YFR032C-A / RPL29

Ribosomal 60S subunit protein L29; not essential for translation, but required for proper joining of large and small ribosomal subunits and for normal translation rate; homologous to mammalian ribosomal protein L29, no bacterial homolog

Zygosity: Homozygous strain
fixedexpanded
Profile for YFR032C-A / RPL29

Click on Significant Values for Screen Details ID:SGTC_65|Compound:0798-0905|FD-Score:3.46|P-value:2.88E-4 ID:SGTC_76|Compound:0433-0009|FD-Score:-3.13|P-value:9.10E-4 ID:SGTC_88|Compound:0180-0332|FD-Score:4.07|P-value:2.52E-5 ID:SGTC_99|Compound:0109-0120|FD-Score:3.53|P-value:2.23E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:4.61|P-value:2.22E-6 ID:SGTC_160|Compound:3453-0671|FD-Score:5.62|P-value:1.11E-8 ID:SGTC_170|Compound:4197-0004|FD-Score:-3.78|P-value:8.24E-5 ID:SGTC_190|Compound:3970-0790|FD-Score:3.14|P-value:8.75E-4 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:9.39|P-value:4.13E-21 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:3.99|P-value:3.62E-5 ID:SGTC_518|Compound:1021-0119|FD-Score:4.46|P-value:4.56E-6 ID:SGTC_552|Compound:k242-0005|FD-Score:3.72|P-value:1.06E-4 ID:SGTC_564|Compound:3555-0129|FD-Score:3.40|P-value:3.51E-4 ID:SGTC_732|Compound:3970-1727|FD-Score:3.79|P-value:8.04E-5 ID:SGTC_881|Compound:0833-0569|FD-Score:3.16|P-value:8.30E-4 ID:SGTC_882|Compound:0843-0131|FD-Score:3.14|P-value:9.00E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:3.16|P-value:8.40E-4 ID:SGTC_991|Compound:3996-0057|FD-Score:4.00|P-value:3.40E-5 ID:SGTC_997|Compound:3996-0078|FD-Score:4.97|P-value:3.81E-7 ID:SGTC_1055|Compound:3448-0672|FD-Score:-3.91|P-value:4.80E-5 ID:SGTC_1056|Compound:3448-1962|FD-Score:-3.46|P-value:2.86E-4 ID:SGTC_1112|Compound:tnp00069|FD-Score:-3.31|P-value:4.80E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:4.59|P-value:2.44E-6 ID:SGTC_1446|Compound:4239-0190|FD-Score:3.54|P-value:2.12E-4 ID:SGTC_1467|Compound:k284-1082|FD-Score:-3.57|P-value:1.86E-4 ID:SGTC_1472|Compound:k841-0093|FD-Score:3.38|P-value:3.82E-4 ID:SGTC_1676|Compound:st018489|FD-Score:3.25|P-value:5.98E-4 ID:SGTC_1733|Compound:st037357|FD-Score:3.46|P-value:2.88E-4 ID:SGTC_1771|Compound:st048882|FD-Score:4.42|P-value:5.34E-6 ID:SGTC_1775|Compound:st081588|FD-Score:3.17|P-value:7.87E-4 ID:SGTC_1851|Compound:st056236|FD-Score:3.60|P-value:1.70E-4 ID:SGTC_1854|Compound:st056233|FD-Score:-3.51|P-value:2.31E-4 ID:SGTC_1936|Compound:st074407|FD-Score:-5.22|P-value:9.68E-8 ID:SGTC_2035|Compound:5154463|FD-Score:3.21|P-value:6.93E-4 ID:SGTC_2068|Compound:5226020|FD-Score:3.88|P-value:5.55E-5 ID:SGTC_2088|Compound:5278280|FD-Score:3.13|P-value:9.14E-4 ID:SGTC_2099|Compound:5377090|FD-Score:-3.34|P-value:4.39E-4 ID:SGTC_2117|Compound:5521686|FD-Score:3.73|P-value:1.01E-4 ID:SGTC_2132|Compound:5317594|FD-Score:5.42|P-value:3.34E-8 ID:SGTC_2135|Compound:5326629|FD-Score:3.40|P-value:3.52E-4 ID:SGTC_2136|Compound:5328288|FD-Score:3.70|P-value:1.14E-4 ID:SGTC_2175|Compound:5807670|FD-Score:3.11|P-value:9.66E-4 ID:SGTC_2176|Compound:5809774|FD-Score:5.25|P-value:8.80E-8 ID:SGTC_2184|Compound:6075246|FD-Score:4.33|P-value:8.12E-6 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-3.13|P-value:8.94E-4 