YFR016C

Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and bud; interacts with Spa2p; YFL016C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YFR016C / YFR016C

Click on Significant Values for Screen Details ID:SGTC_148|Compound:3253-0744|FD-Score:-3.01|P-value:1.43E-4 ID:SGTC_220|Compound:paclitaxel|FD-Score:-2.59|P-value:9.09E-4 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:2.62|P-value:7.95E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:2.93|P-value:2.05E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:2.73|P-value:4.94E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:-2.83|P-value:3.23E-4 ID:SGTC_522|Compound:1273-0010|FD-Score:3.49|P-value:1.34E-5 ID:SGTC_610|Compound:4215-0184|FD-Score:3.02|P-value:1.37E-4 ID:SGTC_742|Compound:0kpi-0133|FD-Score:2.85|P-value:2.93E-4 ID:SGTC_826|Compound:1683-5028|FD-Score:2.93|P-value:2.13E-4 ID:SGTC_866|Compound:0495-0101|FD-Score:-3.16|P-value:7.29E-5 ID:SGTC_870|Compound:0573-2213|FD-Score:-2.73|P-value:5.06E-4 ID:SGTC_879|Compound:0831-1030|FD-Score:-3.38|P-value:2.33E-5 ID:SGTC_927|Compound:2425-1185|FD-Score:-3.09|P-value:9.77E-5 ID:SGTC_1169|Compound:aniline yellow|FD-Score:2.98|P-value:1.68E-4 ID:SGTC_1642|Compound:st009582|FD-Score:2.75|P-value:4.57E-4 ID:SGTC_1650|Compound:st011916|FD-Score:3.14|P-value:7.81E-5 ID:SGTC_1724|Compound:st037281|FD-Score:-3.58|P-value:8.14E-6 ID:SGTC_1732|Compound:st034308|FD-Score:-3.39|P-value:2.27E-5 ID:SGTC_1751|Compound:st044839|FD-Score:3.30|P-value:3.46E-5 ID:SGTC_1760|Compound:st045453|FD-Score:2.68|P-value:6.35E-4 ID:SGTC_1854|Compound:st056233|FD-Score:2.61|P-value:8.25E-4 ID:SGTC_2391|Compound:6285546|FD-Score:2.60|P-value:8.63E-4 ID:SGTC_2504|Compound:purpurogallin|FD-Score:2.63|P-value:7.60E-4 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:2.91|P-value:2.31E-4 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:-3.60|P-value:7.16E-6 ID:SGTC_2807|Compound:7945238|FD-Score:3.99|P-value:7.63E-7 ID:SGTC_2808|Compound:7946468|FD-Score:3.81|P-value:2.20E-6 ID:SGTC_2813|Compound:7971799|FD-Score:-5.32|P-value:7.40E-11 ID:SGTC_2931|Compound:9014674|FD-Score:-3.28|P-value:3.98E-5 ID:SGTC_3026|Compound:9090633|FD-Score:-2.71|P-value:5.46E-4 ID:SGTC_3046|Compound:9092212|FD-Score:-3.25|P-value:4.52E-5 ID:SGTC_3051|Compound:9093778|FD-Score:-3.81|P-value:2.28E-6 ID:SGTC_3053|Compound:9095903|FD-Score:-4.51|P-value:2.84E-8 ID:SGTC_3060|Compound:1327-0027|FD-Score:3.70|P-value:4.14E-6 ID:SGTC_3069|Compound:9117009|FD-Score:2.97|P-value:1.72E-4 ID:SGTC_148|Compound:3253-0744|FD-Score:-3.01|P-value:1.43E-4 ID:SGTC_220|Compound:paclitaxel|FD-Score:-2.59|P-value:9.09E-4 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:2.62|P-value:7.95E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:2.93|P-value:2.05E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:2.73|P-value:4.94E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:-2.83|P-value:3.23E-4 ID:SGTC_522|Compound:1273-0010|FD-Score:3.49|P-value:1.34E-5 ID:SGTC_610|Compound:4215-0184|FD-Score:3.02|P-value:1.37E-4 