YFR011C / AIM13

Mitochondrial protein peripheral to the inner membrane; component of the mitochondrial inner membrane organizing system (MINOS, MitOS, or MICOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture

Zygosity: Homozygous strain
fixedexpanded
Profile for YFR011C / AIM13

Click on Significant Values for Screen Details ID:SGTC_23|Compound:0213-0011|FD-Score:3.33|P-value:1.65E-4 ID:SGTC_441|Compound:propafenone|FD-Score:-3.70|P-value:3.33E-5 ID:SGTC_442|Compound:cape|FD-Score:4.74|P-value:1.58E-7 ID:SGTC_452|Compound:diindolylmethane|FD-Score:3.45|P-value:9.76E-5 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:3.53|P-value:7.12E-5 ID:SGTC_497|Compound:capsazepine|FD-Score:-3.00|P-value:6.08E-4 ID:SGTC_526|Compound:4469-0568|FD-Score:3.09|P-value:4.34E-4 ID:SGTC_659|Compound:k018-0002|FD-Score:5.21|P-value:9.51E-9 ID:SGTC_664|Compound:1222-0054|FD-Score:-4.06|P-value:6.15E-6 ID:SGTC_685|Compound:1278-0033|FD-Score:3.10|P-value:4.18E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:4.61|P-value:3.21E-7 ID:SGTC_769|Compound:0302-0231|FD-Score:4.06|P-value:6.04E-6 ID:SGTC_795|Compound:0685-0265|FD-Score:4.00|P-value:8.01E-6 ID:SGTC_901|Compound:1112-0062|FD-Score:3.20|P-value:2.80E-4 ID:SGTC_942|Compound:3253-1115|FD-Score:-2.91|P-value:8.69E-4 ID:SGTC_986|Compound:1493-0483|FD-Score:4.77|P-value:1.35E-7 ID:SGTC_988|Compound:1497-1057|FD-Score:4.47|P-value:7.03E-7 ID:SGTC_1093|Compound:fluphenazine|FD-Score:3.71|P-value:3.17E-5 ID:SGTC_1357|Compound:1503-1303|FD-Score:3.25|P-value:2.27E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:2.93|P-value:7.86E-4 ID:SGTC_1380|Compound:2291-0730|FD-Score:4.97|P-value:4.01E-8 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:-3.57|P-value:5.90E-5 ID:SGTC_1600|Compound:coumarin 106|FD-Score:-3.61|P-value:5.08E-5 ID:SGTC_1655|Compound:st012546|FD-Score:-2.91|P-value:8.64E-4 ID:SGTC_1670|Compound:st016595|FD-Score:4.16|P-value:3.51E-6 ID:SGTC_1762|Compound:st045503|FD-Score:-3.43|P-value:1.09E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:4.34|P-value:1.40E-6 ID:SGTC_1935|Compound:st074532|FD-Score:3.09|P-value:4.22E-4 ID:SGTC_1981|Compound:st071826|FD-Score:2.95|P-value:7.19E-4 ID:SGTC_2052|Compound:5265182|FD-Score:3.62|P-value:4.77E-5 ID:SGTC_2064|Compound:5220758|FD-Score:3.45|P-value:1.00E-4 ID:SGTC_2065|Compound:5221596|FD-Score:4.17|P-value:3.41E-6 ID:SGTC_2126|Compound:5251174|FD-Score:3.37|P-value:1.39E-4 ID:SGTC_2135|Compound:5326629|FD-Score:2.90|P-value:8.70E-4 ID:SGTC_2161|Compound:5662504|FD-Score:2.90|P-value:8.60E-4 ID:SGTC_2166|Compound:5933061|FD-Score:6.64|P-value:3.82E-13 ID:SGTC_2293|Compound:7624732|FD-Score:-3.19|P-value:2.89E-4 ID:SGTC_2294|Compound:7971431|FD-Score:3.54|P-value:6.56E-5 ID:SGTC_2396|Compound:5342950|FD-Score:-2.93|P-value:7.89E-4 ID:SGTC_2402|Compound:5553605|FD-Score:-3.99|P-value:8.33E-6 ID:SGTC_2434|Compound:5670830|FD-Score:2.99|P-value:6.34E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:3.26|P-value:2.18E-4 ID:SGTC_2602|Compound:kawain|FD-Score:2.90|P-value:8.84E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:3.48|P-value:8.71E-5 ID:SGTC_2657|Compound:nystatin|FD-Score:-4.40|P-value:1.05E-6 ID:SGTC_2661|Compound:dactinomycin|FD-Score:-3.04|P-value:5.31E-4 ID:SGTC_2700|Compound:st077718|FD-Score:3.24|P-value:2.34E-4 ID:SGTC_2727|Compound:riluzole|FD-Score:-3.36|P-value:1.44E-4 ID:SGTC_3141|Compound:9094609|FD-Score:2.97|P-value:6.66E-4 ID:SGTC_3308|Compound:9128332|FD-Score:4.34|P-value:1.42E-6 ID:SGTC_3332|Compound:9141069|FD-Score:-3.15|P-value:3.39E-4 ID:SGTC_3351|Compound:9150312|FD-Score:3.56|P-value:6.01E-5 