YFR025C / HIS2

Histidinolphosphatase, catalyzes the eighth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control

Zygosity: Homozygous strain
fixedexpanded
Profile for YFR025C / HIS2

Click on Significant Values for Screen Details ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:-3.13|P-value:5.99E-4 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:2.93|P-value:8.79E-4 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:-3.12|P-value:6.35E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:-4.24|P-value:5.35E-6 ID:SGTC_545|Compound:4218-0007|FD-Score:-4.08|P-value:1.17E-5 ID:SGTC_555|Compound:4296-0685|FD-Score:-4.02|P-value:1.54E-5 ID:SGTC_851|Compound:0394-0702|FD-Score:3.03|P-value:6.21E-4 ID:SGTC_882|Compound:0843-0131|FD-Score:3.18|P-value:3.52E-4 ID:SGTC_1038|Compound:k292-0204|FD-Score:-3.07|P-value:7.60E-4 ID:SGTC_1092|Compound:toremifene|FD-Score:-4.13|P-value:9.37E-6 ID:SGTC_1133|Compound:3473-0247|FD-Score:-3.04|P-value:8.56E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:2.90|P-value:9.84E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:4.24|P-value:3.42E-6 ID:SGTC_1262|Compound:0737-0114|FD-Score:3.58|P-value:6.86E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.57|P-value:1.11E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.29|P-value:3.40E-4 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:-3.61|P-value:9.18E-5 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:-3.58|P-value:1.06E-4 ID:SGTC_1865|Compound:st057639|FD-Score:-3.20|P-value:4.74E-4 ID:SGTC_1868|Compound:st057644|FD-Score:-3.40|P-value:2.15E-4 ID:SGTC_1878|Compound:temozolomide|FD-Score:3.08|P-value:5.04E-4 ID:SGTC_1958|Compound:st076513|FD-Score:-3.96|P-value:2.04E-5 ID:SGTC_1978|Compound:st071761|FD-Score:-4.24|P-value:5.48E-6 ID:SGTC_1979|Compound:st071809|FD-Score:3.27|P-value:2.44E-4 ID:SGTC_1984|Compound:st072354|FD-Score:-6.23|P-value:4.40E-11 ID:SGTC_1986|Compound:st071812|FD-Score:-3.03|P-value:8.61E-4 ID:SGTC_1989|Compound:st071868|FD-Score:3.31|P-value:2.07E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-3.06|P-value:7.95E-4 ID:SGTC_2303|Compound:7774051|FD-Score:2.93|P-value:8.68E-4 ID:SGTC_2304|Compound:7443016|FD-Score:-3.10|P-value:6.91E-4 ID:SGTC_2306|Compound:7482397|FD-Score:-3.72|P-value:5.89E-5 ID:SGTC_2342|Compound:7990637|FD-Score:5.79|P-value:4.42E-10 ID:SGTC_2346|Compound:9031566|FD-Score:4.73|P-value:2.66E-7 ID:SGTC_2350|Compound:9023895|FD-Score:3.11|P-value:4.54E-4 ID:SGTC_2379|Compound:9035213|FD-Score:3.28|P-value:2.41E-4 ID:SGTC_2424|Compound:5537928|FD-Score:-3.30|P-value:3.21E-4 ID:SGTC_2453|Compound:5731132|FD-Score:2.92|P-value:9.01E-4 ID:SGTC_2483|Compound:5729050|FD-Score:3.35|P-value:1.79E-4 ID:SGTC_2780|Compound:5215298|FD-Score:4.00|P-value:1.07E-5 ID:SGTC_2831|Compound:7999036|FD-Score:4.80|P-value:1.79E-7 ID:SGTC_3154|Compound:9100113|FD-Score:-3.62|P-value:9.07E-5 ID:SGTC_3159|Compound:9100096|FD-Score:-4.32|P-value:3.67E-6 ID:SGTC_3208|Compound:9114115|FD-Score:-5.10|P-value:5.57E-8 ID:SGTC_3209|Compound:9113616|FD-Score:3.05|P-value:5.62E-4 ID:SGTC_3300|Compound:9124615|FD-Score:3.49|P-value:1.02E-4 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:-3.13|P-value:5.99E-4 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:2.93|P-value:8.79E-4 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:-3.12|P-value:6.35E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:-4.24|P-value:5.35E-6 ID:SGTC_545|Compound:4218-0007|FD-Score:-4.08|P-value:1.17E-5 ID:SGTC_555|Compound:4296-0685|FD-Score:-4.02|P-value:1.54E-5 ID:SGTC_851|Compound:0394-0702|FD-Score:3.03|P-value:6.21E-4 ID:SGTC_882|Compound:0843-0131|FD-Score:3.18|P-value:3.52E-4 ID:SGTC_1038|Compound:k292-0204|FD-Score:-3.07|P-value:7.60E-4 ID:SGTC_1092|Compound:toremifene|FD-Score:-4.13|P-value:9.37E-6 ID:SGTC_1133|Compound:3473-0247|FD-Score:-3.04|P-value:8.56E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:2.90|P-value:9.84E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:4.24|P-value:3.42E-6 ID:SGTC_1262|Compound:0737-0114|FD-Score:3.58|P-value:6.86E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.57|P-value:1.11E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.29|P-value:3.40E-4 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:-3.61|P-value:9.18E-5 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:-3.58|P-value:1.06E-4 ID:SGTC_1865|Compound:st057639|FD-Score:-3.20|P-value:4.74E-4 ID:SGTC_1868|Compound:st057644|FD-Score:-3.40|P-value:2.15E-4 ID:SGTC_1878|Compound:temozolomide|FD-Score:3.08|P-value:5.04E-4 ID:SGTC_1958|Compound:st076513|FD-Score:-3.96|P-value:2.04E-5 ID:SGTC_1978|Compound:st071761|FD-Score:-4.24|P-value:5.48E-6 ID:SGTC_1979|Compound:st071809|FD-Score:3.27|P-value:2.44E-4 ID:SGTC_1984|Compound:st072354|FD-Score:-6.23|P-value:4.40E-11 ID:SGTC_1986|Compound:st071812|FD-Score:-3.03|P-value:8.61E-4 ID:SGTC_1989|Compound:st071868|FD-Score:3.31|P-value:2.07E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-3.06|P-value:7.95E-4 ID:SGTC_2303|Compound:7774051|FD-Score:2.93|P-value:8.68E-4 ID:SGTC_2304|Compound:7443016|FD-Score:-3.10|P-value:6.91E-4 ID:SGTC_2306|Compound:7482397|FD-Score:-3.72|P-value:5.89E-5 ID:SGTC_2342|Compound:7990637|FD-Score:5.79|P-value:4.42E-10 ID:SGTC_2346|Compound:9031566|FD-Score:4.73|P-value:2.66E-7 ID:SGTC_2350|Compound:9023895|FD-Score:3.11|P-value:4.54E-4 ID:SGTC_2379|Compound:9035213|FD-Score:3.28|P-value:2.41E-4 ID:SGTC_2424|Compound:5537928|FD-Score:-3.30|P-value:3.21E-4 ID:SGTC_2453|Compound:5731132|FD-Score:2.92|P-value:9.01E-4 ID:SGTC_2483|Compound:5729050|FD-Score:3.35|P-value:1.79E-4 ID:SGTC_2780|Compound:5215298|FD-Score:4.00|P-value:1.07E-5 ID:SGTC_2831|Compound:7999036|FD-Score:4.80|P-value:1.79E-7 ID:SGTC_3154|Compound:9100113|FD-Score:-3.62|P-value:9.07E-5 ID:SGTC_3159|Compound:9100096|FD-Score:-4.32|P-value:3.67E-6 ID:SGTC_3208|Compound:9114115|FD-Score:-5.10|P-value:5.57E-8 ID:SGTC_3209|Compound:9113616|FD-Score:3.05|P-value:5.62E-4 ID:SGTC_3300|Compound:9124615|FD-Score:3.49|P-value:1.02E-4

