YGL089C / MF(ALPHA)2

Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)1, which is more highly expressed than MF(ALPHA)2

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL089C / MF(ALPHA)2

Click on Significant Values for Screen Details ID:SGTC_38|Compound:0929-0051|FD-Score:3.04|P-value:7.53E-4 ID:SGTC_223|Compound:busulfan|FD-Score:3.00|P-value:8.88E-4 ID:SGTC_264|Compound:promethazine|FD-Score:3.05|P-value:7.34E-4 ID:SGTC_569|Compound:4130-2812|FD-Score:3.40|P-value:1.94E-4 ID:SGTC_707|Compound:0865-0008|FD-Score:-4.55|P-value:9.99E-7 ID:SGTC_710|Compound:3448-4187|FD-Score:6.69|P-value:1.51E-12 ID:SGTC_748|Compound:0136-0228|FD-Score:-3.52|P-value:1.15E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:3.62|P-value:8.12E-5 ID:SGTC_949|Compound:1165-0505|FD-Score:-2.99|P-value:8.79E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:4.08|P-value:1.03E-5 ID:SGTC_955|Compound:1216-0110|FD-Score:3.29|P-value:3.03E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:3.64|P-value:7.34E-5 ID:SGTC_1029|Compound:k015-0030|FD-Score:3.02|P-value:8.05E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:3.72|P-value:5.24E-5 ID:SGTC_1091|Compound:telmisartan|FD-Score:3.18|P-value:4.53E-4 ID:SGTC_1279|Compound:0874-0590|FD-Score:3.06|P-value:7.03E-4 ID:SGTC_1299|Compound:1079-1439|FD-Score:4.49|P-value:1.42E-6 ID:SGTC_1337|Compound:1486-1011|FD-Score:3.68|P-value:6.12E-5 ID:SGTC_1530|Compound:rhein|FD-Score:3.46|P-value:1.54E-4 ID:SGTC_2019|Compound:4016004|FD-Score:4.08|P-value:1.03E-5 ID:SGTC_2085|Compound:5307070|FD-Score:-3.09|P-value:6.20E-4 ID:SGTC_2115|Compound:tiliquinol|FD-Score:4.14|P-value:7.66E-6 ID:SGTC_2308|Compound:7584454|FD-Score:4.42|P-value:1.98E-6 ID:SGTC_2394|Compound:5221648|FD-Score:3.85|P-value:2.93E-5 ID:SGTC_2399|Compound:5884133|FD-Score:5.55|P-value:3.51E-9 ID:SGTC_2401|Compound:5128683|FD-Score:-4.67|P-value:5.45E-7 ID:SGTC_2403|Compound:6032726|FD-Score:4.30|P-value:3.55E-6 ID:SGTC_2408|Compound:sulbentine|FD-Score:-3.03|P-value:7.58E-4 ID:SGTC_2511|Compound:berberine|FD-Score:-3.21|P-value:3.99E-4 ID:SGTC_2528|Compound:xanthyletin|FD-Score:5.83|P-value:5.85E-10 ID:SGTC_2537|Compound:larixol|FD-Score:-3.59|P-value:8.82E-5 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:3.23|P-value:3.83E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:5.32|P-value:1.44E-8 ID:SGTC_2612|Compound:dictamnine|FD-Score:4.53|P-value:1.15E-6 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:3.65|P-value:7.11E-5 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:-3.62|P-value:7.61E-5 ID:SGTC_2827|Compound:7993847|FD-Score:4.21|P-value:5.68E-6 ID:SGTC_2830|Compound:7992007|FD-Score:2.97|P-value:9.91E-4 ID:SGTC_2836|Compound:9010338|FD-Score:4.19|P-value:6.28E-6 ID:SGTC_2851|Compound:9015922|FD-Score:-2.96|P-value:9.81E-4 ID:SGTC_2869|Compound:9037858|FD-Score:4.32|P-value:3.32E-6 ID:SGTC_2871|Compound:9038510|FD-Score:3.41|P-value:1.86E-4 ID:SGTC_2874|Compound:9043904|FD-Score:3.02|P-value:8.04E-4 ID:SGTC_2959|Compound:9079155|FD-Score:-3.55|P-value:1.05E-4 ID:SGTC_3006|Compound:9075424|FD-Score:3.14|P-value:5.30E-4 ID:SGTC_3033|Compound:9090887|FD-Score:3.85|P-value:2.99E-5 ID:SGTC_3068|Compound:9116768|FD-Score:-3.13|P-value:5.27E-4 ID:SGTC_3078|Compound:9116413|FD-Score:3.15|P-value:5.07E-4 ID:SGTC_3137|Compound:9097352|FD-Score:4.96|P-value:1.15E-7 ID:SGTC_3263|Compound:9137018|FD-Score:3.32|P-value:2.66E-4 ID:SGTC_3332|Compound:9141069|FD-Score:4.24|P-value:4.93E-6 ID:SGTC_38|Compound:0929-0051|FD-Score:3.04|P-value:7.53E-4 ID:SGTC_223|Compound:busulfan|FD-Score:3.00|P-value:8.88E-4 ID:SGTC_264|Compound:promethazine|FD-Score:3.05|P-value:7.34E-4 ID:SGTC_569|Compound:4130-2812|FD-Score:3.40|P-value:1.94E-4 ID:SGTC_707|Compound:0865-0008|FD-Score:-4.55|P-value:9.99E-7 