YGL101W_p

Putative protein of unknown function; non-essential gene with similarity to YBR242W; interacts with the DNA helicase Hpr5p

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL101W / YGL101W

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:-3.30|P-value:6.59E-4 ID:SGTC_61|Compound:0978-8327|FD-Score:-3.21|P-value:8.67E-4 ID:SGTC_300|Compound:r073-0011|FD-Score:3.21|P-value:8.23E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:4.21|P-value:1.85E-5 ID:SGTC_717|Compound:1532-0246|FD-Score:-3.38|P-value:4.90E-4 ID:SGTC_777|Compound:1315-0167|FD-Score:3.34|P-value:5.22E-4 ID:SGTC_781|Compound:4335-2806|FD-Score:3.60|P-value:2.04E-4 ID:SGTC_837|Compound:0091-0265|FD-Score:3.33|P-value:5.34E-4 ID:SGTC_896|Compound:0964-0007|FD-Score:3.98|P-value:4.77E-5 ID:SGTC_928|Compound:2764-0428|FD-Score:3.49|P-value:3.02E-4 ID:SGTC_938|Compound:3126-1755|FD-Score:-3.26|P-value:7.42E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:-3.54|P-value:2.79E-4 ID:SGTC_995|Compound:3931-2021|FD-Score:4.24|P-value:1.57E-5 ID:SGTC_998|Compound:3996-0085|FD-Score:-4.19|P-value:2.23E-5 ID:SGTC_1029|Compound:k015-0030|FD-Score:3.52|P-value:2.80E-4 ID:SGTC_1180|Compound:1193-0155|FD-Score:3.25|P-value:7.08E-4 ID:SGTC_1284|Compound:0929-0043|FD-Score:-3.21|P-value:8.73E-4 ID:SGTC_1293|Compound:1000-1278|FD-Score:4.27|P-value:1.40E-5 ID:SGTC_1628|Compound:st004252|FD-Score:3.64|P-value:1.75E-4 ID:SGTC_1916|Compound:st067606|FD-Score:-3.29|P-value:6.82E-4 ID:SGTC_1935|Compound:st074532|FD-Score:-3.69|P-value:1.59E-4 ID:SGTC_2004|Compound:4023728|FD-Score:-4.13|P-value:2.81E-5 ID:SGTC_2061|Compound:5245884|FD-Score:-3.59|P-value:2.30E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:-3.48|P-value:3.50E-4 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:3.30|P-value:6.06E-4 ID:SGTC_2796|Compound:7949634|FD-Score:-3.30|P-value:6.47E-4 ID:SGTC_2987|Compound:9018338|FD-Score:3.25|P-value:7.21E-4 ID:SGTC_3051|Compound:9093778|FD-Score:3.39|P-value:4.33E-4 ID:SGTC_3057|Compound:9095946|FD-Score:3.68|P-value:1.52E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.30|P-value:6.59E-4 ID:SGTC_61|Compound:0978-8327|FD-Score:-3.21|P-value:8.67E-4 ID:SGTC_300|Compound:r073-0011|FD-Score:3.21|P-value:8.23E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:4.21|P-value:1.85E-5 ID:SGTC_717|Compound:1532-0246|FD-Score:-3.38|P-value:4.90E-4 ID:SGTC_777|Compound:1315-0167|FD-Score:3.34|P-value:5.22E-4 ID:SGTC_781|Compound:4335-2806|FD-Score:3.60|P-value:2.04E-4 ID:SGTC_837|Compound:0091-0265|FD-Score:3.33|P-value:5.34E-4 ID:SGTC_896|Compound:0964-0007|FD-Score:3.98|P-value:4.77E-5 ID:SGTC_928|Compound:2764-0428|FD-Score:3.49|P-value:3.02E-4 ID:SGTC_938|Compound:3126-1755|FD-Score:-3.26|P-value:7.42E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:-3.54|P-value:2.79E-4 ID:SGTC_995|Compound:3931-2021|FD-Score:4.24|P-value:1.57E-5 ID:SGTC_998|Compound:3996-0085|FD-Score:-4.19|P-value:2.23E-5 ID:SGTC_1029|Compound:k015-0030|FD-Score:3.52|P-value:2.80E-4 ID:SGTC_1180|Compound:1193-0155|FD-Score:3.25|P-value:7.08E-4 ID:SGTC_1284|Compound:0929-0043|FD-Score:-3.21|P-value:8.73E-4 ID:SGTC_1293|Compound:1000-1278|FD-Score:4.27|P-value:1.40E-5 ID:SGTC_1628|Compound:st004252|FD-Score:3.64|P-value:1.75E-4 ID:SGTC_1916|Compound:st067606|FD-Score:-3.29|P-value:6.82E-4 ID:SGTC_1935|Compound:st074532|FD-Score:-3.69|P-value:1.59E-4 ID:SGTC_2004|Compound:4023728|FD-Score:-4.13|P-value:2.81E-5 ID:SGTC_2061|Compound:5245884|FD-Score:-3.59|P-value:2.30E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:-3.48|P-value:3.50E-4 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:3.30|P-value:6.06E-4 ID:SGTC_2796|Compound:7949634|FD-Score:-3.30|P-value:6.47E-4 ID:SGTC_2987|Compound:9018338|FD-Score:3.25|P-value:7.21E-4 ID:SGTC_3051|Compound:9093778|FD-Score:3.39|P-value:4.33E-4 ID:SGTC_3057|Compound:9095946|FD-Score:3.68|P-value:1.52E-4

