YGL038C / OCH1

Mannosyltransferase of the cis-Golgi apparatus, initiates the polymannose outer chain elongation of N-linked oligosaccharides of glycoproteins

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL038C / OCH1

Click on Significant Values for Screen Details ID:SGTC_51|Compound:1013-0126|FD-Score:-5.04|P-value:3.45E-9 ID:SGTC_56|Compound:0957-0365|FD-Score:-2.84|P-value:3.65E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.87|P-value:1.03E-8 ID:SGTC_97|Compound:0535-0701|FD-Score:3.44|P-value:2.20E-4 ID:SGTC_111|Compound:0083-0039|FD-Score:-3.35|P-value:4.09E-5 ID:SGTC_754|Compound:3474-0146|FD-Score:3.60|P-value:1.09E-4 ID:SGTC_756|Compound:0508-1999|FD-Score:-3.22|P-value:7.24E-5 ID:SGTC_766|Compound:1391-0721|FD-Score:3.60|P-value:1.10E-4 ID:SGTC_770|Compound:0389-1121|FD-Score:-6.17|P-value:9.52E-13 ID:SGTC_772|Compound:k072-0172|FD-Score:3.73|P-value:6.33E-5 ID:SGTC_893|Compound:0958-0369|FD-Score:-5.28|P-value:6.94E-10 ID:SGTC_1134|Compound:3477-0009|FD-Score:3.82|P-value:4.17E-5 ID:SGTC_1404|Compound:3909-7820|FD-Score:-2.72|P-value:5.74E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:-2.58|P-value:9.89E-4 ID:SGTC_1521|Compound:st012942|FD-Score:3.20|P-value:5.79E-4 ID:SGTC_2079|Compound:5212404|FD-Score:3.12|P-value:7.62E-4 ID:SGTC_2082|Compound:5219693|FD-Score:3.06|P-value:9.62E-4 ID:SGTC_2093|Compound:5331342|FD-Score:3.46|P-value:2.01E-4 ID:SGTC_2094|Compound:5332512|FD-Score:3.59|P-value:1.16E-4 ID:SGTC_2150|Compound:5556613|FD-Score:3.28|P-value:4.24E-4 ID:SGTC_2196|Compound:6573537|FD-Score:3.43|P-value:2.29E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:4.47|P-value:1.63E-6 ID:SGTC_2292|Compound:7671323|FD-Score:3.90|P-value:2.92E-5 ID:SGTC_2330|Compound:7979373|FD-Score:-3.42|P-value:2.91E-5 ID:SGTC_2406|Compound:ethylparaben|FD-Score:4.04|P-value:1.51E-5 ID:SGTC_2443|Compound:5493264|FD-Score:3.06|P-value:9.50E-4 ID:SGTC_2455|Compound:5377712|FD-Score:3.42|P-value:2.35E-4 ID:SGTC_2532|Compound:xanthone|FD-Score:-2.68|P-value:6.86E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:3.87|P-value:3.33E-5 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:4.46|P-value:1.77E-6 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:3.54|P-value:1.42E-4 ID:SGTC_2623|Compound:humulene|FD-Score:3.56|P-value:1.34E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:-2.80|P-value:4.20E-4 ID:SGTC_2835|Compound:9006588|FD-Score:4.06|P-value:1.36E-5 ID:SGTC_2871|Compound:9038510|FD-Score:-2.87|P-value:3.15E-4 ID:SGTC_2880|Compound:9042983|FD-Score:-3.57|P-value:1.44E-5 ID:SGTC_2881|Compound:9058953|FD-Score:3.34|P-value:3.22E-4 ID:SGTC_2883|Compound:9059145|FD-Score:-3.01|P-value:1.79E-4 ID:SGTC_2897|Compound:9048598|FD-Score:3.89|P-value:2.99E-5 ID:SGTC_2966|Compound:9084041|FD-Score:3.95|P-value:2.23E-5 ID:SGTC_2980|Compound:9014342|FD-Score:-4.94|P-value:6.39E-9 ID:SGTC_2981|Compound:9013952|FD-Score:-5.19|P-value:1.25E-9 ID:SGTC_2996|Compound:9066192|FD-Score:3.98|P-value:1.95E-5 ID:SGTC_3090|Compound:9117696|FD-Score:3.23|P-value:5.12E-4 ID:SGTC_3126|Compound:9127922|FD-Score:-2.92|P-value:2.65E-4 ID:SGTC_3132|Compound:9126706|FD-Score:4.22|P-value:6.08E-6 ID:SGTC_3136|Compound:9095672|FD-Score:-2.62|P-value:8.35E-4 ID:SGTC_3184|Compound:9108758|FD-Score:3.12|P-value:7.63E-4 ID:SGTC_3185|Compound:9108267|FD-Score:3.54|P-value:1.45E-4 ID:SGTC_3199|Compound:9111318|FD-Score:-3.42|P-value:2.96E-5 ID:SGTC_3204|Compound:9114183|FD-Score:-4.96|P-value:5.71E-9 ID:SGTC_51|Compound:1013-0126|FD-Score:-5.04|P-value:3.45E-9 ID:SGTC_56|Compound:0957-0365|FD-Score:-2.84|P-value:3.65E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.87|P-value:1.03E-8 ID:SGTC_97|Compound:0535-0701|FD-Score:3.44|P-value:2.20E-4 