YGL039W

Oxidoreductase shown to reduce carbonyl compounds to chiral alcohols

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL039W / YGL039W

Click on Significant Values for Screen Details ID:SGTC_50|Compound:0929-0078|FD-Score:-3.17|P-value:1.80E-4 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:-2.80|P-value:8.30E-4 ID:SGTC_497|Compound:capsazepine|FD-Score:4.06|P-value:2.47E-6 ID:SGTC_505|Compound:gw-5074|FD-Score:3.01|P-value:3.52E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:-3.54|P-value:3.49E-5 ID:SGTC_548|Compound:1436-0017|FD-Score:2.86|P-value:6.51E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:2.81|P-value:7.93E-4 ID:SGTC_633|Compound:0437-0093|FD-Score:-3.29|P-value:1.11E-4 ID:SGTC_639|Compound:0833-0042|FD-Score:2.87|P-value:6.21E-4 ID:SGTC_735|Compound:3076-0345|FD-Score:3.35|P-value:8.34E-5 ID:SGTC_956|Compound:1185-0240|FD-Score:-2.78|P-value:9.07E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:2.91|P-value:5.37E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:2.88|P-value:6.09E-4 ID:SGTC_1446|Compound:4239-0190|FD-Score:-2.82|P-value:7.52E-4 ID:SGTC_1612|Compound:st002233|FD-Score:-2.80|P-value:8.12E-4 ID:SGTC_1623|Compound:st003709|FD-Score:-2.99|P-value:3.94E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:2.94|P-value:4.64E-4 ID:SGTC_1924|Compound:st058459|FD-Score:4.14|P-value:1.63E-6 ID:SGTC_1937|Compound:st074714|FD-Score:-3.74|P-value:1.31E-5 ID:SGTC_2048|Compound:5246248|FD-Score:3.53|P-value:3.65E-5 ID:SGTC_2219|Compound:9098279|FD-Score:3.09|P-value:2.53E-4 ID:SGTC_2260|Compound:7964312|FD-Score:3.15|P-value:1.95E-4 ID:SGTC_2308|Compound:7584454|FD-Score:3.28|P-value:1.13E-4 ID:SGTC_2316|Compound:5844804|FD-Score:2.91|P-value:5.27E-4 ID:SGTC_2442|Compound:5158906|FD-Score:2.99|P-value:3.82E-4 ID:SGTC_2447|Compound:5741742|FD-Score:3.32|P-value:9.57E-5 ID:SGTC_2693|Compound:st077581|FD-Score:3.30|P-value:1.02E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:-2.87|P-value:6.18E-4 ID:SGTC_2855|Compound:9016525|FD-Score:-2.88|P-value:5.95E-4 ID:SGTC_2898|Compound:9056270|FD-Score:2.92|P-value:5.22E-4 ID:SGTC_2899|Compound:9053889|FD-Score:3.71|P-value:1.49E-5 ID:SGTC_3005|Compound:9076496|FD-Score:-3.22|P-value:1.46E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:-3.17|P-value:1.80E-4 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:-2.80|P-value:8.30E-4 ID:SGTC_497|Compound:capsazepine|FD-Score:4.06|P-value:2.47E-6 ID:SGTC_505|Compound:gw-5074|FD-Score:3.01|P-value:3.52E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:-3.54|P-value:3.49E-5 ID:SGTC_548|Compound:1436-0017|FD-Score:2.86|P-value:6.51E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:2.81|P-value:7.93E-4 ID:SGTC_633|Compound:0437-0093|FD-Score:-3.29|P-value:1.11E-4 ID:SGTC_639|Compound:0833-0042|FD-Score:2.87|P-value:6.21E-4 ID:SGTC_735|Compound:3076-0345|FD-Score:3.35|P-value:8.34E-5 ID:SGTC_956|Compound:1185-0240|FD-Score:-2.78|P-value:9.07E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:2.91|P-value:5.37E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:2.88|P-value:6.09E-4 ID:SGTC_1446|Compound:4239-0190|FD-Score:-2.82|P-value:7.52E-4 ID:SGTC_1612|Compound:st002233|FD-Score:-2.80|P-value:8.12E-4 ID:SGTC_1623|Compound:st003709|FD-Score:-2.99|P-value:3.94E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:2.94|P-value:4.64E-4 ID:SGTC_1924|Compound:st058459|FD-Score:4.14|P-value:1.63E-6 ID:SGTC_1937|Compound:st074714|FD-Score:-3.74|P-value:1.31E-5 ID:SGTC_2048|Compound:5246248|FD-Score:3.53|P-value:3.65E-5 ID:SGTC_2219|Compound:9098279|FD-Score:3.09|P-value:2.53E-4 ID:SGTC_2260|Compound:7964312|FD-Score:3.15|P-value:1.95E-4 ID:SGTC_2308|Compound:7584454|FD-Score:3.28|P-value:1.13E-4 ID:SGTC_2316|Compound:5844804|FD-Score:2.91|P-value:5.27E-4 ID:SGTC_2442|Compound:5158906|FD-Score:2.99|P-value:3.82E-4 ID:SGTC_2447|Compound:5741742|FD-Score:3.32|P-value:9.57E-5 ID:SGTC_2693|Compound:st077581|FD-Score:3.30|P-value:1.02E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:-2.87|P-value:6.18E-4 ID:SGTC_2855|Compound:9016525|FD-Score:-2.88|P-value:5.95E-4 ID:SGTC_2898|Compound:9056270|FD-Score:2.92|P-value:5.22E-4 ID:SGTC_2899|Compound:9053889|FD-Score:3.71|P-value:1.49E-5 ID:SGTC_3005|Compound:9076496|FD-Score:-3.22|P-value:1.46E-4