ID:SGTC_742|Compound:0kpi-0133|FD-Score:2.85|P-value:2.93E-4 ID:SGTC_826|Compound:1683-5028|FD-Score:2.93|P-value:2.13E-4 ID:SGTC_866|Compound:0495-0101|FD-Score:-3.16|P-value:7.29E-5 ID:SGTC_870|Compound:0573-2213|FD-Score:-2.73|P-value:5.06E-4 ID:SGTC_879|Compound:0831-1030|FD-Score:-3.38|P-value:2.33E-5 ID:SGTC_927|Compound:2425-1185|FD-Score:-3.09|P-value:9.77E-5 ID:SGTC_1169|Compound:aniline yellow|FD-Score:2.98|P-value:1.68E-4 ID:SGTC_1642|Compound:st009582|FD-Score:2.75|P-value:4.57E-4 ID:SGTC_1650|Compound:st011916|FD-Score:3.14|P-value:7.81E-5 ID:SGTC_1724|Compound:st037281|FD-Score:-3.58|P-value:8.14E-6 ID:SGTC_1732|Compound:st034308|FD-Score:-3.39|P-value:2.27E-5 ID:SGTC_1751|Compound:st044839|FD-Score:3.30|P-value:3.46E-5 ID:SGTC_1760|Compound:st045453|FD-Score:2.68|P-value:6.35E-4 ID:SGTC_1854|Compound:st056233|FD-Score:2.61|P-value:8.25E-4 ID:SGTC_2391|Compound:6285546|FD-Score:2.60|P-value:8.63E-4 ID:SGTC_2504|Compound:purpurogallin|FD-Score:2.63|P-value:7.60E-4 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:2.91|P-value:2.31E-4 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:-3.60|P-value:7.16E-6 ID:SGTC_2807|Compound:7945238|FD-Score:3.99|P-value:7.63E-7 ID:SGTC_2808|Compound:7946468|FD-Score:3.81|P-value:2.20E-6 ID:SGTC_2813|Compound:7971799|FD-Score:-5.32|P-value:7.40E-11 ID:SGTC_2931|Compound:9014674|FD-Score:-3.28|P-value:3.98E-5 ID:SGTC_3026|Compound:9090633|FD-Score:-2.71|P-value:5.46E-4 ID:SGTC_3046|Compound:9092212|FD-Score:-3.25|P-value:4.52E-5 ID:SGTC_3051|Compound:9093778|FD-Score:-3.81|P-value:2.28E-6 ID:SGTC_3053|Compound:9095903|FD-Score:-4.51|P-value:2.84E-8 ID:SGTC_3060|Compound:1327-0027|FD-Score:3.70|P-value:4.14E-6 ID:SGTC_3069|Compound:9117009|FD-Score:2.97|P-value:1.72E-4

Top fitness defect scores for YFR016C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2807 7945238 3.99 52.0 µM 7.63E-7 21 3.27E-5
2 SGTC_2808 7946468 3.81 45.5 µM 2.20E-6 28 6.88E-5
3 SGTC_3060 1327-0027 3.70 12.5 µM 4.14E-6 43 1.07E-4
4 SGTC_522 1273-0010 3.49 11.6 µM 1.34E-5 60S ribosome export 35 2.44E-4
5 SGTC_1751 st044839 3.30 27.2 µM 3.46E-5 Golgi 23 4.76E-4
6 SGTC_1650 st011916 3.14 45.8 µM 7.81E-5 32 8.47E-4
7 SGTC_610 4215-0184 3.02 155.0 µM 1.37E-4 exosome 44 0.00126
8 SGTC_1169 aniline yellow 2.98 25.8 µM 1.68E-4 41 0.00145
9 SGTC_3069 9117009 2.97 49.5 µM 1.72E-4 60S ribosome export 30 0.00148
10 SGTC_268 camptothecin 2.93 39.6 µM 2.05E-4 DNA damage response 151 0.00168
11 SGTC_826 1683-5028 2.93 118.0 µM 2.13E-4 57 0.00172
12 SGTC_2519 cryptotanshinone 2.91 88.0 µM 2.31E-4 heme biosynthesis & mitochondrial translocase 50 0.00182
13 SGTC_742 0kpi-0133 2.85 140.0 µM 2.93E-4 ERG2 70 0.00215
14 SGTC_1642 st009582 2.75 77.7 µM 4.57E-4 RPP1 & pyrimidine depletion 74 0.00295
15 SGTC_366 0181-0206 2.73 4.3 µM 4.94E-4 Golgi 116 0.00312
16 SGTC_1760 st045453 2.68 10.4 µM 6.35E-4 NEO1-PIK1 211 0.00373
17 SGTC_2504 purpurogallin 2.63 52.3 µM 7.60E-4 RPP1 & pyrimidine depletion 92 0.00424
18 SGTC_243 5hr heat shock (37°C) + splitomicin 2.62 1.0 µM 7.95E-4 heat shock/prefoldin 161 0.00438