ID:SGTC_111|Compound:0083-0039|FD-Score:-3.35|P-value:4.09E-5 ID:SGTC_754|Compound:3474-0146|FD-Score:3.60|P-value:1.09E-4 ID:SGTC_756|Compound:0508-1999|FD-Score:-3.22|P-value:7.24E-5 ID:SGTC_766|Compound:1391-0721|FD-Score:3.60|P-value:1.10E-4 ID:SGTC_770|Compound:0389-1121|FD-Score:-6.17|P-value:9.52E-13 ID:SGTC_772|Compound:k072-0172|FD-Score:3.73|P-value:6.33E-5 ID:SGTC_893|Compound:0958-0369|FD-Score:-5.28|P-value:6.94E-10 ID:SGTC_1134|Compound:3477-0009|FD-Score:3.82|P-value:4.17E-5 ID:SGTC_1404|Compound:3909-7820|FD-Score:-2.72|P-value:5.74E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:-2.58|P-value:9.89E-4 ID:SGTC_1521|Compound:st012942|FD-Score:3.20|P-value:5.79E-4 ID:SGTC_2079|Compound:5212404|FD-Score:3.12|P-value:7.62E-4 ID:SGTC_2082|Compound:5219693|FD-Score:3.06|P-value:9.62E-4 ID:SGTC_2093|Compound:5331342|FD-Score:3.46|P-value:2.01E-4 ID:SGTC_2094|Compound:5332512|FD-Score:3.59|P-value:1.16E-4 ID:SGTC_2150|Compound:5556613|FD-Score:3.28|P-value:4.24E-4 ID:SGTC_2196|Compound:6573537|FD-Score:3.43|P-value:2.29E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:4.47|P-value:1.63E-6 ID:SGTC_2292|Compound:7671323|FD-Score:3.90|P-value:2.92E-5 ID:SGTC_2330|Compound:7979373|FD-Score:-3.42|P-value:2.91E-5 ID:SGTC_2406|Compound:ethylparaben|FD-Score:4.04|P-value:1.51E-5 ID:SGTC_2443|Compound:5493264|FD-Score:3.06|P-value:9.50E-4 ID:SGTC_2455|Compound:5377712|FD-Score:3.42|P-value:2.35E-4 ID:SGTC_2532|Compound:xanthone|FD-Score:-2.68|P-value:6.86E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:3.87|P-value:3.33E-5 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:4.46|P-value:1.77E-6 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:3.54|P-value:1.42E-4 ID:SGTC_2623|Compound:humulene|FD-Score:3.56|P-value:1.34E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:-2.80|P-value:4.20E-4 ID:SGTC_2835|Compound:9006588|FD-Score:4.06|P-value:1.36E-5 ID:SGTC_2871|Compound:9038510|FD-Score:-2.87|P-value:3.15E-4 ID:SGTC_2880|Compound:9042983|FD-Score:-3.57|P-value:1.44E-5 ID:SGTC_2881|Compound:9058953|FD-Score:3.34|P-value:3.22E-4 ID:SGTC_2883|Compound:9059145|FD-Score:-3.01|P-value:1.79E-4 ID:SGTC_2897|Compound:9048598|FD-Score:3.89|P-value:2.99E-5 ID:SGTC_2966|Compound:9084041|FD-Score:3.95|P-value:2.23E-5 ID:SGTC_2980|Compound:9014342|FD-Score:-4.94|P-value:6.39E-9 ID:SGTC_2981|Compound:9013952|FD-Score:-5.19|P-value:1.25E-9 ID:SGTC_2996|Compound:9066192|FD-Score:3.98|P-value:1.95E-5 ID:SGTC_3090|Compound:9117696|FD-Score:3.23|P-value:5.12E-4 ID:SGTC_3126|Compound:9127922|FD-Score:-2.92|P-value:2.65E-4 ID:SGTC_3132|Compound:9126706|FD-Score:4.22|P-value:6.08E-6 ID:SGTC_3136|Compound:9095672|FD-Score:-2.62|P-value:8.35E-4 ID:SGTC_3184|Compound:9108758|FD-Score:3.12|P-value:7.63E-4 ID:SGTC_3185|Compound:9108267|FD-Score:3.54|P-value:1.45E-4 ID:SGTC_3199|Compound:9111318|FD-Score:-3.42|P-value:2.96E-5 ID:SGTC_3204|Compound:9114183|FD-Score:-4.96|P-value:5.71E-9

Top fitness defect scores for YGL038C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2247 cerulenin 4.47 830.0 nM 1.63E-6 11 3.84E-6
2 SGTC_2553 4-methylesculetin 4.46 85.1 µM 1.77E-6 11 4.13E-6
3 SGTC_3132 9126706 4.22 49.5 µM 6.08E-6 15 1.22E-5
4 SGTC_2835 9006588 4.06 71.4 µM 1.36E-5 36 2.48E-5
5 SGTC_2406 ethylparaben 4.04 405.7 µM 1.51E-5 34 2.72E-5
6 SGTC_2996 9066192 3.98 71.4 µM 1.95E-5 32 3.41E-5
7 SGTC_2966 9084041 3.95 48.0 µM 2.23E-5 32 3.85E-5
8 SGTC_2292 7671323 3.90 168.1 µM 2.92E-5 RNA processing & uracil transport 33 4.89E-5
9 SGTC_2897 9048598 3.89 13.0 µM 2.99E-5 16 4.99E-5
10 SGTC_2541 muurolladie-3-one 3.87 83.1 µM 3.33E-5 excess fatty acid 29 5.49E-5
11 SGTC_1134 3477-0009 3.82 42.5 µM 4.17E-5 49 6.69E-5