Top fitness defect scores for YGL039W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1924 st058459 4.14 75.1 µM 1.63E-6 7 1.74E-5
2 SGTC_497 capsazepine 4.06 133.0 µM 2.47E-6 10 2.44E-5
3 SGTC_2899 9053889 3.71 58.4 µM 1.49E-5 14 1.02E-4
4 SGTC_2048 5246248 3.53 200.0 µM 3.65E-5 11 2.10E-4
5 SGTC_735 3076-0345 3.35 636.0 µM 8.34E-5 52 4.07E-4
6 SGTC_2447 5741742 3.32 33.8 µM 9.57E-5 52 4.55E-4
7 SGTC_2693 st077581 3.30 40.7 µM 1.02E-4 65 4.78E-4
8 SGTC_2308 7584454 3.28 197.6 µM 1.13E-4 55 5.21E-4
9 SGTC_2260 7964312 3.15 200.0 µM 1.95E-4 40 8.05E-4
10 SGTC_2219 9098279 3.09 200.0 µM 2.53E-4 19 9.93E-4
11 SGTC_505 gw-5074 3.01 63.9 µM 3.52E-4 95 0.00129
12 SGTC_2442 5158906 2.99 48.5 µM 3.82E-4 59 0.00138
13 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 2.94 70.1 µM 4.64E-4 94 0.00162
14 SGTC_2898 9056270 2.92 58.4 µM 5.22E-4 27 0.00178
15 SGTC_2316 5844804 2.91 197.4 µM 5.27E-4 106 0.00179
16 SGTC_996 3970-0799 2.91 1.8 µM 5.37E-4 167 0.00182
17 SGTC_1125 tnp00248 2.88 1.3 µM 6.09E-4 119 0.00201
18 SGTC_639 0833-0042 2.87 114.0 µM 6.21E-4 109 0.00204
19 SGTC_548 1436-0017 2.86 110.0 µM 6.51E-4 TSC3-RPN4 99 0.00212
20 SGTC_628 1636-0253 2.81 16.0 µM 7.93E-4 sphingolipid biosynthesis & PDR1 106 0.00249

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.136 2.71E-15 YDL171C GLT1 hom NAD(+)-dependent glutamate synthase (GOGAT), synthesizes glutamate from glutamine and alpha-ketoglutarate; with Gln1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source
0.127 1.59E-13 YPL277C_p YPL277C_p hom Putative protein of unknown function; localized to the membranes; gene expression regulated by copper levels
0.122 1.21E-12 YOL011W PLB3 hom Phospholipase B (lysophospholipase) involved in phospholipid metabolism; hydrolyzes phosphatidylinositol and phosphatidylserine and displays transacylase activity in vitro
0.112 6.70E-11 YBR064W_d YBR064W_d hom Dubious open reading frame unlikely to encode a protein; partially overlaps the uncharacterized ORF YBR063C
0.111 1.19E-10 YDR305C HNT2 hom Dinucleoside triphosphate hydrolase; has similarity to the tumor suppressor FHIT and belongs to the histidine triad (HIT) superfamily of nucleotide-binding proteins
0.102 3.85E-9 YIL002W-A_p YIL002W-A_p hom Putative protein of unknown function; identified by expression profiling and mass spectrometry
0.098 1.12E-8 YOR197W MCA1 hom Ca2+-dependent cysteine protease; may cleave specific substrates during the stress response; regulates apoptosis upon H2O2 treatment; required for clearance of insoluble protein aggregates during normal growth; implicated in cell cycle dynamics; undergoes autocatalytic processing; similar to mammalian metacaspases, but exists as a monomer due to an extra pair of anti-parallel beta-strands that form a continuous beta-sheet, blocking potential dimerization
0.096 2.41E-8 YGL037C PNC1 hom Nicotinamidase that converts nicotinamide to nicotinic acid; part of the NAD(+) salvage pathway; required for life span extension by calorie restriction; PNC1 expression responds to all known stimuli that extend replicative life span; protein increases in abundance and relative distribution to cytoplasmic foci decreases upon DNA replication stress
0.091 1.16E-7 YHR049W FSH1 hom Putative serine hydrolase that localizes to both the nucleus and cytoplasm; sequence is similar to S. cerevisiae Fsh2p and Fsh3p and the human candidate tumor suppressor OVCA2
0.091 1.40E-7 YCL076W_d YCL076W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.090 1.53E-7 YOR286W RDL2 hom Protein with rhodanese activity; contains a rhodanese-like domain similar to Rdl1p, Uba4p, Tum1p, and Ych1p; overexpression causes a cell cycle delay; null mutant displays elevated frequency of mitochondrial genome loss
0.090 1.82E-7 YIL051C MMF1 het Mitochondrial protein required for transamination of isoleucine but not of valine or leucine; may regulate specificity of branched-chain transaminases Bat1p and Bat2p; interacts genetically with mitochondrial ribosomal protein genes
0.089 2.21E-7 YER081W SER3 hom 3-phosphoglycerate dehydrogenase; catalyzes the first step in serine and glycine biosynthesis; SER3 has a paralog, SER33, that arose from the whole genome duplication
0.089 2.77E-7 YML116W ATR1 hom Multidrug efflux pump of the major facilitator superfamily; required for resistance to aminotriazole and 4-nitroquinoline-N-oxide; ATR1 has a paralog, YMR279C, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.088 3.01E-7 YGR149W_p YGR149W_p hom Putative protein of unknown function; predicted to be an integal membrane protein