YFR018C_p

Putative protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YFR018C / YFR018C

Click on Significant Values for Screen Details ID:SGTC_49|Compound:0717-0965|FD-Score:3.51|P-value:1.43E-4 ID:SGTC_61|Compound:0978-8327|FD-Score:-3.69|P-value:7.52E-5 ID:SGTC_64|Compound:000l-0018|FD-Score:3.59|P-value:1.01E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:-4.12|P-value:1.14E-5 ID:SGTC_78|Compound:0336-0123|FD-Score:-3.29|P-value:3.70E-4 ID:SGTC_244|Compound:nsc-207895|FD-Score:-3.38|P-value:2.59E-4 ID:SGTC_277|Compound:nystatin|FD-Score:3.06|P-value:7.70E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:-3.30|P-value:3.56E-4 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:4.28|P-value:4.88E-6 ID:SGTC_481|Compound:bay k-8644|FD-Score:3.06|P-value:7.80E-4 ID:SGTC_485|Compound:niflumic acid|FD-Score:-3.12|P-value:6.93E-4 ID:SGTC_529|Compound:4076-0302|FD-Score:3.16|P-value:5.29E-4 ID:SGTC_1079|Compound:idarubicin|FD-Score:3.58|P-value:1.09E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-4.34|P-value:4.17E-6 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.13|P-value:6.60E-4 ID:SGTC_1121|Compound:fusaric acid|FD-Score:-5.75|P-value:1.72E-9 ID:SGTC_1124|Compound:fisetin|FD-Score:5.23|P-value:3.35E-8 ID:SGTC_1127|Compound:asiatic acid|FD-Score:3.35|P-value:2.60E-4 ID:SGTC_1137|Compound:ixabepilone|FD-Score:5.43|P-value:1.05E-8 ID:SGTC_1369|Compound:1866-0067|FD-Score:3.25|P-value:3.82E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:-3.91|P-value:3.05E-5 ID:SGTC_1377|Compound:2944-0135|FD-Score:-3.19|P-value:5.38E-4 ID:SGTC_1570|Compound:verbenone|FD-Score:3.30|P-value:3.15E-4 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:3.10|P-value:6.58E-4 ID:SGTC_1594|Compound:piperine|FD-Score:-3.48|P-value:1.77E-4 ID:SGTC_1915|Compound:st067105|FD-Score:4.07|P-value:1.30E-5 ID:SGTC_1917|Compound:st066507|FD-Score:3.39|P-value:2.24E-4 ID:SGTC_2034|Compound:5197015|FD-Score:-3.40|P-value:2.39E-4 ID:SGTC_2094|Compound:5332512|FD-Score:4.01|P-value:1.70E-5 ID:SGTC_2096|Compound:5468907|FD-Score:3.62|P-value:8.92E-5 ID:SGTC_2102|Compound:5377816|FD-Score:4.51|P-value:1.59E-6 ID:SGTC_2103|Compound:5378138|FD-Score:3.53|P-value:1.30E-4 ID:SGTC_2657|Compound:nystatin|FD-Score:5.04|P-value:9.87E-8 ID:SGTC_2729|Compound:fluphenazine|FD-Score:-3.04|P-value:9.00E-4 ID:SGTC_3058|Compound:9093861|FD-Score:3.05|P-value:7.95E-4 ID:SGTC_3268|Compound:9137683|FD-Score:4.21|P-value:6.71E-6 ID:SGTC_3271|Compound:9137798|FD-Score:-3.31|P-value:3.48E-4 ID:SGTC_3277|Compound:9138724|FD-Score:-3.66|P-value:8.53E-5 ID:SGTC_49|Compound:0717-0965|FD-Score:3.51|P-value:1.43E-4 ID:SGTC_61|Compound:0978-8327|FD-Score:-3.69|P-value:7.52E-5 ID:SGTC_64|Compound:000l-0018|FD-Score:3.59|P-value:1.01E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:-4.12|P-value:1.14E-5 ID:SGTC_78|Compound:0336-0123|FD-Score:-3.29|P-value:3.70E-4 ID:SGTC_244|Compound:nsc-207895|FD-Score:-3.38|P-value:2.59E-4 ID:SGTC_277|Compound:nystatin|FD-Score:3.06|P-value:7.70E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:-3.30|P-value:3.56E-4 