ID:SGTC_23|Compound:0213-0011|FD-Score:3.33|P-value:1.65E-4 ID:SGTC_441|Compound:propafenone|FD-Score:-3.70|P-value:3.33E-5 ID:SGTC_442|Compound:cape|FD-Score:4.74|P-value:1.58E-7 ID:SGTC_452|Compound:diindolylmethane|FD-Score:3.45|P-value:9.76E-5 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:3.53|P-value:7.12E-5 ID:SGTC_497|Compound:capsazepine|FD-Score:-3.00|P-value:6.08E-4 ID:SGTC_526|Compound:4469-0568|FD-Score:3.09|P-value:4.34E-4 ID:SGTC_659|Compound:k018-0002|FD-Score:5.21|P-value:9.51E-9 ID:SGTC_664|Compound:1222-0054|FD-Score:-4.06|P-value:6.15E-6 ID:SGTC_685|Compound:1278-0033|FD-Score:3.10|P-value:4.18E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:4.61|P-value:3.21E-7 ID:SGTC_769|Compound:0302-0231|FD-Score:4.06|P-value:6.04E-6 ID:SGTC_795|Compound:0685-0265|FD-Score:4.00|P-value:8.01E-6 ID:SGTC_901|Compound:1112-0062|FD-Score:3.20|P-value:2.80E-4 ID:SGTC_942|Compound:3253-1115|FD-Score:-2.91|P-value:8.69E-4 ID:SGTC_986|Compound:1493-0483|FD-Score:4.77|P-value:1.35E-7 ID:SGTC_988|Compound:1497-1057|FD-Score:4.47|P-value:7.03E-7 ID:SGTC_1093|Compound:fluphenazine|FD-Score:3.71|P-value:3.17E-5 ID:SGTC_1357|Compound:1503-1303|FD-Score:3.25|P-value:2.27E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:2.93|P-value:7.86E-4 ID:SGTC_1380|Compound:2291-0730|FD-Score:4.97|P-value:4.01E-8 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:-3.57|P-value:5.90E-5 ID:SGTC_1600|Compound:coumarin 106|FD-Score:-3.61|P-value:5.08E-5 ID:SGTC_1655|Compound:st012546|FD-Score:-2.91|P-value:8.64E-4 ID:SGTC_1670|Compound:st016595|FD-Score:4.16|P-value:3.51E-6 ID:SGTC_1762|Compound:st045503|FD-Score:-3.43|P-value:1.09E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:4.34|P-value:1.40E-6 ID:SGTC_1935|Compound:st074532|FD-Score:3.09|P-value:4.22E-4 ID:SGTC_1981|Compound:st071826|FD-Score:2.95|P-value:7.19E-4 ID:SGTC_2052|Compound:5265182|FD-Score:3.62|P-value:4.77E-5 ID:SGTC_2064|Compound:5220758|FD-Score:3.45|P-value:1.00E-4 ID:SGTC_2065|Compound:5221596|FD-Score:4.17|P-value:3.41E-6 ID:SGTC_2126|Compound:5251174|FD-Score:3.37|P-value:1.39E-4 ID:SGTC_2135|Compound:5326629|FD-Score:2.90|P-value:8.70E-4 ID:SGTC_2161|Compound:5662504|FD-Score:2.90|P-value:8.60E-4 ID:SGTC_2166|Compound:5933061|FD-Score:6.64|P-value:3.82E-13 ID:SGTC_2293|Compound:7624732|FD-Score:-3.19|P-value:2.89E-4 ID:SGTC_2294|Compound:7971431|FD-Score:3.54|P-value:6.56E-5 ID:SGTC_2396|Compound:5342950|FD-Score:-2.93|P-value:7.89E-4 ID:SGTC_2402|Compound:5553605|FD-Score:-3.99|P-value:8.33E-6 ID:SGTC_2434|Compound:5670830|FD-Score:2.99|P-value:6.34E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:3.26|P-value:2.18E-4 ID:SGTC_2602|Compound:kawain|FD-Score:2.90|P-value:8.84E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:3.48|P-value:8.71E-5 ID:SGTC_2657|Compound:nystatin|FD-Score:-4.40|P-value:1.05E-6 ID:SGTC_2661|Compound:dactinomycin|FD-Score:-3.04|P-value:5.31E-4 ID:SGTC_2700|Compound:st077718|FD-Score:3.24|P-value:2.34E-4 ID:SGTC_2727|Compound:riluzole|FD-Score:-3.36|P-value:1.44E-4 ID:SGTC_3141|Compound:9094609|FD-Score:2.97|P-value:6.66E-4 ID:SGTC_3308|Compound:9128332|FD-Score:4.34|P-value:1.42E-6 ID:SGTC_3332|Compound:9141069|FD-Score:-3.15|P-value:3.39E-4 ID:SGTC_3351|Compound:9150312|FD-Score:3.56|P-value:6.01E-5

Top fitness defect scores for YFR011C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2166 5933061 6.64 31.5 µM 3.82E-13 tubulin folding & SWR complex 11 1.52E-11
2 SGTC_659 k018-0002 5.21 107.0 µM 9.51E-9 6 9.44E-8
3 SGTC_1380 2291-0730 4.97 164.0 µM 4.01E-8 7 3.27E-7
4 SGTC_986 1493-0483 4.77 84.0 µM 1.35E-7 6 9.30E-7
5 SGTC_442 cape 4.74 100.0 µM 1.58E-7 4 1.07E-6
