YFR031C-A / RPL2A

Ribosomal 60S subunit protein L2A; homologous to mammalian ribosomal protein L2 and bacterial L2; RPL2A has a paralog, RPL2B, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YFR031C-A / RPL2A

Click on Significant Values for Screen Details ID:SGTC_50|Compound:0929-0078|FD-Score:-3.60|P-value:1.24E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:3.33|P-value:3.48E-4 ID:SGTC_152|Compound:4469-0003|FD-Score:3.61|P-value:1.21E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:-3.23|P-value:5.06E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:-3.18|P-value:5.96E-4 ID:SGTC_500|Compound:h-89|FD-Score:-3.88|P-value:3.84E-5 ID:SGTC_543|Compound:3844-1095|FD-Score:3.06|P-value:9.28E-4 ID:SGTC_647|Compound:0140-0236|FD-Score:3.39|P-value:2.76E-4 ID:SGTC_707|Compound:0865-0008|FD-Score:3.05|P-value:9.51E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:3.10|P-value:8.05E-4 ID:SGTC_791|Compound:1348-1292|FD-Score:3.13|P-value:7.31E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:3.10|P-value:8.15E-4 ID:SGTC_896|Compound:0964-0007|FD-Score:3.08|P-value:8.53E-4 ID:SGTC_917|Compound:harmaline|FD-Score:-4.48|P-value:2.54E-6 ID:SGTC_951|Compound:1171-0579|FD-Score:-4.34|P-value:4.91E-6 ID:SGTC_1027|Compound:k015-0025|FD-Score:4.22|P-value:8.63E-6 ID:SGTC_1072|Compound:oxiconazole|FD-Score:-3.25|P-value:4.75E-4 ID:SGTC_1294|Compound:1000-1494|FD-Score:3.19|P-value:5.81E-4 ID:SGTC_1345|Compound:1488-0192|FD-Score:3.85|P-value:4.46E-5 ID:SGTC_1375|Compound:2910-0797|FD-Score:3.12|P-value:7.48E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:3.44|P-value:2.31E-4 ID:SGTC_1441|Compound:4106-0040|FD-Score:4.60|P-value:1.45E-6 ID:SGTC_1547|Compound:harmine|FD-Score:-3.26|P-value:4.57E-4 ID:SGTC_1562|Compound:morin hydrate|FD-Score:3.13|P-value:7.16E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:4.11|P-value:1.46E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.07|P-value:8.91E-4 ID:SGTC_1754|Compound:st042065|FD-Score:-3.04|P-value:9.97E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-4.02|P-value:2.15E-5 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:3.46|P-value:2.16E-4 ID:SGTC_1901|Compound:st060216|FD-Score:-3.35|P-value:3.21E-4 ID:SGTC_1907|Compound:st060210|FD-Score:3.31|P-value:3.78E-4 ID:SGTC_2085|Compound:5307070|FD-Score:-3.23|P-value:4.95E-4 ID:SGTC_2113|Compound:5491891|FD-Score:3.07|P-value:8.94E-4 ID:SGTC_2122|Compound:5258151|FD-Score:3.34|P-value:3.40E-4 ID:SGTC_2165|Compound:5727197|FD-Score:-3.48|P-value:1.98E-4 ID:SGTC_2166|Compound:5933061|FD-Score:-3.58|P-value:1.31E-4 ID:SGTC_2194|Compound:5927483|FD-Score:-3.44|P-value:2.34E-4 ID:SGTC_2218|Compound:6965428|FD-Score:-3.04|P-value:9.88E-4 ID:SGTC_2239|Compound:6685329|FD-Score:4.36|P-value:4.61E-6 ID:SGTC_2332|Compound:7982454|FD-Score:-3.10|P-value:8.08E-4 ID:SGTC_2336|Compound:9001819|FD-Score:-3.81|P-value:5.12E-5 ID:SGTC_2339|Compound:9000433|FD-Score:-5.81|P-value:1.61E-9 ID:SGTC_2373|Compound:9071805|FD-Score:3.41|P-value:2.59E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:3.36|P-value:3.11E-4 ID:SGTC_2480|Compound:5767542|FD-Score:3.09|P-value:8.19E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:3.82|P-value:5.12E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.52|P-value:1.69E-4 