ID:SGTC_710|Compound:3448-4187|FD-Score:6.69|P-value:1.51E-12 ID:SGTC_748|Compound:0136-0228|FD-Score:-3.52|P-value:1.15E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:3.62|P-value:8.12E-5 ID:SGTC_949|Compound:1165-0505|FD-Score:-2.99|P-value:8.79E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:4.08|P-value:1.03E-5 ID:SGTC_955|Compound:1216-0110|FD-Score:3.29|P-value:3.03E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:3.64|P-value:7.34E-5 ID:SGTC_1029|Compound:k015-0030|FD-Score:3.02|P-value:8.05E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:3.72|P-value:5.24E-5 ID:SGTC_1091|Compound:telmisartan|FD-Score:3.18|P-value:4.53E-4 ID:SGTC_1279|Compound:0874-0590|FD-Score:3.06|P-value:7.03E-4 ID:SGTC_1299|Compound:1079-1439|FD-Score:4.49|P-value:1.42E-6 ID:SGTC_1337|Compound:1486-1011|FD-Score:3.68|P-value:6.12E-5 ID:SGTC_1530|Compound:rhein|FD-Score:3.46|P-value:1.54E-4 ID:SGTC_2019|Compound:4016004|FD-Score:4.08|P-value:1.03E-5 ID:SGTC_2085|Compound:5307070|FD-Score:-3.09|P-value:6.20E-4 ID:SGTC_2115|Compound:tiliquinol|FD-Score:4.14|P-value:7.66E-6 ID:SGTC_2308|Compound:7584454|FD-Score:4.42|P-value:1.98E-6 ID:SGTC_2394|Compound:5221648|FD-Score:3.85|P-value:2.93E-5 ID:SGTC_2399|Compound:5884133|FD-Score:5.55|P-value:3.51E-9 ID:SGTC_2401|Compound:5128683|FD-Score:-4.67|P-value:5.45E-7 ID:SGTC_2403|Compound:6032726|FD-Score:4.30|P-value:3.55E-6 ID:SGTC_2408|Compound:sulbentine|FD-Score:-3.03|P-value:7.58E-4 ID:SGTC_2511|Compound:berberine|FD-Score:-3.21|P-value:3.99E-4 ID:SGTC_2528|Compound:xanthyletin|FD-Score:5.83|P-value:5.85E-10 ID:SGTC_2537|Compound:larixol|FD-Score:-3.59|P-value:8.82E-5 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:3.23|P-value:3.83E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:5.32|P-value:1.44E-8 ID:SGTC_2612|Compound:dictamnine|FD-Score:4.53|P-value:1.15E-6 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:3.65|P-value:7.11E-5 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:-3.62|P-value:7.61E-5 ID:SGTC_2827|Compound:7993847|FD-Score:4.21|P-value:5.68E-6 ID:SGTC_2830|Compound:7992007|FD-Score:2.97|P-value:9.91E-4 ID:SGTC_2836|Compound:9010338|FD-Score:4.19|P-value:6.28E-6 ID:SGTC_2851|Compound:9015922|FD-Score:-2.96|P-value:9.81E-4 ID:SGTC_2869|Compound:9037858|FD-Score:4.32|P-value:3.32E-6 ID:SGTC_2871|Compound:9038510|FD-Score:3.41|P-value:1.86E-4 ID:SGTC_2874|Compound:9043904|FD-Score:3.02|P-value:8.04E-4 ID:SGTC_2959|Compound:9079155|FD-Score:-3.55|P-value:1.05E-4 ID:SGTC_3006|Compound:9075424|FD-Score:3.14|P-value:5.30E-4 ID:SGTC_3033|Compound:9090887|FD-Score:3.85|P-value:2.99E-5 ID:SGTC_3068|Compound:9116768|FD-Score:-3.13|P-value:5.27E-4 ID:SGTC_3078|Compound:9116413|FD-Score:3.15|P-value:5.07E-4 ID:SGTC_3137|Compound:9097352|FD-Score:4.96|P-value:1.15E-7 ID:SGTC_3263|Compound:9137018|FD-Score:3.32|P-value:2.66E-4 ID:SGTC_3332|Compound:9141069|FD-Score:4.24|P-value:4.93E-6

Top fitness defect scores for YGL089C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_710 3448-4187 6.69 58.0 µM 1.51E-12 fatty acid desaturase (OLE1) 14 1.15E-11
2 SGTC_2528 xanthyletin 5.83 44.8 µM 5.85E-10 6 2.75E-9
3 SGTC_2399 5884133 5.55 200.0 µM 3.51E-9 cell wall signaling 33 1.43E-8
4 SGTC_2539 epi(13)torulosol 5.32 80.0 µM 1.44E-8 7 5.26E-8
5 SGTC_3137 9097352 4.96 49.5 µM 1.15E-7 18 3.54E-7
6 SGTC_2612 dictamnine 4.53 15.5 µM 1.15E-6 RNA pol III & RNase P/MRP 30 2.97E-6
7 SGTC_1299 1079-1439 4.49 3.7 µM 1.42E-6 TSC3-RPN4 6 3.58E-6
8 SGTC_2308 7584454 4.42 197.6 µM 1.98E-6 14 4.89E-6
9 SGTC_2869 9037858 4.32 32.5 µM 3.32E-6 9 7.87E-6
10 SGTC_2403 6032726 4.30 181.2 µM 3.55E-6 30 8.37E-6
11 SGTC_3332 9141069 4.24 11.2 µM 4.93E-6 9 1.13E-5
12 SGTC_2827 7993847 4.21 71.4 µM 5.68E-6 17 1.29E-5
13 SGTC_2836 9010338 4.19 19.5 µM 6.28E-6 RPP1 & pyrimidine depletion 21 1.41E-5