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:4.28|P-value:4.88E-6 ID:SGTC_481|Compound:bay k-8644|FD-Score:3.06|P-value:7.80E-4 ID:SGTC_485|Compound:niflumic acid|FD-Score:-3.12|P-value:6.93E-4 ID:SGTC_529|Compound:4076-0302|FD-Score:3.16|P-value:5.29E-4 ID:SGTC_1079|Compound:idarubicin|FD-Score:3.58|P-value:1.09E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-4.34|P-value:4.17E-6 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.13|P-value:6.60E-4 ID:SGTC_1121|Compound:fusaric acid|FD-Score:-5.75|P-value:1.72E-9 ID:SGTC_1124|Compound:fisetin|FD-Score:5.23|P-value:3.35E-8 ID:SGTC_1127|Compound:asiatic acid|FD-Score:3.35|P-value:2.60E-4 ID:SGTC_1137|Compound:ixabepilone|FD-Score:5.43|P-value:1.05E-8 ID:SGTC_1369|Compound:1866-0067|FD-Score:3.25|P-value:3.82E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:-3.91|P-value:3.05E-5 ID:SGTC_1377|Compound:2944-0135|FD-Score:-3.19|P-value:5.38E-4 ID:SGTC_1570|Compound:verbenone|FD-Score:3.30|P-value:3.15E-4 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:3.10|P-value:6.58E-4 ID:SGTC_1594|Compound:piperine|FD-Score:-3.48|P-value:1.77E-4 ID:SGTC_1915|Compound:st067105|FD-Score:4.07|P-value:1.30E-5 ID:SGTC_1917|Compound:st066507|FD-Score:3.39|P-value:2.24E-4 ID:SGTC_2034|Compound:5197015|FD-Score:-3.40|P-value:2.39E-4 ID:SGTC_2094|Compound:5332512|FD-Score:4.01|P-value:1.70E-5 ID:SGTC_2096|Compound:5468907|FD-Score:3.62|P-value:8.92E-5 ID:SGTC_2102|Compound:5377816|FD-Score:4.51|P-value:1.59E-6 ID:SGTC_2103|Compound:5378138|FD-Score:3.53|P-value:1.30E-4 ID:SGTC_2657|Compound:nystatin|FD-Score:5.04|P-value:9.87E-8 ID:SGTC_2729|Compound:fluphenazine|FD-Score:-3.04|P-value:9.00E-4 ID:SGTC_3058|Compound:9093861|FD-Score:3.05|P-value:7.95E-4 ID:SGTC_3268|Compound:9137683|FD-Score:4.21|P-value:6.71E-6 ID:SGTC_3271|Compound:9137798|FD-Score:-3.31|P-value:3.48E-4 ID:SGTC_3277|Compound:9138724|FD-Score:-3.66|P-value:8.53E-5

Top fitness defect scores for YFR018C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1137 ixabepilone 5.43 100.0 µM 1.05E-8 8 2.89E-8
2 SGTC_1124 fisetin 5.23 1.2 µM 3.35E-8 11 8.63E-8
3 SGTC_2657 nystatin 5.04 74.4 µM 9.87E-8 3 2.39E-7
4 SGTC_2102 5377816 4.51 72.8 µM 1.59E-6 13 3.27E-6
5 SGTC_392 N-ethylmaleimide 4.28 8.3 µM 4.88E-6 RNA pol III & RNase P/MRP 9 9.40E-6
6 SGTC_3268 9137683 4.21 49.5 µM 6.71E-6 7 1.27E-5
7 SGTC_1915 st067105 4.07 30.6 µM 1.30E-5 RNA pol III & RNase P/MRP 40 2.37E-5
8 SGTC_2094 5332512 4.01 191.7 µM 1.70E-5 22 3.05E-5
9 SGTC_2096 5468907 3.62 200.0 µM 8.92E-5 14 1.45E-4
10 SGTC_64 000l-0018 3.59 272.1 µM 1.01E-4 ubiquinone biosynthesis & proteasome 173 1.63E-4
11 SGTC_1079 idarubicin 3.58 2.4 µM 1.09E-4 DNA damage response 30 1.75E-4
12 SGTC_2103 5378138 3.53 10.0 µM 1.30E-4 27 2.06E-4
13 SGTC_49 0717-0965 3.51 32.1 µM 1.43E-4 60S ribosome export 37 2.27E-4
14 SGTC_1917 st066507 3.39 28.5 µM 2.24E-4 Golgi 69 3.46E-4
15 SGTC_1127 asiatic acid 3.35 681.4 nM 2.60E-4 43 3.97E-4
16 SGTC_1570 verbenone 3.30 133.0 µM 3.15E-4 33 4.77E-4
17 SGTC_1369 1866-0067 3.25 208.0 µM 3.82E-4 RPP1 & pyrimidine depletion 68 5.72E-4