ID:SGTC_2601|Compound:securinine|FD-Score:3.19|P-value:5.96E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:3.26|P-value:4.48E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:-3.13|P-value:7.25E-4 ID:SGTC_2639|Compound:lactacystin|FD-Score:3.32|P-value:3.63E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.25|P-value:7.78E-6 ID:SGTC_2781|Compound:5567276|FD-Score:3.91|P-value:3.51E-5 ID:SGTC_2785|Compound:7756463|FD-Score:6.10|P-value:2.67E-10 ID:SGTC_2887|Compound:9044784|FD-Score:-3.72|P-value:7.54E-5 ID:SGTC_2958|Compound:9077254|FD-Score:3.29|P-value:4.08E-4 ID:SGTC_2959|Compound:9079155|FD-Score:-5.08|P-value:1.15E-7 ID:SGTC_2997|Compound:9067075|FD-Score:-3.71|P-value:7.89E-5 ID:SGTC_3027|Compound:9089541|FD-Score:3.17|P-value:6.30E-4 ID:SGTC_3067|Compound:9117431|FD-Score:3.90|P-value:3.58E-5 ID:SGTC_3147|Compound:9097027|FD-Score:5.02|P-value:1.62E-7 ID:SGTC_3152|Compound:9099253|FD-Score:-8.17|P-value:4.40E-17 ID:SGTC_3154|Compound:9100113|FD-Score:-4.60|P-value:1.40E-6 ID:SGTC_3181|Compound:9108277|FD-Score:3.08|P-value:8.63E-4 ID:SGTC_3225|Compound:9130819|FD-Score:3.70|P-value:8.46E-5 ID:SGTC_3255|Compound:9139072|FD-Score:3.05|P-value:9.69E-4 ID:SGTC_3295|Compound:9122362|FD-Score:-4.83|P-value:4.28E-7 ID:SGTC_3347|Compound:9188721|FD-Score:4.01|P-value:2.20E-5 ID:SGTC_50|Compound:0929-0078|FD-Score:-3.60|P-value:1.24E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:3.33|P-value:3.48E-4 ID:SGTC_152|Compound:4469-0003|FD-Score:3.61|P-value:1.21E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:-3.23|P-value:5.06E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:-3.18|P-value:5.96E-4 ID:SGTC_500|Compound:h-89|FD-Score:-3.88|P-value:3.84E-5 ID:SGTC_543|Compound:3844-1095|FD-Score:3.06|P-value:9.28E-4 ID:SGTC_647|Compound:0140-0236|FD-Score:3.39|P-value:2.76E-4 ID:SGTC_707|Compound:0865-0008|FD-Score:3.05|P-value:9.51E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:3.10|P-value:8.05E-4 ID:SGTC_791|Compound:1348-1292|FD-Score:3.13|P-value:7.31E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:3.10|P-value:8.15E-4 ID:SGTC_896|Compound:0964-0007|FD-Score:3.08|P-value:8.53E-4 ID:SGTC_917|Compound:harmaline|FD-Score:-4.48|P-value:2.54E-6 ID:SGTC_951|Compound:1171-0579|FD-Score:-4.34|P-value:4.91E-6 ID:SGTC_1027|Compound:k015-0025|FD-Score:4.22|P-value:8.63E-6 ID:SGTC_1072|Compound:oxiconazole|FD-Score:-3.25|P-value:4.75E-4 ID:SGTC_1294|Compound:1000-1494|FD-Score:3.19|P-value:5.81E-4 ID:SGTC_1345|Compound:1488-0192|FD-Score:3.85|P-value:4.46E-5 ID:SGTC_1375|Compound:2910-0797|FD-Score:3.12|P-value:7.48E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:3.44|P-value:2.31E-4 ID:SGTC_1441|Compound:4106-0040|FD-Score:4.60|P-value:1.45E-6 ID:SGTC_1547|Compound:harmine|FD-Score:-3.26|P-value:4.57E-4 ID:SGTC_1562|Compound:morin hydrate|FD-Score:3.13|P-value:7.16E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:4.11|P-value:1.46E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.07|P-value:8.91E-4 ID:SGTC_1754|Compound:st042065|FD-Score:-3.04|P-value:9.97E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-4.02|P-value:2.15E-5 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:3.46|P-value:2.16E-4 