19 SGTC_1854 st056233 2.61 32.9 µM 8.25E-4 amide catabolism 88 0.00449
20 SGTC_2391 6285546 2.60 200.0 µM 8.63E-4 115 0.00464

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.121 2.00E-12 YIL088C AVT7 hom Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
0.114 3.55E-11 YDL157C_p YDL157C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.112 8.14E-11 YBR129C OPY1 hom Protein of unknown function, overproduction blocks cell cycle arrest in the presence of mating pheromone; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.112 8.37E-11 YNR039C ZRG17 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Msc2p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; zinc-regulated directly through Zap1p; transcription induced under conditions of zinc deficiency
0.110 1.58E-10 YPL263C KEL3 hom Cytoplasmic protein of unknown function
0.102 3.65E-9 YAL068C PAU8 hom Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions
0.097 1.65E-8 YGR211W ZPR1 het Essential protein with two zinc fingers; present in the nucleus of growing cells but relocates to the cytoplasm in starved cells via a process mediated by Cpr1p; binds to translation elongation factor eEF-1 (Tef1p); relative distribution to the nucleus increases upon DNA replication stress
0.097 1.84E-8 YOR288C MPD1 hom Member of the protein disulfide isomerase (PDI) family; interacts with and inhibits the chaperone activity of Cne1p; MPD1 overexpression in a pdi1 null mutant suppresses defects in Pdi1p functions such as carboxypeptidase Y maturation
0.091 1.21E-7 YOR329C SCD5 het Protein required for normal actin organization and endocytosis; targeting subunit for protein phosphatase type 1; undergoes Crm1p-dependent nuclear-cytoplasmic shuttling; multicopy suppressor of clathrin deficiency
0.089 2.49E-7 YCL076W_d YCL076W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.088 3.22E-7 YGR067C_p YGR067C_p hom Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p
0.088 3.42E-7 YJL042W MHP1 hom Microtubule-associated protein involved in assembly and stabilization of microtubules; overproduction results in cell cycle arrest at G2 phase; similar to Drosophila protein MAP and to mammalian MAP4 proteins
0.087 4.37E-7 YLR097C HRT3 hom Putative SCF-ubiquitin ligase F-box protein, based on both genetic and physical interactions and sequence similarity; identified in association with Cdc53p, Skp1p and Ubi4 in large and small-scale studies
0.087 4.70E-7 YAL017W PSK1 hom PAS domain-containing serine/threonine protein kinase; coordinately regulates protein synthesis and carbohydrate metabolism and storage in response to a unknown metabolite that reflects nutritional status; PSK1 has a paralog, PSK2, that arose from the whole genome duplication
0.086 5.47E-7 YJR127C RSF2 hom Zinc-finger protein; involved in transcriptional control of both nuclear and mitochondrial genes, many of which specify products required for glycerol-based growth, respiration, and other functions; RSF2 has a paralog, TDA9, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasm upon DNA replication stress