-Score:-2.96|P-value:8.18E-4 ID:SGTC_2007|Compound:4011539|FD-Score:-4.18|P-value:4.13E-6 ID:SGTC_2011|Compound:4012611|FD-Score:-2.91|P-value:9.95E-4 ID:SGTC_2063|Compound:5246145|FD-Score:2.97|P-value:6.05E-4 ID:SGTC_2083|Compound:5306046|FD-Score:2.84|P-value:9.59E-4 ID:SGTC_2085|Compound:5307070|FD-Score:3.04|P-value:4.54E-4 ID:SGTC_2109|Compound:5483026|FD-Score:-2.94|P-value:8.79E-4 ID:SGTC_2165|Compound:5727197|FD-Score:-4.11|P-value:5.85E-6 ID:SGTC_2259|Compound:7964009|FD-Score:-2.95|P-value:8.50E-4 ID:SGTC_2276|Compound:7947513|FD-Score:-3.06|P-value:5.63E-4 ID:SGTC_2366|Compound:9070441|FD-Score:3.30|P-value:1.64E-4 ID:SGTC_2383|Compound:9036125|FD-Score:-2.99|P-value:7.51E-4 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:4.03|P-value:5.89E-6 ID:SGTC_2415|Compound:st077333|FD-Score:3.58|P-value:4.89E-5 ID:SGTC_2448|Compound:5185112|FD-Score:-2.94|P-value:8.90E-4 ID:SGTC_2453|Compound:5731132|FD-Score:2.97|P-value:6.05E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.78|P-value:1.92E-5 ID:SGTC_3232|Compound:9132874|FD-Score:2.92|P-value:7.19E-4 ID:SGTC_3265|Compound:9137266|FD-Score:3.22|P-value:2.23E-4 ID:SGTC_45|Compound:0kpi-0036|FD-Score:-3.06|P-value:5.71E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:3.12|P-value:3.32E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:5.00|P-value:2.89E-8 ID:SGTC_195|Compound:4234-0266|FD-Score:-2.96|P-value:8.21E-4 ID:SGTC_298|Compound:1391-0729|FD-Score:2.85|P-value:9.45E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:5.38|P-value:2.72E-9 ID:SGTC_400|Compound:oxethazaine|FD-Score:3.92|P-value:1.03E-5 ID:SGTC_407|Compound:eburnamonine|FD-Score:-4.35|P-value:1.75E-6 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:-3.12|P-value:4.50E-4 ID:SGTC_476|Compound:mead acid|FD-Score:-3.28|P-value:2.42E-4 ID:SGTC_500|Compound:h-89|FD-Score:3.51|P-value:6.70E-5 ID:SGTC_538|Compound:2922-0838|FD-Score:5.87|P-value:9.87E-11 ID:SGTC_939|Compound:1165-0479|FD-Score:3.60|P-value:4.53E-5 ID:SGTC_941|Compound:3237-0776|FD-Score:3.31|P-value:1.55E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:4.18|P-value:2.80E-6 ID:SGTC_1119|Compound:parthenolide|FD-Score:2.89|P-value:7.95E-4 ID:SGTC_1191|Compound:1487-1166|FD-Score:3.01|P-value:5.16E-4 ID:SGTC_1197|Compound:1601-0112|FD-Score:-2.92|P-value:9.76E-4 ID:SGTC_1201|Compound:1889-3372|FD-Score:4.11|P-value:3.99E-6 ID:SGTC_1251|Compound:0490-5699|FD-Score:3.44|P-value:8.84E-5 ID:SGTC_1383|Compound:3049-0032|FD-Score:3.03|P-value:4.83E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-4.76|P-value:1.85E-7 ID:SGTC_1463|Compound:k081-0032|FD-Score:-5.93|P-value:1.09E-10 ID:SGTC_1518|Compound:st038567|FD-Score:-3.02|P-value:6.57E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:3.03|P-value:4.76E-4 ID:SGTC_1611|Compound:st001856|FD-Score:3.90|P-value:1.12E-5 ID:SGTC_1623|Compound:st003709|FD-Score:-3.07|P-value:5.44E-4 ID:SGTC_1741|Compound:st038134|FD-Score:4.65|P-value:2.22E-7 ID:SGTC_1773|Compound:st048542|FD-Score:2.84|P-value:9.61E-4 ID:SGTC_1843|Compound:st055809|FD-Score:2.86|P-value:8.84E-4 ID:SGTC_1960|Compound:st011366|FD-Score:-2.96|P-value:8.18E-4 ID:SGTC_2007|Compound:4011539|FD-Score:-4.18|P-value:4.13E-6 ID:SGTC_2011|Compound:4012611|FD-Score:-2.91|P-value:9.95E-4 ID:SGTC_2063|Compound:5246145|FD-Score:2.97|P-value:6.05E-4 ID:SGTC_2083|Compound:5306046|FD-Score:2.84|P-value:9.59E-4 ID:SGTC_2085|Compound:5307070|FD-Score:3.04|P-value:4.54E-4 ID:SGTC_2109|Compound:5483026|FD-Score:-2.94|P-value:8.79E-4 ID:SGTC_2165|Compound:5727197|FD-Score:-4.11|P-value:5.85E-6 ID:SGTC_2259|Compound:7964009|FD-Score:-2.95|P-value:8.50E-4 ID:SGTC_2276|Compound:7947513|FD-Score:-3.06|P-value:5.63E-4 ID:SGTC_2366|Compound:9070441|FD-Score:3.30|P-value:1.64E-4 ID:SGTC_2383|Compound:9036125|FD-Score:-2.99|P-value:7.51E-4 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:4.03|P-value:5.89E-6 ID:SGTC_2415|Compound:st077333|FD-Score:3.58|P-value:4.89E-5 ID:SGTC_2448|Compound:5185112|FD-Score:-2.94|P-value:8.90E-4 ID:SGTC_2453|Compound:5731132|FD-Score:2.97|P-value:6.05E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.78|P-value:1.92E-5 ID:SGTC_3232|Compound:9132874|FD-Score:2.92|P-value:7.19E-4 ID:SGTC_3265|Compound:9137266|FD-Score:3.22|P-value:2.23E-4

Top fitness defect scores for YFL051C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_538 2922-0838 5.87 53.3 µM 9.87E-11 Golgi 7 2.19E-9
2 SGTC_369 0957-0393 5.38 4.5 µM 2.72E-9 cell wall signaling 7 3.79E-8
3 SGTC_165 k038-0023 5.00 64.4 µM 2.89E-8 ubiquinone biosynthesis & proteasome 43 2.89E-7
4 SGTC_1741 st038134 4.65 10.2 µM 2.22E-7 16 1.67E-6
5 SGTC_1083 didemethylchlorpromazine sulfoxide 4.18 707.4 nM 2.80E-6 redox potentiating 65 1.47E-5
6 SGTC_1201 1889-3372 4.11 45.9 µM 3.99E-6 Golgi 8 2.00E-5
7 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 4.03 200.0 µM 5.89E-6 12 2.80E-5
8 SGTC_400 oxethazaine 3.92 37.5 µM 1.03E-5 calcium & mitochondrial duress 23 4.51E-5
9 SGTC_1611 st001856 3.90 99.4 µM 1.12E-5 19 4.87E-5
10 SGTC_2588 indole-3-carbinol 3.78 100.0 µM 1.92E-5 53 7.74E-5
11 SGTC_939 1165-0479 3.60 45.3 µM 4.53E-5 47 1.62E-4
12 SGTC_2415 st077333 3.58 57.7 µM 4.89E-5 69 1.73E-4
13 SGTC_500 h-89 3.51 112.0 µM 6.70E-5 cell wall signaling 43 2.27E-4
14 SGTC_1251 0490-5699 3.44 265.0 µM 8.84E-5 55 2.88E-4
15 SGTC_941 3237-0776 3.31 460.0 µM 1.55E-4 44 4.66E-4
16 SGTC_2366 9070441 3.30 60.6 µM 1.64E-4 60 4.89E-4
17 SGTC_3265 9137266 3.22 49.5 µM 2.23E-4 25 6.39E-4
18 SGTC_87 0100-0052 3.12 35.5 µM 3.32E-4 200 8.99E-4
19 SGTC_2085 5307070 3.04 144.1 µM 4.54E-4 superoxide 62 0.00118
20 SGTC_1599 8-chlro-1-tetrahydronorharmanone 3.03 90.6 µM 4.76E-4 80 0.00123

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.276 7.16E-60 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.244 6.87E-47 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.237 7.93E-44 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.237 9.31E-44 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.226 3.41E-40 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.223 3.65E-39 YDR530C APA2 hom Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase II; AP4A phosphorylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; APA2 has a paralog, APA1, that arose from the whole genome duplication
0.215 2.44E-36 YOR152C_p YOR152C_p hom Putative protein of unknown function; YOR152C is not an essential gene
0.211 6.13E-35 YDL157C_p YDL157C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.209 1.62E-34 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.209 1.65E-34 YNL218W MGS1 hom Protein with DNA-dependent ATPase and ssDNA annealing activities; involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP); forms nuclear foci upon DNA replication stress
0.208 3.16E-34 YLL054C_p YLL054C_p hom Putative protein of unknown function with similarity to Pip2p, an oleate-specific transcriptional activator of peroxisome proliferation; YLL054C is not an essential gene
0.195 5.16E-30 YPR008W HAA1 hom Transcriptional activator involved in adaptation to weak acid stress; activates transcription of TPO2, YRO2, and other genes encoding membrane stress proteins; HAA1 has a paralog, CUP2, that arose from the whole genome duplication; relocalizes from cytoplasm to nucleus upon DNA replication stress
0.191 7.93E-29 YFL014W HSP12 hom Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension
0.190 1.12E-28 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.189 1.75E-28 YMR074C YMR074C hom Protein with homology to human PDCD5; PDCD5 is involved in programmed cell death; N-terminal region forms a conserved triple-helix bundle structure; overexpression promotes H2O2-induced apoptosis; YMR074C is not an essential gene; protein abundance increases in response to DNA replication stress