ID:SGTC_1901|Compound:st060216|FD-Score:-3.35|P-value:3.21E-4 ID:SGTC_1907|Compound:st060210|FD-Score:3.31|P-value:3.78E-4 ID:SGTC_2085|Compound:5307070|FD-Score:-3.23|P-value:4.95E-4 ID:SGTC_2113|Compound:5491891|FD-Score:3.07|P-value:8.94E-4 ID:SGTC_2122|Compound:5258151|FD-Score:3.34|P-value:3.40E-4 ID:SGTC_2165|Compound:5727197|FD-Score:-3.48|P-value:1.98E-4 ID:SGTC_2166|Compound:5933061|FD-Score:-3.58|P-value:1.31E-4 ID:SGTC_2194|Compound:5927483|FD-Score:-3.44|P-value:2.34E-4 ID:SGTC_2218|Compound:6965428|FD-Score:-3.04|P-value:9.88E-4 ID:SGTC_2239|Compound:6685329|FD-Score:4.36|P-value:4.61E-6 ID:SGTC_2332|Compound:7982454|FD-Score:-3.10|P-value:8.08E-4 ID:SGTC_2336|Compound:9001819|FD-Score:-3.81|P-value:5.12E-5 ID:SGTC_2339|Compound:9000433|FD-Score:-5.81|P-value:1.61E-9 ID:SGTC_2373|Compound:9071805|FD-Score:3.41|P-value:2.59E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:3.36|P-value:3.11E-4 ID:SGTC_2480|Compound:5767542|FD-Score:3.09|P-value:8.19E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:3.82|P-value:5.12E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.52|P-value:1.69E-4 ID:SGTC_2601|Compound:securinine|FD-Score:3.19|P-value:5.96E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:3.26|P-value:4.48E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:-3.13|P-value:7.25E-4 ID:SGTC_2639|Compound:lactacystin|FD-Score:3.32|P-value:3.63E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.25|P-value:7.78E-6 ID:SGTC_2781|Compound:5567276|FD-Score:3.91|P-value:3.51E-5 ID:SGTC_2785|Compound:7756463|FD-Score:6.10|P-value:2.67E-10 ID:SGTC_2887|Compound:9044784|FD-Score:-3.72|P-value:7.54E-5 ID:SGTC_2958|Compound:9077254|FD-Score:3.29|P-value:4.08E-4 ID:SGTC_2959|Compound:9079155|FD-Score:-5.08|P-value:1.15E-7 ID:SGTC_2997|Compound:9067075|FD-Score:-3.71|P-value:7.89E-5 ID:SGTC_3027|Compound:9089541|FD-Score:3.17|P-value:6.30E-4 ID:SGTC_3067|Compound:9117431|FD-Score:3.90|P-value:3.58E-5 ID:SGTC_3147|Compound:9097027|FD-Score:5.02|P-value:1.62E-7 ID:SGTC_3152|Compound:9099253|FD-Score:-8.17|P-value:4.40E-17 ID:SGTC_3154|Compound:9100113|FD-Score:-4.60|P-value:1.40E-6 ID:SGTC_3181|Compound:9108277|FD-Score:3.08|P-value:8.63E-4 ID:SGTC_3225|Compound:9130819|FD-Score:3.70|P-value:8.46E-5 ID:SGTC_3255|Compound:9139072|FD-Score:3.05|P-value:9.69E-4 ID:SGTC_3295|Compound:9122362|FD-Score:-4.83|P-value:4.28E-7 ID:SGTC_3347|Compound:9188721|FD-Score:4.01|P-value:2.20E-5

Top fitness defect scores for YFR031C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2785 7756463 6.10 72.7 µM 2.67E-10 3 5.29E-10
2 SGTC_3147 9097027 5.02 49.5 µM 1.62E-7 8 2.57E-7
3 SGTC_1441 4106-0040 4.60 13.0 µM 1.45E-6 5 2.14E-6
4 SGTC_2239 6685329 4.36 187.6 µM 4.61E-6 18 6.57E-6
5 SGTC_2688 kanamycin b 4.25 96.7 µM 7.78E-6 calcium & mitochondrial duress 330 1.09E-5
6 SGTC_1027 k015-0025 4.22 8.7 µM 8.63E-6 21 1.20E-5
7 SGTC_1631 benzylvanillin 4.11 81.9 µM 1.46E-5 Golgi 22 2.00E-5
8 SGTC_3347 9188721 4.01 44.7 µM 2.20E-5 22 2.98E-5
9 SGTC_2781 5567276 3.91 71.4 µM 3.51E-5 50 4.68E-5
10 SGTC_3067 9117431 3.90 49.5 µM 3.58E-5 10 4.76E-5
11 SGTC_1345 1488-0192 3.85 31.4 µM 4.46E-5 17 5.89E-5
12 SGTC_2566 crystal violet carbinol 3.82 226.0 nM 5.12E-5 43 6.74E-5
