YGL006W-A_p

Putative protein of unknown function; identified by SAGE

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL006W-A / YGL006W-A

Click on Significant Values for Screen Details ID:SGTC_65|Compound:0798-0905|FD-Score:4.75|P-value:1.50E-8 ID:SGTC_169|Compound:k015-0017|FD-Score:2.67|P-value:9.36E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:3.43|P-value:3.18E-5 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:3.01|P-value:2.23E-4 ID:SGTC_246|Compound:cycloheximide|FD-Score:3.15|P-value:1.17E-4 ID:SGTC_295|Compound:k015-0027|FD-Score:4.06|P-value:1.09E-6 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:3.38|P-value:4.00E-5 ID:SGTC_550|Compound:4123-0385|FD-Score:-3.01|P-value:2.06E-4 ID:SGTC_770|Compound:0389-1121|FD-Score:2.66|P-value:9.87E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:2.73|P-value:7.31E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:3.41|P-value:3.49E-5 ID:SGTC_1043|Compound:0916-0009|FD-Score:3.35|P-value:4.59E-5 ID:SGTC_1140|Compound:3229-1848|FD-Score:3.15|P-value:1.19E-4 ID:SGTC_1223|Compound:0764-0573|FD-Score:-4.25|P-value:3.10E-7 ID:SGTC_1249|Compound:0481-0015|FD-Score:-2.89|P-value:3.56E-4 ID:SGTC_1347|Compound:1493-0251|FD-Score:3.07|P-value:1.72E-4 ID:SGTC_1351|Compound:1496-0003|FD-Score:3.51|P-value:2.14E-5 ID:SGTC_1356|Compound:1502-0781|FD-Score:3.87|P-value:3.21E-6 ID:SGTC_1462|Compound:k081-0014|FD-Score:-2.88|P-value:3.73E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:-3.63|P-value:1.03E-5 ID:SGTC_1570|Compound:verbenone|FD-Score:3.41|P-value:3.56E-5 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:3.79|P-value:4.87E-6 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:-2.93|P-value:2.99E-4 ID:SGTC_1635|Compound:st007035|FD-Score:4.16|P-value:5.91E-7 ID:SGTC_1748|Compound:st037455|FD-Score:3.55|P-value:1.71E-5 ID:SGTC_1751|Compound:st044839|FD-Score:3.30|P-value:6.03E-5 ID:SGTC_1758|Compound:st042942|FD-Score:3.26|P-value:7.29E-5 ID:SGTC_1853|Compound:st056710|FD-Score:3.32|P-value:5.54E-5 ID:SGTC_2019|Compound:4016004|FD-Score:3.34|P-value:5.01E-5 ID:SGTC_2035|Compound:5154463|FD-Score:2.88|P-value:3.88E-4 ID:SGTC_2041|Compound:5107442|FD-Score:2.69|P-value:8.67E-4 ID:SGTC_2335|Compound:9018011|FD-Score:3.99|P-value:1.65E-6 ID:SGTC_2355|Compound:9061122|FD-Score:2.70|P-value:8.30E-4 ID:SGTC_2441|Compound:5730946|FD-Score:-2.79|P-value:5.25E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:2.73|P-value:7.19E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:-3.16|P-value:1.04E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-3.28|P-value:5.98E-5 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:-4.01|P-value:1.30E-6 ID:SGTC_2756|Compound:carbadox|FD-Score:-3.01|P-value:2.04E-4 ID:SGTC_2786|Compound:7743617|FD-Score:-2.94|P-value:2.79E-4 ID:SGTC_2787|Compound:5284540|FD-Score:3.69|P-value:8.46E-6 ID:SGTC_2812|Compound:7970281|FD-Score:-2.75|P-value:6.41E-4 ID:SGTC_2858|Compound:9025781|FD-Score:3.09|P-value:1.56E-4 ID:SGTC_2864|Compound:9034755|FD-Score:-3.19|P-value:9.20E-5 ID:SGTC_2867|Compound:9039098|FD-Score:-3.41|P-value:3.15E-5 