HIPHOP chemogenomics database

YGL083W / SCY1

Putative kinase, suppressor of GTPase mutant, similar to bovine rhodopsin kinase

Zygosity: Homozygous strain

fixedexpanded
Profile for YGL083W / SCY1

Click on Significant Values for Screen Details

Top fitness defect scores for YGL083W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_996	3970-0799	14.30	1.8 µM	2.29E-56		6	2.04E-46
2	SGTC_1714	st033236	9.27	13.6 µM	6.09E-25		1	9.46E-21
3	SGTC_1818	st052136	6.05	56.3 µM	1.18E-11	NEO1-PIK1	13	7.17E-10
4	SGTC_1754	st042065	6.02	16.1 µM	1.52E-11	NEO1-PIK1	99	8.86E-10
5	SGTC_3152	9099253	5.71	49.5 µM	1.42E-10	NEO1-PIK1	63	5.56E-9
6	SGTC_445	e6 berbamine	5.41	66.0 µM	1.14E-9	NEO1-PIK1	43	3.07E-8
7	SGTC_2932	9016711	5.32	44.5 µM	2.11E-9		20	5.10E-8
8	SGTC_3037	9091026	5.19	49.5 µM	5.18E-9	NEO1-PIK1	69	1.06E-7
9	SGTC_1333	1482-0047	4.95	286.0 µM	2.44E-8		8	3.81E-7
10	SGTC_221	trifluoperazine	4.82	10.3 µM	5.14E-8	NEO1-PIK1	170	7.04E-7
11	SGTC_689	0833-0039	4.56	98.0 µM	2.43E-7	ergosterol depletion effects on membrane	23	2.53E-6
12	SGTC_1330	1469-0054	4.31	61.8 µM	9.89E-7	iron homeostasis	11	8.05E-6
13	SGTC_998	3996-0085	4.29	177.0 µM	1.11E-6		12	8.83E-6
14	SGTC_1949	st076024	4.20	69.1 µM	1.87E-6		17	1.36E-5
15	SGTC_1924	st058459	4.10	75.1 µM	3.16E-6		8	2.10E-5
16	SGTC_3207	9114163	3.80	49.5 µM	1.39E-5		33	7.15E-5
17	SGTC_408	cantharidin	3.78	100.0 µM	1.53E-5	cell wall signaling	27	7.73E-5
18	SGTC_2693	st077581	3.78	40.7 µM	1.54E-5		42	7.77E-5
19	SGTC_1895	st058434	3.68	18.3 µM	2.56E-5		18	1.18E-4
20	SGTC_3065	9113888	3.65	49.5 µM	2.97E-5		33	1.34E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.461	1.17E-175	YML118W	NGL3	hom	3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.353	5.41E-99	YDR505C	PSP1	hom	Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.332	2.57E-87	YDL099W	BUG1	hom	Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
0.307	4.14E-74	YGL222C	EDC1	hom	RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress
0.305	3.53E-73	YGL040C	HEM2	het	Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus
0.292	8.72E-67	YOR037W	CYC2	hom	Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
0.255	5.40E-51	YGL205W	POX1	hom	Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix
0.238	2.25E-44	YDL186W_p	YDL186W_p	hom	Putative protein of unknown function; YDL186W is not an essential gene
0.232	2.55E-42	YBR067C	TIP1	hom	Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins
0.231	9.27E-42	YNR033W	ABZ1	hom	Para-aminobenzoate (PABA) synthase; has similarity to Escherichia coli PABA synthase components PabA and PabB; required for the synthesis of para-aminobenzoic acid, an important intermediate for folate and ubiquinone Q biosynthesis; protein abundance increases in response to DNA replication stress
0.231	1.07E-41	YDL177C_p	YDL177C_p	hom	Putative protein of unknown function; similar to the mouse IMPACT gene; YDL177C is not an essential gene
0.225	9.53E-40	YGR035C_p	YGR035C_p	hom	Putative protein of unknown function, potential Cdc28p substrate; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance
0.215	1.80E-36	YGL077C	HNM1	hom	Choline/ethanolamine transporter; involved in the uptake of nitrogen mustard and the uptake of glycine betaine during hypersaline stress; co-regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo-inositol
0.214	6.12E-36	YJR014W	TMA22	hom	Protein of unknown function; associates with ribosomes and has a putative RNA binding domain; interacts with Tma20p; similar to human GRAP and human DRP1, which interacts with human Tma20p homolog MCT-1; protein abundance increases in response to DNA replication stress
0.214	6.07E-36	YJL149W	DAS1	hom	Putative SCF ubiquitin ligase F-box protein; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C