13 SGTC_3225 9130819 3.70 49.5 µM 8.46E-5 amide catabolism 35 1.09E-4
14 SGTC_152 4469-0003 3.61 551.2 µM 1.21E-4 30 1.55E-4
15 SGTC_1869 3',7'-dimethoxyflavone 3.46 40.3 µM 2.16E-4 40 2.70E-4
16 SGTC_1401 3807-4679 3.44 7.6 µM 2.31E-4 tubulin folding & SWR complex 31 2.89E-4
17 SGTC_2373 9071805 3.41 200.0 µM 2.59E-4 27 3.23E-4
18 SGTC_647 0140-0236 3.39 81.0 µM 2.76E-4 21 3.43E-4
19 SGTC_2405 ticlatone 3.36 3.5 µM 3.11E-4 96 3.86E-4
20 SGTC_2122 5258151 3.34 111.7 µM 3.40E-4 43 4.20E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.161 6.81E-21 YLL045C RPL8B hom Ribosomal 60S subunit protein L8B; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8B has a paralog, RPL8A, that arose from the whole genome duplication
0.147 1.17E-17 YDL082W RPL13A hom Ribosomal 60S subunit protein L13A; not essential for viability; homologous to mammalian ribosomal protein L13, no bacterial homolog; RPL13A has a paralog, RPL13B, that arose from the whole genome duplication
0.145 4.03E-17 YEL054C RPL12A hom Ribosomal 60S subunit protein L12A; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12A has a paralog, RPL12B, that arose from the whole genome duplication
0.127 1.84E-13 YDR417C_d YDR417C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RPL12B/YDR418W
0.118 6.71E-12 YLR184W_d YLR184W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.118 8.22E-12 YHL033C RPL8A hom Ribosomal 60S subunit protein L8A; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8A has a paralog, RPL8B, that arose from the whole genome duplication
0.116 1.93E-11 YNL067W RPL9B hom Ribosomal 60S subunit protein L9B; nearly identical to paralog Rpl9Ap; homologous to mammalian ribosomal protein L9 and bacterial L6
0.115 3.03E-11 YBR084C-A RPL19A hom Ribosomal 60S subunit protein L19A; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal; homologous to mammalian ribosomal protein L19, no bacterial homolog; RPL19A has a paralog, RPL19B, that arose from the whole genome duplication
0.113 4.98E-11 YDL052C SLC1 hom 1-acyl-sn-glycerol-3-phosphate acyltransferase, catalyzes the acylation of lysophosphatidic acid to form phosphatidic acid, a key intermediate in lipid metabolism; enzymatic activity detected in lipid particles and microsomes
0.113 5.16E-11 YBR191W RPL21A hom Ribosomal 60S subunit protein L21A; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21A has a paralog, RPL21B, that arose from the whole genome duplication
0.112 7.44E-11 YDR447C RPS17B hom Ribosomal protein 51 (rp51) of the small (40s) subunit; homologous to mammalian ribosomal protein S17, no bacterial homolog; RPS17B has a paralog, RPS17A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.111 1.14E-10 YLR367W RPS22B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22B has a paralog, RPS22A, that arose from the whole genome duplication
0.110 1.94E-10 YPL131W RPL5 het Ribosomal 60S subunit protein L5; homologous to mammalian ribosomal protein L5 and bacterial L18; binds 5S rRNA and is required for 60S subunit assembly
0.110 2.00E-10 YBR287W_p YBR287W_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER; YBR287W is not an essential gene
0.106 8.04E-10 YOR282W_d YOR282W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C