ID:SGTC_2945|Compound:9067681|FD-Score:-2.68|P-value:8.45E-4 ID:SGTC_2988|Compound:9073640|FD-Score:2.86|P-value:4.30E-4 ID:SGTC_3015|Compound:9080845|FD-Score:2.96|P-value:2.81E-4 ID:SGTC_3327|Compound:9140648|FD-Score:3.09|P-value:1.56E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:4.75|P-value:1.50E-8 ID:SGTC_169|Compound:k015-0017|FD-Score:2.67|P-value:9.36E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:3.43|P-value:3.18E-5 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:3.01|P-value:2.23E-4 ID:SGTC_246|Compound:cycloheximide|FD-Score:3.15|P-value:1.17E-4 ID:SGTC_295|Compound:k015-0027|FD-Score:4.06|P-value:1.09E-6 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:3.38|P-value:4.00E-5 ID:SGTC_550|Compound:4123-0385|FD-Score:-3.01|P-value:2.06E-4 ID:SGTC_770|Compound:0389-1121|FD-Score:2.66|P-value:9.87E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:2.73|P-value:7.31E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:3.41|P-value:3.49E-5 ID:SGTC_1043|Compound:0916-0009|FD-Score:3.35|P-value:4.59E-5 ID:SGTC_1140|Compound:3229-1848|FD-Score:3.15|P-value:1.19E-4 ID:SGTC_1223|Compound:0764-0573|FD-Score:-4.25|P-value:3.10E-7 ID:SGTC_1249|Compound:0481-0015|FD-Score:-2.89|P-value:3.56E-4 ID:SGTC_1347|Compound:1493-0251|FD-Score:3.07|P-value:1.72E-4 ID:SGTC_1351|Compound:1496-0003|FD-Score:3.51|P-value:2.14E-5 ID:SGTC_1356|Compound:1502-0781|FD-Score:3.87|P-value:3.21E-6 ID:SGTC_1462|Compound:k081-0014|FD-Score:-2.88|P-value:3.73E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:-3.63|P-value:1.03E-5 ID:SGTC_1570|Compound:verbenone|FD-Score:3.41|P-value:3.56E-5 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:3.79|P-value:4.87E-6 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:-2.93|P-value:2.99E-4 ID:SGTC_1635|Compound:st007035|FD-Score:4.16|P-value:5.91E-7 ID:SGTC_1748|Compound:st037455|FD-Score:3.55|P-value:1.71E-5 ID:SGTC_1751|Compound:st044839|FD-Score:3.30|P-value:6.03E-5 ID:SGTC_1758|Compound:st042942|FD-Score:3.26|P-value:7.29E-5 ID:SGTC_1853|Compound:st056710|FD-Score:3.32|P-value:5.54E-5 ID:SGTC_2019|Compound:4016004|FD-Score:3.34|P-value:5.01E-5 ID:SGTC_2035|Compound:5154463|FD-Score:2.88|P-value:3.88E-4 ID:SGTC_2041|Compound:5107442|FD-Score:2.69|P-value:8.67E-4 ID:SGTC_2335|Compound:9018011|FD-Score:3.99|P-value:1.65E-6 ID:SGTC_2355|Compound:9061122|FD-Score:2.70|P-value:8.30E-4 ID:SGTC_2441|Compound:5730946|FD-Score:-2.79|P-value:5.25E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:2.73|P-value:7.19E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:-3.16|P-value:1.04E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-3.28|P-value:5.98E-5 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:-4.01|P-value:1.30E-6 ID:SGTC_2756|Compound:carbadox|FD-Score:-3.01|P-value:2.04E-4 ID:SGTC_2786|Compound:7743617|FD-Score:-2.94|P-value:2.79E-4 ID:SGTC_2787|Compound:5284540|FD-Score:3.69|P-value:8.46E-6 ID:SGTC_2812|Compound:7970281|FD-Score:-2.75|P-value:6.41E-4 ID:SGTC_2858|Compound:9025781|FD-Score:3.09|P-value:1.56E-4 ID:SGTC_2864|Compound:9034755|FD-Score:-3.19|P-value:9.20E-5 ID:SGTC_2867|Compound:9039098|FD-Score:-3.41|P-value:3.15E-5 ID:SGTC_2945|Compound:9067681|FD-Score:-2.68|P-value:8.45E-4 ID:SGTC_2988|Compound:9073640|FD-Score:2.86|P-value:4.30E-4 ID:SGTC_3015|Compound:9080845|FD-Score:2.96|P-value:2.81E-4 ID:SGTC_3327|Compound:9140648|FD-Score:3.09|P-value:1.56E-4

