HIPHOP chemogenomics database
YGL041C-B_p 
Putative protein of unknown function; identified by fungal homology and RT-PCR
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YGL041C-B deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.143 | 8.94E-17 | YMR313C | TGL3 | hom | Bifunctional enzyme with triacylglycerol lipase and lysophosphatidylethanolamine acyltransferase activity; responsible for all the triacylglycerol lipase activity of the lipid particle; required with Tgl4p for timely bud formation |
| 0.127 | 1.41E-13 | YGR295C | COS6 | hom | Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins |
| 0.120 | 2.60E-12 | YDR314C | RAD34 | hom | Protein involved in nucleotide excision repair (NER); homologous to RAD4 |
| 0.119 | 3.80E-12 | YMR020W | FMS1 | hom | Polyamine oxidase, converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis |
| 0.118 | 6.93E-12 | YOL019W-A_p | YOL019W-A_p | hom | Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching |
| 0.109 | 2.65E-10 | YDR382W | RPP2B | hom | Ribosomal protein P2 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm |
| 0.109 | 2.78E-10 | YLR129W | DIP2 | het | Nucleolar protein, specifically associated with the U3 snoRNA, part of the large ribonucleoprotein complex known as the small subunit (SSU) processome, required for 18S rRNA biogenesis, part of the active pre-rRNA processing complex |
| 0.107 | 5.07E-10 | YJR002W | MPP10 | het | Component of the SSU processome and 90S preribosome, required for pre-18S rRNA processing, interacts with and controls the stability of Imp3p and Imp4p, essential for viability; similar to human Mpp10p |
| 0.106 | 7.82E-10 | YDR322W | MRPL35 | hom | Mitochondrial ribosomal protein of the large subunit |
| 0.098 | 1.16E-8 | YGR041W | BUD9 | hom | Protein involved in bud-site selection; mutant has increased aneuploidy tolerance; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the distal pole |
| 0.097 | 1.59E-8 | YOL102C | TPT1 | het | tRNA 2'-phosphotransferase, catalyzes the final step in yeast tRNA splicing: the transfer of the 2'-PO(4) from the splice junction to NAD(+) to form ADP-ribose 1''-2''cyclic phosphate and nicotinamide |
| 0.097 | 1.91E-8 | YMR322C_p | SNO4_p | hom | Possible chaperone and cysteine protease, similar to bacterial Hsp31 and yeast Hsp31p, Hsp32p, and Hsp33p; DJ-1/ThiJ/PfpI superfamily member; predicted involvement in pyridoxine metabolism; induced by mild heat stress and copper deprivation |
| 0.096 | 2.86E-8 | YBL065W_d | YBL065W_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF SEF1/YBL066C; YBL065W is a non-essential gene |
| 0.096 | 2.54E-8 | YDL197C | ASF2 | hom | Anti-silencing protein that causes derepression of silent loci when overexpressed |
| 0.095 | 3.06E-8 | YFL014W | HSP12 | hom | Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension |