YGL062W / PYC1

Pyruvate carboxylase isoform; cytoplasmic enzyme that converts pyruvate to oxaloacetate; differentially regulated than isoform Pyc2p; mutations in the human homolog are associated with lactic acidosis; PYC1 has a paralog, PYC2, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL062W / PYC1

Click on Significant Values for Screen Details ID:SGTC_47|Compound:0149-0135|FD-Score:3.13|P-value:5.14E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:4.56|P-value:8.48E-7 ID:SGTC_115|Compound:0527-0192|FD-Score:4.57|P-value:8.07E-7 ID:SGTC_158|Compound:k038-0087|FD-Score:3.68|P-value:5.54E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:-3.03|P-value:6.77E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:3.25|P-value:3.25E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:3.20|P-value:4.03E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:4.08|P-value:9.42E-6 ID:SGTC_532|Compound:1548-0774|FD-Score:4.41|P-value:1.83E-6 ID:SGTC_566|Compound:0958-0068|FD-Score:3.54|P-value:1.02E-4 ID:SGTC_574|Compound:1315-0397|FD-Score:3.76|P-value:3.94E-5 ID:SGTC_654|Compound:1124-0271|FD-Score:-3.07|P-value:5.87E-4 ID:SGTC_663|Compound:1486-0733|FD-Score:2.98|P-value:8.82E-4 ID:SGTC_731|Compound:3966-0296|FD-Score:-2.97|P-value:8.59E-4 ID:SGTC_737|Compound:1950-0117|FD-Score:3.26|P-value:3.15E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:-3.36|P-value:1.96E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:4.77|P-value:2.71E-7 ID:SGTC_1028|Compound:k015-0029|FD-Score:3.34|P-value:2.31E-4 ID:SGTC_1120|Compound:ficusin|FD-Score:4.97|P-value:8.91E-8 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.76|P-value:4.04E-5 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-2.98|P-value:8.28E-4 ID:SGTC_1143|Compound:3454-2408|FD-Score:3.06|P-value:6.79E-4 ID:SGTC_1158|Compound:4092-0494|FD-Score:6.77|P-value:5.62E-13 ID:SGTC_1355|Compound:1499-0035|FD-Score:3.85|P-value:2.71E-5 ID:SGTC_1451|Compound:4152-0210|FD-Score:3.22|P-value:3.69E-4 ID:SGTC_1776|Compound:st049249|FD-Score:-3.36|P-value:1.97E-4 ID:SGTC_1800|Compound:st050079|FD-Score:-3.18|P-value:3.95E-4 ID:SGTC_1805|Compound:st050013|FD-Score:3.16|P-value:4.54E-4 ID:SGTC_1806|Compound:st050005|FD-Score:3.43|P-value:1.63E-4 ID:SGTC_1812|Compound:st052057|FD-Score:4.01|P-value:1.27E-5 ID:SGTC_1818|Compound:st052136|FD-Score:-3.56|P-value:8.58E-5 ID:SGTC_2024|Compound:5144227|FD-Score:-3.09|P-value:5.43E-4 ID:SGTC_2069|Compound:5228469|FD-Score:-3.69|P-value:4.97E-5 ID:SGTC_2242|Compound:6630449|FD-Score:-3.30|P-value:2.45E-4 ID:SGTC_2413|Compound:inermin|FD-Score:3.40|P-value:1.80E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:3.15|P-value:4.81E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:3.34|P-value:2.32E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:-3.57|P-value:8.32E-5 ID:SGTC_2601|Compound:securinine|FD-Score:-5.22|P-value:1.84E-8 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:3.11|P-value:5.53E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:3.77|P-value:3.77E-5 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:-3.21|P-value:3.47E-4 ID:SGTC_2780|Compound:5215298|FD-Score:3.23|P-value:3.51E-4 ID:SGTC_2808|Compound:7946468|FD-Score:3.42|P-value:1.67E-4 ID:SGTC_2849|Compound:9019321|FD-Score:3.89|P-value:2.21E-5 ID:SGTC_2855|Compound:9016525|FD-Score:3.00|P-value:8.35E-4 ID:SGTC_2906|Compound:7926292|FD-Score:4.20|P-value:5.19E-6 ID:SGTC_2970|Compound:9090938|FD-Score:4.03|P-value:1.16E-5 ID:SGTC_3006|Compound:9075424|FD-Score:2.99|P-value:8.53E-4 ID:SGTC_3025|Compound:9087895|FD-Score:4.39|P-value:2.04E-6 ID:SGTC_3027|Compound:9089541|FD-Score:-4.24|P-value:3.83E-6 ID:SGTC_3029|Compound:9088683|FD-Score:-3.05|P-value:6.37E-4 ID:SGTC_3050|Compound:9093513|FD-Score:-3.78|P-value:3.36E-5 ID:SGTC_3057|Compound:9095946|FD-Score:3.40|P-value:1.82E-4 ID:SGTC_3061|Compound:glucosamine|FD-Score:-3.03|P-value:6.83E-4 ID:SGTC_3072|Compound:9116419|FD-Score:3.64|P-value:6.73E-5 ID:SGTC_3179|Compound:9107801|FD-Score:3.12|P-value:5.33E-4 ID:SGTC_47|Compound:0149-0135|FD-Score:3.13|P-value:5.14E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:4.56|P-value:8.48E-7 ID:SGTC_115|Compound:0527-0192|FD-Score:4.57|P-value:8.07E-7 ID:SGTC_158|Compound:k038-0087|FD-Score:3.68|P-value:5.54E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:-3.03|P-value:6.77E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:3.25|P-value:3.25E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:3.20|P-value:4.03E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:4.08|P-value:9.42E-6 ID:SGTC_532|Compound:1548-0774|FD-Score:4.41|P-value:1.83E-6 ID:SGTC_566|Compound:0958-0068|FD-Score:3.54|P-value:1.02E-4 ID:SGTC_574|Compound:1315-0397|FD-Score:3.76|P-value:3.94E-5 ID:SGTC_654|Compound:1124-0271|FD-Score:-3.07|P-value:5.87E-4 ID:SGTC_663|Compound:1486-0733|FD-Score:2.98|P-value:8.82E-4 ID:SGTC_731|Compound:3966-0296|FD-Score:-2.97|P-value:8.59E-4 ID:SGTC_737|Compound:1950-0117|FD-Score:3.26|P-value:3.15E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:-3.36|P-value:1.96E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:4.77|P-value:2.71E-7 ID:SGTC_1028|Compound:k015-0029|FD-Score:3.34|P-value:2.31E-4 ID:SGTC_1120|Compound:ficusin|FD-Score:4.97|P-value:8.91E-8 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.76|P-value:4.04E-5 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-2.98|P-value:8.28E-4 ID:SGTC_1143|Compound:3454-2408|FD-Score:3.06|P-value:6.79E-4 ID:SGTC_1158|Compound:4092-0494|FD-Score:6.77|P-value:5.62E-13 ID:SGTC_1355|Compound:1499-0035|FD-Score:3.85|P-value:2.71E-5 ID:SGTC_1451|Compound:4152-0210|FD-Score:3.22|P-value:3.69E-4 ID:SGTC_1776|Compound:st049249|FD-Score:-3.36|P-value:1.97E-4 ID:SGTC_1800|Compound:st050079|FD-Score:-3.18|P-value:3.95E-4 ID:SGTC_1805|Compound:st050013|FD-Score:3.16|P-value:4.54E-4 ID:SGTC_1806|Compound:st050005|FD-Score:3.43|P-value:1.63E-4 ID:SGTC_1812|Compound:st052057|FD-Score:4.01|P-value:1.27E-5 ID:SGTC_1818|Compound:st052136|FD-Score:-3.56|P-value:8.58E-5 ID:SGTC_2024|Compound:5144227|FD-Score:-3.09|P-value:5.43E-4 ID:SGTC_2069|Compound:5228469|FD-Score:-3.69|P-value:4.97E-5 ID:SGTC_2242|Compound:6630449|FD-Score:-3.30|P-value:2.45E-4 ID:SGTC_2413|Compound:inermin|FD-Score:3.40|P-value:1.80E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:3.15|P-value:4.81E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:3.34|P-value:2.32E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:-3.57|P-value:8.32E-5 ID:SGTC_2601|Compound:securinine|FD-Score:-5.22|P-value:1.84E-8 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:3.11|P-value:5.53E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:3.77|P-value:3.77E-5 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:-3.21|P-value:3.47E-4 ID:SGTC_2780|Compound:5215298|FD-Score:3.23|P-value:3.51E-4 ID:SGTC_2808|Compound:7946468|FD-Score:3.42|P-value:1.67E-4 ID:SGTC_2849|Compound:9019321|FD-Score:3.89|P-value:2.21E-5 ID:SGTC_2855|Compound:9016525|FD-Score:3.00|P-value:8.35E-4 ID:SGTC_2906|Compound:7926292|FD-Score:4.20|P-value:5.19E-6 ID:SGTC_2970|Compound:9090938|FD-Score:4.03|P-value:1.16E-5 ID:SGTC_3006|Compound:9075424|FD-Score:2.99|P-value:8.53E-4 ID:SGTC_3025|Compound:9087895|FD-Score:4.39|P-value:2.04E-6 ID:SGTC_3027|Compound:9089541|FD-Score:-4.24|P-value:3.83E-6 ID:SGTC_3029|Compound:9088683|FD-Score:-3.05|P-value:6.37E-4 ID:SGTC_3050|Compound:9093513|FD-Score:-3.78|P-value:3.36E-5 ID:SGTC_3057|Compound:9095946|FD-Score:3.40|P-value:1.82E-4 ID:SGTC_3061|Compound:glucosamine|FD-Score:-3.03|P-value:6.83E-4 ID:SGTC_3072|Compound:9116419|FD-Score:3.64|P-value:6.73E-5 ID:SGTC_3179|Compound:9107801|FD-Score:3.12|P-value:5.33E-4