ID:SGTC_2291|Compound:7917025|FD-Score:3.23|P-value:6.60E-4 ID:SGTC_2373|Compound:9071805|FD-Score:3.47|P-value:2.80E-4 ID:SGTC_2381|Compound:9035592|FD-Score:3.16|P-value:8.15E-4 ID:SGTC_2382|Compound:9035899|FD-Score:5.02|P-value:2.93E-7 ID:SGTC_2405|Compound:ticlatone|FD-Score:-4.97|P-value:3.70E-7 ID:SGTC_2408|Compound:sulbentine|FD-Score:-3.99|P-value:3.54E-5 ID:SGTC_2412|Compound:st077135|FD-Score:12.30|P-value:1.04E-34 ID:SGTC_2419|Compound:paclitaxel|FD-Score:-3.67|P-value:1.25E-4 ID:SGTC_2431|Compound:5490079|FD-Score:3.18|P-value:7.84E-4 ID:SGTC_2435|Compound:5706476|FD-Score:4.39|P-value:6.26E-6 ID:SGTC_2455|Compound:5377712|FD-Score:3.71|P-value:1.12E-4 ID:SGTC_2461|Compound:5755302|FD-Score:3.72|P-value:1.05E-4 ID:SGTC_2700|Compound:st077718|FD-Score:-3.34|P-value:4.31E-4 ID:SGTC_2722|Compound:naftopidil|FD-Score:-3.18|P-value:7.71E-4 ID:SGTC_2903|Compound:5923464|FD-Score:4.02|P-value:3.07E-5 ID:SGTC_2994|Compound:9053520|FD-Score:3.10|P-value:9.99E-4 ID:SGTC_3000|Compound:9075062|FD-Score:3.72|P-value:1.08E-4 ID:SGTC_3033|Compound:9090887|FD-Score:3.40|P-value:3.55E-4 ID:SGTC_3037|Compound:9091026|FD-Score:-3.91|P-value:4.92E-5 ID:SGTC_3059|Compound:1327-0034|FD-Score:3.48|P-value:2.61E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-3.19|P-value:7.44E-4 ID:SGTC_3195|Compound:9113082|FD-Score:6.70|P-value:1.28E-11 ID:SGTC_65|Compound:0798-0905|FD-Score:3.46|P-value:2.88E-4 ID:SGTC_76|Compound:0433-0009|FD-Score:-3.13|P-value:9.10E-4 ID:SGTC_88|Compound:0180-0332|FD-Score:4.07|P-value:2.52E-5 ID:SGTC_99|Compound:0109-0120|FD-Score:3.53|P-value:2.23E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:4.61|P-value:2.22E-6 ID:SGTC_160|Compound:3453-0671|FD-Score:5.62|P-value:1.11E-8 ID:SGTC_170|Compound:4197-0004|FD-Score:-3.78|P-value:8.24E-5 ID:SGTC_190|Compound:3970-0790|FD-Score:3.14|P-value:8.75E-4 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:9.39|P-value:4.13E-21 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:3.99|P-value:3.62E-5 ID:SGTC_518|Compound:1021-0119|FD-Score:4.46|P-value:4.56E-6 ID:SGTC_552|Compound:k242-0005|FD-Score:3.72|P-value:1.06E-4 ID:SGTC_564|Compound:3555-0129|FD-Score:3.40|P-value:3.51E-4 ID:SGTC_732|Compound:3970-1727|FD-Score:3.79|P-value:8.04E-5 ID:SGTC_881|Compound:0833-0569|FD-Score:3.16|P-value:8.30E-4 ID:SGTC_882|Compound:0843-0131|FD-Score:3.14|P-value:9.00E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:3.16|P-value:8.40E-4 ID:SGTC_991|Compound:3996-0057|FD-Score:4.00|P-value:3.40E-5 ID:SGTC_997|Compound:3996-0078|FD-Score:4.97|P-value:3.81E-7 ID:SGTC_1055|Compound:3448-0672|FD-Score:-3.91|P-value:4.80E-5 ID:SGTC_1056|Compound:3448-1962|FD-Score:-3.46|P-value:2.86E-4 ID:SGTC_1112|Compound:tnp00069|FD-Score:-3.31|P-value:4.80E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:4.59|P-value:2.44E-6 ID:SGTC_1446|Compound:4239-0190|FD-Score:3.54|P-value:2.12E-4 ID:SGTC_1467|Compound:k284-1082|FD-Score:-3.57|P-value:1.86E-4 ID:SGTC_1472|Compound:k841-0093|FD-Score:3.38|P-value:3.82E-4 ID:SGTC_1676|Compound:st018489|FD-Score:3.25|P-value:5.98E-4 ID:SGTC_1733|Compound:st037357|FD-Score:3.46|P-value:2.88E-4 ID:SGTC_1771|Compound:st048882|FD-Score:4.42|P-value:5.34E-6 