Top fitness defect scores for YFR025C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2342 7990637 5.79 118.9 µM 4.42E-10 RNA processing & uracil transport 6 3.52E-9
2 SGTC_2831 7999036 4.80 19.5 µM 1.79E-7 22 7.93E-7
3 SGTC_2346 9031566 4.73 143.8 µM 2.66E-7 Golgi 9 1.13E-6
4 SGTC_1257 0669-0121 4.24 16.0 µM 3.42E-6 19 1.13E-5
5 SGTC_2780 5215298 4.00 71.4 µM 1.07E-5 34 3.17E-5
6 SGTC_1262 0737-0114 3.58 49.6 µM 6.86E-5 31 1.69E-4
7 SGTC_3300 9124615 3.49 50.5 µM 1.02E-4 33 2.42E-4
8 SGTC_2483 5729050 3.35 27.2 µM 1.79E-4 45 4.03E-4
9 SGTC_1989 st071868 3.31 50.2 µM 2.07E-4 25 4.58E-4
10 SGTC_2379 9035213 3.28 200.0 µM 2.41E-4 48 5.26E-4
11 SGTC_1979 st071809 3.27 45.3 µM 2.44E-4 RPP1 & pyrimidine depletion 39 5.32E-4
12 SGTC_882 0843-0131 3.18 351.0 µM 3.52E-4 38 7.39E-4
13 SGTC_2350 9023895 3.11 38.9 µM 4.54E-4 ergosterol biosynthesis 65 9.30E-4
14 SGTC_1878 temozolomide 3.08 1.0 mM 5.04E-4 36 0.00102
15 SGTC_3209 9113616 3.05 49.5 µM 5.62E-4 77 0.00113
16 SGTC_851 0394-0702 3.03 453.0 µM 6.21E-4 mitochondrial processes 37 0.00123
17 SGTC_2303 7774051 2.93 200.0 µM 8.68E-4 60 0.00167
18 SGTC_261 5-fluorouridine 2.93 15.4 µM 8.79E-4 exosome 63 0.00169
19 SGTC_2453 5731132 2.92 22.2 µM 9.01E-4 81 0.00173
20 SGTC_1255 0566-0045 2.90 221.0 µM 9.84E-4 excess fatty acid 88 0.00187