12 SGTC_772 k072-0172 3.73 35.3 µM 6.33E-5 22 9.69E-5
13 SGTC_754 3474-0146 3.60 171.0 µM 1.09E-4 copper-dependent oxidative stress 38 1.58E-4
14 SGTC_766 1391-0721 3.60 126.0 µM 1.10E-4 22 1.58E-4
15 SGTC_2094 5332512 3.59 191.7 µM 1.16E-4 35 1.66E-4
16 SGTC_2623 humulene 3.56 100.0 µM 1.34E-4 30 1.89E-4
17 SGTC_2595 hexamethylquercetagetin 3.54 100.0 µM 1.42E-4 40 1.99E-4
18 SGTC_3185 9108267 3.54 49.5 µM 1.45E-4 60S ribosome export 30 2.03E-4
19 SGTC_2093 5331342 3.46 194.4 µM 2.01E-4 34 2.71E-4
20 SGTC_97 0535-0701 3.44 19.1 µM 2.20E-4 60S ribosome export 28 2.94E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.103 2.20E-9 YKL074C MUD2 hom Protein involved in early pre-mRNA splicing; component of the pre-mRNA-U1 snRNP complex, the commitment complex; interacts with Msl5p/BBP splicing factor and Sub2p; similar to metazoan splicing factor U2AF65
0.096 2.36E-8 YGR113W DAM1 het Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; Ipl1p target for regulating kinetochore-MT attachments
0.096 2.58E-8 YIR007W_p YIR007W_p hom Putative glycosidase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YIR007W is a non-essential gene
0.087 4.89E-7 YAR007C RFA1 het Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination
0.087 5.02E-7 YMR269W TMA23 hom Nucleolar protein implicated in ribosome biogenesis; deletion extends chronological lifespan
0.082 2.05E-6 YOL143C RIB4 hom Lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, also known as DMRL synthase); catalyzes synthesis of immediate precursor to riboflavin
0.081 2.44E-6 YGR036C CAX4 hom Dolichyl pyrophosphate (Dol-P-P) phosphatase with a luminally oriented active site in the ER, cleaves the anhydride linkage in Dol-P-P, required for Dol-P-P-linked oligosaccharide intermediate synthesis and protein N-glycosylation
0.080 3.14E-6 YOR222W ODC2 hom Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for use in lysine and glutamate biosynthesis and in lysine catabolism
0.077 7.47E-6 YML025C YML6 het Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins
0.076 9.91E-6 YHR060W VMA22 hom Peripheral membrane protein that is required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the yeast endoplasmic reticulum (ER)
0.076 1.01E-5 YOL130W ALR1 het Plasma membrane Mg(2+) transporter, expression and turnover are regulated by Mg(2+) concentration; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions
0.075 1.37E-5 YLR240W VPS34 hom Phosphatidylinositol (PI) 3-kinase that synthesizes PI-3-phosphate; forms membrane-associated signal transduction complex with Vps15p to regulate protein sorting; activated by the GTP-bound form of Gpa1p; a fraction is localized, with Vps15p, to nuclear pores at nucleus-vacuole junctions and may facilitate transcription elongation for genes positioned at the nuclear periphery
0.075 1.43E-5 YIL115C NUP159 het FG-nucleoporin component of central core of the nuclear pore complex (NPC); also part of the NPC cytoplasmic filaments; contributes directly to nucleocytoplasmic transport; regulates ADP release from the ATP-dependent RNA helicase Dbp5p; forms a stable association with Nup82p, Gle2p and two other FG-nucleoporins (Nsp1p and Nup116p)
0.074 1.73E-5 YPR088C SRP54 het Signal recognition particle (SRP) subunit (homolog of mammalian SRP54); contains the signal sequence-binding activity of SRP, interacts with the SRP RNA, and mediates binding of SRP to signal receptor; contains GTPase domain
0.074 1.83E-5 YER007C-A TMA20 hom Protein of unknown function that associates with ribosomes; has a putative RNA binding domain; interacts with Tma22p; null mutant exhibits translation defects; has homology to human oncogene MCT-1; protein abundance increases in response to DNA replication stress