18 SGTC_529 4076-0302 3.16 30.3 µM 5.29E-4 mitochondrial processes 41 7.76E-4
19 SGTC_1584 6-fluoro-dl-tryptophan 3.10 90.0 µM 6.58E-4 mitochondrial processes 49 9.53E-4
20 SGTC_277 nystatin 3.06 15.5 µM 7.70E-4 59 0.00111

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.166 3.85E-22 YKL131W_d YKL131W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.136 2.08E-15 YLR414C PUN1 hom Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress
0.125 4.40E-13 YDL110C TMA17 hom Protein of unknown function that associates with ribosomes; heterozygous deletion demonstrated increases in chromosome instability in a rad9 deletion background; protein abundance is decreased upon intracellular iron depletion
0.104 1.76E-9 YKR065C PAM17 hom Constituent of the TIM23 complex; proposed alternatively to be a component of the import motor (PAM complex) or to interact with and modulate the core TIM23 (Translocase of the Inner mitochondrial Membrane) complex; protein abundance increases in response to DNA replication stress
0.100 5.85E-9 YLR348C DIC1 hom Mitochondrial dicarboxylate carrier, integral membrane protein, catalyzes a dicarboxylate-phosphate exchange across the inner mitochondrial membrane, transports cytoplasmic dicarboxylates into the mitochondrial matrix
0.099 9.98E-9 YLR205C HMX1 hom ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
0.097 1.79E-8 YMR244C-A COA6 hom Protein involved in cytochrome c oxidase assembly; also required for efficient formation of respiratory supercomplexes comprised of Complexes III and IV; localizes to the mitochondrial intermembrane space; has a human homolog; transcription is induced in response to the DNA-damaging agent MMS; protein abundance increases in response to DNA replication stress
0.094 4.63E-8 YDR110W FOB1 hom Nucleolar protein that binds the rDNA replication fork barrier (RFB) site; required for replication fork blocking, recombinational hotspot activity, condensin recruitment to RFB and rDNA repeat segregation; related to retroviral integrases
0.093 6.04E-8 YLR291C GCD7 het Beta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
0.092 1.08E-7 YDR225W HTA1 hom Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical subtypes (see also HTA2); DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p
0.092 1.12E-7 YOL147C PEX11 hom Peroxisomal membrane protein required for medium-chain fatty acid oxidation and peroxisome proliferation, possibly by inducing membrane curvature; localization regulated by phosphorylation; transcription regulated by Adr1p and Pip2p-Oaf1p
0.091 1.25E-7 YOR252W TMA16 hom Protein of unknown function that associates with ribosomes
0.091 1.30E-7 YLR088W GAA1 het Subunit of the GPI (glycosylphosphatidylinositol):protein transamidase complex, removes the GPI-anchoring signal and attaches GPI to proteins in the ER
0.091 1.37E-7 YDL242W_d YDL242W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.090 1.90E-7 YJL122W ALB1 hom Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit; interacts directly with Arx1p; responsible for Tif6p recycling defects in absence of Rei1p