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.166 5.42E-22 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.162 4.28E-21 YKR061W KTR2 hom Mannosyltransferase involved in N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; KTR2 has a paralog, YUR1, that arose from the whole genome duplication
0.156 1.01E-19 YLR457C NBP1 het Spindle pole body (SPB) component; required for the insertion of the duplication plaque into the nuclear membrane during SPB duplication; essential for bipolar spindle formation; component of the Mps2p-Bbp1p complex; NBP1 has a paralog, YPR174C, that arose from the whole genome duplication
0.145 3.56E-17 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.143 1.06E-16 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.142 1.13E-16 YCR089W FIG2 hom Cell wall adhesin, expressed specifically during mating; may be involved in maintenance of cell wall integrity during mating
0.142 1.12E-16 YDR459C PFA5 hom Palmitoyltransferase with autoacylation activity; likely functions in pathway(s) outside Ras; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain
0.140 4.04E-16 YMR182W-A_p YMR182W-A_p hom Putative protein of unknown function
0.133 1.24E-14 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.131 2.61E-14 YCL026C-A FRM2 hom Type II nitroreductase, using NADH as reductant; mutants are defective in fatty acid mediated repression of genes involved in fatty acid biosynthesis indicative of a role in lipid signaling; involved in the oxidative stress response; transcription induction by cadmium and selenite indicates a possible role in the metal stress response; expression induced in cells treated with the mycotoxin patulin
0.131 2.60E-14 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.131 2.93E-14 YLR179C YLR179C hom Protein of unknown function with similarity to Tfs1p; transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus
0.131 3.15E-14 YBR274W CHK1 hom Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase
0.129 6.21E-14 YMR322C_p SNO4_p hom Possible chaperone and cysteine protease, similar to bacterial Hsp31 and yeast Hsp31p, Hsp32p, and Hsp33p; DJ-1/ThiJ/PfpI superfamily member; predicted involvement in pyridoxine metabolism; induced by mild heat stress and copper deprivation
0.128 1.06E-13 YDL091C UBX3 hom Subunit of the DSC ubiquitin ligase complex; UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; ortholog of fission yeast Ucp10