Top fitness defect scores for YGL006W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_65 0798-0905 4.75 35.0 µM 1.50E-8 calcium & mitochondrial duress 60 1.02E-6
2 SGTC_1635 st007035 4.16 42.4 µM 5.91E-7 202 1.56E-5
3 SGTC_295 k015-0027 4.06 31.0 µM 1.09E-6 PDR1 8 2.46E-5
4 SGTC_2335 9018011 3.99 154.2 µM 1.65E-6 25 3.34E-5
5 SGTC_1356 1502-0781 3.87 85.8 µM 3.21E-6 fatty acid desaturase (OLE1) 17 5.48E-5
6 SGTC_1575 cyproterone acetate 3.79 48.0 µM 4.87E-6 28 7.48E-5
7 SGTC_2787 5284540 3.69 71.4 µM 8.46E-6 36 1.13E-4
8 SGTC_1748 st037455 3.55 53.6 µM 1.71E-5 45 1.91E-4
9 SGTC_1351 1496-0003 3.51 46.5 µM 2.14E-5 29 2.25E-4
10 SGTC_236 1509-0011 3.43 5.3 µM 3.18E-5 425 3.02E-4
11 SGTC_1033 k072-0102 3.41 21.3 µM 3.49E-5 60S ribosome export 41 3.24E-4
12 SGTC_1570 verbenone 3.41 133.0 µM 3.56E-5 32 3.29E-4
13 SGTC_474 dl-dihydrosphingosine 3.38 5.0 µM 4.00E-5 57 3.59E-4
14 SGTC_1043 0916-0009 3.35 19.3 µM 4.59E-5 44 3.98E-4
15 SGTC_2019 4016004 3.34 108.0 µM 5.01E-5 54 4.25E-4
16 SGTC_1853 st056710 3.32 91.2 µM 5.54E-5 amide catabolism 52 4.58E-4
17 SGTC_1751 st044839 3.30 27.2 µM 6.03E-5 Golgi 24 4.88E-4
18 SGTC_1758 st042942 3.26 75.2 µM 7.29E-5 40 5.62E-4
19 SGTC_246 cycloheximide 3.15 667.0 µM 1.17E-4 39 8.03E-4
20 SGTC_1140 3229-1848 3.15 3.0 µM 1.19E-4 27 8.13E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.238 2.27E-44 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.238 2.32E-44 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.225 7.35E-40 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.224 3.15E-39 YGR183C QCR9 hom Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
0.219 1.09E-37 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.215 1.99E-36 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.214 4.44E-36 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.210 7.10E-35 YKL087C CYT2 hom Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1
0.208 4.41E-34 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.199 2.48E-31 YLL009C COX17 hom Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs
0.199 2.66E-31 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.197 9.37E-31 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.196 2.31E-30 YDR148C KGD2 hom Dihydrolipoyl transsuccinylase, component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA in the TCA cycle; phosphorylated
0.189 2.30E-28 YGL191W COX13 hom Subunit VIa of cytochrome c oxidase; present in a subclass of cytochrome c oxidase complexes that may have a role in mimimizing generation of reactive oxygen species; not essential for cytochrome c oxidase activity but may modulate activity in response to ATP; required for assembly of Rcf2p into cytochrome c oxidase - cytochrome bc1 supercomplexes
0.189 2.36E-28 YER058W PET117 hom Protein required for assembly of cytochrome c oxidase