ID:SGTC_1775|Compound:st081588|FD-Score:3.17|P-value:7.87E-4 ID:SGTC_1851|Compound:st056236|FD-Score:3.60|P-value:1.70E-4 ID:SGTC_1854|Compound:st056233|FD-Score:-3.51|P-value:2.31E-4 ID:SGTC_1936|Compound:st074407|FD-Score:-5.22|P-value:9.68E-8 ID:SGTC_2035|Compound:5154463|FD-Score:3.21|P-value:6.93E-4 ID:SGTC_2068|Compound:5226020|FD-Score:3.88|P-value:5.55E-5 ID:SGTC_2088|Compound:5278280|FD-Score:3.13|P-value:9.14E-4 ID:SGTC_2099|Compound:5377090|FD-Score:-3.34|P-value:4.39E-4 ID:SGTC_2117|Compound:5521686|FD-Score:3.73|P-value:1.01E-4 ID:SGTC_2132|Compound:5317594|FD-Score:5.42|P-value:3.34E-8 ID:SGTC_2135|Compound:5326629|FD-Score:3.40|P-value:3.52E-4 ID:SGTC_2136|Compound:5328288|FD-Score:3.70|P-value:1.14E-4 ID:SGTC_2175|Compound:5807670|FD-Score:3.11|P-value:9.66E-4 ID:SGTC_2176|Compound:5809774|FD-Score:5.25|P-value:8.80E-8 ID:SGTC_2184|Compound:6075246|FD-Score:4.33|P-value:8.12E-6 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-3.13|P-value:8.94E-4 ID:SGTC_2291|Compound:7917025|FD-Score:3.23|P-value:6.60E-4 ID:SGTC_2373|Compound:9071805|FD-Score:3.47|P-value:2.80E-4 ID:SGTC_2381|Compound:9035592|FD-Score:3.16|P-value:8.15E-4 ID:SGTC_2382|Compound:9035899|FD-Score:5.02|P-value:2.93E-7 ID:SGTC_2405|Compound:ticlatone|FD-Score:-4.97|P-value:3.70E-7 ID:SGTC_2408|Compound:sulbentine|FD-Score:-3.99|P-value:3.54E-5 ID:SGTC_2412|Compound:st077135|FD-Score:12.30|P-value:1.04E-34 ID:SGTC_2419|Compound:paclitaxel|FD-Score:-3.67|P-value:1.25E-4 ID:SGTC_2431|Compound:5490079|FD-Score:3.18|P-value:7.84E-4 ID:SGTC_2435|Compound:5706476|FD-Score:4.39|P-value:6.26E-6 ID:SGTC_2455|Compound:5377712|FD-Score:3.71|P-value:1.12E-4 ID:SGTC_2461|Compound:5755302|FD-Score:3.72|P-value:1.05E-4 ID:SGTC_2700|Compound:st077718|FD-Score:-3.34|P-value:4.31E-4 ID:SGTC_2722|Compound:naftopidil|FD-Score:-3.18|P-value:7.71E-4 ID:SGTC_2903|Compound:5923464|FD-Score:4.02|P-value:3.07E-5 ID:SGTC_2994|Compound:9053520|FD-Score:3.10|P-value:9.99E-4 ID:SGTC_3000|Compound:9075062|FD-Score:3.72|P-value:1.08E-4 ID:SGTC_3033|Compound:9090887|FD-Score:3.40|P-value:3.55E-4 ID:SGTC_3037|Compound:9091026|FD-Score:-3.91|P-value:4.92E-5 ID:SGTC_3059|Compound:1327-0034|FD-Score:3.48|P-value:2.61E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-3.19|P-value:7.44E-4 ID:SGTC_3195|Compound:9113082|FD-Score:6.70|P-value:1.28E-11

Top fitness defect scores for YFR032C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2412 st077135 12.30 33.4 µM 1.04E-34 1 5.74E-35
2 SGTC_219 mitoxanthrone 9.39 164.4 µM 4.13E-21 DNA intercalators 10 2.89E-21
3 SGTC_3195 9113082 6.70 49.5 µM 1.28E-11 1 1.06E-11
4 SGTC_160 3453-0671 5.62 289.7 µM 1.11E-8 12 9.69E-9
5 SGTC_2132 5317594 5.42 122.7 µM 3.34E-8 SWF1 & branched chain AA biosynthesis 16 2.94E-8
6 SGTC_2176 5809774 5.25 34.0 µM 8.80E-8 mitochondrial processes 4 7.81E-8
7 SGTC_2382 9035899 5.02 200.0 µM 2.93E-7 60S ribosome export 8 2.63E-7
8 SGTC_997 3996-0078 4.97 137.0 µM 3.81E-7 7 3.42E-7
9 SGTC_118 0083-0097 4.61 135.3 µM 2.22E-6 translation 79 2.02E-6
10 SGTC_1160 4092-0570 4.59 10.5 µM 2.44E-6 plasma membrane duress 26 2.23E-6
11 SGTC_518 1021-0119 4.46 62.6 µM 4.56E-6 ERG2 24 4.17E-6
12 SGTC_1771 st048882 4.42 4.2 µM 5.34E-6 RPP1 & pyrimidine depletion 10 4.90E-6