Top fitness defect scores for YGL062W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1158 4092-0494 6.77 91.8 µM 5.62E-13 1 6.34E-12
2 SGTC_1120 ficusin 4.97 1.8 µM 8.91E-8 7 3.30E-7
3 SGTC_996 3970-0799 4.77 1.8 µM 2.71E-7 59 9.06E-7
4 SGTC_115 0527-0192 4.57 112.0 µM 8.07E-7 47 2.44E-6
5 SGTC_114 0364-0001 4.56 490.3 µM 8.48E-7 29 2.55E-6
6 SGTC_532 1548-0774 4.41 215.0 µM 1.83E-6 11 5.13E-6
7 SGTC_3025 9087895 4.39 49.5 µM 2.04E-6 PDR1 31 5.68E-6
8 SGTC_2906 7926292 4.20 26.4 µM 5.19E-6 19 1.33E-5
9 SGTC_513 4245-1575 4.08 41.7 µM 9.42E-6 unfolded protein response 107 2.28E-5
10 SGTC_2970 9090938 4.03 41.9 µM 1.16E-5 RNA processing & uracil transport 36 2.76E-5
11 SGTC_1812 st052057 4.01 4.3 µM 1.27E-5 calcium & mitochondrial duress 22 2.99E-5
12 SGTC_2849 9019321 3.89 13.0 µM 2.21E-5 31 4.94E-5
13 SGTC_1355 1499-0035 3.85 1.7 µM 2.71E-5 19 5.97E-5
14 SGTC_2730 imipramine 3.77 71.3 µM 3.77E-5 32 8.04E-5
15 SGTC_574 1315-0397 3.76 40.0 µM 3.94E-5 40 8.38E-5
16 SGTC_1125 tnp00248 3.76 1.3 µM 4.04E-5 35 8.57E-5
17 SGTC_158 k038-0087 3.68 26.4 µM 5.54E-5 ubiquinone biosynthesis & proteasome 159 1.14E-4
18 SGTC_3072 9116419 3.64 49.5 µM 6.73E-5 ERG2 26 1.36E-4
19 SGTC_566 0958-0068 3.54 16.5 µM 1.02E-4 RSC & ERG11 28 2.00E-4
20 SGTC_1806 st050005 3.43 60.3 µM 1.63E-4 30 3.06E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.187 8.33E-28 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.141 2.66E-16 YDL072C YET3 hom Protein of unknown function; YET3 null mutant decreases the level of secreted invertase; homolog of human BAP31 protein; protein abundance increases in response to DNA replication stress
0.130 5.29E-14 YGL040C HEM2 het Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus
0.127 1.49E-13 YDL099W BUG1 hom Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
0.126 2.85E-13 YLR394W CST9 hom SUMO E3 ligase; required for synaptonemal complex formation; localizes to synapsis initiation sites on meiotic chromosomes; potential Cdc28p substrate
0.126 2.96E-13 YLL001W DNM1 hom Dynamin-related GTPase required for mitochondrial fission and morphology; assembles on the cytoplasmic face of mitochondrial tubules at sites at which division will occur; also participates in endocytosis and regulating peroxisome abundance
0.118 6.40E-12 YGR035C_p YGR035C_p hom Putative protein of unknown function, potential Cdc28p substrate; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance
0.114 4.05E-11 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.112 9.92E-11 YNR033W ABZ1 hom Para-aminobenzoate (PABA) synthase; has similarity to Escherichia coli PABA synthase components PabA and PabB; required for the synthesis of para-aminobenzoic acid, an important intermediate for folate and ubiquinone Q biosynthesis; protein abundance increases in response to DNA replication stress
0.108 3.20E-10 YBR067C TIP1 hom Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins
0.107 5.80E-10 YDL186W_p YDL186W_p hom Putative protein of unknown function; YDL186W is not an essential gene
0.106 8.46E-10 YNR011C PRP2 het RNA-dependent ATPase in the DEAH-box family, required for activation of the spliceosome before the first transesterification step in RNA splicing; orthologous to human protein DHX16
0.104 1.49E-9 YJL149W DAS1 hom Putative SCF ubiquitin ligase F-box protein; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C
0.103 2.14E-9 YGL222C EDC1 hom RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress
0.102 3.57E-9 YJR127C RSF2 hom Zinc-finger protein; involved in transcriptional control of both nuclear and mitochondrial genes, many of which specify products required for glycerol-based growth, respiration, and other functions; RSF2 has a paralog, TDA9, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasm upon DNA replication stress