6 SGTC_743 1275-0778 4.61 158.0 µM 3.21E-7 excess fatty acid 25 1.97E-6
7 SGTC_988 1497-1057 4.47 103.0 µM 7.03E-7 5 3.88E-6
8 SGTC_1787 fluconazole 4.34 80.0 µM 1.40E-6 iron homeostasis 17 7.06E-6
9 SGTC_3308 9128332 4.34 17.6 µM 1.42E-6 plasma membrane duress 65 7.15E-6
10 SGTC_2065 5221596 4.17 34.3 µM 3.41E-6 10 1.52E-5
11 SGTC_1670 st016595 4.16 4.0 µM 3.51E-6 8 1.56E-5
12 SGTC_769 0302-0231 4.06 76.0 µM 6.04E-6 36 2.50E-5
13 SGTC_795 0685-0265 4.00 78.0 µM 8.01E-6 excess fatty acid 25 3.19E-5
14 SGTC_1093 fluphenazine 3.71 8.0 µM 3.17E-5 20 1.05E-4
15 SGTC_2052 5265182 3.62 7.1 µM 4.77E-5 41 1.49E-4
16 SGTC_3351 9150312 3.56 21.6 µM 6.01E-5 cell wall 44 1.82E-4
17 SGTC_2294 7971431 3.54 200.0 µM 6.56E-5 23 1.97E-4
18 SGTC_454 lyso-paf C-16 3.53 6.7 µM 7.12E-5 33 2.11E-4
19 SGTC_2603 homopterocarpin 3.48 100.0 µM 8.71E-5 64 2.52E-4
20 SGTC_452 diindolylmethane 3.45 8.0 µM 9.76E-5 RNA processing & uracil transport 20 2.78E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.153 4.24E-19 YMR115W MGR3 hom Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr1p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA
0.141 2.74E-16 YDR479C PEX29 hom Peroxisomal integral membrane peroxin; involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p; forms ER foci upon DNA replication stress
0.110 1.59E-10 YDR438W THI74 hom Mitochondrial transporter repressible by thiamine; THI74 has a paralog, YML018C, that arose from the whole genome duplication
0.104 1.40E-9 YNL011C_p YNL011C_p hom Putative protein of unknown function; YNL011C is not an essential gene
0.101 4.97E-9 YOR045W TOM6 hom Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex
0.099 8.63E-9 YLL026W HSP104 hom Disaggregase; heat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p (Hsp70) to refold and reactivate previously denatured, aggregated proteins; responsive to stresses including: heat, ethanol, and sodium arsenite; involved in [PSI+] propagation; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress
0.095 3.24E-8 YLR324W PEX30 hom Peroxisomal integral membrane protein, involved in negative regulation of peroxisome number; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p
0.095 4.01E-8 YCL044C MGR1 hom Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr3p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA
0.091 1.38E-7 YBR093C PHO5 hom Repressible acid phosphatase (1 of 3) that also mediates extracellular nucleotide-derived phosphate hydrolysis; secretory pathway derived cell surface glycoprotein; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2
0.088 3.48E-7 YOL134C_d YOL134C_d het Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps HRT1, a verified gene that encodes an SCF ubiquitin ligase subunit
0.087 4.94E-7 YLL001W DNM1 hom Dynamin-related GTPase required for mitochondrial fission and morphology; assembles on the cytoplasmic face of mitochondrial tubules at sites at which division will occur; also participates in endocytosis and regulating peroxisome abundance
0.086 6.89E-7 YML131W YML131W hom Protein of unknown function; similar to medium chain dehydrogenase/reductases; expression induced by stresses including osmotic shock, DNA damaging agents, and other chemicals; GFP-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress
0.083 1.45E-6 YJL125C GCD14 het Subunit of tRNA (1-methyladenosine) methyltransferase, with Gcd10p, required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression
0.082 1.88E-6 YOR003W YSP3 hom Putative precursor to the subtilisin-like protease III
0.081 2.29E-6 YNL057W_d YNL057W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data