13 SGTC_2435 5706476 4.39 10.6 µM 6.26E-6 19 5.74E-6
14 SGTC_2184 6075246 4.33 200.0 µM 8.12E-6 16 7.47E-6
15 SGTC_88 0180-0332 4.07 8.7 µM 2.52E-5 21 2.33E-5
16 SGTC_2903 5923464 4.02 63.9 µM 3.07E-5 7 2.85E-5
17 SGTC_991 3996-0057 4.00 64.7 µM 3.40E-5 18 3.16E-5
18 SGTC_471 1-acyl-paf 3.99 4.0 µM 3.62E-5 DNA intercalators 30 3.37E-5
19 SGTC_2068 5226020 3.88 147.0 µM 5.55E-5 32 5.18E-5
20 SGTC_732 3970-1727 3.79 52.7 µM 8.04E-5 11 7.53E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.126 2.24E-13 YDR406W PDR15 hom Plasma membrane ATP binding cassette (ABC) transporter, multidrug transporter and general stress response factor implicated in cellular detoxification; regulated by Pdr1p, Pdr3p and Pdr8p; promoter contains a PDR responsive element
0.119 3.73E-12 YBR169C SSE2 hom Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; SSE2 has a paralog, SSE1, that arose from the whole genome duplication
0.111 1.18E-10 YKL083W_d YKL083W_d het Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified essential gene RRP14
0.110 1.44E-10 YMR168C CEP3 het Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain
0.107 4.64E-10 YNR038W DBP6 het Essential protein involved in ribosome biogenesis; putative ATP-dependent RNA helicase of the DEAD-box protein family
0.106 7.94E-10 YPL262W FUM1 hom Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial distribution determined by the N-terminal targeting sequence, protein conformation, and status of glyoxylate shunt; phosphorylated in mitochondria
0.105 9.01E-10 YHL039W EFM1 hom Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.105 9.09E-10 YMR006C PLB2 hom Phospholipase B (lysophospholipase) involved in phospholipid metabolism; displays transacylase activity in vitro; overproduction confers resistance to lysophosphatidylcholine
0.100 6.16E-9 YOR076C SKI7 hom Coupling protein that mediates interactions between the Ski complex and the cytoplasmic exosome during 3'-5' RNA degradation; eRF3-like domain targets nonstop mRNA for degradation; null mutants have superkiller phenotype
0.099 9.86E-9 YMR162C DNF3 hom Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vesicles; localizes to the trans-Golgi network; likely involved in protein transport; type 4 P-type ATPase
0.097 1.60E-8 YMR166C_p YMR166C_p hom Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene
0.094 5.45E-8 YCR102C_p YCR102C_p hom Putative protein of unknown function, involved in copper metabolism; similar to C. carbonum toxD gene; member of the quinone oxidoreductase family
0.092 8.50E-8 YKL084W HOT13 hom Zinc-binding mitochondrial intermembrane space (IMS) protein involved in a disulfide relay system for IMS import of cysteine-containing proteins; binds Mia40p and stimulates its Erv1p-dependent oxidation, probably by sequestering zinc
0.092 8.57E-8 YHR159W_p TDA11_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; potential Cdc28p substrate; null mutant is sensitive to expression of the top1-T722A allele
0.092 8.70E-8 YDL224C WHI4 hom Putative RNA binding protein; regulates the cell size requirement for passage through Start and commitment to cell division; WHI4 has a paralog, WHI3, that arose from the whole genome duplication