Top fitness defect scores for YGL101W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1293 1000-1278 4.27 195.0 µM 1.40E-5 7 9.71E-6
2 SGTC_995 3931-2021 4.24 34.6 µM 1.57E-5 RPP1 & pyrimidine depletion 19 1.09E-5
3 SGTC_304 1310-0298 4.21 97.0 µM 1.85E-5 cell wall 54 1.30E-5
4 SGTC_896 0964-0007 3.98 44.5 µM 4.77E-5 15 3.49E-5
5 SGTC_3057 9095946 3.68 49.5 µM 1.52E-4 Golgi 19 1.17E-4
6 SGTC_1628 st004252 3.64 77.7 µM 1.75E-4 30 1.35E-4
7 SGTC_781 4335-2806 3.60 94.4 µM 2.04E-4 30 1.58E-4
8 SGTC_1029 k015-0030 3.52 64.7 µM 2.80E-4 45 2.20E-4
9 SGTC_928 2764-0428 3.49 58.7 µM 3.02E-4 cell wall 76 2.38E-4
10 SGTC_3051 9093778 3.39 49.5 µM 4.33E-4 8 3.45E-4
11 SGTC_777 1315-0167 3.34 517.0 µM 5.22E-4 Golgi 46 4.19E-4
12 SGTC_837 0091-0265 3.33 12.5 µM 5.34E-4 ubiquinone biosynthesis & proteasome 41 4.30E-4
13 SGTC_2635 hydroquinidine 3.30 100.0 µM 6.06E-4 40 4.90E-4
14 SGTC_1180 1193-0155 3.25 285.0 µM 7.08E-4 40 5.76E-4
15 SGTC_2987 9018338 3.25 71.4 µM 7.21E-4 RPP1 & pyrimidine depletion 51 5.86E-4
16 SGTC_300 r073-0011 3.21 5.0 µM 8.23E-4 47 6.73E-4
17 SGTC_690 glyoxal 3.11 20.3 µM 0.00112 138 9.29E-4
18 SGTC_2712 st079126 3.08 47.7 µM 0.00124 48 0.00103
19 SGTC_1375 2910-0797 3.07 186.0 µM 0.00128 58 0.00106
20 SGTC_2633 5,7-dihydroxyisoflavone 2.86 100.0 µM 0.00248 78 0.00211

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.131 2.41E-14 YLR319C BUD6 hom Actin- and formin-interacting protein; stimulates actin cable nucleation by recruiting actin monomers to Bni1p; involved in polarized cell growth; isolated as bipolar budding mutant; potential Cdc28p substrate
0.131 2.95E-14 YLR173W_p YLR173W_p hom Putative protein of unknown function
0.119 3.97E-12 YPL036W PMA2 hom Plasma membrane H+-ATPase, isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential
0.116 1.44E-11 YLR028C ADE16 hom Enzyme of 'de novo' purine biosynthesis; contains both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities; ADE16 has a paralog, ADE17, that arose from the whole genome duplication; ade16 ade17 mutants require adenine and histidine
0.115 2.39E-11 YDR099W BMH2 hom 14-3-3 protein, minor isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress
0.107 4.89E-10 YKR034W DAL80 hom Negative regulator of genes in multiple nitrogen degradation pathways; expression is regulated by nitrogen levels and by Gln3p; member of the GATA-binding family, forms homodimers and heterodimers with Gzf3p; DAL80 has a paralog, GZF3, that arose from the whole genome duplication
0.105 1.11E-9 YGL145W TIP20 het Peripheral membrane protein required for fusion of COPI vesicles with the ER; prohibits back-fusion of COPII vesicles with the ER; forms a tethering complex with Sec39p and Dsl1p that interacts with ER SNAREs Sec20p and Use1p
0.102 3.11E-9 YMR275C BUL1 hom Ubiquitin-binding component of the Rsp5p E3-ubiquitin ligase complex; disruption causes temperature-sensitive growth, overexpression causes missorting of amino acid permeases; BUL1 has a paralog, BUL2, that arose from the whole genome duplication
0.100 6.94E-9 YKL094W YJU3 hom Monoglyceride lipase (MGL), functional ortholog of mammalian MGL, localizes to lipid particles and membranes, also member of the eukaryotic serine hydrolase family
0.095 3.53E-8 YJR092W BUD4 hom Anillin-like protein involved in bud-site selection; required for the axial budding pattern; localizes with septins to the bud neck in mitosis and may constitute an axial landmark for the next round of budding; required for the formation and disassembly of the double septin ring structure, and generally for septin organization; in vivo substrate of Cdc28p/Clb2p
0.094 5.01E-8 YGR275W RTT102 hom Component of both the SWI/SNF and RSC chromatin remodeling complexes; suggested role in chromosome maintenance; possible weak regulator of Ty1 transposition; protein abundance increases in response to DNA replication stress
0.093 6.02E-8 YGL245W GUS1 het Glutamyl-tRNA synthetase (GluRS); forms a complex with methionyl-tRNA synthetase (Mes1p) and Arc1p; complex formation increases the catalytic efficiency of both tRNA synthetases and ensures their correct localization to the cytoplasm; protein abundance increases in response to DNA replication stress
0.089 2.11E-7 YMR041C ARA2 hom NAD-dependent arabinose dehydrogenase, involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase
0.088 3.02E-7 YGR190C_d YGR190C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene HIP1/YGR191W
0.086 6.37E-7 YIL046W-A_p YIL046W-A_p hom Putative protein of unknown function; identified by expression profiling and mass spectrometry