14 SGTC_2115 tiliquinol 4.14 12.8 µM 7.66E-6 7 1.70E-5
15 SGTC_2019 4016004 4.08 108.0 µM 1.03E-5 29 2.23E-5
16 SGTC_951 1171-0579 4.08 82.7 µM 1.03E-5 cell wall 72 2.23E-5
17 SGTC_2394 5221648 3.85 200.0 µM 2.93E-5 25 5.84E-5
18 SGTC_3033 9090887 3.85 49.5 µM 2.99E-5 fatty acid desaturase (OLE1) 27 5.97E-5
19 SGTC_1036 k216-0215 3.72 33.5 µM 5.24E-5 mitochondrial response to ROS 59 1.00E-4
20 SGTC_1337 1486-1011 3.68 40.3 µM 6.12E-5 22 1.15E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.147 1.30E-17 YBR290W BSD2 hom Heavy metal ion homeostasis protein, facilitates trafficking of Smf1p and Smf2p metal transporters to the vacuole where they are degraded, controls metal ion transport, prevents metal hyperaccumulation, functions in copper detoxification
0.112 7.94E-11 YIL029C_p YIL029C_p hom Putative protein of unknown function; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); YIL029C has paralog YPR071W
0.110 1.84E-10 YMR244C-A COA6 hom Protein involved in cytochrome c oxidase assembly; also required for efficient formation of respiratory supercomplexes comprised of Complexes III and IV; localizes to the mitochondrial intermembrane space; has a human homolog; transcription is induced in response to the DNA-damaging agent MMS; protein abundance increases in response to DNA replication stress
0.094 4.78E-8 YMR306W FKS3 hom Protein involved in spore wall assembly, has similarity to 1,3-beta-D-glucan synthase catalytic subunits Fks1p and Gsc2p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.093 6.23E-8 YBL091C MAP2 hom Methionine aminopeptidase, catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map1p
0.092 1.04E-7 YDL231C BRE4 hom Zinc finger protein containing five transmembrane domains; null mutant exhibits strongly fragmented vacuoles and sensitivity to brefeldin A, a drug which is known to affect intracellular transport
0.090 1.63E-7 YBR260C RGD1 hom GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization
0.086 6.67E-7 YPL057C SUR1 hom Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p; SUR1 has a paralog, CSH1, that arose from the whole genome duplication
0.085 7.06E-7 YBR128C ATG14 hom Autophagy-specific subunit of phosphatidylinositol 3-kinase complex I (with Vps34/15/30p); Atg14p targets complex I to the phagophore assembly site (PAS); required for localizing additional ATG proteins to the PAS; required for overflow degradation of misfolded proteins when ERAD is saturated; homolog of human Barkor
0.085 8.34E-7 YBL058W SHP1 hom UBX (ubiquitin regulatory X) domain-containing protein that regulates Glc7p phosphatase activity and interacts with Cdc48p; interacts with ubiquitylated proteins in vivo and is required for degradation of a ubiquitylated model substrate
0.085 8.91E-7 YJL183W MNN11 hom Subunit of a Golgi mannosyltransferase complex that also contains Anp1p, Mnn9p, Mnn10p, and Hoc1p, and mediates elongation of the polysaccharide mannan backbone; has homology to Mnn10p
0.084 1.11E-6 YAL053W FLC2 hom Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance; FLC2 has a paralog, YOR365C, that arose from the whole genome duplication
0.084 1.17E-6 YJL105W SET4 hom Protein of unknown function, contains a SET domain; SET4 has a paralog, SET3, that arose from the whole genome duplication
0.083 1.49E-6 YDR211W GCD6 het Catalytic epsilon subunit of the translation initiation factor eIF2B; eIF2B is the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression; forms cytoplasmic foci upon DNA replication stress
0.082 1.87E-6 YBR217W ATG12 hom Conserved ubiquitin-like modifier involved in autophagy and the Cvt pathway; conjugated to Atg5p to form a complex involved in Atg8p lipidation; Atg12p-Atg5p also forms a complex with Atg16p that is required for autophagosome formation